Trista E North
Affiliation: Harvard University
Cox A, Saunders D, Kelsey P, Conway A, Tesmenitsky Y, Marchini J, et al
. S-nitrosothiol signaling regulates liver development and improves outcome following toxic liver injury. Cell Rep. 2014;6:56-69 pubmed publisher
..These studies demonstrate that GSNOR inhibitors will be beneficial therapeutic candidates for treating liver injury. ..
Carroll K, North T. Oceans of opportunity: exploring vertebrate hematopoiesis in zebrafish. Exp Hematol. 2014;42:684-96 pubmed publisher
Esain V, Cortes M, North T. Enumerating Hematopoietic Stem and Progenitor Cells in Zebrafish Embryos. Methods Mol Biol. 2016;1451:191-206 pubmed publisher
..While live imaging and FACS analysis allows enumeration of total or site-specific HSPCs, the cell culture assay provides the unique opportunity to test the functional potential of isolated HSPCs, similar to those employed in mammals. ..
Goessling W, North T. EnaBILEing Growth in the Fetal Liver. Cell Stem Cell. 2016;18:427-8 pubmed publisher
..Sigurdsson et al. (2016) provide justification for transient fetal liver residence, where select bile acid composition, derived from mother and embryo, provides a protective environment, enabling rapid stem cell expansion. ..
Kwan W, Cortes M, Frost I, Esain V, Theodore L, Liu S, et al
. The Central Nervous System Regulates Embryonic HSPC Production via Stress-Responsive Glucocorticoid Receptor Signaling. Cell Stem Cell. 2016;19:370-82 pubmed publisher
..Our data establish that embryonic HSC production responds to physiologic stress via CNS-derived serotonin synthesis and central feedback regulation to control HSC numbers. ..
Carroll K, Esain V, Garnaas M, Cortes M, Dovey M, Nissim S, et al
. Estrogen defines the dorsal-ventral limit of VEGF regulation to specify the location of the hemogenic endothelial niche. Dev Cell. 2014;29:437-53 pubmed publisher
..Together, these data suggest that yolk-derived E2 sets the ventral boundary of hemogenic vascular niche specification by antagonizing the dorsal-ventral regulatory limits of VEGF. ..
Cortes M, Liu S, Kwan W, Alexa K, Goessling W, North T. Accumulation of the Vitamin D Precursor Cholecalciferol Antagonizes Hedgehog Signaling to Impair Hemogenic Endothelium Formation. Stem Cell Reports. 2015;5:471-9 pubmed publisher
..These findings highlight a direct impact of inefficient vitamin D synthesis on cell fate commitment and maturation in Hh-regulated tissues, which may have implications beyond hemogenic endothelium specification. ..
Cortes M, Chen M, Stachura D, Liu S, Kwan W, Wright F, et al
. Developmental Vitamin D Availability Impacts Hematopoietic Stem Cell Production. Cell Rep. 2016;17:458-468 pubmed publisher
..Together, these findings highlight the relevance of developmental 1,25(OH)D3 availability for definitive hematopoiesis and suggest potential therapeutic utility in HSPC expansion. ..
Kwan W, North T. Netting Novel Regulators of Hematopoiesis and Hematologic Malignancies in Zebrafish. Curr Top Dev Biol. 2017;124:125-160 pubmed publisher