Alexander R Opotowsky

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint Trends in hospitalizations for adults with congenital heart disease in the U.S
    Alexander R Opotowsky
    Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    J Am Coll Cardiol 54:460-7. 2009
  2. pmc A shifting approach to management of the thoracic aorta in bicuspid aortic valve
    Alexander R Opotowsky
    Department of Cardiology, Boston Children s Hospital, Boston, Mass 02115, USA
    J Thorac Cardiovasc Surg 146:339-46. 2013
  3. doi request reprint Maternal cardiovascular events during childbirth among women with congenital heart disease
    Alexander R Opotowsky
    Boston Adult Congenital Heart Program, Department of Cardiology, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Heart 98:145-51. 2012
  4. doi request reprint Successful pregnancies in two women with hypoplastic left heart syndrome
    Alexander R Opotowsky
    Department of Cardiology, Children s Hospital Boston, 300 Longwood Avenue, Bader 209, Boston, MA 02115, USA
    Congenit Heart Dis 5:476-81. 2010
  5. pmc A simple echocardiographic method to estimate pulmonary vascular resistance
    Alexander R Opotowsky
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Am J Cardiol 112:873-82. 2013
  6. doi request reprint Correlation of exercise response in repaired coarctation of the aorta to left ventricular mass and geometry
    Eric V Krieger
    Department of Cardiology, Boston Children s Hospital, Massachusetts, USA
    Am J Cardiol 111:406-11. 2013
  7. pmc Clinical profile and underdiagnosis of pulmonary hypertension in US veteran patients
    Bradley A Maron
    Department of Cardiology, Veterans Affairs Boston Healthcare System, Parkway, Boston, MA
    Circ Heart Fail 6:906-12. 2013
  8. doi request reprint Aortic valve dysfunction and aortic dilation in adults with coarctation of the aorta
    Mathieu Clair
    Department of Cardiology, Boston Children s Hospital, Boston, Mass, USA
    Congenit Heart Dis 9:235-43. 2014
  9. pmc Effectiveness of spironolactone plus ambrisentan for treatment of pulmonary arterial hypertension (from the [ARIES] study 1 and 2 trials)
    Bradley A Maron
    Veterans Affairs Boston Healthcare System, Department of Cardiology, 1400 VFW, Parkway, Boston, MA, USA
    Am J Cardiol 112:720-5. 2013
  10. doi request reprint The exceptional and far-flung manifestations of heart failure in Eisenmenger syndrome
    Alexander R Opotowsky
    Boston Adult Congenital Heart and Pulmonary Hypertension Service, Boston Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Heart Fail Clin 10:91-104. 2014

Detail Information

Publications26

  1. doi request reprint Trends in hospitalizations for adults with congenital heart disease in the U.S
    Alexander R Opotowsky
    Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    J Am Coll Cardiol 54:460-7. 2009
    ..The purpose of this study was to better define the epidemiology of hospitalizations for adults with congenital heart disease (ACHD) in the U.S...
  2. pmc A shifting approach to management of the thoracic aorta in bicuspid aortic valve
    Alexander R Opotowsky
    Department of Cardiology, Boston Children s Hospital, Boston, Mass 02115, USA
    J Thorac Cardiovasc Surg 146:339-46. 2013
    ..We aimed to evaluate secular trends and predictors of thoracic aortic surgery among patients with BAV in the United States...
  3. doi request reprint Maternal cardiovascular events during childbirth among women with congenital heart disease
    Alexander R Opotowsky
    Boston Adult Congenital Heart Program, Department of Cardiology, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Heart 98:145-51. 2012
    ..To define the epidemiology of adverse cardiovascular events among women with congenital heart disease (CHD) hospitalised for childbirth in the USA...
  4. doi request reprint Successful pregnancies in two women with hypoplastic left heart syndrome
    Alexander R Opotowsky
    Department of Cardiology, Children s Hospital Boston, 300 Longwood Avenue, Bader 209, Boston, MA 02115, USA
    Congenit Heart Dis 5:476-81. 2010
    ..e., Norwood procedure), HLHS was almost universally fatal within months of birth. Early survivors of the Norwood procedure are now reaching reproductive age. We report successful pregnancies in two such women...
  5. pmc A simple echocardiographic method to estimate pulmonary vascular resistance
    Alexander R Opotowsky
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Am J Cardiol 112:873-82. 2013
    ....
  6. doi request reprint Correlation of exercise response in repaired coarctation of the aorta to left ventricular mass and geometry
    Eric V Krieger
    Department of Cardiology, Boston Children s Hospital, Massachusetts, USA
    Am J Cardiol 111:406-11. 2013
    ..001). In conclusion, HRE was associated with increased LVMVR, even after adjusting for multiple covariates...
  7. pmc Clinical profile and underdiagnosis of pulmonary hypertension in US veteran patients
    Bradley A Maron
    Department of Cardiology, Veterans Affairs Boston Healthcare System, Parkway, Boston, MA
    Circ Heart Fail 6:906-12. 2013
    ..Pulmonary hypertension (PH) is a key contributor to cardiovascular morbidity and early mortality; however, reports are lacking on the epidemiology of PH in at-risk patient populations...
