Shuji Ogino

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Epigenetic profiling of synchronous colorectal neoplasias by quantitative DNA methylation analysis
    Shuji Ogino
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Mod Pathol 19:1083-90. 2006
  2. ncbi request reprint CpG island methylation, response to combination chemotherapy, and patient survival in advanced microsatellite stable colorectal carcinoma
    Shuji Ogino
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Virchows Arch 450:529-37. 2007
  3. pmc Molecular pathological epidemiology of epigenetics: emerging integrative science to analyze environment, host, and disease
    Shuji Ogino
    Department of Pathology, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02215, USA
    Mod Pathol 26:465-84. 2013
  4. pmc Cancer classification using the Immunoscore: a worldwide task force
    Jerome Galon
    INSERM, U872, Laboratory of Integrative Cancer Immunology, Paris, F 75006, France
    J Transl Med 10:205. 2012
  5. pmc Prospective study of family history and colorectal cancer risk by tumor LINE-1 methylation level
    Shuji Ogino
    Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, 450 Brookline Ave, Rm JF 215C, Boston, MA 02215, USA
    J Natl Cancer Inst 105:130-40. 2013
  6. pmc How many molecular subtypes? Implications of the unique tumor principle in personalized medicine
    Shuji Ogino
    Department of Pathology, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA, USA
    Expert Rev Mol Diagn 12:621-8. 2012
  7. pmc Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum
    Mai Yamauchi
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA
    Gut 61:847-54. 2012
  8. pmc Predictive and prognostic roles of BRAF mutation in stage III colon cancer: results from intergroup trial CALGB 89803
    Shuji Ogino
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02215, USA
    Clin Cancer Res 18:890-900. 2012
  9. pmc Cyclooxygenase-2 overexpression is common in serrated and non-serrated colorectal adenoma, but uncommon in hyperplastic polyp and sessile serrated polyp/adenoma
    Takako Kawasaki
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA
    BMC Cancer 8:33. 2008
  10. pmc 18q loss of heterozygosity in microsatellite stable colorectal cancer is correlated with CpG island methylator phenotype-negative (CIMP-0) and inversely with CIMP-low and CIMP-high
    Shuji Ogino
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    BMC Cancer 7:72. 2007

Research Grants

Detail Information

Publications110 found, 100 shown here

  1. ncbi request reprint Epigenetic profiling of synchronous colorectal neoplasias by quantitative DNA methylation analysis
    Shuji Ogino
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Mod Pathol 19:1083-90. 2006
    ..KRAS mutations were not concordant in any synchronous neoplasia pair. In conclusion, epigenetic alterations at CIMP-specific promoter CpG islands in synchronous colorectal neoplasias likely have both random and nonrandom components...
  2. ncbi request reprint CpG island methylation, response to combination chemotherapy, and patient survival in advanced microsatellite stable colorectal carcinoma
    Shuji Ogino
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Virchows Arch 450:529-37. 2007
    ..Additional studies are necessary to examine the role of DNA methylation in treatment efficacy...
  3. pmc Molecular pathological epidemiology of epigenetics: emerging integrative science to analyze environment, host, and disease
    Shuji Ogino
    Department of Pathology, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02215, USA
    Mod Pathol 26:465-84. 2013
    ....
  4. pmc Cancer classification using the Immunoscore: a worldwide task force
    Jerome Galon
    INSERM, U872, Laboratory of Integrative Cancer Immunology, Paris, F 75006, France
    J Transl Med 10:205. 2012
    ..The results of this international validation may result in the implementation of the Immunoscore as a new component for the classification of cancer, designated TNM-I (TNM-Immune)...
  5. pmc Prospective study of family history and colorectal cancer risk by tumor LINE-1 methylation level
    Shuji Ogino
    Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, 450 Brookline Ave, Rm JF 215C, Boston, MA 02215, USA
    J Natl Cancer Inst 105:130-40. 2013
    ..We tested the hypothesis that CRC family history might confer a higher risk of LINE-1 methylation-low CRC...
  6. pmc How many molecular subtypes? Implications of the unique tumor principle in personalized medicine
    Shuji Ogino
    Department of Pathology, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA, USA
    Expert Rev Mol Diagn 12:621-8. 2012
    ..Starting from the unique tumor concept and paradigm, we can better classify tumors by molecular methods, and move closer toward personalized cancer medicine and prevention...
  7. pmc Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum
    Mai Yamauchi
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA
    Gut 61:847-54. 2012
    ..Considering a possible role of bowel contents (including microbiome) in carcinogenesis, this study hypothesised that tumour molecular features might gradually change along bowel subsites, rather than change abruptly at splenic flexure...
