Paul L Nguyen

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Cost implications of the rapid adoption of newer technologies for treating prostate cancer
    Paul L Nguyen
    Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    J Clin Oncol 29:1517-24. 2011
  2. doi High-dose-rate brachytherapy for prostate cancer in a previously radiated patient with polyethylene glycol hydrogel spacing to reduce rectal dose: case report and review of the literature
    Paul L Nguyen
    Department of Radiation Oncology, Dana Farber Cancer Institute, Brigham and Women s Cancer Center, Harvard Medical School, Boston, MA 02115, USA
    Brachytherapy 12:77-83. 2013
  3. pmc Updated results of magnetic resonance imaging guided partial prostate brachytherapy for favorable risk prostate cancer: implications for focal therapy
    Paul L Nguyen
    Department of Radiation Oncology, Dana Farber Cancer Institute, and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Urol 188:1151-6. 2012
  4. doi Cardiovascular comorbidity and treatment regret in men with recurrent prostate cancer
    Paul L Nguyen
    Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    BJU Int 110:201-5. 2012
  5. doi Influence of androgen deprivation therapy on all-cause mortality in men with high-risk prostate cancer and a history of congestive heart failure or myocardial infarction
    Paul L Nguyen
    Department of Radiation Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Int J Radiat Oncol Biol Phys 82:1411-6. 2012
  6. doi Survival following radiation and androgen suppression therapy for prostate cancer in healthy older men: implications for screening recommendations
    Paul L Nguyen
    Harvard Radiation Oncology Program, Department of Radiation Oncology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Int J Radiat Oncol Biol Phys 76:337-41. 2010
  7. doi Comorbidity, body mass index, and age and the risk of nonprostate-cancer-specific mortality after a postradiation prostate-specific antigen recurrence
    Paul L Nguyen
    Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer 116:610-5. 2010
  8. pmc Patient-reported quality of life after salvage brachytherapy for radio-recurrent prostate cancer: A prospective Phase II study
    Paul L Nguyen
    Harvard Radiation Oncology Program, Boston, MA 02115, USA
    Brachytherapy 8:345-52. 2009
  9. doi The impact of Skp2 overexpression on recurrence-free survival following radical prostatectomy
    Paul L Nguyen
    Harvard Radiation Oncology Program, Brigham and Women s Hospital Dana Farber Cancer Institute, Boston, MA 02115, USA
    Urol Oncol 29:302-8. 2011
  10. doi Radiation with or without 6 months of androgen suppression therapy in intermediate- and high-risk clinically localized prostate cancer: a postrandomization analysis by risk group
    Paul L Nguyen
    Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Int J Radiat Oncol Biol Phys 77:1046-52. 2010

Detail Information

Publications78

  1. pmc Cost implications of the rapid adoption of newer technologies for treating prostate cancer
    Paul L Nguyen
    Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    J Clin Oncol 29:1517-24. 2011
    ..We assessed temporal trends in their utilization and their impact on national health care spending...
  2. doi High-dose-rate brachytherapy for prostate cancer in a previously radiated patient with polyethylene glycol hydrogel spacing to reduce rectal dose: case report and review of the literature
    Paul L Nguyen
    Department of Radiation Oncology, Dana Farber Cancer Institute, Brigham and Women s Cancer Center, Harvard Medical School, Boston, MA 02115, USA
    Brachytherapy 12:77-83. 2013
    ..To describe the use of a temporary spacer to reduce rectal dose prior to prostate radiation in a man with prior pelvic radiotherapy and review the relevant literature...
  3. pmc Updated results of magnetic resonance imaging guided partial prostate brachytherapy for favorable risk prostate cancer: implications for focal therapy
    Paul L Nguyen
    Department of Radiation Oncology, Dana Farber Cancer Institute, and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Urol 188:1151-6. 2012
    ..We report updated results of magnetic resonance imaging guided partial prostate brachytherapy and propose a definition of biochemical failure following focal therapy...
  4. doi Cardiovascular comorbidity and treatment regret in men with recurrent prostate cancer
    Paul L Nguyen
    Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    BJU Int 110:201-5. 2012
    ....
  5. doi Influence of androgen deprivation therapy on all-cause mortality in men with high-risk prostate cancer and a history of congestive heart failure or myocardial infarction
    Paul L Nguyen
    Department of Radiation Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Int J Radiat Oncol Biol Phys 82:1411-6. 2012
    ....
