Brian J North

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase
    Bjorn Schwer
    Gladstone Institute of Virology and Immunology, University of California San Francisco, 365 Vermont Street, San Francisco, CA 94103, USA
    J Cell Biol 158:647-57. 2002
  2. pmc Sirtuins: a conserved key unlocking AceCS activity
    Brian J North
    Department of Pathology, Paul F Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Trends Biochem Sci 32:1-4. 2007
  3. pmc The intersection between aging and cardiovascular disease
    Brian J North
    Glenn Laboratories for the Biological Mechanisms of Aging, Department of Genetics, Harvard Medical School, Boston, MA, USA
    Circ Res 110:1097-108. 2012
  4. ncbi request reprint The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase
    Brian J North
    Department of Physiology, University of California, San Francisco, 94141, San Francisco, CA, USA
    Mol Cell 11:437-44. 2003
  5. pmc Sirtuins: Sir2-related NAD-dependent protein deacetylases
    Brian J North
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94141, USA
    Genome Biol 5:224. 2004
  6. pmc SIRT1 regulates HIV transcription via Tat deacetylation
    Sara Pagans
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, USA
    PLoS Biol 3:e41. 2005
  7. ncbi request reprint Preparation of enzymatically active recombinant class III protein deacetylases
    Brian J North
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA, USA
    Methods 36:338-45. 2005
  8. ncbi request reprint Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation
    Brian J North
    Gladstone Institute of Virology and Immunology, University of California San Francisco, California 94158, USA
    J Biol Chem 282:19546-55. 2007
  9. ncbi request reprint Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase
    Nidhi Ahuja
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, California 94158, USA
    J Biol Chem 282:33583-92. 2007

Collaborators

  • David A Sinclair
  • JOHN DENU
  • Michael W McBurney
  • Eric Verdin
  • Nidhi Ahuja
  • Sara Pagans
  • Melanie Ott
  • Bjorn Schwer
  • David Waltregny
  • Bjoern Schwer
  • Stefania Carobbio
  • Vincenzo Castronovo
  • Pierre Maechler
  • Brett L Marshall
  • Roy Frye
  • Angelika Pedal
  • Manfred Jung
  • Peter Henklein
  • Alexander Dorr
  • Katrin Kaehlcke
  • Henning Hruby
  • Claudia Hetzer-Egger
  • Roy A Frye

Detail Information

Publications9

  1. pmc The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase
    Bjorn Schwer
    Gladstone Institute of Virology and Immunology, University of California San Francisco, 365 Vermont Street, San Francisco, CA 94103, USA
    J Cell Biol 158:647-57. 2002
    ..These observations demonstrate the existence of a latent class III deacetylase that becomes catalytically activated upon import into the human mitochondria...
  2. pmc Sirtuins: a conserved key unlocking AceCS activity
    Brian J North
    Department of Pathology, Paul F Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Trends Biochem Sci 32:1-4. 2007
    ..These findings highlight a metabolic regulatory network controlled by sirtuins that has implications for the mechanisms of calorie restriction and modulation of mammalian lifespan...
  3. pmc The intersection between aging and cardiovascular disease
    Brian J North
    Glenn Laboratories for the Biological Mechanisms of Aging, Department of Genetics, Harvard Medical School, Boston, MA, USA
    Circ Res 110:1097-108. 2012
    ....
  4. ncbi request reprint The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase
    Brian J North
    Department of Physiology, University of California, San Francisco, 94141, San Francisco, CA, USA
    Mol Cell 11:437-44. 2003
    ..These observations establish SIRT2 as a bona fide tubulin deacetylase...
  5. pmc Sirtuins: Sir2-related NAD-dependent protein deacetylases
    Brian J North
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94141, USA
    Genome Biol 5:224. 2004
    ..In addition to the catalytic domain, eukaryotic sirtuins contain variable amino- and carboxy-terminal extensions that regulate their subcellular localizations and catalytic activity...
  6. pmc SIRT1 regulates HIV transcription via Tat deacetylation
    Sara Pagans
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, USA
    PLoS Biol 3:e41. 2005
    ..These results support a model in which cycles of Tat acetylation and deacetylation regulate HIV transcription. SIRT1 recycles Tat to its unacetylated form and acts as a transcriptional coactivator during Tat transactivation...
  7. ncbi request reprint Preparation of enzymatically active recombinant class III protein deacetylases
    Brian J North
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA, USA
    Methods 36:338-45. 2005
    ..This review discusses protocols for the purification of enzymatically active human sirtuin 1, 2, and 3 and their activities on histone and nonhistone substrates...
  8. ncbi request reprint Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation
    Brian J North
    Gladstone Institute of Virology and Immunology, University of California San Francisco, California 94158, USA
    J Biol Chem 282:19546-55. 2007
    ..Overexpression of SIRT2 mediates a delay in cellular proliferation that is dependent on serine 368 phosphorylation. Furthermore, mutation of serine 368 reduces hyperploidy in cells under mitotic stress due to microtubule poisons...
  9. ncbi request reprint Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase
    Nidhi Ahuja
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, California 94158, USA
    J Biol Chem 282:33583-92. 2007
    ..Depletion of SIRT4 from insulin-producing INS-1E cells results in increased insulin secretion in response to glucose. These observations define a new role for mitochondrial SIRT4 in the regulation of insulin secretion...