A M O'Reilly

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Structural determinants of SHP-2 function and specificity in Xenopus mesoderm induction
    A M O'Reilly
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Mol Cell Biol 18:161-77. 1998
  2. pmc Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2
    E S Oh
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Cell Biol 19:3205-15. 1999
  3. ncbi request reprint SHPS-1 is a scaffold for assembling distinct adhesion-regulated multi-protein complexes in macrophages
    J F Timms
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Curr Biol 9:927-30. 1999
  4. pmc Lack of SHPTP1 results in src-family kinase hyperactivation and thymocyte hyperresponsiveness
    U Lorenz
    Molecular Medicine Unit, Beth Israel Hospital, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 93:9624-9. 1996
  5. ncbi request reprint Divergent roles of SHP-2 in ERK activation by leptin receptors
    C Bjørbaek
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Biol Chem 276:4747-55. 2001
  6. ncbi request reprint From form to function: signaling by protein tyrosine phosphatases
    N K Tonks
    Cold Spring Harbor Laboratory, New York 11724 2208, USA
    Cell 87:365-8. 1996
  7. ncbi request reprint The B-cell transmembrane protein CD72 binds to and is an in vivo substrate of the protein tyrosine phosphatase SHP-1
    Y Wu
    Program in Molecular Biology, Mount Sinai Hospital, University of Toronto, Ontario, Canada
    Curr Biol 8:1009-17. 1998
  8. ncbi request reprint Role of the tyrosine phosphatase SHP-1 in K562 cell differentiation
    B Bruecher-Encke
    Department of Medicine, Beth Israel-Deaconess Medical Center, Boston, MA, USA
    Leukemia 15:1424-32. 2001
  9. pmc Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1
    M David
    Division of Cytokine Biology, Center for Biologics Evaluation and Research, Bethesda, Maryland 20892, USA
    Mol Cell Biol 15:7050-8. 1995
  10. ncbi request reprint Protein tyrosine phosphatases in signal transduction
    B G Neel
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, HIM 1047, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Curr Opin Cell Biol 9:193-204. 1997

Collaborators

Detail Information

Publications43

  1. pmc Structural determinants of SHP-2 function and specificity in Xenopus mesoderm induction
    A M O'Reilly
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Mol Cell Biol 18:161-77. 1998
    ..Thus, PTP domains exhibit biologically relevant specificity in vivo, and noncatalytic and catalytic domains of PTPs contribute to specificity in a combinatorial fashion...
  2. pmc Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2
    E S Oh
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Cell Biol 19:3205-15. 1999
    ....
  3. ncbi request reprint SHPS-1 is a scaffold for assembling distinct adhesion-regulated multi-protein complexes in macrophages
    J F Timms
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Curr Biol 9:927-30. 1999
    ..Other inhibitory immunoreceptors might have similar scaffold-like functions...
  4. pmc Lack of SHPTP1 results in src-family kinase hyperactivation and thymocyte hyperresponsiveness
    U Lorenz
    Molecular Medicine Unit, Beth Israel Hospital, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 93:9624-9. 1996
    ..Taken together, our data suggest that SHPTP1 is an important negative regulator of TCR signaling, acting at least in part to inactivate Lck and Fyn...
  5. ncbi request reprint Divergent roles of SHP-2 in ERK activation by leptin receptors
    C Bjørbaek
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Biol Chem 276:4747-55. 2001
    ..SHP-2 is thus a positive regulator of ERK by leptin receptors, and both the adaptor function and the phosphatase activity of SHP-2 are critical for this regulation...
  6. ncbi request reprint From form to function: signaling by protein tyrosine phosphatases
    N K Tonks
    Cold Spring Harbor Laboratory, New York 11724 2208, USA
    Cell 87:365-8. 1996
  7. ncbi request reprint The B-cell transmembrane protein CD72 binds to and is an in vivo substrate of the protein tyrosine phosphatase SHP-1
    Y Wu
    Program in Molecular Biology, Mount Sinai Hospital, University of Toronto, Ontario, Canada
    Curr Biol 8:1009-17. 1998
    ..Moreover, direct substrates of SHP-1 have not been identified in any B-cell signaling pathway...