  6. doi Survival following radiation and androgen suppression therapy for prostate cancer in healthy older men: implications for screening recommendations
    Paul L Nguyen
    Harvard Radiation Oncology Program, Department of Radiation Oncology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Int J Radiat Oncol Biol Phys 76:337-41. 2010
    ..The U.S. Preventive Services Task Force has recommended against screening men over 75 for prostate cancer. We examined whether older healthy men could benefit from aggressive prostate cancer treatment...
  7. doi Comorbidity, body mass index, and age and the risk of nonprostate-cancer-specific mortality after a postradiation prostate-specific antigen recurrence
    Paul L Nguyen
    Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer 116:610-5. 2010
    ..Therefore, our ability to determine who would benefit from salvage hormonotherapy (HT) would be enhanced if an individual's risk of nonprostate-cancer-specific mortality were known...
  8. pmc Patient-reported quality of life after salvage brachytherapy for radio-recurrent prostate cancer: A prospective Phase II study
    Paul L Nguyen
    Harvard Radiation Oncology Program, Boston, MA 02115, USA
    Brachytherapy 8:345-52. 2009
    ..Patient-reported quality of life (QOL) after salvage brachytherapy for radiorecurrent prostate cancer has not been well-characterized prospectively...
  9. doi The impact of Skp2 overexpression on recurrence-free survival following radical prostatectomy
    Paul L Nguyen
    Harvard Radiation Oncology Program, Brigham and Women s Hospital Dana Farber Cancer Institute, Boston, MA 02115, USA
    Urol Oncol 29:302-8. 2011
    ..We examined whether Skp2 overexpression is associated with recurrence following radical prostatectomy (RP) for prostate cancer...
  10. doi Radiation with or without 6 months of androgen suppression therapy in intermediate- and high-risk clinically localized prostate cancer: a postrandomization analysis by risk group
    Paul L Nguyen
    Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Int J Radiat Oncol Biol Phys 77:1046-52. 2010
    ..RT alone in men with unfavorable risk localized prostate cancer (PCa), but it is unknown if this benefit applies to all risk subgroups and, in particular, the intermediate-risk group...
  11. doi Rectal dose-volume histogram parameters are associated with long-term patient-reported gastrointestinal quality of life after conventional and high-dose radiation for prostate cancer: a subgroup analysis of a randomized trial
    Paul L Nguyen
    Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Int J Radiat Oncol Biol Phys 78:1081-5. 2010
    ..2 GyE) or high-dose (79.2 GyE) radiation for prostate cancer...
  12. doi Coronary revascularization and mortality in men with congestive heart failure or prior myocardial infarction who receive androgen deprivation
    Paul L Nguyen
    Department of Radiation Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer 117:406-13. 2011
    ....
  13. doi Biochemical recurrence after radical prostatectomy for prevalent versus incident cases of prostate cancer : implications for management
    Paul L Nguyen
    Radiation Oncology Program, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer 113:3146-52. 2008
    ....
  14. doi Predicting prostate cancer mortality among men with intermediate to high-risk disease and multiple unfavorable risk factors
    Paul L Nguyen
    Harvard Radiation Oncology Program, Boston, MA 02115, USA
    Int J Radiat Oncol Biol Phys 73:659-64. 2009
    ..To determine whether the number of unfavorable risk factors could be used to predict the risk of prostate cancer-specific mortality (PCSM) among men with intermediate- to high-risk prostate cancer...
  15. ncbi Patient selection, cancer control, and complications after salvage local therapy for postradiation prostate-specific antigen failure: a systematic review of the literature
    Paul L Nguyen
    Department of Radiation Oncology, Brigham and Women s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer 110:1417-28. 2007
    ....
  16. ncbi Effect of definition of preradiotherapy prostate-specific antigen velocity on its association with prostate cancer-specific mortality and all-cause mortality
    Paul L Nguyen
    Harvard Radiation Oncology Program, Department of Radiation Oncology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Urology 70:288-93. 2007
    ..This study examined the effect on this association when the PSAV was estimated using all PSA values (PSAV-all) instead of the PSA values within 18 months before diagnosis (PSAV-18)...
