Georg Northoff

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi How does our brain constitute defense mechanisms? First-person neuroscience and psychoanalysis
    Georg Northoff
    Department of Psychiatry, Psychotherapy and Psychosomatics, University of Magdeburg, Magdeburg, Germany
    Psychother Psychosom 76:141-53. 2007
  2. ncbi NMDA hypofunction in the posterior cingulate as a model for schizophrenia: an exploratory ketamine administration study in fMRI
    Georg Northoff
    Department of Neurology, Division of Behavioral Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Schizophr Res 72:235-48. 2005
  3. ncbi What catatonia can tell us about "top-down modulation": a neuropsychiatric hypothesis
    Georg Northoff
    Laboratory for Magnetic Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Behav Brain Sci 25:555-77; discussion 578-604. 2002
  4. ncbi Cortical midline structures and the self
    Georg Northoff
    Laboratory for Magnetic Brain Stimulation, Division of Behavioral Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Trends Cogn Sci 8:102-7. 2004
  5. doi The relationship between aberrant neuronal activation in the pregenual anterior cingulate, altered glutamatergic metabolism, and anhedonia in major depression
    Martin Walter
    Department of Psychiatry, Ottovon Guericke University of Magdeburg, Magdeburg, Germany
    Arch Gen Psychiatry 66:478-86. 2009
  6. ncbi Attentional modulation of emotional stimulus processing: an fMRI study using emotional expectancy
    Felix Bermpohl
    Center for Non Invasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Hum Brain Mapp 27:662-77. 2006
  7. doi Distinguishing specific sexual and general emotional effects in fMRI-subcortical and cortical arousal during erotic picture viewing
    Martin Walter
    Department of Psychiatry, University Hospital, Magdeburg, Germany
    Neuroimage 40:1482-94. 2008
  8. ncbi Preceding attention and the dorsomedial prefrontal cortex: process specificity versus domain dependence
    Martin Walter
    Department of Psychiatry, Otto von Guericke University Magdeburg, Magdeburg, Germany
    Hum Brain Mapp 30:312-26. 2009
  9. ncbi Differential parametric modulation of self-relatedness and emotions in different brain regions
    Georg Northoff
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    Hum Brain Mapp 30:369-82. 2009
  10. ncbi How do we modulate our emotions? Parametric fMRI reveals cortical midline structures as regions specifically involved in the processing of emotional valences
    Alexander Heinzel
    Behavioral Neurology Unit, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston 02215, USA
    Brain Res Cogn Brain Res 25:348-58. 2005

Detail Information

Publications43

  1. ncbi How does our brain constitute defense mechanisms? First-person neuroscience and psychoanalysis
    Georg Northoff
    Department of Psychiatry, Psychotherapy and Psychosomatics, University of Magdeburg, Magdeburg, Germany
    Psychother Psychosom 76:141-53. 2007
    ....
  2. ncbi NMDA hypofunction in the posterior cingulate as a model for schizophrenia: an exploratory ketamine administration study in fMRI
    Georg Northoff
    Department of Neurology, Division of Behavioral Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Schizophr Res 72:235-48. 2005
    ..We therefore conducted an fMRI study using the NMDA antagonist ketamine in healthy human subjects during episodic memory retrieval, which is supposed to activate the posterior cingulate...
  3. ncbi What catatonia can tell us about "top-down modulation": a neuropsychiatric hypothesis
    Georg Northoff
    Laboratory for Magnetic Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Behav Brain Sci 25:555-77; discussion 578-604. 2002
    ....
  4. ncbi Cortical midline structures and the self
    Georg Northoff
    Laboratory for Magnetic Brain Stimulation, Division of Behavioral Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Trends Cogn Sci 8:102-7. 2004
    ..All of these subfunctions are related to distinct regions within the CMS. This relationship between self-referential processing and CMS might provide novel insight into the neural correlates underlying the constitution of the self...
