A James O'Malley

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc The analysis of social network data: an exciting frontier for statisticians
    A James O'Malley
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115 5899, U S A
    Stat Med 32:539-55. 2013
  2. pmc Egocentric social network structure, health, and pro-social behaviors in a national panel study of Americans
    A James O'Malley
    Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e36250. 2012
  3. doi request reprint Improving observational study estimates of treatment effects using joint modeling of selection effects and outcomes: the case of AAA repair
    A James O'Malley
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115 5899, USA
    Med Care 49:1126-32. 2011
  4. pmc Predictors of nursing home residents' time to hospitalization
    A James O'Malley
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Avenue, Boston, MA 02115 5899, USA
    Health Serv Res 46:82-104. 2011
  5. pmc Longitudinal analysis of large social networks: estimating the effect of health traits on changes in friendship ties
    A James O'Malley
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Avenue, Boston, MA 02115, USA
    Stat Med 30:950-64. 2011
  6. ncbi request reprint Application of models for multivariate mixed outcomes to medical device trials: coronary artery stenting
    A James O'Malley
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Avenue, Boston, MA 02115, USA
    Stat Med 22:313-36. 2003
  7. pmc Bayesian multivariate hierarchical transformation models for ROC analysis
    A James O'Malley
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    Stat Med 25:459-79. 2006
  8. ncbi request reprint Sample size calculation for a historically controlled clinical trial with adjustment for covariates
    A James O'Malley
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    J Biopharm Stat 12:227-47. 2002
  9. doi request reprint A Bayesian precision profile for measuring the quality of immunoassay experiments
    A James O'Malley
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Avenue, Boston, MA 02115 5899, USA
    Philos Trans A Math Phys Eng Sci 366:2301-12. 2008
  10. ncbi request reprint Likelihood methods for treatment noncompliance and subsequent nonresponse in randomized trials
    A James O'Malley
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Avenue, Boston, Massachusetts 02115 5899, USA
    Biometrics 61:325-34. 2005

Detail Information

Publications129 found, 100 shown here

  1. pmc The analysis of social network data: an exciting frontier for statisticians
    A James O'Malley
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115 5899, U S A
    Stat Med 32:539-55. 2013
    ..We entertain possible solutions to some of the difficulties encountered in accounting for confounding effects in analyses of peer effects and provide comments on the contributions of CF...
  2. pmc Egocentric social network structure, health, and pro-social behaviors in a national panel study of Americans
    A James O'Malley
    Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e36250. 2012
    ....
  3. doi request reprint Improving observational study estimates of treatment effects using joint modeling of selection effects and outcomes: the case of AAA repair
    A James O'Malley
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115 5899, USA
    Med Care 49:1126-32. 2011
    ..When 2 treatment approaches are available, there are likely to be unmeasured confounders that influence choice of procedure, which complicates estimation of the causal effect of treatment on outcomes using observational data...
  4. pmc Predictors of nursing home residents' time to hospitalization
    A James O'Malley
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Avenue, Boston, MA 02115 5899, USA
    Health Serv Res 46:82-104. 2011
    ..To model the predictors of the time to first acute hospitalization for nursing home residents, and accounting for previous hospitalizations, model the predictors of time between subsequent hospitalizations...
  5. pmc Longitudinal analysis of large social networks: estimating the effect of health traits on changes in friendship ties
    A James O'Malley
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Avenue, Boston, MA 02115, USA
    Stat Med 30:950-64. 2011
    ..We also validated previously known findings regarding homophily on age and gender, and found evidence that homophily also depends upon geographic separation...
  6. ncbi request reprint Application of models for multivariate mixed outcomes to medical device trials: coronary artery stenting
    A James O'Malley
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Avenue, Boston, MA 02115, USA
    Stat Med 22:313-36. 2003
    ..When considering proportion diameter stenosis, the corresponding posterior means are 0.375 (0.020) and 0.427 (0.030). The correlation coefficient of the components of the OPC lies in the range 0.042 to 0.116...
  7. pmc Bayesian multivariate hierarchical transformation models for ROC analysis
    A James O'Malley
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    Stat Med 25:459-79. 2006
    ..The proposed methodology is illustrated on prostate cancer biopsy data from a multi-centre clinical trial...
  8. ncbi request reprint Sample size calculation for a historically controlled clinical trial with adjustment for covariates
    A James O'Malley
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    J Biopharm Stat 12:227-47. 2002
    ..Our principle conclusions are that exact sample size calculations can be substantially different from current approximations, and stochastic optimization provides a convenient method of computation...
