Kyoung Joon Oh

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint A membrane-targeted BID BCL-2 homology 3 peptide is sufficient for high potency activation of BAX in vitro
    Kyoung Joon Oh
    Howard Hughes Medical Institute, the Department of Pathology and Medicine, Harvard Medical School, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Biol Chem 281:36999-7008. 2006
  2. ncbi request reprint A stapled BID BH3 helix directly binds and activates BAX
    Loren D Walensky
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell 24:199-210. 2006
  3. ncbi request reprint Conformational changes in BID, a pro-apoptotic BCL-2 family member, upon membrane binding. A site-directed spin labeling study
    Kyoung Joon Oh
    Howard Hughes Medical Institute, the Department of Pathology and Medicine, Harvard Medical School, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Biol Chem 280:753-67. 2005
  4. doi request reprint HIV-1 broadly neutralizing antibody extracts its epitope from a kinked gp41 ectodomain region on the viral membrane
    Zhen Yu J Sun
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Immunity 28:52-63. 2008

Collaborators

Detail Information

Publications4

  1. ncbi request reprint A membrane-targeted BID BCL-2 homology 3 peptide is sufficient for high potency activation of BAX in vitro
    Kyoung Joon Oh
    Howard Hughes Medical Institute, the Department of Pathology and Medicine, Harvard Medical School, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Biol Chem 281:36999-7008. 2006
    ..These results highlight the importance of membrane targeting of the BID BH3 domain in tBID-mediated BAX activation and support a model in which tBID engages BAX to trigger its pro-apoptotic activity...
  2. ncbi request reprint A stapled BID BH3 helix directly binds and activates BAX
    Loren D Walensky
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell 24:199-210. 2006
    ..We further demonstrate that membrane targeting of stapled BID BH3 optimizes its ability to activate BAX, supporting a model in which BID directly engages BAX to trigger mitochondrial apoptosis...
  3. ncbi request reprint Conformational changes in BID, a pro-apoptotic BCL-2 family member, upon membrane binding. A site-directed spin labeling study
    Kyoung Joon Oh
    Howard Hughes Medical Institute, the Department of Pathology and Medicine, Harvard Medical School, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Biol Chem 280:753-67. 2005
    ..Our study presents a more detailed model for the reorganization of the structure of tBID on membranes...
  4. doi request reprint HIV-1 broadly neutralizing antibody extracts its epitope from a kinked gp41 ectodomain region on the viral membrane
    Zhen Yu J Sun
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Immunity 28:52-63. 2008
    ....