Affiliation: Harvard University
- A liposome-based therapeutic vaccine against beta -amyloid plaques on the pancreas of transgenic NORBA miceClaude Nicolau
Ecole Superieure de Biotechnologie de Strasbourg, Universite Louis Pasteur, 67091 Strasbourg, France
Proc Natl Acad Sci U S A 99:2332-7. 2002..Possible implications for the therapy of Alzheimer's disease are discussed...
- Liposomal vaccines with conformation-specific amyloid peptide antigens define immune response and efficacy in APP transgenic miceAndreas Muhs
AC Immune, PSE B, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
Proc Natl Acad Sci U S A 104:9810-5. 2007..This finding supports the hypothesis that Alzheimer's disease is a "conformational" disease, implying that antibodies against amyloid sequences in the beta-sheet conformation are preferred as potential therapeutic agents...
- Induction of autoantibodies to murine P-glycoprotein: consequences on drug sensitivity in MDR cancer cells and on the expression of mdr genes in organsLaura Perrin
Laboratory of Biochemistry, EA 3796, IFR 53 Biomolecules, 51 Rue Cognac Jay, 51096 Reims Cedex, France
Biochem Biophys Res Commun 358:325-30. 2007..These results suggest that the induction of autoantibodies to P-gp is a safe strategy to overcome MDR in cancer chemotherapy...
- Immunization with liposome-anchored pegylated peptides modulates doxorubicin sensitivity in P-glycoprotein-expressing P388 cellsGregory Gatouillat
Laboratory of Biochemistry, IFR53, Faculty of Pharmacy, 51 rue Cognacq Jay, 51096 Reims Cedex, France
Cancer Lett 257:165-71. 2007..Overall, these results suggest that this approach can modulate Pgp activity by blocking drug efflux and may have clinical relevance as an alternative strategy to toxic chemosensitizers in drug-resistant cancer therapy...