Peter Oettgen

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Erg is a crucial regulator of endocardial-mesenchymal transformation during cardiac valve morphogenesis
    Preethi Vijayaraj
    Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Development 139:3973-85. 2012
  2. pmc The role of ets factors in tumor angiogenesis
    Peter Oettgen
    Division of Cardiology, and Molecular and Vascular Biology, Department of Medicine, Research North RM 270D, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02115, USA
    J Oncol 2010:767384. 2010
  3. ncbi request reprint Cardiac Stem Cell Therapy. Need for Optimization of Efficacy and Safety Monitoring
    Peter Oettgen
    Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    Circulation 114:353-8. 2006
  4. ncbi request reprint Regulation of vascular inflammation and remodeling by ETS factors
    Peter Oettgen
    Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Circ Res 99:1159-66. 2006
  5. pmc Alterations in transcriptional responses associated with vascular aging
    Yumei Zhan
    Division of Cardiology, and Molecular and Vascular Biology, Department of Medicine, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Inflamm (Lond) 6:16. 2009
  6. pmc ESE-1 is a potent repressor of type II collagen gene (COL2A1) transcription in human chondrocytes
    Haibing Peng
    Department of Medicine, Beth Israel Deaconess Medical Center, New England Baptist Bone and Joint Institute, Boston, Massachusetts, USA
    J Cell Physiol 215:562-73. 2008
  7. pmc A GABP-binding element in the Robo4 promoter is necessary for endothelial expression in vivo
    Yoshiaki Okada
    Center for Vascular Biology Research and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Blood 112:2336-9. 2008
  8. pmc Antiinflammatory effects of the ETS factor ERG in endothelial cells are mediated through transcriptional repression of the interleukin-8 gene
    Lei Yuan
    Division of Cardiology, Department of Medicine, and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Circ Res 104:1049-57. 2009
  9. pmc Differential roles for ETS, CREB, and EGR binding sites in mediating VEGF receptor 1 expression in vivo
    Enjing Jin
    The Center for Vascular Biology Research and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Blood 114:5557-66. 2009
  10. ncbi request reprint ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation
    Courtney Brown
    Beth Israel Deaconess Medical Center, Department of Medicine, New England Baptist Bone and Joint Institute, Harvard Institutes of Medicine, 4 Blackfan Circle, Boston, MA 02115, USA
    J Biol Chem 279:12794-803. 2004

Collaborators

Detail Information

Publications41

  1. pmc Erg is a crucial regulator of endocardial-mesenchymal transformation during cardiac valve morphogenesis
    Preethi Vijayaraj
    Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Development 139:3973-85. 2012
    ..We show that Erg is required for the maintenance of the core EnMT regulatory factors that include Snail1 and Snail2 by binding to their promoter and intronic regions...
  2. pmc The role of ets factors in tumor angiogenesis
    Peter Oettgen
    Division of Cardiology, and Molecular and Vascular Biology, Department of Medicine, Research North RM 270D, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02115, USA
    J Oncol 2010:767384. 2010
    ....
  3. ncbi request reprint Cardiac Stem Cell Therapy. Need for Optimization of Efficacy and Safety Monitoring
    Peter Oettgen
    Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    Circulation 114:353-8. 2006
  4. ncbi request reprint Regulation of vascular inflammation and remodeling by ETS factors
    Peter Oettgen
    Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Circ Res 99:1159-66. 2006
    ....
  5. pmc Alterations in transcriptional responses associated with vascular aging
    Yumei Zhan
    Division of Cardiology, and Molecular and Vascular Biology, Department of Medicine, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Inflamm (Lond) 6:16. 2009
    ..The purpose of this review is to summarize our current knowledge of these age-related changes in transcriptional responses, and to discuss the therapeutic potential of targeting some of these factors...
  6. pmc ESE-1 is a potent repressor of type II collagen gene (COL2A1) transcription in human chondrocytes
    Haibing Peng
    Department of Medicine, Beth Israel Deaconess Medical Center, New England Baptist Bone and Joint Institute, Boston, Massachusetts, USA
    J Cell Physiol 215:562-73. 2008
    ..Intracellular ESE-1 staining in chondrocytes in cartilage from patients with osteoarthritis (OA), but not in normal cartilage, further suggests a fundamental role for ESE-1 in cartilage degeneration and suppression of repair...
