Paul L Nguyen

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Cost implications of the rapid adoption of newer technologies for treating prostate cancer
    Paul L Nguyen
    Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    J Clin Oncol 29:1517-24. 2011
  2. ncbi High-dose-rate brachytherapy for prostate cancer in a previously radiated patient with polyethylene glycol hydrogel spacing to reduce rectal dose: case report and review of the literature
    Paul L Nguyen
    Department of Radiation Oncology, Dana Farber Cancer Institute, Brigham and Women s Cancer Center, Harvard Medical School, Boston, MA 02115, USA
    Brachytherapy 12:77-83. 2013
  3. ncbi Updated results of magnetic resonance imaging guided partial prostate brachytherapy for favorable risk prostate cancer: implications for focal therapy
    Paul L Nguyen
    Department of Radiation Oncology, Dana Farber Cancer Institute, and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Urol 188:1151-6. 2012
  4. ncbi Cardiovascular comorbidity and treatment regret in men with recurrent prostate cancer
    Paul L Nguyen
    Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    BJU Int 110:201-5. 2012
  5. ncbi Influence of androgen deprivation therapy on all-cause mortality in men with high-risk prostate cancer and a history of congestive heart failure or myocardial infarction
    Paul L Nguyen
    Department of Radiation Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Int J Radiat Oncol Biol Phys 82:1411-6. 2012
  6. ncbi Radiation with or without 6 months of androgen suppression therapy in intermediate- and high-risk clinically localized prostate cancer: a postrandomization analysis by risk group
    Paul L Nguyen
    Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Int J Radiat Oncol Biol Phys 77:1046-52. 2010
  7. ncbi The impact of Skp2 overexpression on recurrence-free survival following radical prostatectomy
    Paul L Nguyen
    Harvard Radiation Oncology Program, Brigham and Women s Hospital Dana Farber Cancer Institute, Boston, MA 02115, USA
    Urol Oncol 29:302-8. 2011
  8. ncbi Patient-reported quality of life after salvage brachytherapy for radio-recurrent prostate cancer: A prospective Phase II study
    Paul L Nguyen
    Harvard Radiation Oncology Program, Boston, MA 02115, USA
    Brachytherapy 8:345-52. 2009
  9. ncbi Comorbidity, body mass index, and age and the risk of nonprostate-cancer-specific mortality after a postradiation prostate-specific antigen recurrence
    Paul L Nguyen
    Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer 116:610-5. 2010
  10. ncbi Biochemical recurrence after radical prostatectomy for prevalent versus incident cases of prostate cancer : implications for management
    Paul L Nguyen
    Radiation Oncology Program, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer 113:3146-52. 2008

Detail Information

Publications63

  1. ncbi Cost implications of the rapid adoption of newer technologies for treating prostate cancer
    Paul L Nguyen
    Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    J Clin Oncol 29:1517-24. 2011
    ..We assessed temporal trends in their utilization and their impact on national health care spending...
  2. ncbi High-dose-rate brachytherapy for prostate cancer in a previously radiated patient with polyethylene glycol hydrogel spacing to reduce rectal dose: case report and review of the literature
    Paul L Nguyen
    Department of Radiation Oncology, Dana Farber Cancer Institute, Brigham and Women s Cancer Center, Harvard Medical School, Boston, MA 02115, USA
    Brachytherapy 12:77-83. 2013
    ..To describe the use of a temporary spacer to reduce rectal dose prior to prostate radiation in a man with prior pelvic radiotherapy and review the relevant literature...
  3. ncbi Updated results of magnetic resonance imaging guided partial prostate brachytherapy for favorable risk prostate cancer: implications for focal therapy
    Paul L Nguyen
    Department of Radiation Oncology, Dana Farber Cancer Institute, and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Urol 188:1151-6. 2012
    ..We report updated results of magnetic resonance imaging guided partial prostate brachytherapy and propose a definition of biochemical failure following focal therapy...
  4. ncbi Cardiovascular comorbidity and treatment regret in men with recurrent prostate cancer
    Paul L Nguyen
    Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    BJU Int 110:201-5. 2012
    ....
  5. ncbi Influence of androgen deprivation therapy on all-cause mortality in men with high-risk prostate cancer and a history of congestive heart failure or myocardial infarction
    Paul L Nguyen
    Department of Radiation Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Int J Radiat Oncol Biol Phys 82:1411-6. 2012
    ....