  8. pmc Predictive and prognostic roles of BRAF mutation in stage III colon cancer: results from intergroup trial CALGB 89803
    Shuji Ogino
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02215, USA
    Clin Cancer Res 18:890-900. 2012
    ..irinotecan (CPT11), FU and LV (IFL); CALGB 89803]. Cox proportional hazards model was used to assess the prognostic role of BRAF mutation, adjusting for clinical features, adjuvant chemotherapy arm, and MSI status...
  9. pmc Cyclooxygenase-2 overexpression is common in serrated and non-serrated colorectal adenoma, but uncommon in hyperplastic polyp and sessile serrated polyp/adenoma
    Takako Kawasaki
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA
    BMC Cancer 8:33. 2008
    ..Therefore, we hypothesized that COX-2 may play a less important role in the serrated pathway...
  10. pmc 18q loss of heterozygosity in microsatellite stable colorectal cancer is correlated with CpG island methylator phenotype-negative (CIMP-0) and inversely with CIMP-low and CIMP-high
    Shuji Ogino
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    BMC Cancer 7:72. 2007
    ..However, no study has examined 18q LOH in relation to CIMP-high, CIMP-low (less extensive promoter methylation) and CIMP-0 (CIMP-negative), determined by quantitative DNA methylation analysis...
  11. pmc Evaluation of markers for CpG island methylator phenotype (CIMP) in colorectal cancer by a large population-based sample
    Shuji Ogino
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Mol Diagn 9:305-14. 2007
    ..In conclusion, a panel of markers including at least RUNX3, CACNA1G, IGF2, and MLH1 can serve as a sensitive and specific marker panel for CIMP-high...
  12. ncbi request reprint Fatty acid synthase overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype
    Shuji Ogino
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Pathol 38:842-9. 2007
    ..Fatty acid synthase overexpression was not significantly correlated with sex, tumor location, p53, or KRAS/BRAF status. In conclusion, FASN overexpression in colorectal cancer is associated with MSI-H, independent of CIMP status...
  13. pmc Molecular correlates with MGMT promoter methylation and silencing support CpG island methylator phenotype-low (CIMP-low) in colorectal cancer
    Shuji Ogino
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, 75 Francis St, BWH Pathology, Boston, MA 02115, USA
    Gut 56:1564-71. 2007
    ..O-6-methylguanine-DNA methyltransferase (MGMT) promoter methylation and silencing have been associated with G>A mutations and microsatellite instability-low (MSI-low)...
  14. ncbi request reprint Bayesian risk assessment in genetic testing for autosomal dominant disorders with age-dependent penetrance
    Shuji Ogino
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA
    J Genet Couns 16:29-39. 2007
    ..Our methods can be applied to many different scenarios, including those where the sensitivity of genetic testing varies for different family members at risk...
  15. ncbi request reprint TGFBR2 mutation is correlated with CpG island methylator phenotype in microsatellite instability-high colorectal cancer
    Shuji Ogino
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Pathol 38:614-20. 2007
    ....
  16. pmc Standard mutation nomenclature in molecular diagnostics: practical and educational challenges
    Shuji Ogino
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    J Mol Diagn 9:1-6. 2007
    ..Our aim is to alert laboratory scientists and other health care professionals to the important issues and provide a foundation for further discussions that will ultimately lead to solutions...
  17. pmc Cytoplasmic localization of p27 (cyclin-dependent kinase inhibitor 1B/KIP1) in colorectal cancer: inverse correlations with nuclear p27 loss, microsatellite instability, and CpG island methylator phenotype
    Shuji Ogino
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Pathol 38:585-92. 2007
    ....
  18. pmc Negative lymph node count is associated with survival of colorectal cancer patients, independent of tumoral molecular alterations and lymphocytic reaction
    Shuji Ogino
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Gastroenterol 105:420-33. 2010
    ....
  19. ncbi request reprint MGMT germline polymorphism is associated with somatic MGMT promoter methylation and gene silencing in colorectal cancer
    Shuji Ogino
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Carcinogenesis 28:1985-90. 2007
    ..56C>T) of the MGMT promoter and promoter methylation/silencing of MGMT in colorectal cancer. Our data provide compelling evidence for common susceptibility for MGMT promoter CpG island methylation...
  20. pmc p21 expression in colon cancer and modifying effects of patient age and body mass index on prognosis
    Shuji Ogino
    Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 18:2513-21. 2009
    ..Patient BMI also differentially influences prognosis according to p21 CDKN1A status. Our data suggest host-tumor interactions influencing tumor aggressiveness...
  21. pmc Prognostic significance and molecular associations of 18q loss of heterozygosity: a cohort study of microsatellite stable colorectal cancers
    Shuji Ogino
    Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, 44 Binney St, Room JF 215C, Boston, MA 02115 USA
    J Clin Oncol 27:4591-8. 2009
    ..However, it is unclear whether 18q LOH in colorectal cancer has any prognostic implication independent of MSI status and other potential predictors of clinical outcome...
