Research Topics
Genomes and Genes | A M O'ReillySummaryAffiliation: Harvard University Country: USA Publications
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Publications
Structural determinants of SHP-2 function and specificity in Xenopus mesoderm inductionA M O'Reilly
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Mol Cell Biol 18:161-77. 1998..Thus, PTP domains exhibit biologically relevant specificity in vivo, and noncatalytic and catalytic domains of PTPs contribute to specificity in a combinatorial fashion...- Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2E S Oh
Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Mol Cell Biol 19:3205-15. 1999.... - SHPS-1 is a scaffold for assembling distinct adhesion-regulated multi-protein complexes in macrophagesJ F Timms
Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Curr Biol 9:927-30. 1999..Other inhibitory immunoreceptors might have similar scaffold-like functions... - Lack of SHPTP1 results in src-family kinase hyperactivation and thymocyte hyperresponsivenessU Lorenz
Molecular Medicine Unit, Beth Israel Hospital, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 93:9624-9. 1996..Taken together, our data suggest that SHPTP1 is an important negative regulator of TCR signaling, acting at least in part to inactivate Lck and Fyn... - From form to function: signaling by protein tyrosine phosphatasesN K Tonks
Cold Spring Harbor Laboratory, New York 11724-2208, USA
Cell 87:365-8. 1996 - The B-cell transmembrane protein CD72 binds to and is an in vivo substrate of the protein tyrosine phosphatase SHP-1Y Wu
Program in Molecular Biology, Mount Sinai Hospital, University of Toronto, Ontario, Canada
Curr Biol 8:1009-17. 1998..Moreover, direct substrates of SHP-1 have not been identified in any B-cell signaling pathway... - Role of the tyrosine phosphatase SHP-1 in K562 cell differentiationB Bruecher-Encke
Department of Medicine, Beth Israel-Deaconess Medical Center, Boston, MA, USA
Leukemia 15:1424-32. 2001.... - Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1M David
Division of Cytokine Biology, Center for Biologics Evaluation and Research, Bethesda, Maryland 20892, USA
Mol Cell Biol 15:7050-8. 1995..Our results establish that SHPTP1 selectively regulates distinct components of Jak/Stat signal transduction pathways in vivo... - Protein-tyrosine phosphatase SHP-1 is dispensable for FcgammaRIIB-mediated inhibition of B cell antigen receptor activationM J Nadler
Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
J Biol Chem 272:20038-43. 1997..FcgammaRIIB-mediated CD19 dephosphorylation also occurs in the presence or the absence of SHP-1. Our results establish that SHP-1 is dispensable for FcgammaRIIB-mediated inhibition of sIgM antigen receptor signaling... - Identification of major binding proteins and substrates for the SH2-containing protein tyrosine phosphatase SHP-1 in macrophagesJ F Timms
Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Mol Cell Biol 18:3838-50. 1998..Our data suggest that BIT and PIR-B recruit multiple signaling molecules to receptor complexes, where they are regulated by SHP-1 and/or SHP-2... - Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activationH Gu
Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
Mol Cell 2:729-40. 1998..Our results identify p97 as an important regulator of receptor signaling that controls a novel pathway to immediate-early gene activation and suggest multiple functions for SHP2 in cytokine receptor signaling... - Receptor-type protein-tyrosine phosphatase mu is expressed in specific vascular endothelial beds in vivoC Bianchi
Cancer Biology Program, Department of Medicine, Department of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, 02215, USA
Exp Cell Res 248:329-38. 1999..Our results identify RPTPmu as a new marker of endothelial cell heterogeneity and suggest a possible role in endothelial-specific functions, involving cell-cell contact... - New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathwayL C Cantley
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 96:4240-5. 1999..PTEN appears to negatively control the phosphoinositide 3-kinase signaling pathway for regulation of cell growth and survival by dephosphorylating the 3 position of phosphoinositides... - New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathwayH Gu
Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts 02115, USA
Mol Cell Biol 20:7109-20. 2000..Our results suggest that cytokine receptors lacking direct PI-3K binding sites activate Akt via a Shc/Grb2/Gab2/PI-3K pathway, thereby regulating cell survival and/or proliferation... - Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistanceJ M Zabolotny