  6. ncbi Radiation with or without 6 months of androgen suppression therapy in intermediate- and high-risk clinically localized prostate cancer: a postrandomization analysis by risk group
    Paul L Nguyen
    Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Int J Radiat Oncol Biol Phys 77:1046-52. 2010
    ..RT alone in men with unfavorable risk localized prostate cancer (PCa), but it is unknown if this benefit applies to all risk subgroups and, in particular, the intermediate-risk group...
  7. ncbi The impact of Skp2 overexpression on recurrence-free survival following radical prostatectomy
    Paul L Nguyen
    Harvard Radiation Oncology Program, Brigham and Women s Hospital Dana Farber Cancer Institute, Boston, MA 02115, USA
    Urol Oncol 29:302-8. 2011
    ..We examined whether Skp2 overexpression is associated with recurrence following radical prostatectomy (RP) for prostate cancer...
  8. ncbi Patient-reported quality of life after salvage brachytherapy for radio-recurrent prostate cancer: A prospective Phase II study
    Paul L Nguyen
    Harvard Radiation Oncology Program, Boston, MA 02115, USA
    Brachytherapy 8:345-52. 2009
    ..Patient-reported quality of life (QOL) after salvage brachytherapy for radiorecurrent prostate cancer has not been well-characterized prospectively...
  9. ncbi Comorbidity, body mass index, and age and the risk of nonprostate-cancer-specific mortality after a postradiation prostate-specific antigen recurrence
    Paul L Nguyen
    Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer 116:610-5. 2010
    ..Therefore, our ability to determine who would benefit from salvage hormonotherapy (HT) would be enhanced if an individual's risk of nonprostate-cancer-specific mortality were known...
  10. ncbi Biochemical recurrence after radical prostatectomy for prevalent versus incident cases of prostate cancer : implications for management
    Paul L Nguyen
    Radiation Oncology Program, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer 113:3146-52. 2008
    ....
  11. ncbi Association of androgen deprivation therapy with cardiovascular death in patients with prostate cancer: a meta-analysis of randomized trials
    Paul L Nguyen
    Department of Radiation Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    JAMA 306:2359-66. 2011
    ....
  12. ncbi Predicting prostate cancer mortality among men with intermediate to high-risk disease and multiple unfavorable risk factors
    Paul L Nguyen
    Harvard Radiation Oncology Program, Boston, MA 02115, USA
    Int J Radiat Oncol Biol Phys 73:659-64. 2009
    ..To determine whether the number of unfavorable risk factors could be used to predict the risk of prostate cancer-specific mortality (PCSM) among men with intermediate- to high-risk prostate cancer...
  13. ncbi Survival following radiation and androgen suppression therapy for prostate cancer in healthy older men: implications for screening recommendations
    Paul L Nguyen
    Harvard Radiation Oncology Program, Department of Radiation Oncology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Int J Radiat Oncol Biol Phys 76:337-41. 2010
    ..The U.S. Preventive Services Task Force has recommended against screening men over 75 for prostate cancer. We examined whether older healthy men could benefit from aggressive prostate cancer treatment...
  14. ncbi Proton-beam vs intensity-modulated radiation therapy. Which is best for treating prostate cancer?
    Paul L Nguyen
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, MA 02114, USA
    Oncology (Williston Park) 22:748-54; discussion 754, 757. 2008
    ..In this article, we review the current status of the evidence supporting the use of protons in prostate cancer and discuss the active controversies that surround this modality...
  15. ncbi Coronary revascularization and mortality in men with congestive heart failure or prior myocardial infarction who receive androgen deprivation
    Paul L Nguyen
    Department of Radiation Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer 117:406-13. 2011
    ....
  16. ncbi Rectal dose-volume histogram parameters are associated with long-term patient-reported gastrointestinal quality of life after conventional and high-dose radiation for prostate cancer: a subgroup analysis of a randomized trial
    Paul L Nguyen
    Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Int J Radiat Oncol Biol Phys 78:1081-5. 2010
    ..2 GyE) or high-dose (79.2 GyE) radiation for prostate cancer...
  17. ncbi Patient selection, cancer control, and complications after salvage local therapy for postradiation prostate-specific antigen failure: a systematic review of the literature
    Paul L Nguyen
    Department of Radiation Oncology, Brigham and Women s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer 110:1417-28. 2007
    ....