  22. pmc Cyclooxygenase-2 expression is an independent predictor of poor prognosis in colon cancer
    Shuji Ogino
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Clin Cancer Res 14:8221-7. 2008
    ..However, previous data on the influence of COX-2 expression on patient outcome have been conflicting...
  23. pmc Colorectal cancer expression of peroxisome proliferator-activated receptor gamma (PPARG, PPARgamma) is associated with good prognosis
    Shuji Ogino
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, and Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Gastroenterology 136:1242-50. 2009
    ..There is controversy over the pro-oncogenic or antioncogenic effects of PPARG, and little is known about its prognostic significance in colon cancer...
  24. pmc PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer
    Shuji Ogino
    Department of Medical Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, 44 Binney St, Room JF 215C, Boston, MA 02115 USA
    J Clin Oncol 27:1477-84. 2009
    ..PIK3CA mutation and subsequent activation of the AKT pathway play an important role in colorectal carcinogenesis. However, little is known about the prognostic role of PIK3CA mutation in colon cancer...
  25. pmc Cohort study of fatty acid synthase expression and patient survival in colon cancer
    Shuji Ogino
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    J Clin Oncol 26:5713-20. 2008
    ..Fatty acid synthase (FASN) is physiologically regulated by energy balance and is often upregulated in colorectal cancer. Nonetheless, the influence of FASN expression on patient outcome is uncertain...
  26. pmc CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer
    Shuji Ogino
    Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115 USA
    Gut 58:90-6. 2009
    ..The independent effect of CIMP, MSI and BRAF mutation on prognosis remains uncertain...
  27. pmc A cohort study of STMN1 expression in colorectal cancer: body mass index and prognosis
    Shuji Ogino
    Department of Medical Oncology, Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Brigham and Women s Hospital and Harvard Medical School, 44 Binney St, Room JF 215C, Boston, Massachusetts 02115, USA
    Am J Gastroenterol 104:2047-56. 2009
    ..STMN1 activity is influenced by p53, p27, and the PI3K/AKT pathway. However, its prognostic significance in colon cancer is uncertain...
  28. pmc LINE-1 hypomethylation is inversely associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer
    Shuji Ogino
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Int J Cancer 122:2767-73. 2008
    ..Our data also support a possible link between global hypomethylation and chromosomal instability...
  29. pmc A cohort study of cyclin D1 expression and prognosis in 602 colon cancer cases
    Shuji Ogino
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, USA
    Clin Cancer Res 15:4431-8. 2009
    ....
  30. pmc Molecular classification and correlates in colorectal cancer
    Shuji Ogino
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Mol Diagn 10:13-27. 2008
    ....
  31. pmc A cohort study of tumoral LINE-1 hypomethylation and prognosis in colon cancer
    Shuji Ogino
    Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 100:1734-8. 2008
    ..In conclusion, tumoral LINE-1 hypomethylation is independently associated with shorter survival among colon cancer patients...
  32. ncbi request reprint Loss of nuclear p27 (CDKN1B/KIP1) in colorectal cancer is correlated with microsatellite instability and CIMP
    Shuji Ogino
    Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
    Mod Pathol 20:15-22. 2007
    ..These associations are stronger among p53 wild-type tumors, implying important interplay of p27 and p53 functions (or dysfunctions) in the development of various molecular subtypes of colorectal cancer...
  33. pmc CpG island methylator phenotype-low (CIMP-low) in colorectal cancer: possible associations with male sex and KRAS mutations
    Shuji Ogino
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    J Mol Diagn 8:582-8. 2006
    ..In conclusion, CIMP-low colorectal cancer is associated with male sex and KRAS mutations. The hypothesis that CIMP-low tumors are different from CIMP-high and CIMP-0 tumors needs to be tested further...
  34. ncbi request reprint Bayesian analysis for cystic fibrosis risks in prenatal and carrier screening
    Shuji Ogino
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Genet Med 6:439-49. 2004
    ..Our methods are particularly useful for calculating the CF disease risk for a fetus with echogenic bowel. In genetics practice, however, there are other scenarios for which our previous methods are inadequate...
  35. ncbi request reprint New insights on the evolution of the SMN1 and SMN2 region: simulation and meta-analysis for allele and haplotype frequency calculations
    Shuji Ogino
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Eur J Hum Genet 12:1015-23. 2004
    ..Our data also suggest selection of the 1-1 haplotype and the presence of rare chromosomes with three copies of SMN1...
  36. ncbi request reprint Risk calculations for cystic fibrosis in neonatal screening by immunoreactive trypsinogen and CFTR mutation tests
    Shuji Ogino
    Department of Pathology, Brigham and Womens Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genet Med 7:317-27. 2005
    ..Although neonatal screening (or newborn screening) for cystic fibrosis (CF) is commonly practiced, systematic methods for accurate risk calculations are currently lacking...