Division of Endocrinology and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 98:5187-92. 2001..Our data suggest that increased expression and/or activity of LAR or related PTPs in insulin target tissues of obese humans may contribute to the pathogenesis of insulin resistance... - Essential role for Gab2 in the allergic responseH Gu
Cancer Biology Program, Division of Hematology and Oncology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Nature 412:186-90. 2001..Gab2 and/or its associated signalling molecules may be new targets for developing drugs to treat allergy... - Role of phosphatases in lymphocyte activationB G Neel
Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, HIM 1047, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
Curr Opin Immunol 9:405-20. 1997..Progress has also been made in elucidating the function and targets of specific nontransmembrane PTPs, particularly those with Src homology 2 domains... - Characterization of two SHP-2-associated binding proteins and potential substrates in hematopoietic cellsH Gu
Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
J Biol Chem 272:16421-30. 1997..Our results indicate that SHP-2 forms at least two separate complexes in hematopoietic cells and point to new potential SHP-2 targets... - Protein tyrosine phosphatases in signal transductionB G Neel
Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, HIM 1047, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
Curr Opin Cell Biol 9:193-204. 1997..Finally, progress has been made in understanding signaling by Src homology 2 domain containing PTPs and PTPs controlling yeast osmoregulatory pathways... - Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrewR M Freeman
Committee on Virology, Harvard University, Boston, MA 02115
Proc Natl Acad Sci U S A 89:11239-43. 1992.... - A common epitope is shared by activated signal transducer and activator of transcription-5 (STAT5) and the phosphorylated erythropoietin receptor: implications for the docking model of STAT activationD L Barber
Division of Cellular and Molecular Biology, Ontario Cancer Institute, Toronto, Canada
Blood 97:2230-7. 2001..These data uncover a novel aspect of STAT SH2 domain recognition and demonstrate the utility of activation-specific antibodies for examining the specificity of STAT-cytokine receptor interactions... - Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signalsU Klingmuller
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142
Cell 80:729-38. 1995..Our results suggest that activation of SH-PTP1 by binding to the EPO-R plays a major role in terminating proliferative signals... - The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus developmentT L Tang
Department of Microbiology and Molecular Genetics, Harvard Medical School, Beth Israel Hospital, Boston, Massachusetts 02215
Cell 80:473-83. 1995..Our results indicate that SH-PTP2 is required for early vertebrate development, acting as a positive component in FGF signaling downstream of the FGF receptor and upstream of MAP kinase... - Lck-dependent tyrosyl phosphorylation of the phosphotyrosine phosphatase SH-PTP1 in murine T cellsU Lorenz
Molecular Medicine Unit, Beth Israel Hospital, Boston, Massachusetts 02215
Mol Cell Biol 14:1824-34. 1994..One of these sites (Y-564) is phosphorylated in T cells in response to Lck activation. We conclude that SH-PTP1 undergoes Lck-dependent tyrosyl phosphorylation in T cells and likely plays a role in early T-cell signaling... - Tyrosine phosphorylation of the proto-oncoprotein Raf-1 is regulated by Raf-1 itself and the phosphatase Cdc25AK Xia
Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Mol Cell Biol 19:4819-24. 1999..These data suggest that the tyrosine phosphorylation of Raf-1 is regulated not only by itself but also by Cdc25A... - Regulation of in vitro and in vivo immune functions by the cytosolic adaptor protein SKAP-HOMM Togni
Institute of Immunology, Otto von Guericke University, Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
Mol Cell Biol 25:8052-63. 2005..In summary, our data suggest that SKAP-HOM is required for proper activation of the immune system, likely by regulating the cross-talk between immunoreceptors and integrins... - Genetic analysis reveals cell type-specific regulation of receptor tyrosine kinase c-Kit by the protein tyrosine phosphatase SHP1U Lorenz
Molecular Medicine Unit, Beth Israel Hospital, Boston, Massachusetts, USA