  9. doi request reprint A Bayesian precision profile for measuring the quality of immunoassay experiments
    A James O'Malley
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Avenue, Boston, MA 02115 5899, USA
    Philos Trans A Math Phys Eng Sci 366:2301-12. 2008
    ..This leads to a natural procedure for evaluating a precision profile that avoids using approximations such as those inherent in traditional methods...
  10. ncbi request reprint Likelihood methods for treatment noncompliance and subsequent nonresponse in randomized trials
    A James O'Malley
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Avenue, Boston, Massachusetts 02115 5899, USA
    Biometrics 61:325-34. 2005
    ..We illustrate methods using data from a trial to compare the efficacy of two antipsychotics for adults with refractory schizophrenia...
  11. pmc Estimating cost-offsets of new medications: use of new antipsychotics and mental health costs for schizophrenia
    A James O'Malley
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115 5899, USA
    Stat Med 30:1971-88. 2011
    ..We illustrate that in general supplemental information is needed to determine which analysis, if any, is trustworthy and reaffirm that comparing results from different approaches is a valuable sensitivity analysis...
  12. ncbi request reprint Effects of stent length and lesion length on coronary restenosis
    Laura Mauri
    Division of Clinical Biometrics, Brigham and Women s Hospital, 1620 Tremont Street, Boston, MA 02120, USA
    Am J Cardiol 93:1340-6, A5. 2004
    ..This analysis supports a conservative approach of matching stent length to lesion length to reduce the risk of restenosis with bare metal stents...
  13. pmc Risk prediction for perioperative mortality of endovascular vs open repair of abdominal aortic aneurysms using the Medicare population
    Kristina A Giles
    Beth Israel Deaconess Medical Center, Boston, Mass 02215, USA
    J Vasc Surg 50:256-62. 2009
    ..In order to investigate this, we developed a differential predictive model of perioperative mortality after AAA repair...
  14. pmc Does comorbidity influence the risk of myocardial infarction or diabetes during androgen-deprivation therapy for prostate cancer?
    Nancy L Keating
    Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Eur Urol 64:159-66. 2013
    ..Some data suggest that men with certain conditions may be more susceptible to developing cardiovascular disease than others...
  15. ncbi request reprint Relationship of late loss in lumen diameter to coronary restenosis in sirolimus-eluting stents
    Laura Mauri
    Brigham and Women s Hospital, Boston, Mass 02116, USA
    Circulation 111:321-7. 2005
    ..Observed rates of restenosis after drug-eluting stenting are low (<10%). Identification of a reliable and powerful angiographic end point will be useful in future trials...
  16. pmc Case-mix adjustment of the CAHPS Hospital Survey
    A James O'Malley
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115 5899, USA
    Health Serv Res 40:2162-81. 2005
    ..To develop a model for case-mix adjustment of Consumer Assessment of Healthcare Providers and Systems (CAHPS) Hospital survey responses, and to assess the impact of adjustment on comparisons of hospital quality...
  17. pmc A Bayesian hierarchical non-linear regression model in receiver operating characteristic analysis of clustered continuous diagnostic data
    Kelly H Zou
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Avenue, Boston, MA 02115, USA
    Biom J 47:417-27. 2005
    ..A hierarchical regression analysis incorporating the effects of cluster (clinical center) and cancer risk (low, intermediate, and high) was performed, and the area under the ROC curve (AUC) was estimated...
  18. pmc Thirty-day mortality and late survival with reinterventions and readmissions after open and endovascular aortic aneurysm repair in Medicare beneficiaries
    Kristina A Giles
    Division of Vascular and Endovascular Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA
    J Vasc Surg 53:6-12,13.e1. 2011
    ..The effect of reinterventions on survival, however, is unknown. We therefore evaluated the rate of reinterventions and readmission after initial AAA repair, 30-day mortality, and the effect on long-term survival...
  19. ncbi request reprint Quality of care for the treatment of acute medical conditions in US hospitals
    Bruce E Landon
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    Arch Intern Med 166:2511-7. 2006
    ..The Joint Commission on Accreditation of Healthcare Organizations and the Centers for Medicare and Medicaid Services recently began reporting on quality of care for acute myocardial infarction, congestive heart failure, and pneumonia...
  20. ncbi request reprint Improving the management of chronic disease at community health centers
    Bruce E Landon
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 356:921-34. 2007
    ....
  21. ncbi request reprint Comparison of thrombosis and restenosis risk from stent length of sirolimus-eluting stents versus bare metal stents
    Laura Mauri
    Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Cardiol 95:1140-5. 2005
    ..Longer stent-to-lesion length strategies should be used only when a shorter stent is likely to result in incomplete lesion coverage and edge dissection, a strong determinant of stent thrombosis...
