Jordan S Orange

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Wiskott-Aldrich syndrome protein is required for NK cell cytotoxicity and colocalizes with actin to NK cell-activating immunologic synapses
    Jordan S Orange
    Department of Molecular and Cellular Biology, 7 Divinity Avenue, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 99:11351-6. 2002
  2. pmc The mature activating natural killer cell immunologic synapse is formed in distinct stages
    Jordan S Orange
    Department of Molecular and Cellular Biology, 7 Divinity Avenue, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 100:14151-6. 2003
  3. pmc Myosin IIA is required for cytolytic granule exocytosis in human NK cells
    Milena M Andzelm
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    J Exp Med 204:2285-91. 2007
  4. pmc Formation of a WIP-, WASp-, actin-, and myosin IIA-containing multiprotein complex in activated NK cells and its alteration by KIR inhibitory signaling
    Konrad Krzewski
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    J Cell Biol 173:121-32. 2006
  5. pmc Human decidual natural killer cells are a unique NK cell subset with immunomodulatory potential
    Louise A Koopman
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    J Exp Med 198:1201-12. 2003
  6. ncbi request reprint Allogeneic transplantation successfully corrects immune defects, but not susceptibility to colitis, in a patient with nuclear factor-kappaB essential modulator deficiency
    Sung Yun Pai
    Division of Hematology Oncology, Children s Hospital Boston, Boston, MA 02115, USA
    J Allergy Clin Immunol 122:1113-1118.e1. 2008
  7. ncbi request reprint Management of an anaphylactoid reaction to methotrexate with a stepwise graded challenge
    Andrew J MacGinnitie
    Division of Allergy Immunology, Children s Hospital, Boston, MA 02446, USA
    Pediatr Allergy Immunol 14:409-11. 2003
  8. ncbi request reprint Human natural killer cell deficiencies and susceptibility to infection
    Jordan S Orange
    Division of Immunology, Children s Hospital and Department of Pediatrics, Harvard Medical School, 300 Longwood Avenue, MA, Boston, USA
    Microbes Infect 4:1545-58. 2002
  9. ncbi request reprint Viral evasion of natural killer cells
    Jordan S Orange
    Department of Molecular and Cellular Biology, Harvard University, Cambridge MA, USA
    Nat Immunol 3:1006-12. 2002
  10. pmc Cdc42-interacting protein-4 functionally links actin and microtubule networks at the cytolytic NK cell immunological synapse
    Pinaki P Banerjee
    Children s Hospital of Philadelphia, Division of Immunology, Abramson Research Center, Philadelphia, PA 19104, USA
    J Exp Med 204:2305-20. 2007

Collaborators

Detail Information

Publications34

  1. pmc Wiskott-Aldrich syndrome protein is required for NK cell cytotoxicity and colocalizes with actin to NK cell-activating immunologic synapses
    Jordan S Orange
    Department of Molecular and Cellular Biology, 7 Divinity Avenue, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 99:11351-6. 2002
    ..Thus, WASp has an important function in NK cells. In patients with WASp mutations, the resulting NK cell defects are likely to contribute to their disease...
  2. pmc The mature activating natural killer cell immunologic synapse is formed in distinct stages
    Jordan S Orange
    Department of Molecular and Cellular Biology, 7 Divinity Avenue, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 100:14151-6. 2003
    ..Thus the process of CD2, CD11a, CD11b, and F-actin accumulation in the pSMAC and perforin accumulation in the central SMAC of the NKIS are sequential processes with distinct cytoskeletal requirements...
  3. pmc Myosin IIA is required for cytolytic granule exocytosis in human NK cells
    Milena M Andzelm
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    J Exp Med 204:2285-91. 2007
    ..Thus, myosin IIA is required for a critical step between NKIS formation and granule exocytosis...
  4. pmc Formation of a WIP-, WASp-, actin-, and myosin IIA-containing multiprotein complex in activated NK cells and its alteration by KIR inhibitory signaling
    Konrad Krzewski
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    J Cell Biol 173:121-32. 2006
    ....