  7. pmc A GABP-binding element in the Robo4 promoter is necessary for endothelial expression in vivo
    Yoshiaki Okada
    Center for Vascular Biology Research and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Blood 112:2336-9. 2008
    ..Together, these data provide strong support for the role of the GABP-binding motif in mediating Robo4 expression in the intact endothelium...
  8. pmc Antiinflammatory effects of the ETS factor ERG in endothelial cells are mediated through transcriptional repression of the interleukin-8 gene
    Lei Yuan
    Division of Cardiology, Department of Medicine, and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Circ Res 104:1049-57. 2009
    ..In summary, our findings support a role for ERG in promoting antiinflammatory effects in ECs through repression of inflammatory genes such as IL-8...
  9. pmc Differential roles for ETS, CREB, and EGR binding sites in mediating VEGF receptor 1 expression in vivo
    Enjing Jin
    The Center for Vascular Biology Research and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Blood 114:5557-66. 2009
    ..In contrast, mutation of the -39 ETS site resulted in increased LacZ staining in multiple vascular beds. Together, these results provide new insights into the transcriptional regulatory mechanisms of VEGFR1...
  10. ncbi request reprint ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation
    Courtney Brown
    Beth Israel Deaconess Medical Center, Department of Medicine, New England Baptist Bone and Joint Institute, Harvard Institutes of Medicine, 4 Blackfan Circle, Boston, MA 02115, USA
    J Biol Chem 279:12794-803. 2004
    ..Our results support a novel paradigm for the ETS factor ESE-1 as a transcriptional mediator of angiogenesis in the setting of inflammation...
  11. pmc A novel role for GADD45beta as a mediator of MMP-13 gene expression during chondrocyte terminal differentiation
    Kosei Ijiri
    Beth Israel Deaconess Medical Center, New England Baptist Bone and Joint Institute, and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 280:38544-55. 2005
    ..These observations indicated that GADD45beta plays an essential role during chondrocyte terminal differentiation...
  12. pmc ERG is required for the differentiation of embryonic stem cells along the endothelial lineage
    Vesna Nikolova-Krstevski
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA 02215, USA
    BMC Dev Biol 9:72. 2009
    ..The specific role of the ETS factor ERG during endothelial differentiation has not been evaluated...
  13. pmc Vascular bed-specific regulation of the von Willebrand factor promoter in the heart and skeletal muscle
    Ju Liu
    Center for Vascular Biology Research and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Blood 117:342-51. 2011
    ..Together, these data indicate that distinct DNA modules regulate vascular bed-specific expression of VWF...
  14. ncbi request reprint A three-kilobase fragment of the human Robo4 promoter directs cell type-specific expression in endothelium
    Yoshiaki Okada
    Center for Vascular Biology Research and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Circ Res 100:1712-22. 2007
    ..Together, these data suggest that 3-kb upstream promoter of human Robo4 contains information for cell type-specific expression in the intact endothelium...
  15. ncbi request reprint Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86
    Hong Wang
    Cardiology Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    J Biol Chem 279:25241-50. 2004
    ..In summary, our results demonstrated that the activity of ESE-1 is positively and negatively modulated by other interacting proteins including Ku70, Ku86, p300, and CBP...
  16. pmc Critical role for the Ets transcription factor ELF-1 in the development of tumor angiogenesis
    Xuling Huang
    Beth Israel Deaconess Medical Center, Division of Cardiology, Department of Medicine, Boston, MA, USA
    Blood 107:3153-60. 2006
    ..These results support the function of ELF-1 in the regulation of Tie2 gene expression during the development of tumor angiogenesis...
  17. ncbi request reprint Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene
    Je Yoel Cho
    BIDMC Genomics Center and the New England Baptist Bone and Joint Institute, Beth Israel Deaconess Medical Center, 4 Blackfan Circle, Boston, MA 02115, USA
    J Biol Chem 279:19512-22. 2004
    ....
  18. pmc Bioinformatic identification and characterization of human endothelial cell-restricted genes
    Manoj Bhasin
    Division of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    BMC Genomics 11:342. 2010
    ....