  22. pmc Bone density testing among prostate cancer survivors treated with androgen-deprivation therapy
    Alicia K Morgans
    Division of Hematology and Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Cancer 119:863-70. 2013
    ..Guidelines recommend bone density testing before and during ADT to characterize fracture risk. The authors of the current report assessed bone density testing among men who received ADT for ≥ 1 year...
  23. pmc Reasons for choice of referral physician among primary care and specialist physicians
    Michael L Barnett
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Avenue, Boston, MA 02215, USA
    J Gen Intern Med 27:506-12. 2012
    ..For a given clinical problem, referring physicians usually have a choice of several physicians to whom they can refer. Once the decision to refer is made, the choice of individual physician may have important downstream effects...
  24. doi request reprint Impact of health disparities collaboratives on racial/ethnic and insurance disparities in US community health centers
    LeRoi S Hicks
    Department of Health Care Policy, Harvard Medical School, Boston, MA, USA
    Arch Intern Med 170:279-86. 2010
    ..The Health Resources and Services Administration Health Disparities Collaboratives (HDCs) were developed to improve care for chronic medical conditions in community health centers (CHCs)...
  25. ncbi request reprint Detection of prostate cancer by integration of line-scan diffusion, T2-mapping and T2-weighted magnetic resonance imaging; a multichannel statistical classifier
    Ian Chan
    Surgical Planning Laboratory, Department of Radiology, Division of MRI, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Med Phys 30:2390-8. 2003
    ....
  26. pmc Minimal social network effects evident in cancer screening behavior
    Nancy L Keating
    Division of General Internal Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Cancer 117:3045-52. 2011
    ..Social networks may influence screening behaviors. We assessed whether screening for breast, prostate, or colorectal cancer is influenced by the actual screening behaviors of siblings, friends, spouses, and coworkers...
  27. ncbi request reprint Covariate adjustment in clinical trials with non-ignorable missing data and non-compliance
    Douglas E Levy
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Avenue, Boston, MA 02115, USA
    Stat Med 23:2319-39. 2004
    ..We recommend the new estimators as they are unbiased even when outcomes are not missing at random and they are more efficient than established estimators in the presence of covariate effects under the widest variety of circumstances...
  28. pmc Risk of late-onset adhesions and incisional hernia repairs after surgery
    Rodney P Bensley
    Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Am Coll Surg 216:1159-67, 1167.e1-12. 2013
    ..Long-term adhesion-related complications and incisional hernias after abdominal surgery are common and costly. There are few data on the risk of these complications after different abdominal operations...
  29. pmc Variation in patient-sharing networks of physicians across the United States
    Bruce E Landon
    Department of Health Care Policy, School of Medicine, Harvard University, Cambridge, Massachusetts, USA
    JAMA 308:265-73. 2012
    ..Physicians are embedded in informal networks that result from their sharing of patients, information, and behaviors...
  30. doi request reprint Volume-outcome relationships and abdominal aortic aneurysm repair
    Bruce E Landon
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Ave, Boston, MA 02215, USA
    Circulation 122:1290-7. 2010
    ..There is a well-established literature relating procedure volume to outcomes, but incorporating such information into clinical decision making is problematic when there is >1 treatment option for a condition...
  31. pmc Mapping physician networks with self-reported and administrative data
    Michael L Barnett
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02215, USA
    Health Serv Res 46:1592-609. 2011
    ..To assess whether connections between physicians based on shared patients in administrative data correspond with professional relationships between physicians...
  32. pmc Defining perioperative mortality after open and endovascular aortic aneurysm repair in the US Medicare population
    Marc L Schermerhorn
    Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA
    J Am Coll Surg 212:349-55. 2011
    ..Often, 30-day mortality is reported because in-hospital mortality may be biased in favor of endovascular repair given the shorter length of stay. However, the duration of increased risk of death after aneurysm repair is unknown...
  33. pmc Population trends and variation in body mass index from 1971 to 2008 in the Framingham Heart Study Offspring Cohort
    Jason P Block
    Obesity Prevention Program, Department of Population Medicine, Harvard Medical School Harvard Pilgrim Health Care Institute, Boston, Massachusetts, United States of America
    PLoS ONE 8:e63217. 2013
    ..We examined body mass index (BMI) across place and time to determine the pattern of BMI mean and standard deviation trajectories...