  5. pmc Human decidual natural killer cells are a unique NK cell subset with immunomodulatory potential
    Louise A Koopman
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    J Exp Med 198:1201-12. 2003
    ..Additionally, two secreted proteins, galectin-1 and progestagen-associated protein 14, known to have immunomodulatory functions, were selectively expressed in dNK cells...
  6. ncbi request reprint Allogeneic transplantation successfully corrects immune defects, but not susceptibility to colitis, in a patient with nuclear factor-kappaB essential modulator deficiency
    Sung Yun Pai
    Division of Hematology Oncology, Children s Hospital Boston, Boston, MA 02115, USA
    J Allergy Clin Immunol 122:1113-1118.e1. 2008
    ..Boys with X-linked ectodermal dysplasia and immunodeficiency caused by mutations of nuclear factor-kappaB essential modulator have defects in innate and adaptive immunity, and some have colitis...
  7. ncbi request reprint Management of an anaphylactoid reaction to methotrexate with a stepwise graded challenge
    Andrew J MacGinnitie
    Division of Allergy Immunology, Children s Hospital, Boston, MA 02446, USA
    Pediatr Allergy Immunol 14:409-11. 2003
    ..Because weekly methotrexate therapy is an important component of continuation chemotherapy for pediatric ALL, a stepwise graded challenge was employed to achieve drug tolerance...
  8. ncbi request reprint Human natural killer cell deficiencies and susceptibility to infection
    Jordan S Orange
    Division of Immunology, Children s Hospital and Department of Pediatrics, Harvard Medical School, 300 Longwood Avenue, MA, Boston, USA
    Microbes Infect 4:1545-58. 2002
    ..A resounding theme of NK cell deficiencies is susceptibility to herpesviruses, suggesting that unexplained severe herpesviral infection should raise the possibility of an NK cell deficit...
  9. ncbi request reprint Viral evasion of natural killer cells
    Jordan S Orange
    Department of Molecular and Cellular Biology, Harvard University, Cambridge MA, USA
    Nat Immunol 3:1006-12. 2002
    ..These NK cell-specific evasion mechanisms fall into distinct mechanistic categories used in numerous virus families...
  10. pmc Cdc42-interacting protein-4 functionally links actin and microtubule networks at the cytolytic NK cell immunological synapse
    Pinaki P Banerjee
    Children s Hospital of Philadelphia, Division of Immunology, Abramson Research Center, Philadelphia, PA 19104, USA
    J Exp Med 204:2305-20. 2007
    ..Thus, CIP4 is an important cytoskeletal adaptor that functions after filamentous actin accumulation and Cdc42 activation to enable MTOC polarization and NK cell cytotoxicity...
  11. ncbi request reprint Human natural killer cell deficiencies
    Jordan S Orange
    Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Curr Opin Allergy Clin Immunol 6:399-409. 2006
    ..Since previously reviewing these disorders, significant developments warrant their reconsideration...
  12. ncbi request reprint The lytic NK cell immunological synapse and sequential steps in its formation
    Jordan S Orange
    University of Pennsylvania School of Medicine, Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Adv Exp Med Biol 601:225-33. 2007
    ..These events unfold in a definitive sequence and lead to critical checkpoints that provide regulatory control at specific stages in the formation of the NK cell lytic synapse...
  13. ncbi request reprint Asymmetric T lymphocyte division in the initiation of adaptive immune responses
    John T Chang
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 315:1687-91. 2007
    ..These results suggest a mechanism by which a single lymphocyte can apportion diverse cell fates necessary for adaptive immunity...
  14. ncbi request reprint Superantigen presentation by airway smooth muscle to CD4+ T lymphocytes elicits reciprocal proasthmatic changes in airway function
    Haviva Veler
    Division of Pulmonary Medicine, Joseph Stokes Jr Research Institute, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 178:3627-36. 2007
    ....