  5. doi The relationship between aberrant neuronal activation in the pregenual anterior cingulate, altered glutamatergic metabolism, and anhedonia in major depression
    Martin Walter
    Department of Psychiatry, Ottovon Guericke University of Magdeburg, Magdeburg, Germany
    Arch Gen Psychiatry 66:478-86. 2009
    ..Major depressive disorder (MDD) is characterized by diverse metabolic and functional abnormalities that occur in, among other regions, the pregenual anterior cingulate cortex (pgACC), a cortical region linked to anhedonia...
  6. ncbi Attentional modulation of emotional stimulus processing: an fMRI study using emotional expectancy
    Felix Bermpohl
    Center for Non Invasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Hum Brain Mapp 27:662-77. 2006
    ..This enhancement effect is not present in neutral pictures and might parallel accentuated subjective feeling states...
  7. doi Distinguishing specific sexual and general emotional effects in fMRI-subcortical and cortical arousal during erotic picture viewing
    Martin Walter
    Department of Psychiatry, University Hospital, Magdeburg, Germany
    Neuroimage 40:1482-94. 2008
    ..No differences were found in these effects when comparing females and males. Our findings demonstrate for the first time neural differentiation between emotional and sexual components in the neural network underlying sexual arousal...
  8. ncbi Preceding attention and the dorsomedial prefrontal cortex: process specificity versus domain dependence
    Martin Walter
    Department of Psychiatry, Otto von Guericke University Magdeburg, Magdeburg, Germany
    Hum Brain Mapp 30:312-26. 2009
    ..This suggests that the anterior and posterior DMPFC is involved in the process of attending mental states while remaining more (posterior DMPFC) or less (anterior DMPFC) independent of the type or domain of the respective stimulus...
  9. ncbi Differential parametric modulation of self-relatedness and emotions in different brain regions
    Georg Northoff
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    Hum Brain Mapp 30:369-82. 2009
    ..hum..
  10. ncbi How do we modulate our emotions? Parametric fMRI reveals cortical midline structures as regions specifically involved in the processing of emotional valences
    Alexander Heinzel
    Behavioral Neurology Unit, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston 02215, USA
    Brain Res Cogn Brain Res 25:348-58. 2005
    ..We conclude that the psychological concept of emotional valence may be related to neural processing in cortical midline regions...
  11. ncbi Self-referential processing in our brain--a meta-analysis of imaging studies on the self
    Georg Northoff
    Department of Neurology, Harvard University, Cambridge, MA 02138, USA
    Neuroimage 31:440-57. 2006
    ..We conclude that self-referential processing in CMS constitutes the core of our self and is critical for elaborating experiential feelings of self, uniting several distinct concepts evident in current neuroscience...
  12. ncbi Brain pathology in pedophilic offenders: evidence of volume reduction in the right amygdala and related diencephalic structures
    Kolja Schiltz
    Department of Psychiatry, Otto von Guericke University, Magdeburg, Saxony Anhalt 39120, Germany
    Arch Gen Psychiatry 64:737-46. 2007
    ..However, the role of alterations in brain structures that are crucial in the development of sexual behavior has not yet been systematically studied in pedophilic subjects...
  13. doi Abnormal body perception and neural activity in the insula in depression: an fMRI study of the depressed "material me"
    Christine Wiebking
    Department of Psychiatry, Otto von Guericke University, Magdeburg, Germany
    World J Biol Psychiatry 11:538-49. 2010
    ..Since the "material me" has been especially associated with the anterior insula in healthy subjects, we hypothesized abnormalities in this region during interoceptive awareness in MDD...
  14. ncbi Dissociable networks for the expectancy and perception of emotional stimuli in the human brain
    Felix Bermpohl
    Center for Non Invasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02132, USA
    Neuroimage 30:588-600. 2006
    ..This dissociation may reflect a distinction between anticipatory and perceptive components of emotional stimulus processing...