  17. doi Association of androgen deprivation therapy with cardiovascular death in patients with prostate cancer: a meta-analysis of randomized trials
    Paul L Nguyen
    Department of Radiation Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    JAMA 306:2359-66. 2011
    ....
  18. ncbi Proton-beam vs intensity-modulated radiation therapy. Which is best for treating prostate cancer?
    Paul L Nguyen
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, MA 02114, USA
    Oncology (Williston Park) 22:748-54; discussion 754, 757. 2008
    ..In this article, we review the current status of the evidence supporting the use of protons in prostate cancer and discuss the active controversies that surround this modality...
  19. doi Reduced penile size and treatment regret in men with recurrent prostate cancer after surgery, radiotherapy plus androgen deprivation, or radiotherapy alone
    Arti Parekh
    Department of Radiation Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Urology 81:130-4. 2013
    ..To report the relative incidence of the perceived reduction in penile size across prostate cancer treatment modalities and to describe its effect on quality of life and treatment regret...
  20. ncbi Lack of reduction in racial disparities in cancer-specific mortality over a 20-year period
    Ayal A Aizer
    Harvard Radiation Oncology Program, Harvard Medical School, Boston, Massachusetts
    Cancer 120:1532-9. 2014
    ..In the current study, the authors assessed whether racial disparities in cancer-specific mortality have improved over the last 20 years...
  21. ncbi Identification of comorbidities that place men at highest risk of death from androgen deprivation therapy before brachytherapy for prostate cancer
    Arti Parekh
    Department of Radiation Oncology, Dana Farber Brigham and Women s Hospital, Harvard Medical School, Boston, MA
    Brachytherapy 12:415-21. 2013
    ..To determine which specific comorbidities predispose men to excess mortality by androgen deprivation therapy (ADT) given before and during brachytherapy for prostate cancer...
  22. ncbi The impact of a delay in initiating radiation therapy on prostate-specific antigen outcome for patients with clinically localized prostate carcinoma
    Paul L Nguyen
    Department of Radiation Oncology, Brigham and Women s Hospital, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer 103:2053-9. 2005
    ..4 Gy for clinically localized prostate cancer between 1992 and 2001, were studied...
  23. doi The association between biological subtype and isolated regional nodal failure after breast-conserving therapy
    Jennifer Y Wo
    Harvard Radiation Oncology Program, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 77:188-96. 2010
    ....
  24. doi Evaluating the combined effect of comorbidity and prostate-specific antigen kinetics on the risk of death in men after prostate-specific antigen recurrence
    Jennifer Y Wo
    Harvard Radiation Oncology Program, Harvard Medical School, Boston, MA, USA
    J Clin Oncol 27:6000-5. 2009
    ....
  25. doi Risk of all-cause and prostate cancer-specific mortality after brachytherapy in men with small prostate size
    Paul L Nguyen
    Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Boston, MA 02115, USA
    Int J Radiat Oncol Biol Phys 79:1318-22. 2011
    ..Brachytherapy for prostate cancer can be technically challenging in men with small prostates (≤20 cc), but it is unknown whether their outcomes are different than those of men with larger prostates...
  26. doi Impact of postoperative prostate-specific antigen disease recurrence and the use of salvage therapy on the risk of death
    Toni K Choueiri
    Department of Medical Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer 116:1887-92. 2010
    ..BCR) as a time-dependent covariate (t) after radical prostatectomy (RP) for prostate cancer was associated with the risk of death and whether salvage therapy with radiotherapy (RT) and/or hormonal therapy (HT) can lessen this risk..
  27. ncbi Outcomes in stage I testicular seminoma: a population-based study of 9193 patients
    Clair J Beard
    Department of Radiation Oncology, Dana Farber Cancer Institute Brigham and Women s Hospital, Boston, MA 02115, USA
    Cancer 119:2771-7. 2013
    ..In particular, data describing long-term risks of cardiovascular disease (CVD) are conflicting...
  28. ncbi Multidisciplinary care and pursuit of active surveillance in low-risk prostate cancer
    Ayal A Aizer
    Harvard Radiation Oncology Program, Massachusetts General Hospital, Department of Radiation Oncology, 100 Blossom St, Cox 3, Boston, MA 02114, USA
    J Clin Oncol 30:3071-6. 2012
    ..The purpose of this study was to determine whether consultation at a multidisciplinary clinic is associated with selection of active surveillance in patients with low-risk prostate cancer...