  37. pmc Sensitive sequencing method for KRAS mutation detection by Pyrosequencing
    Shuji Ogino
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    J Mol Diagn 7:413-21. 2005
    ..In addition, the applicability of this assay for DNA amplified by whole-genome amplification technique provides an expanded source of DNA for large-scale studies...
  38. ncbi request reprint Distinct molecular features of colorectal carcinoma with signet ring cell component and colorectal carcinoma with mucinous component
    Shuji Ogino
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Mod Pathol 19:59-68. 2006
    ..Signet ring cell carcinoma and mucinous carcinoma are related subtypes of colorectal adenocarcinoma, but have molecular features distinct from each other...
  39. ncbi request reprint Molecular alterations in tumors and response to combination chemotherapy with gefitinib for advanced colorectal cancer
    Shuji Ogino
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Clin Cancer Res 11:6650-6. 2005
    ..Abnormalities of EGFR and related pathways may have an effect on responsiveness of advanced colorectal cancer to combination chemotherapy with gefitinib...
  40. pmc Prognostic significance of CDKN2A (p16) promoter methylation and loss of expression in 902 colorectal cancers: Cohort study and literature review
    Kaori Shima
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA
    Int J Cancer 128:1080-94. 2011
    ..Despite its well-established role in carcinogenesis, CDKN2A (p16) promoter methylation or loss of expression in colorectal cancer is not independently associated with patient prognosis...
  41. pmc CpG island methylator phenotype (CIMP) of colorectal cancer is best characterised by quantitative DNA methylation analysis and prospective cohort studies
    S Ogino
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Gut 55:1000-6. 2006
    ..Previous studies primarily used methylation specific polymerase chain reaction which might detect biologically insignificant low levels of methylation...
  42. pmc Precision and performance characteristics of bisulfite conversion and real-time PCR (MethyLight) for quantitative DNA methylation analysis
    Shuji Ogino
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    J Mol Diagn 8:209-17. 2006
    ..In conclusion, sodium bisulfite conversion and quantitative MethyLight assays have good precision and linearity and can be effectively used for high-throughput DNA methylation analysis on paraffin-embedded tissue...
  43. pmc Lymphocytic reaction to colorectal cancer is associated with longer survival, independent of lymph node count, microsatellite instability, and CpG island methylator phenotype
    Shuji Ogino
    Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Clin Cancer Res 15:6412-20. 2009
    ....
  44. ncbi request reprint Correlation of pathologic features with CpG island methylator phenotype (CIMP) by quantitative DNA methylation analysis in colorectal carcinoma
    Shuji Ogino
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Surg Pathol 30:1175-83. 2006
    ..Both MSI and CIMP appear to play a role in the pathogenesis of specific morphologic patterns of colorectal carcinoma...
  45. ncbi request reprint Down-regulation of p21 (CDKN1A/CIP1) is inversely associated with microsatellite instability and CpG island methylator phenotype (CIMP) in colorectal cancer
    S Ogino
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Pathol 210:147-54. 2006
    ..In conclusion, down-regulation of p21 is inversely correlated with CIMP-high and MSI-H in colorectal cancer, independent of TP53 and BRAF status...
  46. pmc KRAS mutation in stage III colon cancer and clinical outcome following intergroup trial CALGB 89803
    Shuji Ogino
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
    Clin Cancer Res 15:7322-9. 2009
    ....
  47. pmc A cohort study of p27 localization in colon cancer, body mass index, and patient survival
    Shuji Ogino
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Brigham and Women s Hospital, Boston, and Harvard Medical School 02115, USA
    Cancer Epidemiol Biomarkers Prev 18:1849-58. 2009
    ..08). In conclusion, p27 alterations in colon cancer are associated with superior prognosis. Adverse prognostic effect of obesity seems limited to patients with nuclear p27 expression, suggesting a host-tumor interaction...
  48. pmc Molecular pathological epidemiology of colorectal neoplasia: an emerging transdisciplinary and interdisciplinary field
    Shuji Ogino
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Gut 60:397-411. 2011
    ..In this review, we overview this relatively new field of research and discuss measures to overcome challenges and move this field forward...
  49. pmc Cancer immunology--analysis of host and tumor factors for personalized medicine
    Shuji Ogino
    Dana Farber Cancer Institute, Brigham and Women s Hospital and Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA
    Nat Rev Clin Oncol 8:711-9. 2011
    ..Pathological immunity evaluation may provide information on prognosis and help identify patients who are more likely to benefit from immunotherapy...
  50. pmc PIK3CA mutation in colorectal cancer: relationship with genetic and epigenetic alterations
    Katsuhiko Nosho
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Neoplasia 10:534-41. 2008
    ..In addition, Pyrosequencing is useful in detecting PIK3CA mutation in archival paraffin tumor tissue. PIK3CA mutational data further emphasize heterogeneity of colorectal cancer at the molecular level...