  34. doi request reprint Saphenous vein graft stenting and major adverse cardiac events: a predictive model derived from a pooled analysis of 3958 patients
    Alanna Coolong
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 117:790-7. 2008
    ..Although MACE rates are reduced significantly by the use of embolic protection devices (EPDs), neither the level of baseline risk nor the benefit provided by EPDs has been well characterized...
  35. pmc Diabetes and cardiovascular disease during androgen deprivation therapy: observational study of veterans with prostate cancer
    Nancy L Keating
    Division of General Internal Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    J Natl Cancer Inst 102:39-46. 2010
    ..We evaluated the relationship between androgen deprivation therapy and incident diabetes and cardiovascular disease in men of all ages with prostate cancer...
  36. pmc Validation of image segmentation by estimating rater bias and variance
    Simon K Warfield
    Computational Radiology Laboratory, Department of Radiology, Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Philos Trans A Math Phys Eng Sci 366:2361-75. 2008
    ....
  37. pmc Statistical validation based on parametric receiver operating characteristic analysis of continuous classification data
    Kelly H Zou
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 180 Longwood Ave, Boston, MA 02115 USA
    Acad Radiol 10:1359-68. 2003
    ..Statistical validations of classification accuracy was conducted based on parametric receiver operating characteristic analysis, illustrated on three radiologic examples,..
  38. pmc Medicare Part D plan generosity and medication use among dual-eligible nursing home residents
    Haiden A Huskamp
    Department of Health Care Policy, Harvard Medical School, Boston, MA The Dartmouth Institute and Geisel Medical School at Dartmouth, Lebanon, NH Division of General Medicine and Clinical Epidemiology, School of Medicine Department of Health Policy and Management, Gillings School of Global Public Health Cecil G Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, Chapel Hill, NC Institute for Aging Research, Hebrew SeniorLife, Deaconess Medical Center Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA Omnicare Inc, Livonia, MI Department of Health Policy and Management, Harvard School of Public Health, Boston Harvard Kennedy School, Cambridge, MA
    Med Care 51:894-900. 2013
    ..Therefore, residents' assigned plans may be relatively more or less generous for their particular drugs. The impact of generosity on residents' medication use and health outcomes is unknown...
  39. pmc Impact of alternative interventions on changes in generic dispensing rates
    A James O'Malley
    Department of Health Care Policy, 180 Longwood Avenue, Boston, MA 02115 5899, USA
    Health Serv Res 41:1876-94. 2006
    ....
  40. pmc Exploratory factor analyses of the CAHPS Hospital Pilot Survey responses across and within medical, surgical, and obstetric services
    A James O'Malley
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115 5899, USA
    Health Serv Res 40:2078-95. 2005
    ....
  41. ncbi request reprint Receiver-operating characteristic analysis for evaluating diagnostic tests and predictive models
    Kelly H Zou
    Children s Hospital Boston, Boston, MA, USA
    Circulation 115:654-7. 2007
  42. pmc Gonadotrophin-releasing hormone agonists, diabetes and cardiovascular disease in men with prostate cancer: which metabolic syndrome?
    Matthew R Smith
    Hematology Oncology Division, Massachusetts General Hospital, Boston, MA 02114, USA
    BJU Int 101:1335-6. 2008
  43. doi request reprint Endovascular vs. open repair of abdominal aortic aneurysms in the Medicare population
    Marc L Schermerhorn
    Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    N Engl J Med 358:464-74. 2008
    ..Longer-term survival rates, however, were similar for the two procedures. There are currently no long-term, population-based data from the comparison of these strategies...
  44. pmc Patterns of bone density evaluation in a community population treated with aromatase inhibitors
    Jennifer A Ligibel
    Dana Farber Cancer Institute, 450 Brookline Ave, Boston, MA 02215, USA
    Breast Cancer Res Treat 134:1305-13. 2012
    ..Attention is needed to insure that unnecessary fractures are avoided in breast cancer patients taking AIs...
  45. pmc Proximity to food establishments and body mass index in the Framingham Heart Study offspring cohort over 30 years
    Jason P Block
    Department of Population Medicine, Harvard Pilgrim Health Care Institute, Harvard Medical School, 133 Brookline Avenue, Boston, MA 02215, USA
    Am J Epidemiol 174:1108-14. 2011
    ....
  46. pmc Can choice of the sample population affect perceived performance: implications for performance assessment
    Bruce E Landon
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Avenue, Boston, MA 02215, USA
    J Gen Intern Med 25:104-9. 2010
    ..There is accelerating interest in measuring and reporting the quality of care delivered by health care providers and organizations, but methods for defining the patient panels for which they are held accountable are not well defined...