  19. pmc ETS-related gene (ERG) controls endothelial cell permeability via transcriptional regulation of the claudin 5 (CLDN5) gene
    Lei Yuan
    Division of Cardiology, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 287:6582-91. 2012
    ..Thus, our results suggest that ERG plays a pivotal role in regulating EC barrier function and that this effect is mediated in part through its regulation of CLDN5 gene expression...
  20. pmc Role of RNA splicing in mediating lineage-specific expression of the von Willebrand factor gene in the endothelium
    Lei Yuan
    Center for Vascular Biology Research, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Blood 121:4404-12. 2013
    ..Intron-mediated enhancement of expression was mediated at a posttranscriptional level. Together, these findings implicate a role for intronic splicing in mediating lineage-specific expression of vWF in the endothelium...
  21. pmc RhoJ is an endothelial cell-restricted Rho GTPase that mediates vascular morphogenesis and is regulated by the transcription factor ERG
    Lei Yuan
    Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Blood 118:1145-53. 2011
    ..Finally, in contrast to other Rho GTPases, RhoJ exhibits a highly EC-restricted expression pattern in several different tissues, including the brain, heart, lung, and liver...
  22. ncbi request reprint The Ets transcription factor ESE-1 mediates induction of the COX-2 gene by LPS in monocytes
    Franck T Grall
    New England Baptist Bone and Joint Institute and BIDMC Genomics Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    FEBS J 272:1676-87. 2005
    ....
  23. ncbi request reprint Ets-1 is a critical transcriptional regulator of reactive oxygen species and p47(phox) gene expression in response to angiotensin II
    Weihua Ni
    Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Circ Res 101:985-94. 2007
    ..In summary, Ets-1 functions as a critical downstream transcriptional mediator of Ang II ROS generation by regulating the expression of NAD(P)H oxidase subunits such as p47(phox)...
  24. ncbi request reprint RTEF-1, a novel transcriptional stimulator of vascular endothelial growth factor in hypoxic endothelial cells
    Jue Lon Shie
    Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 279:25010-6. 2004
    ..In addition, RTEF-1-induced VEGF promoter activity was enhanced in a hypoxic condition, indicating that RTEF-1 may play an important role in the regulation of VEGF under hypoxia...
  25. ncbi request reprint Homing of intravenously infused embryonic stem cell-derived cells to injured hearts after myocardial infarction
    Jiang Yong Min
    Cardiovascular Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass, USA
    J Thorac Cardiovasc Surg 131:889-97. 2006
    ..The present study was designed to test whether intravenously infused embryonic stem cell-derived cells could translocate to injured myocardium after myocardial infarction and improve cardiac function...
  26. pmc Gene expression analysis of embryonic stem cells expressing VE-cadherin (CD144) during endothelial differentiation
    Vesna Nikolova-Krstevski
    Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Institutes of Medicine, Boston, USA
    BMC Genomics 9:240. 2008
    ..The molecular mechanisms of endothelial differentiation remain incompletely understood. Novel approaches are needed to identify the factors that regulate endothelial differentiation...
  27. pmc The counter-regulatory effects of ESE-1 during angiotensin II-mediated vascular inflammation and remodeling
    Yumei Zhan
    Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Am J Hypertens 23:1312-7. 2010
    ....
  28. pmc Ets-1 is a critical regulator of Ang II-mediated vascular inflammation and remodeling
    Yumei Zhan
    Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA
    J Clin Invest 115:2508-16. 2005
    ..In summary, our results support a critical role for Ets-1 as a transcriptional mediator of vascular inflammation and remodeling in response to Ang II...
  29. ncbi request reprint Is stem cell therapy ready for patients? Stem Cell Therapy for Cardiac Repair. Ready for the Next Step
    Andrew J Boyle
    Department of Medicine, Division of Cardiology, Institute for Cell Engineering, and Specialized Center for Cell Based Therapy, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Circulation 114:339-52. 2006
  30. pmc Engineering robust and functional vascular networks in vivo with human adult and cord blood-derived progenitor cells
    Juan M Melero-Martin
    Vascular Biology Program and Department of Surgery, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Circ Res 103:194-202. 2008
    ..This rapid formation of long-lasting microvascular networks by postnatal progenitor cells obtained from noninvasive sources constitutes an important step forward in the development of clinical strategies for tissue vascularization...