  51. pmc Predictive and prognostic analysis of PIK3CA mutation in stage III colon cancer intergroup trial
    Shuji Ogino
    Affiliations of authors Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA SO, XL, YI, MY, NJM, KN, RJM, JAM, CSF Department of Pathology SO, Channing Division of Network Medicine, Department of Medicine DS, CSF, and Department of Surgery MMB, Brigham and Women s Hospital and Harvard Medical School, Boston, MA SO Department of Epidemiology SO, DS and Department of Biostatistics DS, Harvard School of Public Health, Boston, MA Alliance Statistics and Data Center, Duke University Medical Center, Durham, NC DN Memorial Sloan Kettering Cancer Center, New York, NY LBS Hôpital du Sacré Coeur de Montréal, Montreal, Canada RW Loyola University Stritch School of Medicine, Maywood, IL AH current Edward Cancer Center, Naperville, IL AH Northwestern University, Chicago, IL ABB Toledo Community Hospital Oncology Program, Toledo, OH RBM Division of Medical Oncology, Germany
    J Natl Cancer Inst 105:1789-98. 2013
    ..Somatic mutations in PIK3CA (phosphatidylinositol-4,5-bisphosphonate 3-kinase [PI3K], catalytic subunit alpha gene) activate the PI3K-AKT signaling pathway and contribute to pathogenesis of various malignancies, including colorectal cancer...
  52. pmc SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer
    Katsuhiko Nosho
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
    Mod Pathol 22:922-32. 2009
    ..In conclusion, SIRT1 expression is associated with CIMP-high MSI-high colon cancer, suggesting involvement of SIRT1 in gene silencing in this unique tumor subtype...
  53. pmc CDK8 expression in 470 colorectal cancers in relation to beta-catenin activation, other molecular alterations and patient survival
    Ron Firestein
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Int J Cancer 126:2863-73. 2010
    ..These data support a potential link between CDK8 and beta-catenin, and suggest that CDK8 may identify a subset of colon cancer patients with a poor prognosis...
  54. pmc Epigenomic diversity of colorectal cancer indicated by LINE-1 methylation in a database of 869 tumors
    Yoshifumi Baba
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
    Mol Cancer 9:125. 2010
    ..Thus, it is of particular interest to examine whether its wide variation can be attributed to clinical, pathologic or molecular features...
  55. pmc A prospective cohort study shows unique epigenetic, genetic, and prognostic features of synchronous colorectal cancers
    Katsuhiko Nosho
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
    Gastroenterology 137:1609-20.e1-3. 2009
    ..Synchronous colon cancers have not been compared with control solitary cancers in a prospective study...
  56. pmc Vitamin D receptor expression is associated with PIK3CA and KRAS mutations in colorectal cancer
    Shoko Kure
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 18:2765-72. 2009
    ..Our data support potential interactions between the VDR, RAS-MAPK and PI3K-AKT pathways, and possible influence by KRAS or PIK3CA mutation on therapy or chemoprevention targeting VDR...
  57. pmc Insulin-like growth factor 2 messenger RNA binding protein 3 (IGF2BP3) is a marker of unfavourable prognosis in colorectal cancer
    Paul Lochhead
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, United States
    Eur J Cancer 48:3405-13. 2012
    ..However, the clinical, pathological, molecular and prognostic features of IGF2BP3-positive colorectal cancers remain uncertain...
  58. pmc TGFBR2 and BAX mononucleotide tract mutations, microsatellite instability, and prognosis in 1072 colorectal cancers
    Kaori Shima
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e25062. 2011
    ..However, a role of TGFBR2 or BAX mononucleotide mutation in colorectal cancer as a prognostic biomarker remains uncertain...
  59. pmc MGMT promoter methylation, loss of expression and prognosis in 855 colorectal cancers
    Kaori Shima
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Cancer Causes Control 22:301-9. 2011
    ..MGMT promoter hypermethylation and epigenetic silencing often occur as early events in carcinogenesis. However, prognostic significance of MGMT alterations in colorectal cancer remains uncertain...
  60. pmc DNMT3B expression might contribute to CpG island methylator phenotype in colorectal cancer
    Katsuhiko Nosho
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA
    Clin Cancer Res 15:3663-71. 2009
    ..We hypothesized that cellular DNMT3B level might influence the occurrence of widespread CpG island methylation (i.e., the CpG island methylator phenotype, CIMP) in colon cancer...
  61. pmc Prognostic role of PIK3CA mutation in colorectal cancer: cohort study and literature review
    Xiaoyun Liao
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02215, USA
    Clin Cancer Res 18:2257-68. 2012
    ..Thus, we hypothesized that PIK3CA exon 9 and exon 20 mutations might have differential effects on clinical outcome in colorectal cancer, and that concomitant PIK3CA exon 9 and 20 mutations might confer aggressive tumor behavior...