  47. doi request reprint On the prospects for a blame-free medical culture
    Molly E Collins
    Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, United States of America
    Soc Sci Med 69:1287-90. 2009
    ..Given that physicians' ideology of self-blame is ingrained, accompanied by benefits, and limits a systems perspective on error, it may subvert attempts to establish a blame-free culture...
  48. pmc Don't just blame the system
    Nicholas A Christakis
    BMJ 336:747. 2008
  49. pmc When networks can teach us about drug use
    Nicholas A Christakis
    Harvard Medical School, Cambridge, Massachusetts, USA
    BMJ 336:420. 2008
  50. pmc Emotions as infectious diseases in a large social network: the SISa model
    Alison L Hill
    Program for Evolutionary Dynamics, Berkman Center for Internet and Society, Department of Mathematics, Harvard University, Cambridge, MA 02138, USA
    Proc Biol Sci 277:3827-35. 2010
    ..Our model provides a theoretical framework for studying the interpersonal spread of any state that may also arise spontaneously, such as emotions, behaviours, health states, ideas or diseases with reservoirs...
  51. doi request reprint Measuring clinically significant chemotherapy-related toxicities using Medicare claims from Cancer and Leukemia Group B (CALGB) trial participants
    Elizabeth B Lamont
    Massachusetts General Hospital, Boston, Massachusetts, USA
    Med Care 46:303-8. 2008
    ..Because the elderly are underrepresented on clinical trials, physicians have few sources of information to estimate the risks (ie, toxicities) and benefits of chemotherapy administration to the elderly...
  52. pmc The spread of alcohol consumption behavior in a large social network
    J Niels Rosenquist
    Massachusetts General Hospital, Harvard Medical School, and Boston University School of Medicine, 180 A Longwood Avenue, Boston, MA 02115, USA
    Ann Intern Med 152:426-33, W141. 2010
    ..Alcohol consumption has important health-related consequences and numerous biological and social determinants...
  53. pmc Infectious disease modeling of social contagion in networks
    Alison L Hill
    Program for Evolutionary Dynamics, Harvard University, Cambridge, Massachusetts, United States of America
    PLoS Comput Biol 6:e1000968. 2010
    ..It provides a theoretical framework for studying the interpersonal spread of any state that may also arise spontaneously, such as emotions, behaviors, health states, ideas or diseases with reservoirs...
  54. pmc The collective dynamics of smoking in a large social network
    Nicholas A Christakis
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 358:2249-58. 2008
    ..We examined the extent of the person-to-person spread of smoking behavior and the extent to which groups of widely connected people quit together...
  55. pmc Health care in a web
    Nicholas A Christakis
    Harvard Medical School, USA
    BMJ 336:1468. 2008
  56. doi request reprint Too quietly into the night
    Nicholas A Christakis
    Harvard Medical School, USA
    BMJ 337:a696. 2008
  57. ncbi request reprint The spread of obesity in a large social network over 32 years
    Nicholas A Christakis
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 357:370-9. 2007
    ..The prevalence of obesity has increased substantially over the past 30 years. We performed a quantitative analysis of the nature and extent of the person-to-person spread of obesity as a possible factor contributing to the obesity epidemic...
  58. doi request reprint Valuing the well connected
    Nicholas A Christakis
    Harvard Medical School, USA
    BMJ 337:a1675. 2008
  59. pmc Social network sensors for early detection of contagious outbreaks
    Nicholas A Christakis
    Faculty of Arts and Sciences, Harvard University, Boston, Massachusetts, United States of America
    PLoS ONE 5:e12948. 2010
    ..The amount of lead time will depend on features of the outbreak and the network at hand. The method could in principle be generalized to other biological, psychological, informational, or behavioral contagions that spread in networks...
  60. ncbi request reprint The health impact of health care on families: a matched cohort study of hospice use by decedents and mortality outcomes in surviving, widowed spouses
    Nicholas A Christakis
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Avenue, Boston, MA 02115, USA
    Soc Sci Med 57:465-75. 2003
    ..Health care may have positive, group-level health "externalities": it may affect the health not only of patients but also of patients' family members...
  61. ncbi request reprint Measuring disease-free survival and cancer relapse using Medicare claims from CALGB breast cancer trial participants (companion to 9344)
    Elizabeth B Lamont
    Massachusetts General Hospital Cancer Center and Institute for Technology Assessment, Massachusetts General Hospital, Boston, MA, USA
    J Natl Cancer Inst 98:1335-8. 2006
    ....