  8. doi request reprint Aortic valve dysfunction and aortic dilation in adults with coarctation of the aorta
    Mathieu Clair
    Department of Cardiology, Boston Children s Hospital, Boston, Mass, USA
    Congenit Heart Dis 9:235-43. 2014
    ..To determine the prevalence of aortic valve dysfunction, aortic dilation, and aortic valve and ascending aortic intervention in adults with coarctation of the aorta (CoA)...
  9. pmc Effectiveness of spironolactone plus ambrisentan for treatment of pulmonary arterial hypertension (from the [ARIES] study 1 and 2 trials)
    Bradley A Maron
    Veterans Affairs Boston Healthcare System, Department of Cardiology, 1400 VFW, Parkway, Boston, MA, USA
    Am J Cardiol 112:720-5. 2013
    ..In conclusion, these pilot data suggest that coupling spironolactone and endothelin type-A receptor antagonism may be clinically beneficial in PAH. Prospective clinical trials are required to further characterize our findings...
  10. doi request reprint The exceptional and far-flung manifestations of heart failure in Eisenmenger syndrome
    Alexander R Opotowsky
    Boston Adult Congenital Heart and Pulmonary Hypertension Service, Boston Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Heart Fail Clin 10:91-104. 2014
    ..The introduction of targeted pulmonary hypertension therapies aimed has subtly shifted clinical focus from preventing iatrogenic and other adverse events toward cautious therapeutic activism...
  11. doi request reprint Hospitalizations and mortality in the United States for adults with Down syndrome and congenital heart disease
    Fernando Baraona
    Department of Cardiology, Boston Children s Hospital, Boston, MA, USA
    Am J Cardiol 111:1046-51. 2013
    ..In conclusion, DS/CHD hospitalizations represent a decreasing proportion of admissions for adults with CHD typical of DS; patients with DS/CHD are more likely to die during hospitalization but less likely to undergo a cardiac procedure...
  12. pmc E/e' Ratio in Patients With Unexplained Dyspnea: Lack of Accuracy in Estimating Left Ventricular Filling Pressure
    Mário Santos
    From the Department of Physiology and Cardiothoracic Surgery, Cardiovascular R and D Unit, Faculty of Medicine, University of Porto, Portugal M S Divisions of Cardiovascular Medicine J R, S d M, E W, A R O, A M S and Pulmonary and Critical Care Medicine A B W, D M S, Brigham and Women s Hospital, Boston, MA and Department of Cardiology, Boston Children s Hospital, MA A R O
    Circ Heart Fail 8:749-56. 2015
    ..Mitral E/e' ratio has been proposed as a noninvasive measure of left ventricular filling pressure. We studied the accuracy of E/e' to estimate and track changes of left ventricular filling pressure in patients with unexplained dyspnea...
  13. pmc Physical activity is associated with improved aerobic exercise capacity over time in adults with congenital heart disease
    Ana Ubeda Tikkanen
    Department of Cardiology, Boston Children s Hospital, Boston, MA, United States Electronic address
    Int J Cardiol 168:4685-91. 2013
    ..We studied the influence of the frequency of at least moderately strenuous physical activity (PhysAct) on changes in exercise capacity of ACHD patients over time...
  14. pmc Plasma aldosterone levels are elevated in patients with pulmonary arterial hypertension in the absence of left ventricular heart failure: a pilot study
    Bradley A Maron
    Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Eur J Heart Fail 15:277-83. 2013
    ..Thus, the central aim of the current study is to determine if hyperaldosteronism is an unrecognized component of the PAH clinical syndrome...
  15. pmc A simple echocardiographic prediction rule for hemodynamics in pulmonary hypertension
    Alexander R Opotowsky
    Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Circ Cardiovasc Imaging 5:765-75. 2012
    ..Differentiating patients with primarily elevated pulmonary vascular resistance (PVR) from those with PH predominantly because of elevated left-sided filling pressure is critical...
  16. doi request reprint Comparison of risk of hypertensive complications of pregnancy among women with versus without coarctation of the aorta
    Eric V Krieger
    Department of Cardiology, Children s Hospital Boston, Boston, Massachusetts, USA
    Am J Cardiol 107:1529-34. 2011
    ....
  17. doi request reprint Transient elastography may identify Fontan patients with unfavorable hemodynamics and advanced hepatic fibrosis
    Fred M Wu
    Department of Cardiology, Boston Children s Hospital, Harvard Medical School, Boston, Mass, USA Division of Cardiology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Congenit Heart Dis 9:438-47. 2014
    ..However, factors other than fibrosis affect liver stiffness. We sought to determine whether hepatic congestion related to hemodynamics in Fontan circulation influences liver stiffness measurement (LSM) assessed by TE...