J Exp Med 184:1111-26. 1996..Taken together, our results establish that SHP1 negatively regulates signaling from c-Kit in vivo, but in a cell type-specific manner... - Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesisB Chen
Cancer Biology Program, Hematology Oncology Division, Boston, Massachusetts, USA
Nat Genet 24:296-9. 2000.... - Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient miceL D Klaman
Cancer Biology Program, Division of Hematology Oncology, Boston, Massachusetts 02215, USA
Mol Cell Biol 20:5479-89. 2000..Our results identify PTP-1B as a major regulator of energy balance, insulin sensitivity, and body fat stores in vivo... - Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptorR J Lechleider
Molecular Medicine Unit, Beth Israel Hospital, Boston, Massachusetts
J Biol Chem 268:21478-81. 1993..Our data suggest that binding of SH-PTP2 to the activated receptor in vivo should result in stimulation of SH-PTP2 activity... - A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptorE Maestrini
Institute of Genetics Biochemistry and Evolution, Consiglio Nazionale delle Ricerche, Pavia, Italy
Proc Natl Acad Sci U S A 93:674-8. 1996..These data define a gene family (SEX family) involved in the development of neural and epithelial tissues, which encodes putative receptors with unexpected enzymatic or binding properties... - Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to RasA M Bennett
Molecular Medicine Unit, Beth Israel Hospital, Boston, MA 02215
Proc Natl Acad Sci U S A 91:7335-9. 1994..These data indicate that phosphorylation of SHPTP2 couples Grb2 to PDGFR in vivo, providing a mechanism for Ras activation by PDGFR and for positive signaling via SHPTP2 and Csw... - Genetic analysis of protein tyrosine phosphatasesD Van Vactor
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Curr Opin Genet Dev 8:112-26. 1998..Finally, very recent studies of other mammalian PTPs suggest that they have critical roles in processes as diverse as hematopoiesis and liver and pituitary development... - Isolation of a src homology 2-containing tyrosine phosphataseJ Plutzky
Department of Medicine, Brigham and Women s Hospital, Boston, MA 02118
Proc Natl Acad Sci U S A 89:1123-7. 1992..The structure of SH-PTP1 establishes an additional branch of the tyrosine phosphatase family and suggests mechanisms through which tyrosine phosphatases might participate in signal transduction pathways... - The tyrosine phosphatase SHP-1 influences thymocyte selection by setting TCR signaling thresholdsJ D Carter
Department of Microbiology, University of Virginia, HSC, 1300 Jefferson Park Avenue, Charlottesville, VA 22908, USA
Int Immunol 11:1999-2014. 1999.... - Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21C Shou
Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts 02111
Nature 358:351-4. 1992..An understanding of Ras-GRF function will enhance our knowledge of the many signal transduction pathways mediated by Ras proteins... - The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequenceJ V Frangioni
Molecular Medicine Unit, Beth Israel Hospital, Boston, Massachusetts 02215
Cell 68:545-60. 1992..The C-terminal 35 amino acids of PTP-1B are both necessary and sufficient for targeting to the ER. The finding of a tyrosine phosphatase on the ER suggests new possibilities for cellular events controlled by tyrosine phosphorylation... - Chromosomal localization of an SH2-containing tyrosine phosphatase (PTPN6)J Plutzky
Molecular Medicine Unit, Beth Israel Hospital, Boston, Massachusetts 02215
Genomics 13:869-72. 1992..Since PTPN6 is expressed at high levels in hematopoietic cells of all lineages and its expression is induced early in hematopoietic differentiation, altered expression and/or structure of PTPN6 may play a role in leukemogenesis... - Identification of an early-growth-response gene encoding a novel putative protein kinaseD L Simmons
Department of Chemistry, Brigham Young University, Provo, Utah 84602
Mol Cell Biol 12:4164-9. 1992..Hence, Snk represents a new type of protein kinase involved in the early mitogenic response whose activity is transcriptionally and posttranscriptionally regulated... - Cloning of a cDNA for a major human protein-tyrosine-phosphataseJ Chernoff
Department of Cellular and Developmental Biology, Harvard University, Cambridge, MA 02138
Proc Natl Acad Sci U S A 87:2735-9. 1990..3-kb insert produces a protein of Mr 56,000, in general agreement with the predicted size. The phosphatase gene appears to be present as a single copy in human genomic DNA and is transcribed into a 3.5-kb message in a variety of tissues...