  62. ncbi request reprint Criterion validity of Medicare chemotherapy claims in Cancer and Leukemia Group B breast and lung cancer trial participants
    Elizabeth B Lamont
    Department of Medicine and Institute for Technology Assessment, Massachusetts General Hospital, Boston, MA 02114, USA
    J Natl Cancer Inst 97:1080-3. 2005
    ..Administrative Medicare claims data appear to be a valid source of information for chemotherapy administered to elderly Medicare beneficiaries with cancer...
  63. ncbi request reprint Care after the onset of serious illness: a novel claims-based dataset exploiting substantial cross-set linkages to study end-of-life care
    Nicholas A Christakis
    Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Palliat Med 5:515-29. 2002
    ..Detailed health information about cohort members' spouses was also collected. We conclude by highlighting the types of analyses that can be conducted in this data set...
  64. pmc Medicine may change our genes
    Nicholas A Christakis
    Harvard Medical School, USA
    BMJ 336:1101. 2008
  65. ncbi request reprint Mortality after the hospitalization of a spouse
    Nicholas A Christakis
    Department of Health Care Policy, Harvard Medical School, and the Palliative Care Service, Department of Medicine, Massachusetts General Hospital, Boston, MA 02115, USA
    N Engl J Med 354:719-30. 2006
    ..The illness of a spouse can affect the health of a caregiving partner. We examined the association between the hospitalization of a spouse and a partner's risk of death among elderly people...
  66. ncbi request reprint Correlation and simple linear regression
    Kelly H Zou
    Department of Radiology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Radiology 227:617-22. 2003
    ..These statistical methods are important for exploring the relationships between variables and can be applied to many radiologic studies...
  67. pmc Rater-dependent accuracy in predicting the spatial location of functional centers on anatomical MR images
    Hillary K Rolls
    Harvard Medical School, Boston, MA, USA
    Clin Neurol Neurosurg 109:225-35. 2007
    ..This study examined the abilities of medical personnel of various backgrounds to predict the location of functional cortex using anatomical information provided by MR imaging...
  68. pmc Simultaneous truth and performance level estimation (STAPLE): an algorithm for the validation of image segmentation
    Simon K Warfield
    Harvard Medical School and the Department of Radiology of Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    IEEE Trans Med Imaging 23:903-21. 2004
    ..STAPLE is straightforward to apply to clinical imaging data, it readily enables assessment of the performance of an automated image segmentation algorithm, and enables direct comparison of human rater and algorithm performance...
  69. ncbi request reprint Three-dimensional assessment of MR imaging-guided percutaneous cryotherapy using multi-performer repeated segmentations: the value of supervised learning
    Kelly H Zou
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Acad Radiol 12:444-50. 2005
    ..We evaluated whether supervised learning methods would improve multiperformer repeated segmentations of magnetic resonance images (MRI) obtained before and after MRI-guided cryotherapy of renal cell carcinoma...
  70. pmc Three validation metrics for automated probabilistic image segmentation of brain tumours
    Kelly H Zou
    Department of Radiology, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, U S A
    Stat Med 23:1259-82. 2004
    ..The performances of these validation metrics were also investigated via Monte Carlo simulation. Extensions of incorporating spatial correlation structures using a Markov random field model were considered...
  71. ncbi request reprint Functional MRI of auditory verbal working memory: long-term reproducibility analysis
    Xingchang Wei
    Center for Neurological Imaging, Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuroimage 21:1000-8. 2004
    ..The quantitative estimation of the proportions of within-subject and between-subject variabilities in the overall variability may be helpful for the design of future studies...
  72. pmc Volumetric assessment of tumor infiltration of adjacent white matter based on anatomic MRI and diffusion tensor tractography
    Ion Florin Talos
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Acad Radiol 14:431-6. 2007
    ..We hypothesized that white matter infiltration may be common among different types of tumor...
  73. ncbi request reprint What is evidence-based medicine?
    Kelly H Zou
    Radiology Management Group, Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Acad Radiol 11:127-33. 2004
    ..In this review article, we present the definition and useful concepts of evidence-based medicine (EBM). The principles of EBM are provided and major steps of practicing EBM are described...
  74. doi request reprint Axial oblique CT to assess femoral anteversion
    Delma Y Jarrett
    Department of Radiology, Children s Hospital Boston, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA
    AJR Am J Roentgenol 194:1230-3. 2010
    ....
  75. ncbi request reprint Hypothesis testing I: proportions
    Kelly H Zou
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Radiology 226:609-13. 2003
    ..The statistical formulas used for these analyses are explained and demonstrated. These methods may enable systematic analysis of proportions and may be applied to many other radiologic investigations...
