Research Topics
Genomes and Genes
| Peter OettgenSummaryAffiliation: Harvard University Country: USA Publications
| Collaborators
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Detail Information
Publications
Cardiac Stem Cell Therapy. Need for Optimization of Efficacy and Safety MonitoringPeter Oettgen
Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
Circulation 114:353-8. 2006- Regulation of vascular inflammation and remodeling by ETS factorsPeter Oettgen
Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
Circ Res 99:1159-66. 2006.... 
Alterations in transcriptional responses associated with vascular agingYumei Zhan
Division of Cardiology, and Molecular and Vascular Biology, Department of Medicine, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
J Inflamm (Lond) 6:16. 2009..The purpose of this review is to summarize our current knowledge of these age-related changes in transcriptional responses, and to discuss the therapeutic potential of targeting some of these factors...- ESE-1 is a potent repressor of type II collagen gene (COL2A1) transcription in human chondrocytesHaibing Peng
Department of Medicine, Beth Israel Deaconess Medical Center, New England Baptist Bone and Joint Institute, Boston, Massachusetts, USA
J Cell Physiol 215:562-73. 2008..Intracellular ESE-1 staining in chondrocytes in cartilage from patients with osteoarthritis (OA), but not in normal cartilage, further suggests a fundamental role for ESE-1 in cartilage degeneration and suppression of repair... - ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammationCourtney Brown
Beth Israel Deaconess Medical Center, Department of Medicine, New England Baptist Bone and Joint Institute, Harvard Institutes of Medicine, 4 Blackfan Circle, Boston, MA 02115, USA
J Biol Chem 279:12794-803. 2004..Our results support a novel paradigm for the ETS factor ESE-1 as a transcriptional mediator of angiogenesis in the setting of inflammation... - A novel role for GADD45beta as a mediator of MMP-13 gene expression during chondrocyte terminal differentiationKosei Ijiri
Beth Israel Deaconess Medical Center, New England Baptist Bone and Joint Institute, and Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 280:38544-55. 2005..These observations indicated that GADD45beta plays an essential role during chondrocyte terminal differentiation... - Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86Hong Wang
Cardiology Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
J Biol Chem 279:25241-50. 2004..In summary, our results demonstrated that the activity of ESE-1 is positively and negatively modulated by other interacting proteins including Ku70, Ku86, p300, and CBP... - Differential roles for ETS, CREB, and EGR binding sites in mediating VEGF receptor 1 expression in vivoEnjing Jin
The Center for Vascular Biology Research and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
Blood 114:5557-66. 2009..In contrast, mutation of the -39 ETS site resulted in increased LacZ staining in multiple vascular beds. Together, these results provide new insights into the transcriptional regulatory mechanisms of VEGFR1... - A three-kilobase fragment of the human Robo4 promoter directs cell type-specific expression in endotheliumYoshiaki Okada
Center for Vascular Biology Research and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Circ Res 100:1712-22. 2007..Together, these data suggest that 3-kb upstream promoter of human Robo4 contains information for cell type-specific expression in the intact endothelium... - ERG is required for the differentiation of embryonic stem cells along the endothelial lineageVesna Nikolova-Krstevski
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA 02215, USA
BMC Dev Biol 9:72. 2009..The specific role of the ETS factor ERG during endothelial differentiation has not been evaluated... - The Ets transcription factor ESE-1 mediates induction of the COX-2 gene by LPS in monocytesFranck T Grall
New England Baptist Bone and Joint Institute and BIDMC Genomics Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
FEBS J 272:1676-87. 2005.... - Erg is a crucial regulator of endocardial-mesenchymal transformation during cardiac valve morphogenesisPreethi Vijayaraj
Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Development 139:3973-85. 2012..We show that Erg is required for the maintenance of the core EnMT regulatory factors that include Snail1 and Snail2 by binding to their promoter and intronic regions... - Vascular bed-specific regulation of the von Willebrand factor promoter in the heart and skeletal muscleJu Liu
Center for Vascular Biology Research and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
Blood 117:342-51. 2011..Together, these data indicate that distinct DNA modules regulate vascular bed-specific expression of VWF... - Bioinformatic identification and characterization of human endothelial cell-restricted genesManoj Bhasin
Division of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
BMC Genomics 11:342. 2010.... 