  29. pmc Basal subtype of invasive breast cancer is associated with a higher risk of true recurrence after conventional breast-conserving therapy
    Jona A Hattangadi-Gluth
    Harvard Radiation Oncology Program, Boston, Massachusetts, USA
    Int J Radiat Oncol Biol Phys 82:1185-91. 2012
    ....
  30. doi Population-based comparative effectiveness of salvage radical prostatectomy vs cryotherapy
    David F Friedlander
    Division of Urology, Brigham and Women s Hospital, Boston, MA
    Urology 83:653-7. 2014
    ..To characterize population-based practice patterns, disease-specific and overall mortality, and cost associated with salvage cryotherapy (SCT) vs salvage radical prostatectomy (SRP)...
  31. doi Comparative analysis of outcomes and costs following open radical cystectomy versus robot-assisted laparoscopic radical cystectomy: results from the US Nationwide Inpatient Sample
    Hua yin Yu
    Division of Urology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Eur Urol 61:1239-44. 2012
    ..Although robot-assisted laparoscopic radical cystectomy (RARC) was first reported in 2003 and has gained popularity, comparisons with open radical cystectomy (ORC) are limited to reports from high-volume referral centers...
  32. doi Comparative effectiveness of cryotherapy vs brachytherapy for localised prostate cancer
    Stephen B Williams
    Division of Urologic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    BJU Int 110:E92-8. 2012
    ..Conversely, cryotherapy was associated with fewer bowel complications. Patients and providers alike should consider these population-based outcomes when discussing therapeutic options for localised prostate cancer...
  33. ncbi Underutilization of radiation therapy in patients with glioblastoma: predictive factors and outcomes
    Ayal A Aizer
    Harvard Radiation Oncology Program, Boston, Massachusetts
    Cancer 120:238-43. 2014
    ..Randomized trials have demonstrated that radiation improves survival in patients with glioblastoma. The purpose of this study was to characterize the risk factors and impact of omission of radiation therapy in such patients...
  34. ncbi Marital status and survival in patients with cancer
    Ayal A Aizer
    Ayal A Aizer, Harvard Radiation Oncology Program Ellen P McCarthy, Beth Israel Deaconess Medical Center Mallika L Mendu, Sophia Koo, Powell L Graham, Neil E Martin, and Paul L Nguyen, Dana Farber Brigham and Women s Cancer Center Tyler J Wilhite, Harvard Medical School, Boston, MA Ming Hui Chen, University of Connecticut, Storrs, CT Karen E Hoffman, The University of Texas MD Anderson Cancer Center, Houston, TX and Jim C Hu, University of California at Los Angeles, Los Angeles, CA
    J Clin Oncol 31:3869-76. 2013
    ..To examine the impact of marital status on stage at diagnosis, use of definitive therapy, and cancer-specific mortality among each of the 10 leading causes of cancer-related death in the United States...
  35. ncbi Magnetic resonance image-guided salvage brachytherapy after radiation in select men who initially presented with favorable-risk prostate cancer: a prospective phase 2 study
    Paul L Nguyen
    Department of Radiation Oncology, Brigham and Women s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts
    Cancer 110:1485-92. 2007
    ....
  36. doi Patterns of care and outcomes of radiotherapy for lymph node positivity after radical prostatectomy
    Joshua R Kaplan
    Division of Urologic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    BJU Int 111:1208-14. 2013
    ..To evaluate the use and outcomes of adjuvant radiation therapy (ART) for men with lymph node (LN)-positive disease after radical prostatectomy (RP) using a population-based approach...
  37. doi Posttreatment prostate specific antigen nadir predicts prostate cancer specific and all cause mortality
    Yolanda D Tseng
    Harvard Radiation Oncology Program, Department of Radiation Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Urol 187:2068-73. 2012
    ..We investigated whether the prostate specific antigen nadir predicts prostate cancer specific and all cause mortality in men treated in a randomized trial of radiation with or without 6 months of androgen deprivation therapy...