  15. ncbi request reprint A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene
    Hakon Hakonarson
    Center for Applied Genomics, Abramson Research Center, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Nature 448:591-4. 2007
    ..These results indicate that KIAA0350 might be involved in the pathogenesis of T1D and demonstrate the utility of the genome-wide association approach in the identification of previously unsuspected genetic determinants of complex traits...
  16. doi request reprint 1. Lymphocytes
    David F LaRosa
    University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Allergy Clin Immunol 121:S364-9; quiz S412. 2008
    ..This chapter provides an overview of the major lymphocyte populations with emphasis on their development, distinguishing characteristics, and functions...
  17. ncbi request reprint NKp30 ligation induces rapid activation of the canonical NF-kappaB pathway in NK cells
    Rahul Pandey
    Division of Allergy and Immunology, The Joseph Stokes Jr Research Institute, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 179:7385-96. 2007
    ..The latter was prevented by the Syk inhibitor piceatannol. Thus, NK cell activation signaling specifically induces transcriptional activation and synthesis of new NF-kappaB dependent proteins during the initiation of cytotoxicity...
  18. doi request reprint Evaluation and clinical interpretation of hypergammaglobulinemia E: differentiating atopy from immunodeficiency
    Gary C Pien
    Division of Allergy and Immunology, The Children s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Ann Allergy Asthma Immunol 100:392-5. 2008
    ..However, total IgE level is neither a sensitive nor a specific diagnostic marker for any particular disease and, therefore, should not be relied on to establish a diagnosis of either atopy or primary immunodeficiency...
  19. doi request reprint Immunodeficiency disorders. Preface
    Jordan S Orange
    Immunol Allergy Clin North Am 28:xv-xviii. 2008
  20. pmc IKBKG (nuclear factor-kappa B essential modulator) mutation can be associated with opportunistic infection without impairing Toll-like receptor function
    Bryn H Salt
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 121:976-82. 2008
    ..Patients with hypomorphic nuclear factor-kappaB essential modulator (NEMO) mutations have extensive phenotypic variability that can include atypical infectious susceptibility...
  21. ncbi request reprint Use of intravenous immunoglobulin in human disease: a review of evidence by members of the Primary Immunodeficiency Committee of the American Academy of Allergy, Asthma and Immunology
    Jordan S Orange
    Department of Pediatrics, University of Pennsylvania School of Medicine, The Children s Hospital of Philadelphia, Philadelphia 19104, USA
    J Allergy Clin Immunol 117:S525-53. 2006
    ..Given the potential risks and inherent scarcity of IGIV, careful consideration of the indications for and administration of IGIV is warranted...
  22. ncbi request reprint Acute chylothorax in children: selective retention of memory T cells and natural killer cells
    Jordan S Orange
    Division of Immunology, Children s Hospital, Enders Building, 300 Longwood Avenue, Boston, MA 02115, USA
    J Pediatr 143:243-9. 2003
    ..To assess for immunodeficiency in patients with hypogammaglobulinemia in the setting of draining acute chylothorax...
  23. ncbi request reprint Disseminated varicella infection due to the vaccine strain of varicella-zoster virus, in a patient with a novel deficiency in natural killer T cells
    Ofer Levy
    Division Infectious Diseases, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Infect Dis 188:948-53. 2003
    ....
  24. pmc Finding NEMO: genetic disorders of NF-[kappa]B activation
    Jordan S Orange
    Division of Immunology, Children s Hospital, Boston, Massachusetts, USA
    J Clin Invest 112:983-5. 2003
    ....
  25. ncbi request reprint A patient with severe black fly (Simuliidae) hypersensitivity referred for evaluation of suspected immunodeficiency
    Jordan S Orange
    Department of Pediatrics, Harvard University Medical School, Children s Hospital, Boston, Massachusetts 02115, USA
    Ann Allergy Asthma Immunol 92:276-80. 2004
    ..Biting flies of the Diptera order and specifically the black fly (Simuliidae family) can be rare causes of severe hypersensitivity reactions...