Antiinflammatory effects of the ETS factor ERG in endothelial cells are mediated through transcriptional repression of the interleukin-8 geneLei Yuan
Division of Cardiology, Department of Medicine, and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Circ Res 104:1049-57. 2009..In summary, our findings support a role for ERG in promoting antiinflammatory effects in ECs through repression of inflammatory genes such as IL-8...- Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk geneJe Yoel Cho
BIDMC Genomics Center and the New England Baptist Bone and Joint Institute, Beth Israel Deaconess Medical Center, 4 Blackfan Circle, Boston, MA 02115, USA
J Biol Chem 279:19512-22. 2004.... - ETS-related gene (ERG) controls endothelial cell permeability via transcriptional regulation of the claudin 5 (CLDN5) geneLei Yuan
Division of Cardiology, Harvard Medical School, Boston, Massachusetts 02215, USA
J Biol Chem 287:6582-91. 2012..Thus, our results suggest that ERG plays a pivotal role in regulating EC barrier function and that this effect is mediated in part through its regulation of CLDN5 gene expression... - RTEF-1, a novel transcriptional stimulator of vascular endothelial growth factor in hypoxic endothelial cellsJue-Lon Shie
Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
J Biol Chem 279:25010-6. 2004..In addition, RTEF-1-induced VEGF promoter activity was enhanced in a hypoxic condition, indicating that RTEF-1 may play an important role in the regulation of VEGF under hypoxia... - RhoJ is an endothelial cell-restricted Rho GTPase that mediates vascular morphogenesis and is regulated by the transcription factor ERGLei Yuan
Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Blood 118:1145-53. 2011..Finally, in contrast to other Rho GTPases, RhoJ exhibits a highly EC-restricted expression pattern in several different tissues, including the brain, heart, lung, and liver... - Ets-1 is a critical transcriptional regulator of reactive oxygen species and p47(phox) gene expression in response to angiotensin IIWeihua Ni
Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
Circ Res 101:985-94. 2007..In summary, Ets-1 functions as a critical downstream transcriptional mediator of Ang II ROS generation by regulating the expression of NAD(P)H oxidase subunits such as p47(phox)... - The counter-regulatory effects of ESE-1 during angiotensin II-mediated vascular inflammation and remodelingYumei Zhan
Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Am J Hypertens 23:1312-7. 2010.... - Opposing functions of the Ets factors NERF and ELF-1 during chicken blood vessel developmentJohn Gaspar
Cardiology Division, New England Baptist Bone and Joint Institute, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass, USA
Arterioscler Thromb Vasc Biol 22:1106-12. 2002..CONCLUSIONS: cNERF2 is enriched during embryonic and extraembryonic blood vessel development in the chicken and facilitates tight control of Tie1 and Tie2 gene regulation... - Is stem cell therapy ready for patients? Stem Cell Therapy for Cardiac Repair. Ready for the Next Step Andrew J Boyle
Department of Medicine, Division of Cardiology, Institute for Cell Engineering, and Specialized Center for Cell Based Therapy, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Circulation 114:339-52. 2006 - Responses to the proinflammatory cytokines interleukin-1 and tumor necrosis factor alpha in cells derived from rheumatoid synovium and other joint tissues involve nuclear factor kappaB-mediated induction of the Ets transcription factor ESE-1Franck Grall
New England Baptist Bone and Joint Institute, Beth Israel Deaconess Medical Center and Harvard Medical School, and Beth Israel Deaconess Medical Center Genomics Center, Boston, Massachusetts 02115, USA
Arthritis Rheum 48:1249-60. 2003..ESE-1 may play a role in mediating some effects of proinflammatory stimuli in cells at sites of inflammation... - Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinomaRichard C Bates
Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
J Clin Invest 115:339-47. 2005..These findings define the alphavbeta6 integrin as an important risk factor for early-stage disease and a novel therapeutic candidate for colorectal cancer... - Critical role for the Ets transcription factor ELF-1 in the development of tumor angiogenesisXuling Huang
Beth Israel Deaconess Medical Center, Division of Cardiology, Department of Medicine, Boston, MA, USA
Blood 107:3153-60. 2006..These results support the function of ELF-1 in the regulation of Tie2 gene expression during the development of tumor angiogenesis... - Homing of intravenously infused embryonic stem cell-derived cells to injured hearts after myocardial infarctionJiang-Yong Min