  18. ncbi Effect of definition of preradiotherapy prostate-specific antigen velocity on its association with prostate cancer-specific mortality and all-cause mortality
    Paul L Nguyen
    Harvard Radiation Oncology Program, Department of Radiation Oncology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Urology 70:288-93. 2007
    ..This study examined the effect on this association when the PSAV was estimated using all PSA values (PSAV-all) instead of the PSA values within 18 months before diagnosis (PSAV-18)...
  19. ncbi Reduced penile size and treatment regret in men with recurrent prostate cancer after surgery, radiotherapy plus androgen deprivation, or radiotherapy alone
    Arti Parekh
    Department of Radiation Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Urology 81:130-4. 2013
    ..To report the relative incidence of the perceived reduction in penile size across prostate cancer treatment modalities and to describe its effect on quality of life and treatment regret...
  20. ncbi The impact of a delay in initiating radiation therapy on prostate-specific antigen outcome for patients with clinically localized prostate carcinoma
    Paul L Nguyen
    Department of Radiation Oncology, Brigham and Women's Hospital, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer 103:2053-9. 2005
    ..5 months versus > or = 2.5 months respectively. The median delay was 2.5 months. CONCLUSIONS: Treatment delay adversely affected PSA outcome for high-risk patients but not for low-risk patients following RT...
  21. ncbi Evaluating the combined effect of comorbidity and prostate-specific antigen kinetics on the risk of death in men after prostate-specific antigen recurrence
    Jennifer Y Wo
    Harvard Radiation Oncology Program, Harvard Medical School, Boston, MA, USA
    J Clin Oncol 27:6000-5. 2009
    ....
  22. ncbi The association between biological subtype and isolated regional nodal failure after breast-conserving therapy
    Jennifer Y Wo
    Harvard Radiation Oncology Program, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 77:188-96. 2010
    ....
  23. ncbi Risk of all-cause and prostate cancer-specific mortality after brachytherapy in men with small prostate size
    Paul L Nguyen
    Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Boston, MA 02115, USA
    Int J Radiat Oncol Biol Phys 79:1318-22. 2011
    ..Brachytherapy for prostate cancer can be technically challenging in men with small prostates (≤20 cc), but it is unknown whether their outcomes are different than those of men with larger prostates...
  24. ncbi Impact of postoperative prostate-specific antigen disease recurrence and the use of salvage therapy on the risk of death
    Toni K Choueiri
    Department of Medical Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer 116:1887-92. 2010
    ..BCR) as a time-dependent covariate (t) after radical prostatectomy (RP) for prostate cancer was associated with the risk of death and whether salvage therapy with radiotherapy (RT) and/or hormonal therapy (HT) can lessen this risk..
  25. ncbi Multidisciplinary care and pursuit of active surveillance in low-risk prostate cancer
    Ayal A Aizer
    Harvard Radiation Oncology Program, Massachusetts General Hospital, Department of Radiation Oncology, 100 Blossom St, Cox 3, Boston, MA 02114, USA
    J Clin Oncol 30:3071-6. 2012
    ..The purpose of this study was to determine whether consultation at a multidisciplinary clinic is associated with selection of active surveillance in patients with low-risk prostate cancer...
  26. ncbi Basal subtype of invasive breast cancer is associated with a higher risk of true recurrence after conventional breast-conserving therapy
    Jona A Hattangadi-Gluth
    Harvard Radiation Oncology Program, Boston, Massachusetts, USA
    Int J Radiat Oncol Biol Phys 82:1185-91. 2012
    ....
  27. ncbi Comparative effectiveness of cryotherapy vs brachytherapy for localised prostate cancer
    Stephen B Williams
    Division of Urologic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    BJU Int 110:E92-8. 2012
    ..Conversely, cryotherapy was associated with fewer bowel complications. Patients and providers alike should consider these population-based outcomes when discussing therapeutic options for localised prostate cancer...
  28. ncbi Biopsy Gleason score and the duration of testosterone suppression among men treated with external beam radiation and 6 months of combined androgen blockade
    Neil E Martin
    Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Harvard Medical School, Boston, MA Department of Statistics, University of Connecticut, Storrs, CT Department of Medical Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    BJU Int 110:1252-6. 2012
    ..In this study, we found that among men treated with 6 months of combined androgen blockade and radiation therapy, higher biopsy Gleason grade was associated with a shorter time to testosterone normalization...