  62. pmc Tumor TP53 expression status, body mass index and prognosis in colorectal cancer
    Teppei Morikawa
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, and Department of Medicine Brigham and Women s Hospital, Boston, MA 02215, USA
    Int J Cancer 131:1169-78. 2012
    ..These molecular pathological epidemiology data may support a dual role of TP53 alterations in cell-cycle deregulation and cell autonomy with respect to energy balance status...
  63. pmc IGFBP3 promoter methylation in colorectal cancer: relationship with microsatellite instability, CpG island methylator phenotype, and p53
    Takako Kawasaki
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Neoplasia 9:1091-8. 2007
    ..Our data suggest complex relationship between global genomic/epigenomic phenomena (such as MSI/CIMP), single molecular events (e.g., IGFBP3 methylation, TP53 mutation, and TGFBR2 mutation), and the related pathways...
  64. pmc Germline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancer
    Aditi Hazra
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Causes Control 21:331-45. 2010
    ..Collectively, these exploratory data provide suggestive evidence for the association of MTHFR 429 Ala/ Ala and TCN2 259 Arg/Arg and CIMP status in colorectal cancer...
  65. pmc Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sample
    Katsuhiko Nosho
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
    PLoS ONE 3:e3698. 2008
    ..In stratified analyses, the relations of CIMP-high with poor differentiation, KRAS mutation and LINE-1 hypomethylation significantly differed according to MSI status...
  66. pmc Aurora-A expression is independently associated with chromosomal instability in colorectal cancer
    Yoshifumi Baba
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Neoplasia 11:418-25. 2009
    ..In conclusion, AURKA overexpression is independently associated with CIN in colorectal cancer, supporting a potential role of Aurora kinase-A in colorectal carcinogenesis through genomic instability (rather than epigenomic instability)...
  67. doi request reprint CpG island methylator phenotype-low (CIMP-low) colorectal cancer shows not only few methylated CIMP-high-specific CpG islands, but also low-level methylation at individual loci
    Takako Kawasaki
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA
    Mod Pathol 21:245-55. 2008
    ..Our data may provide supporting evidence for a difference in pathogenesis of DNA methylation between CIMP-low and CIMP-high tumors...
  68. pmc Body mass index and risk of colorectal cancer according to fatty acid synthase expression in the nurses' health study
    Aya Kuchiba
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA
    J Natl Cancer Inst 104:415-20. 2012
    ..9 and 7.1, respectively, per 100,000 person-years. This molecular pathological epidemiology study supports a role of energy metabolism in colorectal cancer pathogenesis...
  69. pmc JC virus T-antigen in colorectal cancer is associated with p53 expression and chromosomal instability, independent of CpG island methylator phenotype
    Katsuhiko Nosho
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Neoplasia 11:87-95. 2009
    ..JCVT was unrelated with patient survival. In conclusion, JCVT expression in colorectal cancer is independently associated with p53 expression and CIN, which may lead to uncontrolled cell proliferation...
  70. pmc Correlation of beta-catenin localization with cyclooxygenase-2 expression and CpG island methylator phenotype (CIMP) in colorectal cancer
    Takako Kawasaki
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Neoplasia 9:569-77. 2007
    ..Cytoplasmic beta-catenin is associated with COX-2 overexpression, supporting the role of cytoplasmic beta-catenin in stabilizing PTGS2 (COX-2) mRNA...
  71. ncbi request reprint WRN promoter methylation possibly connects mucinous differentiation, microsatellite instability and CpG island methylator phenotype in colorectal cancer
    Takako Kawasaki
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Mod Pathol 21:150-8. 2008
    ..Our data suggest a possible role of WRN methylation in mucinous differentiation, and may provide explanation to the enigmatic association between mucin and MSI/CIMP...
  72. pmc NRAS mutations are rare in colorectal cancer
    Natsumi Irahara
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA
    Diagn Mol Pathol 19:157-63. 2010
    ..NRAS mutations were detected in 5 (2.2%) of the 225 colorectal cancers and tended to occur in left-sided cancers arising in women, but did not seem to be associated with any of the molecular features that were examined...
  73. pmc Association of CTNNB1 (beta-catenin) alterations, body mass index, and physical activity with survival in patients with colorectal cancer
    Teppei Morikawa
    Department of Medical Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, 450 Brookline Ave, Boston, MA 02215, USA
    JAMA 305:1685-94. 2011
    ..Alterations of the WNT signaling pathway and cadherin-associated protein β 1 (CTNNB1 or β-catenin) have been implicated in colorectal carcinogenesis and metabolic diseases...
  74. pmc Novel application of structural equation modeling to correlation structure analysis of CpG island methylation in colorectal cancer
    Noriko Tanaka
    Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA
    Am J Pathol 177:2731-40. 2010
    ..Our novel data suggest two distinct perturbations, resulting in differential locus-specific propensity of CpG methylation...