  76. pmc Providing concept-oriented views for clinical data using a knowledge-based system: an evaluation
    Qing Zeng
    Decision System Group, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Med Inform Assoc 9:294-305. 2002
    ..g., laboratory, radiology). This study evaluates the functionality and utility of a knowledge-based system that generates concept-oriented views (organized around clinical concepts such as disease or organ system) of clinical data...
  77. doi request reprint Whole-body MRI in suspected infant abuse
    Jeannette M Perez-Rossello
    Department of Radiology, Children s Hospital Boston and Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA
    AJR Am J Roentgenol 195:744-50. 2010
    ..The purpose of our study was to examine the utility of whole-body MRI (WB-MRI) in the detection of skeletal and soft-tissue injuries in suspected infant abuse...
  78. ncbi request reprint Sample size considerations in observational health care quality studies
    Sharon Lise T Normand
    Department of Health Care Policy, Harvard Medical School, Boston, MA 02115, USA
    Stat Med 21:331-45. 2002
    ..If researchers are interested in comparing clusters, hierarchical models are preferred...
  79. pmc Combining classifiers using their receiver operating characteristics and maximum likelihood estimation
    Steven Haker
    Surgical Planning Lab, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, 02115, USA
    Med Image Comput Comput Assist Interv 8:506-14. 2005
    ..We offer some insights into the use of ROC analysis in the field of medical imaging...
  80. ncbi request reprint Validation of image segmentation by estimating rater bias and variance
    Simon K Warfield
    Computational Radiology Laboratory, Dept Radiology, Children s Hospital 2 Dept Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Med Image Comput Comput Assist Interv 9:839-47. 2006
    ....
  81. pmc Statistical combination schemes of repeated diagnostic test data
    Kelly H Zou
    Department of Radiology L 2, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Acad Radiol 13:566-72. 2006
    ..When diagnostic tests are repeated and combined, a number of schemes may be adopted. Guidelines for their interpretations are required...
  82. pmc Role of endorectal coil magnetic resonance imaging in treatment of patients with prostate cancer and in determining radical prostatectomy surgical margin status: report of a single surgeon's practice
    Jian Qing Zhang
    Department of Radiology, Brigham and Women s Hospital and Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Urology 69:1134-7. 2007
    ..To evaluate the role of the combination of endorectal coil and external multicoil array magnetic resonance imaging (MRI) in the management of prostate cancer and predicting the surgical margin status in a single-surgeon practice...
  83. pmc Reproducibility of functional MR imaging: preliminary results of prospective multi-institutional study performed by Biomedical Informatics Research Network
    Kelly H Zou
    Surgical Planning Laboratory, Dept of Radiology, Brigham and Women s Hosp, Harvard Medical School, Boston, MA 02115, USA
    Radiology 237:781-9. 2005
    ....
  84. ncbi request reprint The use of receiver operating characteristic curves in biomedical informatics
    Thomas A Lasko
    Decision Systems Group, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Biomed Inform 38:404-15. 2005
    ..In this article, we review the basic concepts of ROC analysis, illustrate their use with sample calculations, make recommendations drawn from the literature, and list readily available software...
  85. ncbi request reprint A global goodness-of-fit test for receiver operating characteristic curve analysis via the bootstrap method
    Kelly H Zou
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, MIT, MA, USA
    J Biomed Inform 38:395-403. 2005
    ..The main objective was to develop a global statistical hypothesis test for assessing the goodness-of-fit (GOF) for parametric ROC curves via the bootstrap...
  86. pmc Assessment of multiple sclerosis lesions with spherical harmonics: comparison of MR imaging and pathologic findings
    Daniel Goldberg-Zimring
    Department of Biomedical Engineering, Technion, Israel Institute of Technology, Haifa, Israel
    Radiology 235:1036-44. 2005
    ..Mean DSC was significantly higher than 70% (P < .001). SH method provided unbiased lesion volume and added geometric information that may enable a better understanding of the pathogenesis and lesion evolution over time...
  87. pmc Statistical validation of brain tumor shape approximation via spherical harmonics for image-guided neurosurgery
    Daniel Goldberg-Zimring
    Department of Radiology, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Acad Radiol 12:459-66. 2005
    ..We performed a preliminary evaluation of the use of spherical harmonics (SH) in approximating the 3D shape and estimating the volume of brain tumors of varying characteristics...
  88. doi request reprint Gender differences in research grant applications and funding outcomes for medical school faculty
    Susan E Waisbren
    Children s Hospital, Boston, Massachusetts, USA
    J Womens Health (Larchmt) 17:207-14. 2008
    ..To evaluate whether there were differences in acquisition of research grant support between male and female faculty at eight Harvard Medical School-affiliated institutions...