  29. ncbi Age, breast cancer subtype approximation, and local recurrence after breast-conserving therapy
    Nils D Arvold
    Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Boston, MA 02215, USA
    J Clin Oncol 29:3885-91. 2011
    ..Prior results of breast-conserving therapy (BCT) have shown substantial rates of local recurrence (LR) in young patients with breast cancer (BC)...
  30. ncbi Overuse of imaging for staging low risk prostate cancer
    Wesley W Choi
    Division of Urologic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02130, USA
    J Urol 185:1645-9. 2011
    ..Routine imaging for staging low risk prostate cancer is not recommended according to current guidelines. We characterized patterns of care and factors associated with imaging overuse...
  31. ncbi Radiotherapy treatment of early-stage prostate cancer with IMRT and protons: a treatment planning comparison
    Alexei Trofimov
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 69:444-53. 2007
    ..To compare intensity-modulated photon radiotherapy (IMRT) with three-dimensional conformal proton therapy (3D-CPT) for early-stage prostate cancer, and explore the potential utility of intensity-modulated proton therapy (IMPT)...
  32. ncbi Comparative analysis of outcomes and costs following open radical cystectomy versus robot-assisted laparoscopic radical cystectomy: results from the US Nationwide Inpatient Sample
    Hua yin Yu
    Division of Urology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Eur Urol 61:1239-44. 2012
    ..Although robot-assisted laparoscopic radical cystectomy (RARC) was first reported in 2003 and has gained popularity, comparisons with open radical cystectomy (ORC) are limited to reports from high-volume referral centers...
  33. ncbi Magnetic resonance image-guided salvage brachytherapy after radiation in select men who initially presented with favorable-risk prostate cancer: a prospective phase 2 study
    Paul L Nguyen
    Department of Radiation Oncology, Brigham and Women s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts
    Cancer 110:1485-92. 2007
    ....
  34. ncbi Determinants of performing radical prostatectomy pelvic lymph node dissection and the number of lymph nodes removed in elderly men
    Jim C Hu
    Division of Urologic Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
    Urology 77:402-6. 2011
    ..We characterized determinants of performance and extent of PLND during radical prostatectomy in elderly men...
  35. ncbi Hormonal therapy or external-beam radiation with brachytherapy and the risk of death from prostate cancer in men with intermediate risk prostate cancer
    Jonathan E Rosenberg
    Lank Center for Genitourinary Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Clin Genitourin Cancer 10:21-5. 2012
    ..To determine whether external-beam radiotherapy (EBRT) improves disease control compared with supplemental androgen suppression therapy (AST) in men with intermediate-risk prostate cancer who are being treated with brachytherapy...
  36. ncbi Predicting the risk of pelvic node involvement among men with prostate cancer in the contemporary era
    Paul L Nguyen
    Harvard Radiation Oncology Program, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 74:104-9. 2009
    ..We examined the accuracy of this formula in contemporary patients...
  37. ncbi Stepwise approach for nerve sparing without countertraction during robot-assisted radical prostatectomy: technique and outcomes
    Keith J Kowalczyk
    Division of Urologic Surgery, Brigham and Women s Faulkner Hospital, Harvard Medical School, Boston, MA 02130, USA
    Eur Urol 60:536-47. 2011
    ..However, the impact of active assistant/surgeon neurovascular bundle (NVB) countertraction on sexual function outcomes has not been studied or quantified...
  38. ncbi Fatty acid synthase polymorphisms, tumor expression, body mass index, prostate cancer risk, and survival
    Paul L Nguyen
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    J Clin Oncol 28:3958-64. 2010
    ..We examined whether common germline single nucleotide polymorphisms (SNPs) in the FASN gene affect prostate cancer (PCa) risk or PCa-specific mortality and whether these effects vary by body mass index (BMI)...
  39. ncbi Posttreatment prostate specific antigen nadir predicts prostate cancer specific and all cause mortality
    Yolanda D Tseng
    Harvard Radiation Oncology Program, Department of Radiation Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Urol 187:2068-73. 2012
    ..We investigated whether the prostate specific antigen nadir predicts prostate cancer specific and all cause mortality in men treated in a randomized trial of radiation with or without 6 months of androgen deprivation therapy...
  40. ncbi Recommendations for post-prostatectomy radiation therapy in the United States before and after the presentation of randomized trials
    Karen E Hoffman
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Urol 185:116-20. 2011
    ....