  8. ncbi request reprint Role of the tyrosine phosphatase SHP-1 in K562 cell differentiation
    B Bruecher-Encke
    Department of Medicine, Beth Israel-Deaconess Medical Center, Boston, MA, USA
    Leukemia 15:1424-32. 2001
    ....
  9. pmc Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1
    M David
    Division of Cytokine Biology, Center for Biologics Evaluation and Research, Bethesda, Maryland 20892, USA
    Mol Cell Biol 15:7050-8. 1995
    ..Our results establish that SHPTP1 selectively regulates distinct components of Jak/Stat signal transduction pathways in vivo...
  10. ncbi request reprint Protein tyrosine phosphatases in signal transduction
    B G Neel
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, HIM 1047, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Curr Opin Cell Biol 9:193-204. 1997
    ..Finally, progress has been made in understanding signaling by Src homology 2 domain containing PTPs and PTPs controlling yeast osmoregulatory pathways...
  11. ncbi request reprint Role of phosphatases in lymphocyte activation
    B G Neel
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, HIM 1047, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Curr Opin Immunol 9:405-20. 1997
    ..Progress has also been made in elucidating the function and targets of specific nontransmembrane PTPs, particularly those with Src homology 2 domains...
  12. pmc New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
    L C Cantley
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 96:4240-5. 1999
    ..PTEN appears to negatively control the phosphoinositide 3-kinase signaling pathway for regulation of cell growth and survival by dephosphorylating the 3 position of phosphoinositides...
  13. ncbi request reprint Essential role for Gab2 in the allergic response
    H Gu
    Cancer Biology Program, Division of Hematology and Oncology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 412:186-90. 2001
    ..Gab2 and/or its associated signalling molecules may be new targets for developing drugs to treat allergy...
  14. ncbi request reprint Protein-tyrosine phosphatase SHP-1 is dispensable for FcgammaRIIB-mediated inhibition of B cell antigen receptor activation
    M J Nadler
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Biol Chem 272:20038-43. 1997
    ..FcgammaRIIB-mediated CD19 dephosphorylation also occurs in the presence or the absence of SHP-1. Our results establish that SHP-1 is dispensable for FcgammaRIIB-mediated inhibition of sIgM antigen receptor signaling...
  15. pmc Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistance
    J M Zabolotny
    Division of Endocrinology and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 98:5187-92. 2001
    ..Our data suggest that increased expression and/or activity of LAR or related PTPs in insulin target tissues of obese humans may contribute to the pathogenesis of insulin resistance...
  16. ncbi request reprint Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation
    H Gu
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell 2:729-40. 1998
    ..Our results identify p97 as an important regulator of receptor signaling that controls a novel pathway to immediate-early gene activation and suggest multiple functions for SHP2 in cytokine receptor signaling...
  17. ncbi request reprint Receptor-type protein-tyrosine phosphatase mu is expressed in specific vascular endothelial beds in vivo
    C Bianchi
    Cancer Biology Program, Department of Medicine, Department of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, 02215, USA
    Exp Cell Res 248:329-38. 1999
    ..Our results identify RPTPmu as a new marker of endothelial cell heterogeneity and suggest a possible role in endothelial-specific functions, involving cell-cell contact...
  18. pmc Identification of major binding proteins and substrates for the SH2-containing protein tyrosine phosphatase SHP-1 in macrophages
    J F Timms
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Cell Biol 18:3838-50. 1998
    ..Our data suggest that BIT and PIR-B recruit multiple signaling molecules to receptor complexes, where they are regulated by SHP-1 and/or SHP-2...
  19. pmc New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway
    H Gu
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 20:7109-20. 2000
    ..Our results suggest that cytokine receptors lacking direct PI-3K binding sites activate Akt via a Shc/Grb2/Gab2/PI-3K pathway, thereby regulating cell survival and/or proliferation...
  20. ncbi request reprint Characterization of two SHP-2-associated binding proteins and potential substrates in hematopoietic cells
    H Gu
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 272:16421-30. 1997
    ..Our results indicate that SHP-2 forms at least two separate complexes in hematopoietic cells and point to new potential SHP-2 targets...