  18. doi request reprint Exercise oscillatory ventilation in patients with Fontan physiology
    Ashwin S Nathan
    From the Department of Medicine, Brigham and Women s Hospital, Boston, MA A S N, F W, D M S, K S, M J L, A R O Departments of Cardiology B L, L M, F W, J R, R H R, A U T, K S, M J L, A R O and Cardiovascular Surgery A U T, Boston Children s Hospital, MA and Department of Medicine, Massachusetts General Hospital, Boston G D L
    Circ Heart Fail 8:304-11. 2015
    ..Its presence correlates with heart failure severity and worse prognosis in adults with acquired heart failure. We evaluated the prevalence and predictive value of EOV in patients with single ventricle Fontan physiology...
  19. pmc Abnormal spirometry after the Fontan procedure is common and associated with impaired aerobic capacity
    Alexander R Opotowsky
    Department of Cardiology, Boston Children s Hospital, Boston, Massachusetts Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts
    Am J Physiol Heart Circ Physiol 307:H110-7. 2014
    ..A large subset has a pathologically low breathing reserve, consistent with a pulmonary mechanical contribution to exercise limitation...
  20. doi request reprint Improving heart disease knowledge and research participation in adults with congenital heart disease (the Health, Education and Access Research Trial: HEART-ACHD)
    Anne Marie Valente
    Boston Adult Congenital Heart Program, Department of Cardiology, Boston Children s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA, USA Electronic address
    Int J Cardiol 168:3236-40. 2013
    ....
  21. doi request reprint Transcatheter Potts shunt creation in patients with severe pulmonary arterial hypertension: initial clinical experience
    Jesse J Esch
    Department of Cardiology, Boston Children s Hospital, Boston, Massachusetts, USA
    J Heart Lung Transplant 32:381-7. 2013
    ..Surgical shunt placement between the left PA and descending aorta (Potts shunt) appears promising for PAH palliation in children; however, surgical mortality is likely to be unacceptably high in adults with PAH...
  22. doi request reprint Percutaneous closure of patent foramen ovale and atrial septal defect in adults: the impact of clinical variables and hospital procedure volume on in-hospital adverse events
    Alexander R Opotowsky
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am Heart J 157:867-74. 2009
    ..There are no population-based estimates of in-hospital adverse event rates of percutaneous PFO/ASD closure...
  23. doi request reprint Central cardiac limit to aerobic capacity in patients with exertional pulmonary venous hypertension: implications for heart failure with preserved ejection fraction
    Mário Santos
    From the Department of Physiology and Cardiothoracic Surgery, Cardiovascular R and D Unit, Faculty of Medicine, University of Porto, Porto, Portugal M S Pulmonary and Critical Care Medicine J T, A B W, D M S and Division of Cardiovascular Medicine A R O, A M S, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA Department of Cardiology, Boston Children s Hospital, MA A R O
    Circ Heart Fail 8:278-85. 2015
    ....
  24. pmc Pheochromocytoma and paraganglioma in cyanotic congenital heart disease
    Alexander R Opotowsky
    Department of Cardiology A R O, L E M, M J L, M N S, F W, Boston Children s Hospital, Boston, Massachusetts 02115 Division of Cardiovascular Medicine, A R O, M J L, M N S, F W, Division of Endocrinology A V, Diabetes, and Hypertension, Brigham and Women s Hospital, Boston, Massachusetts 02115 Department of Medicine J Gi, M R, Columbia University Medical Center, New York, New York 10027 Adult Congenital Heart Disease Program M G, University Hospital Zurich, CH 8032 Zurich, Switzerland Department of Medicine J A, A H, Division of Cardiology, University of California, Los Angeles, Medical Center, Ahmanson UCLA Adult Congenital Heart Disease Center, Los Angeles, California 90095 Department of Cardiology Y K, L X D, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 Department of Medicine Y K, L X D, Australia
    J Clin Endocrinol Metab 100:1325-34. 2015
    ..Aberrant cellular oxygen sensing is a leading theory for development of pheochromocytoma (PHEO) and paraganglioma (PGL)...
  25. doi request reprint Shape of the right ventricular Doppler envelope predicts hemodynamics and right heart function in pulmonary hypertension
    Jeffrey S Arkles
    Department of Medicine, Cardiovascular Division, Heart Failure and Pulmonary Hypertension Program, Hospital of University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Respir Crit Care Med 183:268-76. 2011
    ..Systolic deceleration or "notching" of the right ventricular outflow tract Doppler flow velocity envelope (FVE(RVOT)) relates to pathologic wave reflection in the setting of elevated pulmonary artery impedance...
  26. doi request reprint The CALF (Congenital Heart Disease in Adults Lower Extremity Systemic Venous Health in Fontan Patients) study
    Anne Marie Valente
    Boston Adult Congenital Heart Program, Department of Cardiology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 56:144-50. 2010
    ..The objective of this study was to document the prevalence of chronic venous insufficiency (CVI) and its associated factors in adults with Fontan physiology...