  26. ncbi request reprint The presentation and natural history of immunodeficiency caused by nuclear factor kappaB essential modulator mutation
    Jordan S Orange
    Department of Immunology, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
    J Allergy Clin Immunol 113:725-33. 2004
    ..Hypomorphic mutations in the NFkappaB essential modulator (NEMO) impair NFkappaB function and are linked to both immunodeficiency and ectodermal dysplasia (ED), as well as susceptibility to atypical mycobacterial infections...
  27. ncbi request reprint Natural killer cells inhibit hepatitis C virus expression
    Yuan Li
    Division of Allergy and Immunology, Joseph Stokes, Jr Research Institute at The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 34th Street and Civic Center Blvd, Philadelphia, PA 19104, USA
    J Leukoc Biol 76:1171-9. 2004
    ..Thus, NK cells hold the potential to play a vital role in controlling HCV replication in hepatic cells using an IFN-gamma-dependent mechanism...
  28. ncbi request reprint Human nuclear factor kappa B essential modulator mutation can result in immunodeficiency without ectodermal dysplasia
    Jordan S Orange
    Division of Immunology, Children s Hospital of Philadelphia, PA, USA
    J Allergy Clin Immunol 114:650-6. 2004
    ..Male subjects with these mutant NEMO molecules have an X-linked syndrome known as ectodermal dysplasia with immunodeficiency, which is characterized by severe infections, with herpesviruses, bacteria, and mycobacterial susceptibility...
  29. pmc Specific NEMO mutations impair CD40-mediated c-Rel activation and B cell terminal differentiation
    Ashish Jain
    Laboratory of Host Defense, National Institute of Allergy and Infectious Diseases NIAID, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 114:1593-602. 2004
    ..Finally, using microarray analysis of patient B cells we identified downstream effects of impaired NF-kappaB activation and candidate factors that may be necessary for CSR and SHM in B cells...
  30. ncbi request reprint Human disease resulting from gene mutations that interfere with appropriate nuclear factor-kappaB activation
    Jordan S Orange
    Division of Immunology, Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Immunol Rev 203:21-37. 2005
    ..A detailed study of these diseases can provide insight into the biochemistry of NF-kappaB activation as well as the role of NF-kappaB in human health...
  31. ncbi request reprint Congenital immunodeficiencies and sepsis
    Jordan S Orange
    Department of Pediatrics, University of Pennsylvania School of Medicine, Division of Allergic and Immunologic diseases, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Pediatr Crit Care Med 6:S99-S107. 2005
    ..Because a hallmark of congenital immunodeficiency disorders is susceptibility to recurrent, unusual and/or severe infections, an effort was undertaken to identify a subset of these patients with an increased risk for sepsis...
  32. ncbi request reprint Practice parameter for the diagnosis and management of primary immunodeficiency
    Francisco A Bonilla
    Department of Medicine, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    Ann Allergy Asthma Immunol 94:S1-63. 2005
  33. ncbi request reprint Natural killer cells in human health and disease
    Jordan S Orange
    University of Pennsylvania School of Medicine, Department of Pediatrics, Children s Hospital of Philadelphia, Division of Allergy and Immunology, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA
    Clin Immunol 118:1-10. 2006
    ..NK cells play important roles in viral infections, autoimmunity, pregnancy, cancer and bone marrow transplantation. This review highlights recent developments in the understanding of the role of human NK cells in health and disease...
  34. pmc Deficient natural killer cell cytotoxicity in patients with IKK-gamma/NEMO mutations
    Jordan S Orange
    Division of Immunology, Children s Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 109:1501-9. 2002
    ..These data suggest that NEMO participates in signaling pathways leading to NK cell cytotoxicity and that IL-2 can activate NF-kappaB and partially overcome the NK cell defect in patients with NEMO mutations...