  21. pmc Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew
    R M Freeman
    Committee on Virology, Harvard University, Boston, MA 02115
    Proc Natl Acad Sci U S A 89:11239-43. 1992
    ....
  22. ncbi request reprint Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals
    U Klingmuller
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142
    Cell 80:729-38. 1995
    ..Our results suggest that activation of SH-PTP1 by binding to the EPO-R plays a major role in terminating proliferative signals...
  23. ncbi request reprint A common epitope is shared by activated signal transducer and activator of transcription-5 (STAT5) and the phosphorylated erythropoietin receptor: implications for the docking model of STAT activation
    D L Barber
    Division of Cellular and Molecular Biology, Ontario Cancer Institute, Toronto, Canada
    Blood 97:2230-7. 2001
    ..These data uncover a novel aspect of STAT SH2 domain recognition and demonstrate the utility of activation-specific antibodies for examining the specificity of STAT-cytokine receptor interactions...
  24. pmc Activated mutants of SHP-2 preferentially induce elongation of Xenopus animal caps
    A M O'Reilly
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts
    Mol Cell Biol 20:299-311. 2000
    ..Our activated mutants also may be useful for determining the specific functions of SHP-2 in other signaling systems...
  25. pmc Multiple requirements for SHPTP2 in epidermal growth factor-mediated cell cycle progression
    A M Bennett
    Molecular Medicine Unit, Beth Israel Hospital, Boston, Massachusetts, USA
    Mol Cell Biol 16:1189-202. 1996
    ..Therefore, SHPTP2 is absolutely required for immediate-early and late events induced by some, but not all, growth factors, and the immediate-early and late signal transduction pathways regulated by SHPTP2 are distinguishable...
  26. ncbi request reprint The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development
    T L Tang
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Beth Israel Hospital, Boston, Massachusetts 02215
    Cell 80:473-83. 1995
    ..Our results indicate that SH-PTP2 is required for early vertebrate development, acting as a positive component in FGF signaling downstream of the FGF receptor and upstream of MAP kinase...
  27. pmc Tyrosine phosphorylation of the proto-oncoprotein Raf-1 is regulated by Raf-1 itself and the phosphatase Cdc25A
    K Xia
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 19:4819-24. 1999
    ..These data suggest that the tyrosine phosphorylation of Raf-1 is regulated not only by itself but also by Cdc25A...
  28. pmc Lck-dependent tyrosyl phosphorylation of the phosphotyrosine phosphatase SH-PTP1 in murine T cells
    U Lorenz
    Molecular Medicine Unit, Beth Israel Hospital, Boston, Massachusetts 02215
    Mol Cell Biol 14:1824-34. 1994
    ..One of these sites (Y-564) is phosphorylated in T cells in response to Lck activation. We conclude that SH-PTP1 undergoes Lck-dependent tyrosyl phosphorylation in T cells and likely plays a role in early T-cell signaling...
  29. pmc Regulation of in vitro and in vivo immune functions by the cytosolic adaptor protein SKAP-HOM
    M Togni
    Institute of Immunology, Otto von Guericke University, Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Mol Cell Biol 25:8052-63. 2005
    ..In summary, our data suggest that SKAP-HOM is required for proper activation of the immune system, likely by regulating the cross-talk between immunoreceptors and integrins...
  30. pmc Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice
    L D Klaman
    Cancer Biology Program, Division of Hematology Oncology, Boston, Massachusetts 02215, USA
    Mol Cell Biol 20:5479-89. 2000
    ..Our results identify PTP-1B as a major regulator of energy balance, insulin sensitivity, and body fat stores in vivo...
  31. pmc Genetic analysis reveals cell type-specific regulation of receptor tyrosine kinase c-Kit by the protein tyrosine phosphatase SHP1
    U Lorenz
    Molecular Medicine Unit, Beth Israel Hospital, Boston, Massachusetts, USA
    J Exp Med 184:1111-26. 1996
    ..Taken together, our results establish that SHP1 negatively regulates signaling from c-Kit in vivo, but in a cell type-specific manner...
  32. ncbi request reprint Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis
    B Chen
    Cancer Biology Program, Hematology Oncology Division, Boston, Massachusetts, USA
    Nat Genet 24:296-9. 2000
    ....