  15. ncbi GABA concentrations in the human anterior cingulate cortex predict negative BOLD responses in fMRI
    Georg Northoff
    Department of Psychiatry, Otto von Guericke University Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Nat Neurosci 10:1515-7. 2007
    ..Our findings show that default-mode network negative BOLD responses during emotions are mediated by GABA...
  16. doi Decreased neural activity in reward circuitry during personal reference in abstinent alcoholics--a fMRI study
    Moritz de Greck
    Department of Psychiatry, Otto von Guericke University Magdeburg, Leipziger Strasse 44, Magdeburg, Germany
    Hum Brain Mapp 30:1691-704. 2009
    ..Our results underline the important role of the reward circuitry during personal reference in the pathophysiology of alcohol addiction...
  17. doi Involvement of glutamate in rest-stimulus interaction between perigenual and supragenual anterior cingulate cortex: a combined fMRI-MRS study
    Niall W Duncan
    Mind, Brain Imaging and Neuroethics, Institute of Mental Health Research, University of Ottawa, Ottawa, ON, Canada
    Hum Brain Mapp 32:2172-82. 2011
    ..This provides insight into the neuronal and biochemical mechanisms by means of which the resting state activity of the brain potentially impacts upon subsequent stimulus-induced activity...
  18. pmc Is our self nothing but reward? Neuronal overlap and distinction between reward and personal relevance and its relation to human personality
    Björn Enzi
    Department of Psychiatry, Otto von Guericke University Magdeburg, Magdeburg, Germany
    PLoS ONE 4:e8429. 2009
    ..Although previous research demonstrated a relationship between reward and personal relevance, their exact neuronal relationship including the impact of personality traits remains unclear...
  19. doi High resolution fMRI of subcortical regions during visual erotic stimulation at 7 T
    Martin Walter
    Department of Psychiatry, University Hospital Otto v Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    MAGMA 21:103-11. 2008
    ....
  20. doi Are emotions associated with activity during rest or interoception? An exploratory fMRI study in healthy subjects
    Christine Wiebking
    Clinic of Psychiatry, Otto von Guericke University, Magdeburg, Germany
    Neurosci Lett 491:87-92. 2011
    ..Our findings provide further insight into the psychological functions underlying rest activity. Our findings in healthy subjects may also have future implications for a better understanding of mood disorders...
  21. doi The role of hippocampus dysfunction in deficient memory encoding and positive symptoms in schizophrenia
    Kathrin Zierhut
    Department of Psychiatry, Otto von Guericke University of Magdeburg, Germany
    Psychiatry Res 183:187-94. 2010
    ..Declarative memory disturbances, known to substantially contribute to cognitive impairment in schizophrenia, have previously been attributed to prefrontal as well as hippocampal dysfunction...
  22. ncbi Effect of low-frequency transcranial magnetic stimulation on an affective go/no-go task in patients with major depression: role of stimulation site and depression severity
    Felix Bermpohl
    Harvard Center for Non Invasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Psychiatry Res 141:1-13. 2006
    ..Further studies are needed to determine whether the present paradigm could be used to predict antidepressant treatment success or to individualize stimulation parameters according to specific pathology...
  23. doi Novelty seeking modulates medial prefrontal activity during the anticipation of emotional stimuli
    Felix Bermpohl
    Berenson Allen Center for Non Invasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Psychiatry Res 164:81-5. 2008
    ..BOLD responses to emotional expectancy were positively correlated with novelty-seeking scores in the medial prefrontal cortex. This correlation was strongest for the sub-dimension of exploratory excitability...
  24. ncbi Psychopathology and pathophysiology of the self in depression - neuropsychiatric hypothesis
    Georg Northoff
    Laboratory of Neuroimaging and Neurophilosophy, Department of Psychiatry, Otto von Guericke University of Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    J Affect Disord 104:1-14. 2007
    ..The question of the self has intrigued philosophers and psychologists for a long time. More recently distinct concepts of self have also been suggested in neuroscience more specifically in neuroimaging...