  41. ncbi Utilization and expense of adjuvant cancer therapies following radical prostatectomy
    Stephen B Williams
    Division of Urologic Surgery, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Cancer 117:4846-54. 2011
    ..We sought to identify the costs of adjuvant therapies following radical prostatectomy (RP) and factors associated with their receipt...
  42. ncbi Interfractional variations in the setup of pelvic bony anatomy and soft tissue, and their implications on the delivery of proton therapy for localized prostate cancer
    Alexei Trofimov
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 80:928-37. 2011
    ....
  43. ncbi Patient-reported quality of life during radiation treatment for localized prostate cancer: results from a prospective phase II trial
    Ronald C Chen
    Department of Radiation Oncology and Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC 27599 7512, USA
    BJU Int 110:1690-5. 2012
    ....
  44. ncbi Quantifying the impact of seminal vesicle invasion identified using endorectal magnetic resonance imaging on PSA outcome after radiation therapy for patients with clinically localized prostate cancer
    Paul L Nguyen
    Department of Radiation Oncology, Brigham and Women's Hospital, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Int J Radiat Oncol Biol Phys 59:400-5. 2004
    ..Consideration should be given to combining EBRT with hormonal therapy in these patients...
  45. ncbi The impact of pathology review on treatment recommendations for patients with adenocarcinoma of the prostate
    Paul L Nguyen
    Department of Radiation Oncology, Brigham and Women's Hospital, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Urol Oncol 22:295-9. 2004
    ..2%, but was changed from intermediate or high risk to low risk in only 0.9%. Genitourinary pathology review would have changed management in approximately 10% of men, mainly in the direction of combined therapy over monotherapy...
  46. ncbi Thermal ablation vs surgery for localized kidney cancer: a Surveillance, Epidemiology, and End Results (SEER) database analysis
    Toni K Choueiri
    Dana Farber Cancer Institute, Boston, MA 02115, USA
    Urology 78:93-8. 2011
    ....
  47. ncbi High-dose external beam radiation for localized prostate cancer: current status and future challenges
    Paul L Nguyen
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Cancer J 13:295-301. 2007
    ....
  48. ncbi Prostate cancer screening in men 75 years old or older: an assessment of self-reported health status and life expectancy
    Karen E Hoffman
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Urol 183:1798-802. 2010
    ..In this study we evaluated the influence of health status and life expectancy on prostate specific antigen screening in older men in the United States before the 2008 United States Preventive Services Task Force guidelines...
  49. ncbi Barriers to the implementation of surveillance for stage I testicular seminoma
    Nils D Arvold
    Harvard Radiation Oncology Program, Harvard Medical School, Boston, Massachusetts, USA
    Int J Radiat Oncol Biol Phys 84:383-9. 2012
    ..Because studies suggest that radiation oncologists in the United States continue to recommend RT for these patients, we sought to identify factors associated with management recommendations...
  50. ncbi Hospital volume, utilization, costs and outcomes of robot-assisted laparoscopic radical prostatectomy
    Hua yin Yu
    Division of Urology, Lank Center for Genitourinary Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    J Urol 187:1632-7. 2012
    ....
  51. ncbi Congestive heart failure risk in patients with breast cancer treated with bevacizumab
    Toni K Choueiri
    Dana Farber Cancer Institute, 44 Binney St Dana 1230, Boston MA 02115, USA
    J Clin Oncol 29:632-8. 2011
    ..We performed an up-to-date, comprehensive meta-analysis to determine the risk of serious CHF in patients with breast cancer receiving bevacizumab...
  52. ncbi Prediagnostic body-mass index, plasma C-peptide concentration, and prostate cancer-specific mortality in men with prostate cancer: a long-term survival analysis
    Jing Ma
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Lancet Oncol 9:1039-47. 2008
    ..We assessed the effect of prediagnostic BMI and plasma C-peptide concentration (reflecting insulin secretion) on prostate cancer-specific mortality after diagnosis...
  53. ncbi Results of whole-brain radiation as salvage of methotrexate failure for immunocompetent patients with primary CNS lymphoma
    Paul L Nguyen
    Massachusetts General Hospital, Department of Radiation Oncology, 100 Blossom St, Boston, MA 02114, USA
    J Clin Oncol 23:1507-13. 2005
    ..9 months. Age less than 60 years and response to WBRT predict post-WBRT survival. Modest rates of late neurotoxicity (15%) were seen and were associated with a total dose greater than 36 Gy...