Cardiovascular Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass, USA
J Thorac Cardiovasc Surg 131:889-97. 2006.... - Engineering robust and functional vascular networks in vivo with human adult and cord blood-derived progenitor cellsJuan M Melero-Martin
Vascular Biology Program and Department of Surgery, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
Circ Res 103:194-202. 2008..This rapid formation of long-lasting microvascular networks by postnatal progenitor cells obtained from noninvasive sources constitutes an important step forward in the development of clinical strategies for tissue vascularization... - Gene expression analysis of embryonic stem cells expressing VE-cadherin (CD144) during endothelial differentiationVesna Nikolova-Krstevski
Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Institutes of Medicine, Boston, USA
BMC Genomics 9:240. 2008..The molecular mechanisms of endothelial differentiation remain incompletely understood. Novel approaches are needed to identify the factors that regulate endothelial differentiation... - In vivo MRI of embryonic stem cells in a mouse model of myocardial infarctionNathan Himes
Department of Radiology, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA
Magn Reson Med 52:1214-9. 2004..These findings support the ability of MRI to test the long-term therapeutic potential of embryonic stem cells in small animals in the setting of myocardial infarction... - Molecular mechanisms of endothelial differentiationAlex Le Bras
Division of Cardiology, and Molecular and Vascular Biology, Department of Medicine and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Vasc Med 15:321-31. 2010..The purpose of this review is to summarize the recent advances in our understanding of the molecular mechanisms underlying endothelial differentiation... - Bone marrow transplantation for the heart: fact or fiction?Roger J Laham
Angiogenesis Research Center, Cardiology Division and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Lancet 361:11-2. 2003 - A GABP-binding element in the Robo4 promoter is necessary for endothelial expression in vivoYoshiaki Okada
Center for Vascular Biology Research and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Blood 112:2336-9. 2008..Together, these data provide strong support for the role of the GABP-binding motif in mediating Robo4 expression in the intact endothelium... - Ets-1 is a critical regulator of Ang II-mediated vascular inflammation and remodelingYumei Zhan
Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA
J Clin Invest 115:2508-16. 2005..In summary, our results support a critical role for Ets-1 as a transcriptional mediator of vascular inflammation and remodeling in response to Ang II... - Cloning and characterization of the human lung endothelial-cell-specific molecule-1 promoterJo C Tsai
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Mass 02215, USA
J Vasc Res 39:148-59. 2002..Taken together, these results provide an important foundation for studying endothelial-cell-subtype-specific gene regulation... - Flt-1-dependent survival characterizes the epithelial-mesenchymal transition of colonic organoidsRichard C Bates
Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Curr Biol 13:1721-7. 2003..A role for Flt-1 in cell survival is unprecedented and has significant implications for Flt-1 function in tumor progression, as well as in other biological processes, including angiogenesis and development... - Which lipid measures are prognostic indicators of cardiovascular disease in women?Peter Oettgen
Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
Nat Clin Pract Endocrinol Metab 2:190-1. 2006 - NERF2, a member of the Ets family of transcription factors, is increased in response to hypoxia and angiopoietin-1: a potential mechanism for Tie2 regulation during hypoxiaRial A Christensen
Division of Cardiovascular Research, St Elizabeth s Medical Center, Boston, Massachusetts, USA
J Cell Biochem 85:505-15. 2002..In addition, angiopoietin-1 directly induced expression of NERF2 in quiescent cells. These novel findings suggest that angiopoietin-1 regulates expression of NERF2 and its own receptor in hypoxic cells... - Antiapoptotic effect of implanted embryonic stem cell-derived early-differentiated cells in aging rats after myocardial infarctionMeixiang Xiang
The 2nd Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China
J Gerontol A Biol Sci Med Sci 61:1219-27. 2006..This study demonstrates that functional improvement of EDC transplantation may at least in part be related to a reduction in cardiomyocyte apoptosis...