  89. ncbi request reprint Capturing intraoperative deformations: research experience at Brigham and Women's Hospital
    Simon K Warfield
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Med Image Anal 9:145-62. 2005
    ..This paper reviews the experience at Brigham and Women's Hospital through the process of developing and applying novel algorithms for capturing intraoperative deformations in support of image guided therapy...
  90. doi request reprint Androgen-deprivation therapy and diabetes control among diabetic men with prostate cancer
    Nancy L Keating
    Division of General Internal Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA Department of Health Care Policy, Harvard Medical School, Boston, MA, USA Electronic address
    Eur Urol 65:816-24. 2014
    ..Few data are available about the effects of ADT on diabetes control among men with diabetes...
  91. ncbi request reprint The costs and potential savings associated with nursing home hospitalizations
    David C Grabowski
    Health Care Policy, Harvard Medical School in Boston, Massachusetts, USA
    Health Aff (Millwood) 26:1753-61. 2007
    ..These data highlight the potential for cost savings associated with programs designed to reduce these potentially avoidable hospitalizations from the nursing home setting...
  92. ncbi request reprint Three-dimensional magnetic resonance imaging technique for myocardial-delayed hyperenhancement: a comparison with the two-dimensional technique
    Servet Tatli
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Magn Reson Imaging 20:378-82. 2004
    ..To compare two-dimensional and three-dimensional techniques in the detection of myocardial infarction (MI) and in the grading transmural extent (TE)...
  93. pmc Supratentorial low-grade glioma resectability: statistical predictive analysis based on anatomic MR features and tumor characteristics
    Ion Florin Talos
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Radiology 239:506-13. 2006
    ..To retrospectively assess the main variables that affect the complete magnetic resonance (MR) imaging-guided resection of supratentorial low-grade gliomas...
  94. pmc Decreases in ventricular volume correlate with decreases in ventricular pressure in idiopathic normal pressure hydrocephalus patients who experienced clinical improvement after implantation with adjustable valve shunts
    Kathleen A McConnell
    Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Neurosurgery 55:582-92; discussion 592-3. 2004
    ..We also examined whether these pressure-volume curves and other patient variables would co-occur with a positive clinical response to shunting...
  95. doi request reprint Culture change and nursing home quality of care
    David C Grabowski
    Address correspondence to David C Grabowski, Harvard Medical School, Department of Health Care Policy, 180 Longwood Avenue, Boston, MA 02115 5899 E mail
    Gerontologist 54:S35-45. 2014
    ..We evaluated the impact of the implementation of nursing home culture change on the quality of care, as measured by staffing, health-related survey deficiencies, and Minimum Data Set (MDS) quality indicators...
  96. doi request reprint How quickly do physicians adopt new drugs? The case of second-generation antipsychotics
    Haiden A Huskamp
    Department of Health Care Policy, Harvard Medical School, 180 Longwood Ave, Boston, MA 02115, USA
    Psychiatr Serv 64:324-30. 2013
    ..The authors examined physician adoption of second-generation antipsychotic medications and identified physician-level factors associated with early adoption...
  97. pmc The relationship between physician compensation strategies and the intensity of care delivered to Medicare beneficiaries
    Bruce E Landon
    Department of Health Care Policy, Harvard Medical School and the Division of General Medicine, 180 Longwood Avenue, Boston, MA 02115, USA
    Health Serv Res 46:1863-82. 2011
    ..To examine the relationship between primary care physicians' (PCPs) payment arrangements and the total costs and intensity of care for specific episodes of care for Medicare beneficiaries...
  98. pmc Factors influencing changes in employment among women with newly diagnosed breast cancer
    Michael J Hassett
    Center for Outcomes and Policy Research, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA
    Cancer 115:2775-82. 2009
    ..The authors of this report assessed whether chemotherapy or radiation therapy was associated with a disruption in employment during the year after a breast cancer diagnosis...
  99. ncbi request reprint The quality of chronic disease care in U.S. community health centers
    LeRoi S Hicks
    Harvard Medical School, Boston, Massachusetts, USA
    Health Aff (Millwood) 25:1712-23. 2006
    ..Although the quality of chronic disease care in CHCs compares favorably with that of care received in other settings, gaps in quality were observed for the uninsured...
  100. pmc Use of androgen deprivation therapy for metastatic prostate cancer in older men
    Nancy L Keating
    Division of General Internal Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    BJU Int 101:1077-83. 2008
    ....