  54. ncbi Which patients with undetectable PSA levels 5 years after radical prostatectomy are still at risk of recurrence?--implications for a risk-adapted follow-up strategy
    Deborah A Ahove
    Smith College, Northhampton, Massachusetts, USA
    Urology 76:1201-5. 2010
    ..To determine the predictors of late prostate-specific antigen (PSA) failure among men with an undetectable PSA level 5 years after radical prostatectomy (RP)...
  55. ncbi Microinvasive breast cancer: ER, PR, and HER-2/neu status and clinical outcomes after breast-conserving therapy or mastectomy
    Danielle N Margalit
    Department of Radiation Oncology, Brigham and Women s Hospital Dana Farber Cancer Institute, Boston, MA, USA
    Ann Surg Oncol 20:811-8. 2013
    ..We document the immunophenotype, incidence of axillary metastases, and rate of recurrence in a well-defined case series...
  56. ncbi Fatty acid synthase as a potential therapeutic target in cancer
    Richard Flavin
    Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Harvard Medical School, Brigham and Women s Hospital, Boston, MA, USA
    Future Oncol 6:551-62. 2010
    ..Furthermore, novel sources of FASN inhibitors, such as green tea and dietary soy, make both dietary manipulation and chemoprevention potential alternative modes of therapy in the future...
  57. ncbi A single nucleotide polymorphism in inflammatory gene RNASEL predicts outcome after radiation therapy for localized prostate cancer
    Jonathan D Schoenfeld
    Harvard Radiation Oncology Program, Boston, Massachusetts, USA
    Clin Cancer Res 19:1612-9. 2013
    ..To study associations between single nucleotide polymorphisms (SNP) in Ribonuclease L (RNASEL), a gene implicated in inflammation and prostate cancer risk, and outcomes after radiation therapy...
  58. ncbi The effect of excessive anticoagulation on mortality and morbidity in hospitalized patients with anticoagulant-related major hemorrhage
    Sophia Koo
    Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
    Arch Intern Med 164:1557-60. 2004
    ..17; 95% CI, 1.25-3.78; P =.006). CONCLUSION: In a cohort of patients with anticoagulation-associated hemorrhage, excessive anticoagulation contributed independently to increased morbidity and mortality...
  59. ncbi Breast cancer subtype approximated by estrogen receptor, progesterone receptor, and HER-2 is associated with local and distant recurrence after breast-conserving therapy
    Paul L Nguyen
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA
    J Clin Oncol 26:2373-8. 2008
    ..To determine whether breast cancer subtype is associated with outcome after breast-conserving therapy (BCT) consisting of lumpectomy and radiation therapy...
  60. ncbi Expanded prostate cancer index composite for clinical practice: development and validation of a practical health related quality of life instrument for use in the routine clinical care of patients with prostate cancer
    Peter Chang
    Division of Urology, Department of Surgery, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Urol 186:865-72. 2011
    ..Thus, we developed an instrument for this purpose...
  61. ncbi Overexpression of fatty acid synthase is associated with palmitoylation of Wnt1 and cytoplasmic stabilization of beta-catenin in prostate cancer
    Michelangelo Fiorentino
    Department of Medical Oncology, Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Boston, MA, USA
    Lab Invest 88:1340-8. 2008
    ..001, Spearman's rho=0.33). We propose that cytoplasmic stabilization of beta-catenin through palmitoylation of Wnt-1 and subsequent activation of the pathway is a potential mechanism of FASN oncogenicity in prostate cancer...
  62. ncbi Linear accelerator-based stereotactic radiosurgery for brainstem metastases: the Dana-Farber/Brigham and Women's Cancer Center experience
    Paul J Kelly
    Department of Radiation Oncology, Dana Farber Brigham and Women s Cancer Center, Boston, MA 02115, USA
    J Neurooncol 104:553-7. 2011
    ..6% at 1 year. RTOG grade 3 toxicities were recorded in two patients (ataxia, confusion). Linac-based SRS for small volume brainstem metastases using a median dose of 13 Gy is associated with acceptable local control and low morbidity...
  63. ncbi Targeting pelvic lymph nodes in men with intermediate- and high-risk prostate cancer despite two negative randomized trials
    Paul L Nguyen
    J Clin Oncol 26:2055-6; author reply 2056-7. 2008