Affiliation: Harvard University
Otterbein L. The evolution of carbon monoxide into medicine. Respir Care. 2009;54:925-32 pubmed
..CO's mechanisms of action at the cellular level depend on the disease and the experimental focus, but the one constant is that CO reestablishes homeostasis. ..
Xie A, Robles R, Mukherjee S, Zhang H, Feldbrügge L, Csizmadia E, et al
. HIF-1α-induced xenobiotic transporters promote Th17 responses in Crohn's disease. J Autoimmun. 2018;94:122-133 pubmed publisher
..Targeting HIF-1α-ABC transporters could provide innovative therapeutic pathways for IBD. ..
Zheng Y, Ji X, Yu B, Ji K, Gallo D, Csizmadia E, et al
. Enrichment-triggered prodrug activation demonstrated through mitochondria-targeted delivery of doxorubicin and carbon monoxide. Nat Chem. 2018;: pubmed publisher
..Taken together, these two 'click and release' pairs clearly demonstrate the concept of enrichment-triggered drug release and the critical feasibility of treating clinically relevant diseases such as acute liver injury and cancer. ..
Wegiel B, Hauser C, Otterbein L. Heme as a danger molecule in pathogen recognition. Free Radic Biol Med. 2015;89:651-61 pubmed publisher
..We discuss this intimate communication that occurs between host and bacteria and how these molecules serve as critical regulators of the acute inflammatory response, the overall redox status of the cell, and survival of the host. ..
Correa Costa M, Gallo D, Csizmadia E, Gomperts E, Lieberum J, Hauser C, et al
. Carbon monoxide protects the kidney through the central circadian clock and CD39. Proc Natl Acad Sci U S A. 2018;115:E2302-E2310 pubmed publisher
..As CO also increases serum EPO levels in human volunteers, these findings continue to support therapeutic use of CO to treat IRI in association with organ transplantation, stroke, and myocardial infarction. ..
Schallner N, Lieberum J, Gallo D, LeBlanc R, Fuller P, Hanafy K, et al
. Carbon Monoxide Preserves Circadian Rhythm to Reduce the Severity of Subarachnoid Hemorrhage in Mice. Stroke. 2017;48:2565-2573 pubmed publisher
..Exposure to CO rescues the loss of HO-1 and thus merits further investigation in patients with SAH. ..