Tihamer Orban

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Heterophile antibodies indicate progression of autoimmunity in human type 1 diabetes mellitus before clinical onset
    T Orban
    Joslin Diabetes Center, Immunology Section, Harvard Medical School, Boston, MA 02215, USA
    Autoimmunity 34:247-64. 2001
  2. ncbi Reduced CD4+ T-cell-specific gene expression in human type 1 diabetes mellitus
    Tihamer Orban
    Section of Immunology and Immunogenetics, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02115, USA
    J Autoimmun 28:177-87. 2007
  3. ncbi Autoantigen-specific regulatory T cells induced in patients with type 1 diabetes mellitus by insulin B-chain immunotherapy
    Tihamer Orban
    Joslin Diabetes Center, Boston, MA 02215, USA
    J Autoimmun 34:408-15. 2010
  4. ncbi Characterization of human invariant natural killer T cells expressing FoxP3
    Peter Engelmann
    Section for Immunology and Immunogenetics, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02115, USA
    Int Immunol 23:473-84. 2011
  5. ncbi Reduced CD4+ subset and Th1 bias of the human iNKT cells in Type 1 diabetes mellitus
    Janos Kis
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    J Leukoc Biol 81:654-62. 2007
  6. ncbi Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells
    Elizabeth M Bradshaw
    Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 183:4432-9. 2009
  7. ncbi TGF-beta induces IL-9 production from human Th17 cells
    Gaëlle Beriou
    Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, MA 02215, USA
    J Immunol 185:46-54. 2010
  8. ncbi Pathology of an islet transplant 2 years after transplantation: evidence for a nonimmunological loss
    R Neal Smith
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Transplantation 86:54-62. 2008
  9. ncbi Pancreatic islet autoantibodies as predictors of type 1 diabetes in the Diabetes Prevention Trial-Type 1
    Tihamer Orban
    Joslin Diabetes Center, Boston, Massachusetts, USA
    Diabetes Care 32:2269-74. 2009
  10. ncbi Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial
    Tihamer Orban
    Joslin Diabetes Center, Boston, MA, USA
    Lancet 378:412-9. 2011

Collaborators

Detail Information

Publications16

  1. ncbi Heterophile antibodies indicate progression of autoimmunity in human type 1 diabetes mellitus before clinical onset
    T Orban
    Joslin Diabetes Center, Immunology Section, Harvard Medical School, Boston, MA 02215, USA
    Autoimmunity 34:247-64. 2001
    ..Thus, anti-Ig heterophilic antibodies with different immunochemical reactivities are linked to the progression of or protection from Type 1 diabetes autoimmunity...
  2. ncbi Reduced CD4+ T-cell-specific gene expression in human type 1 diabetes mellitus
    Tihamer Orban
    Section of Immunology and Immunogenetics, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02115, USA
    J Autoimmun 28:177-87. 2007
    ..The CD4+ T cells showed impaired function, including an abnormal immune response, which may be a key element that leads to the breakdown of self-tolerance...
  3. ncbi Autoantigen-specific regulatory T cells induced in patients with type 1 diabetes mellitus by insulin B-chain immunotherapy
    Tihamer Orban
    Joslin Diabetes Center, Boston, MA 02215, USA
    J Autoimmun 34:408-15. 2010
    ..The induction of a lasting, robust immune response generating autoantigen-specific regulatory T cells provides strong justification for further testing of this therapy in type 1 diabetes. (clinicaltrials.gov identifier NCT00057499)...
  4. ncbi Characterization of human invariant natural killer T cells expressing FoxP3
    Peter Engelmann
    Section for Immunology and Immunogenetics, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02115, USA
    Int Immunol 23:473-84. 2011
    ..Our data indicate that the FoxP3 expression in iNKT cells may be a key transcriptional factor in controlling the regulatory function of the iNKT cells...
  5. ncbi Reduced CD4+ subset and Th1 bias of the human iNKT cells in Type 1 diabetes mellitus
    Janos Kis
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    J Leukoc Biol 81:654-62. 2007
    ..The decrease in the CD4+ population among the iNKT cells and their Th1 shift indicates dysfunction of these potentially important regulatory cells in T1DM...
  6. ncbi Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells
    Elizabeth M Bradshaw
    Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 183:4432-9. 2009
    ..These data suggest that the innate immune system in T1D may drive the adaptive immune system by expanding the Th17 population of effector T cells...
  7. ncbi TGF-beta induces IL-9 production from human Th17 cells
    Gaëlle Beriou
    Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, MA 02215, USA
    J Immunol 185:46-54. 2010
    ..These data demonstrate the presence of IL-17(+)IL-9(+) CD4 cells induced by IL-1beta that may play a role in human autoimmune disease...
  8. ncbi Pathology of an islet transplant 2 years after transplantation: evidence for a nonimmunological loss
    R Neal Smith
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Transplantation 86:54-62. 2008
    ..After each islet transplant, she gradually lost insulin independence while maintaining low levels of C-peptide secretion...
  9. ncbi Pancreatic islet autoantibodies as predictors of type 1 diabetes in the Diabetes Prevention Trial-Type 1
    Tihamer Orban
    Joslin Diabetes Center, Boston, Massachusetts, USA
    Diabetes Care 32:2269-74. 2009
    ..Thus, we studied the extent to which specific autoantibodies are predictive of type 1 diabetes...
  10. ncbi Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial
    Tihamer Orban
    Joslin Diabetes Center, Boston, MA, USA
    Lancet 378:412-9. 2011
    ..Abatacept modulates co-stimulation and prevents full T-cell activation. We evaluated the effect of abatacept in recent-onset type 1 diabetes...
  11. ncbi Concurrent detection of secreted products from human lymphocytes by microengraving: cytokines and antigen-reactive antibodies
    Elizabeth M Bradshaw
    Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Clin Immunol 129:10-8. 2008
    ..These data demonstrate the utility of microengraving for interrogating multiple phenotypes of single human cells concurrently and for detecting rare populations of cells by their secreted products...
  12. ncbi GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetes
    Vissia Viglietta
    Laboratory of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 109:895-903. 2002
    ....
  13. ncbi Preclinical serum 25-hydroxyvitamin D levels and risk of type 1 diabetes in a cohort of US military personnel
    Kassandra L Munger
    Department of Nutrition, Harvard School of Public Health, Harvard University, Boston, MA 02115, USA
    Am J Epidemiol 177:411-9. 2013
    ..There was no association between 25(OH)D levels and risk of T1D among non-Hispanic blacks or Hispanics. Low 25(OH)D levels may predispose healthy, young, non-Hispanic white adults to the development of T1D...
  14. ncbi Specific human leukocyte antigen DQ influence on expression of antiislet autoantibodies and progression to type 1 diabetes
    Maria J Redondo
    Department of Endocrinology, University Clinic of Navarra, 31008 Pamplona, Spain
    J Clin Endocrinol Metab 91:1705-13. 2006
    ..Human leukocyte antigen (HLA) DQ haplotypes have the strongest genetic association with type 1 diabetes (T1DM) risk...
  15. ncbi Elevated C-reactive protein levels do not correspond to autoimmunity in type 1 diabetes
    Andras Treszl
    Diabetes Care 27:2769-70. 2004
  16. ncbi Screening strategies for the identification of multiple antibody-positive relatives of individuals with type 1 diabetes
    Jeffrey P Krischer
    H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida 33612 9497, USA
    J Clin Endocrinol Metab 88:103-8. 2003
    ..Further follow-up and analysis of actual progression to diabetes will be essential to define actual diabetes risk in this large cohort...