  75. pmc Relationship between statin use and colon cancer recurrence and survival: results from CALGB 89803
    Kimmie Ng
    Department of Medical Oncology, Dana Farber Cancer Institute, 450 Brookline Ave, Boston, MA 02215, USA
    J Natl Cancer Inst 103:1540-51. 2011
    ..Although preclinical and epidemiological data suggest that statins may have antineoplastic properties, the impact of statin use on patient survival after a curative resection of stage III colon cancer is unknown...
  76. pmc HIF1A overexpression is associated with poor prognosis in a cohort of 731 colorectal cancers
    Yoshifumi Baba
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Am J Pathol 176:2292-301. 2010
    ..039). In conclusion, HIF1A expression is independently associated with poor prognosis in colorectal cancer, suggesting HIF1A as a biomarker with potentially important therapeutic implications...
  77. pmc Precision of pyrosequencing assay to measure LINE-1 methylation in colon cancer, normal colonic mucosa, and peripheral blood cells
    Natsumi Irahara
    Molecular Oncologic Pathology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, 44 Binney St, Room JF 215C, Boston, MA 02115, USA
    J Mol Diagn 12:177-83. 2010
    ..9) in leukocyte DNA. In conclusion, bisulfite conversion and PCR-pyrosequencing assay can measure LINE-1 methylation in macrodissected colon cancer, normal colon, and blood DNA, and may be useful in clinical and research settings...
  78. pmc Relationship of CDX2 loss with molecular features and prognosis in colorectal cancer
    Yoshifumi Baba
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA
    Clin Cancer Res 15:4665-73. 2009
    ....
  79. pmc Interaction of molecular markers and physical activity on mortality in patients with colon cancer
    Jeffrey A Meyerhardt
    Dana Farber Cancer Institute, Boston, MA 02115, USA
    Clin Cancer Res 15:5931-6. 2009
    ..Physical activity in colon cancer survivors has been associated with lower cancer recurrences and improved survival. Whether molecular features of the tumor portend more or less likelihood for benefit from exercise is unknown...
  80. pmc Combined analysis of COX-2 and p53 expressions reveals synergistic inverse correlations with microsatellite instability and CpG island methylator phenotype in colorectal cancer
    Shuji Ogino
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Neoplasia 8:458-64. 2006
    ..Our data suggest that a combined analysis of COX-2 and p53 may be more useful for the molecular classification of colorectal cancer than either COX-2 or p53 analysis alone...
  81. ncbi request reprint Genetic testing and risk assessment for spinal muscular atrophy (SMA)
    Shuji Ogino
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Genet 111:477-500. 2002
    ..New technologies, such as haploid analysis techniques, may be widely available in the future...
  82. pmc Bayesian analysis and risk assessment in genetic counseling and testing
    Shuji Ogino
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Mol Diagn 6:1-9. 2004
    ..We illustrate herein the application of Bayes' theorem and describe important basic principles in genetic risk assessment...
  83. pmc Quantification of PCR bias caused by a single nucleotide polymorphism in SMN gene dosage analysis
    Shuji Ogino
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Mol Diagn 4:185-90. 2002
    ..As additional clinically significant single nucleotide polymorphisms (SNPs) are discovered, assessment of PCR bias, and judicious selection of standards and controls, will be increasingly important for quantitative PCR assays...
  84. pmc The Cables gene on chromosome 18q is silenced by promoter hypermethylation and allelic loss in human colorectal cancer
    Do Youn Park
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Pathol 171:1509-19. 2007
    ..Loss of Cables expression in 65% of CRCs suggests that it is a common event in colonic carcinogenesis, with promoter methylation and LOH appearing to be important mechanisms of Cables gene inactivation...
  85. ncbi request reprint Phase I study of gefitinib, irinotecan, 5-fluorouracil and leucovorin in patients with metastatic colorectal cancer
    Jeffrey A Meyerhardt
    Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cancer Chemother Pharmacol 60:661-70. 2007
    ....
  86. ncbi request reprint Spinal muscular atrophy: molecular genetics and diagnostics
    Shuji Ogino
    Department of Pathology, Brigham and Women s Hospital, 75 Francis Street, Amory 3rd Floor, Boston, MA 02115, USA
    Expert Rev Mol Diagn 4:15-29. 2004
    ..New technologies, such as monosomal analysis techniques, may be widely available in the future...
  87. pmc PTGER2 overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype
    Yoshifumi Baba
    Department of Medical Oncology, Dana FarberCancer Institute and Harvard Medical School, Boston, Massachusetts, USA
    Cancer Epidemiol Biomarkers Prev 19:822-31. 2010
    ..However, the prognostic significance of PTGER2 expression or its relationship with MSI, CIMP, LINE-1 hypomethylation, or PTGS2 (COX-2) remains uncertain...