  31. pmc Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma
    Richard C Bates
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 115:339-47. 2005
    ..These findings define the alphavbeta6 integrin as an important risk factor for early-stage disease and a novel therapeutic candidate for colorectal cancer...
  32. ncbi request reprint Opposing functions of the Ets factors NERF and ELF-1 during chicken blood vessel development
    John Gaspar
    Cardiology Division, New England Baptist Bone and Joint Institute, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass, USA
    Arterioscler Thromb Vasc Biol 22:1106-12. 2002
    ..The purpose of this study was to evaluate the role of the Ets factor NERF in the regulation of the Tie1 and Tie2 genes during chicken blood vessel development...
  33. ncbi request reprint In vivo MRI of embryonic stem cells in a mouse model of myocardial infarction
    Nathan Himes
    Department of Radiology, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA
    Magn Reson Med 52:1214-9. 2004
    ..These findings support the ability of MRI to test the long-term therapeutic potential of embryonic stem cells in small animals in the setting of myocardial infarction...
  34. doi request reprint Molecular mechanisms of endothelial differentiation
    Alex Le Bras
    Division of Cardiology, and Molecular and Vascular Biology, Department of Medicine and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Vasc Med 15:321-31. 2010
    ..The purpose of this review is to summarize the recent advances in our understanding of the molecular mechanisms underlying endothelial differentiation...
  35. ncbi request reprint Responses to the proinflammatory cytokines interleukin-1 and tumor necrosis factor alpha in cells derived from rheumatoid synovium and other joint tissues involve nuclear factor kappaB-mediated induction of the Ets transcription factor ESE-1
    Franck Grall
    New England Baptist Bone and Joint Institute, Beth Israel Deaconess Medical Center and Harvard Medical School, and Beth Israel Deaconess Medical Center Genomics Center, Boston, Massachusetts 02115, USA
    Arthritis Rheum 48:1249-60. 2003
    ....
  36. ncbi request reprint Bone marrow transplantation for the heart: fact or fiction?
    Roger J Laham
    Angiogenesis Research Center, Cardiology Division and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Lancet 361:11-2. 2003
  37. ncbi request reprint Cloning and characterization of the human lung endothelial-cell-specific molecule-1 promoter
    Jo C Tsai
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Mass 02215, USA
    J Vasc Res 39:148-59. 2002
    ..Taken together, these results provide an important foundation for studying endothelial-cell-subtype-specific gene regulation...
  38. ncbi request reprint Flt-1-dependent survival characterizes the epithelial-mesenchymal transition of colonic organoids
    Richard C Bates
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Curr Biol 13:1721-7. 2003
    ..A role for Flt-1 in cell survival is unprecedented and has significant implications for Flt-1 function in tumor progression, as well as in other biological processes, including angiogenesis and development...
  39. ncbi request reprint Which lipid measures are prognostic indicators of cardiovascular disease in women?
    Peter Oettgen
    Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Nat Clin Pract Endocrinol Metab 2:190-1. 2006
  40. ncbi request reprint NERF2, a member of the Ets family of transcription factors, is increased in response to hypoxia and angiopoietin-1: a potential mechanism for Tie2 regulation during hypoxia
    Rial A Christensen
    Division of Cardiovascular Research, St Elizabeth s Medical Center, Boston, Massachusetts, USA
    J Cell Biochem 85:505-15. 2002
    ..In addition, angiopoietin-1 directly induced expression of NERF2 in quiescent cells. These novel findings suggest that angiopoietin-1 regulates expression of NERF2 and its own receptor in hypoxic cells...
  41. pmc Antiapoptotic effect of implanted embryonic stem cell-derived early-differentiated cells in aging rats after myocardial infarction
    Meixiang Xiang
    The 2nd Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China
    J Gerontol A Biol Sci Med Sci 61:1219-27. 2006
    ..This study demonstrates that functional improvement of EDC transplantation may at least in part be related to a reduction in cardiomyocyte apoptosis...