  25. ncbi Reciprocal modulation and attenuation in the prefrontal cortex: an fMRI study on emotional-cognitive interaction
    Georg Northoff
    Laboratory for Magnetic Brain Stimulation, Division of Behavioral Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Hum Brain Mapp 21:202-12. 2004
    ..Reciprocal modulation and attenuation in medial and lateral prefrontal cortex might constitute the neurophysiologic basis for emotional-cognitive interaction as observed in both healthy and psychiatric subjects...
  26. doi How is informed consent related to emotions and empathy? An exploratory neuroethical investigation
    Alexander Supady
    Department of Psychiatry, Otto von Guericke University, Magdeburg, Germany
    J Med Ethics 37:311-7. 2011
    ..While cognitive functions have been shown to play a central role, the impact of empathy and emotions on subjects' decisions in informed consent remains unclear...
  27. ncbi Pedophilia is linked to reduced activation in hypothalamus and lateral prefrontal cortex during visual erotic stimulation
    Martin Walter
    Department of Psychiatry, Otto von Guericke University of Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Biol Psychiatry 62:698-701. 2007
    ..Although pedophilic patients are sexually attracted to prepubescent children, they show no sexual interest toward adults. This study aimed to investigate the neural correlates of deficits of sexual and emotional arousal in pedophiles...
  28. ncbi Orbitofrontal cortical dysfunction in akinetic catatonia: a functional magnetic resonance imaging study during negative emotional stimulation
    Georg Northoff
    University of Magdeburg, Department of Psychiatry, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Schizophr Bull 30:405-27. 2004
    ..Because we investigated postacute patients, orbitofrontal cortical alterations may be interpreted as a trait marker predisposing for development of catatonic syndrome in schizophrenic or affective psychosis...
  29. doi The trans-species concept of self and the subcortical-cortical midline system
    Georg Northoff
    Department of Psychiatry, University of Magdeburg, Leipziger Strasse 44, Magdeburg, Germany
    Trends Cogn Sci 12:259-64. 2008
    ..Recent data suggest that SRP is operating via a central integrative neural system made up of subcortical-cortical midline structures (SCMSs), that are homologous across mammalian species...
  30. doi S-ketamine and GABA-A-receptor interaction in humans: an exploratory study with I-123-iomazenil SPECT
    Alexander Heinzel
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    Hum Psychopharmacol 23:549-54. 2008
    ..We aimed to probe for regional cerebral effects of S-ketamine on in vivo GABA-A-receptor binding in healthy human subjects...
  31. ncbi Volume and neuron number of the mediodorsal thalamic nucleus in schizophrenia: a replication study
    Peter Danos
    Department of Psychiatry, University Hospital Giessen and Marburg, Location Giessen, Germany
    Psychiatry Res 140:281-9. 2005
    ..Taken together, the present results suggest that schizophrenia is associated with a moderate volume reduction in the left mediodorsal thalamic nucleus, while the neuron density and the total neuron number are unchanged...
  32. ncbi GABA-ergic modulation of prefrontal spatio-temporal activation pattern during emotional processing: a combined fMRI/MEG study with placebo and lorazepam
    Georg Northoff
    Department of Neurology, Section of Behavioral Neurology, Beth Israel Deaconess Medical Center, Harvard University, Kirstein Building KS 454, 330 Brookline Avenue, Boston, 02215 MA, USA
    J Cogn Neurosci 14:348-70. 2002
    ..Such a modulation of orbito-frontal cortical emotional function by lorazepam has to be distinguished from its effects on cortical motor function as being independent from the kind of processing either emotional or nonemotional...
  33. pmc Neuroscience of decision making and informed consent: an investigation in neuroethics
    Georg Northoff
    Department of Psychiatry, Section for Neurophilosophy, University of Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    J Med Ethics 32:70-3. 2006
    ..It is concluded that current progress in the neurosciences could complement and change the way in which we approach ethical problems in neuropsychiatry...