  33. pmc A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor
    E Maestrini
    Institute of Genetics Biochemistry and Evolution, Consiglio Nazionale delle Ricerche, Pavia, Italy
    Proc Natl Acad Sci U S A 93:674-8. 1996
    ..These data define a gene family (SEX family) involved in the development of neural and epithelial tissues, which encodes putative receptors with unexpected enzymatic or binding properties...
  34. pmc Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras
    A M Bennett
    Molecular Medicine Unit, Beth Israel Hospital, Boston, MA 02215
    Proc Natl Acad Sci U S A 91:7335-9. 1994
    ..These data indicate that phosphorylation of SHPTP2 couples Grb2 to PDGFR in vivo, providing a mechanism for Ras activation by PDGFR and for positive signaling via SHPTP2 and Csw...
  35. ncbi request reprint Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor
    R J Lechleider
    Molecular Medicine Unit, Beth Israel Hospital, Boston, Massachusetts
    J Biol Chem 268:21478-81. 1993
    ..Our data suggest that binding of SH-PTP2 to the activated receptor in vivo should result in stimulation of SH-PTP2 activity...
  36. ncbi request reprint Genetic analysis of protein tyrosine phosphatases
    D Van Vactor
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Genet Dev 8:112-26. 1998
    ..Finally, very recent studies of other mammalian PTPs suggest that they have critical roles in processes as diverse as hematopoiesis and liver and pituitary development...
  37. pmc Isolation of a src homology 2-containing tyrosine phosphatase
    J Plutzky
    Department of Medicine, Brigham and Women s Hospital, Boston, MA 02118
    Proc Natl Acad Sci U S A 89:1123-7. 1992
    ..The structure of SH-PTP1 establishes an additional branch of the tyrosine phosphatase family and suggests mechanisms through which tyrosine phosphatases might participate in signal transduction pathways...
  38. ncbi request reprint Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21
    C Shou
    Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts 02111
    Nature 358:351-4. 1992
    ..An understanding of Ras-GRF function will enhance our knowledge of the many signal transduction pathways mediated by Ras proteins...
  39. ncbi request reprint The tyrosine phosphatase SHP-1 influences thymocyte selection by setting TCR signaling thresholds
    J D Carter
    Department of Microbiology, University of Virginia, HSC, 1300 Jefferson Park Avenue, Charlottesville, VA 22908, USA
    Int Immunol 11:1999-2014. 1999
    ....
  40. ncbi request reprint The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence
    J V Frangioni
    Molecular Medicine Unit, Beth Israel Hospital, Boston, Massachusetts 02215
    Cell 68:545-60. 1992
    ..The C-terminal 35 amino acids of PTP-1B are both necessary and sufficient for targeting to the ER. The finding of a tyrosine phosphatase on the ER suggests new possibilities for cellular events controlled by tyrosine phosphorylation...
  41. ncbi request reprint Chromosomal localization of an SH2-containing tyrosine phosphatase (PTPN6)
    J Plutzky
    Molecular Medicine Unit, Beth Israel Hospital, Boston, Massachusetts 02215
    Genomics 13:869-72. 1992
    ..Since PTPN6 is expressed at high levels in hematopoietic cells of all lineages and its expression is induced early in hematopoietic differentiation, altered expression and/or structure of PTPN6 may play a role in leukemogenesis...
  42. pmc Cloning of a cDNA for a major human protein-tyrosine-phosphatase
    J Chernoff
    Department of Cellular and Developmental Biology, Harvard University, Cambridge, MA 02138
    Proc Natl Acad Sci U S A 87:2735-9. 1990
    ..3-kb insert produces a protein of Mr 56,000, in general agreement with the predicted size. The phosphatase gene appears to be present as a single copy in human genomic DNA and is transcribed into a 3.5-kb message in a variety of tissues...
  43. pmc Identification of an early-growth-response gene encoding a novel putative protein kinase
    D L Simmons
    Department of Chemistry, Brigham Young University, Provo, Utah 84602
    Mol Cell Biol 12:4164-9. 1992
    ..Hence, Snk represents a new type of protein kinase involved in the early mitogenic response whose activity is transcriptionally and posttranscriptionally regulated...