  88. pmc Cyclin D1 is frequently overexpressed in microsatellite unstable colorectal cancer, independent of CpG island methylator phenotype
    K Nosho
    Department of Medical Oncology, Dana Farber Cancer Institute, and Harvard Medical School, Boston, MA, USA
    Histopathology 53:588-98. 2008
    ..Microsatellite instability (MSI) and CpG island methylator phenotype (CIMP) are important molecular classifiers in colorectal cancer. The aim was to clarify the relationship between cyclin D1, MSI and CIMP...
  89. pmc Prognostic significance of AMP-activated protein kinase expression and modifying effect of MAPK3/1 in colorectal cancer
    Y Baba
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Room JF 215C, Boston, MA 02115, USA
    Br J Cancer 103:1025-33. 2010
    ..AMP-activated protein kinase activation is cytotoxic to cancer cells, supporting AMPK as a tumour suppressor and a potential therapeutic target. However, no study has examined its prognostic role in colorectal cancers...
  90. ncbi request reprint The practice of science at its best
    Shuji Ogino
    Fertil Steril 80:228-9; author reply 229. 2003
  91. ncbi request reprint Inverse correlation between SMN1 and SMN2 copy numbers: evidence for gene conversion from SMN2 to SMN1
    Shuji Ogino
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Eur J Hum Genet 11:275-7. 2003
    ..In conclusion, our data provide evidence that gene conversion from SMN2 to SMN1 occurs, and that SMN1 converted from SMN2 is present in the general population...
  92. ncbi request reprint Comparison of PCR-RFLP with allele-specific PCR in genetic testing for spinal muscular atrophy
    Ruliang Xu
    Department of Pathology, Harvard Medical School, and Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Genet Test 7:277-81. 2003
    ..Our data indicate that PCR-RFLP can be used for most diagnostic purposes, whereas the use of allelespecific PCR may be considered with caution under certain circumstances...
  93. ncbi request reprint Genetic risk assessment in carrier testing for spinal muscular atrophy
    Shuji Ogino
    Molecular Pathology Laboratory, Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    Am J Med Genet 110:301-7. 2002
    ..We present updated calculations for disease and non-disease allele frequencies and we describe how these frequencies can be used for genetic risk assessment in carrier testing for SMA...
  94. pmc SMN dosage analysis and risk assessment for spinal muscular atrophy
    Shuji Ogino
    Am J Hum Genet 70:1596-8; author reply 1598-9. 2002
  95. ncbi request reprint Comment on SMN2 deletion in childhood-onset spinal muscular atrophy
    Shuji Ogino
    Am J Med Genet 109:243-4; author reply 245. 2002
  96. pmc Folate and vitamin B6 intake and risk of colon cancer in relation to p53 expression
    Eva S Schernhammer
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Gastroenterology 135:770-80. 2008
    ..In laboratory models, folate deficiency appears to induce p53 mutation...
  97. ncbi request reprint Importance of standard nomenclature for SMN1 small intragenic ("subtle") mutations
    Shuji Ogino
    Hum Mutat 23:392-3. 2004
  98. doi request reprint DNA methylation in breast and colorectal cancers
    Wade S Samowitz
    Mod Pathol 21:1054; author reply 1054-5. 2008
  99. pmc Spinal muscular atrophy genetic testing experience at an academic medical center
    Shuji Ogino
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    J Mol Diagn 4:53-8. 2002
    ..We conclude that comprehensive SMA testing, including SMN1 deletion analysis, SMN1 gene dosage analysis, and linkage analysis, offers the most complete evaluation of SMA patients and their families...
  100. ncbi request reprint Efficacy of cetuximab after treatment with oral epidermal growth factor receptor tyrosine kinase inhibitor-based chemotherapy in metastatic colorectal cancer
    Jeffrey A Meyerhardt
    Dana Farber Cancer Institute, Brigham Women s Hospital, Boston, MA 02115, USA
    Clin Colorectal Cancer 6:59-65. 2006
    ..Whether these results apply to other cancer types is unknown but worthy of further study...
  101. ncbi request reprint DNA methylation, field effects, and colorectal cancer
    Edward Giovannucci
    J Natl Cancer Inst 97:1317-9. 2005

Research Grants3

  1. MOLECULAR EPIDEMIOLOGY OF COLORECTAL CANCER
    Shuji Ogino; Fiscal Year: 2007
    ..Charles Fuchs, a well-established researcher in clinical oncology and epidemiology. At the completion of the projects, I will have gained the experience to become an independent researcher in cancer epidemiology. ..
  2. Epigenetic Events and Colorectal Cancer Epidemiology
    Shuji Ogino; Fiscal Year: 2010
    ..Through better understanding of epigenetic mechanisms of colorectal cancer development and progression, we can provide a scientific basis for dietary recommendations and help optimize preventive strategies. ..