  34. ncbi Deficit in decision making in catatonic schizophrenia: an exploratory study
    Raiko Bark
    Department of Psychiatry, Otto von Guericke University of Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Psychiatry Res 134:131-41. 2005
    ..In conclusion, our preliminary results suggest a specific deficit in catatonic schizophrenia in those neuropsychological measures that are associated with ventral prefrontal cortical function...
  35. pmc The association of interoceptive awareness and alexithymia with neurotransmitter concentrations in insula and anterior cingulate
    Jutta Ernst
    Clinic for Affective Disorders and General Psychiatry, Department of Psychiatry, Psychotherapy, and Psychosomatics, Psychiatric University Hospital, 8029 Zurich, Switzerland, Center for Anxiety and Depression, 8008 Zurich, Switzerland, University of Ottawa, Institute of Mental Health Research, Ottawa K1Z 7K4, Canada, Department of Psychiatry, Campus Benjamin Franklin, Charite, 14050 Berlin, and Languages of Emotion Cluster of Excellence, Freie Universitat Berlin, 14195 Berlin, Germany
    Soc Cogn Affect Neurosci 9:857-63. 2014
    ..Suppression of the unspecific emotional arousal evoked by increased awareness of bodily responses in alexithymics might thus be reflected in decreased neuronal activity mediated by increased GABA concentration in ACC. ..
  36. doi Neuropsychiatry. An old discipline in a new gestalt bridging biological psychiatry, neuropsychology, and cognitive neurology
    Georg Northoff
    Department of Psychiatry, Otto von Guericke University of Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Eur Arch Psychiatry Clin Neurosci 258:226-38. 2008
    ....
  37. ncbi Executive dysfunction, self, and ego pathology in schizophrenia: an exploratory study of neuropsychology and personality
    Heinz Boeker
    Department of Psychiatry, University of Zurich, CH 8032 Zurich, Switzerland
    Compr Psychiatry 47:7-19. 2006
    ..It can therefore be concluded that ego pathology must be distinguished from positive and negative symptoms in both underlying neuropsychological dysfunction and predisposing changes in personality...
  38. ncbi Imbalance between left and right dorsolateral prefrontal cortex in major depression is linked to negative emotional judgment: an fMRI study in severe major depressive disorder
    Simone Grimm
    Department of Psychiatry, University of Zurich, Switzerland
    Biol Psychiatry 63:369-76. 2008
    ....
  39. ncbi Segregated neural representation of distinct emotion dimensions in the prefrontal cortex-an fMRI study
    Simone Grimm
    Department of Psychiatry, University of Zurich, Switzerland
    Neuroimage 30:325-40. 2006
    ..In conclusion, our results indicate segregated neural representation of the different emotion dimensions in different prefrontal cortical regions...
  40. ncbi Affective judgment and beneficial decision making: ventromedial prefrontal activity correlates with performance in the Iowa Gambling Task
    Georg Northoff
    Department of Psychiatry, University of Zurich, Zurich, Switzerland
    Hum Brain Mapp 27:572-87. 2006
    ..These findings suggest that the degree to which subjects recruit the VMPFC during affective judgment is related to beneficial performance in decision making in gambling...
  41. ncbi Left prefrontal repetitive transcranial magnetic stimulation impairs performance in affective go/no-go task
    Felix Bermpohl
    Psychiatry and Psychology Institute, University of Sao Paulo, Brazil
    Neuroreport 16:615-9. 2005
    ..Our findings demonstrate a functionally relevant lateralization of the prefrontal contribution to affective go/no-go tasks...
  42. ncbi Is emotion regulation self-regulation?
    Georg Northoff
    Trends Cogn Sci 9:408-9; author reply 409-10. 2005
  43. doi Culture-sensitive neural substrates of human cognition: a transcultural neuroimaging approach
    Shihui Han
    Culture and Social Cognitive Neuroscience Laboratory, Department of Psychology, Peking University, 5 Yiheyuan Road, Beijing, China
    Nat Rev Neurosci 9:646-54. 2008
    ..The findings provide a novel approach by which to distinguish culture-sensitive from culture-invariant neural mechanisms of human cognition...