  38. doi Biopsy Gleason score and the duration of testosterone suppression among men treated with external beam radiation and 6 months of combined androgen blockade
    Neil E Martin
    Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    BJU Int 110:1252-6. 2012
    ..In this study, we found that among men treated with 6 months of combined androgen blockade and radiation therapy, higher biopsy Gleason grade was associated with a shorter time to testosterone normalization...
  39. pmc Age, breast cancer subtype approximation, and local recurrence after breast-conserving therapy
    Nils D Arvold
    Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Boston, MA 02215, USA
    J Clin Oncol 29:3885-91. 2011
    ..Prior results of breast-conserving therapy (BCT) have shown substantial rates of local recurrence (LR) in young patients with breast cancer (BC)...
  40. doi Overuse of imaging for staging low risk prostate cancer
    Wesley W Choi
    Division of Urologic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02130, USA
    J Urol 185:1645-9. 2011
    ..Routine imaging for staging low risk prostate cancer is not recommended according to current guidelines. We characterized patterns of care and factors associated with imaging overuse...
  41. pmc Radiotherapy treatment of early-stage prostate cancer with IMRT and protons: a treatment planning comparison
    Alexei Trofimov
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 69:444-53. 2007
    ..To compare intensity-modulated photon radiotherapy (IMRT) with three-dimensional conformal proton therapy (3D-CPT) for early-stage prostate cancer, and explore the potential utility of intensity-modulated proton therapy (IMPT)...
  42. ncbi Microinvasive breast cancer: ER, PR, and HER-2/neu status and clinical outcomes after breast-conserving therapy or mastectomy
    Danielle N Margalit
    Department of Radiation Oncology, Brigham and Women s Hospital Dana Farber Cancer Institute, Boston, MA, USA
    Ann Surg Oncol 20:811-8. 2013
    ..We document the immunophenotype, incidence of axillary metastases, and rate of recurrence in a well-defined case series...
  43. doi Determinants of performing radical prostatectomy pelvic lymph node dissection and the number of lymph nodes removed in elderly men
    Jim C Hu
    Division of Urologic Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
    Urology 77:402-6. 2011
    ..We characterized determinants of performance and extent of PLND during radical prostatectomy in elderly men...
  44. ncbi Natural history and role of radiation in patients with supratentorial and infratentorial WHO grade II ependymomas: results from a population-based study
    Ayal A Aizer
    Harvard Radiation Oncology Program, Department of Radiation Oncology, Massachusetts General Hospital, 55 Fruit Street, Lunder LL3, Boston, MA, 02114, USA
    J Neurooncol 115:411-9. 2013
    ..Observation, with radiation reserved as a salvage option, may be a reasonable postoperative strategy in this population...
  45. ncbi Refusal of curative radiation therapy and surgery among patients with cancer
    Ayal A Aizer
    Harvard Radiation Oncology Program, Boston, Massachusetts Electronic address
    Int J Radiat Oncol Biol Phys 89:756-64. 2014
    ..This study characterized factors associated with refusal of surgical or radiation therapy as well as the impact of refusal of recommended therapy on patients with localized malignancies...
  46. ncbi Impact of national guidelines on brachytherapy monotherapy practice patterns for prostate cancer
    Yolanda D Tseng
    Harvard Radiation Oncology Program, Boston, Massachusetts
    Cancer 120:824-32. 2014
    ..This study examined rates of BT use before and after publication of these guidelines, as compared with 4 other treatment options...
  47. ncbi Models of care and NCCN guideline adherence in very-low-risk prostate cancer
    Ayal A Aizer
    From the aHarvard Radiation Oncology Program, and bDepartment of Radiation Oncology, Massachusetts General Hospital cDepartment of Radiation Oncology, Brigham and Women s Hospital Dana Farber Cancer Institute dDepartment of Medicine, Division of General Internal Medicine, Massachusetts General Hospital eDepartment of Radiation Oncology, Beth Israel Deaconess Medical Center fDepartment of Radiation Oncology, Division of Biostatistics and Biomathematics, Massachusetts General Hospital gDepartment of Pathology, Brigham and Women s Hospital and hDepartment of Pathology, iDepartment of Urology, and jDepartment of Medicine, Division of Hematology Oncology, Massachusetts General Hospital, Boston, Massachusetts
    J Natl Compr Canc Netw 11:1364-72. 2013
    ..001; OR, 5.19; P<.001, respectively). Multidisciplinary care is strongly associated with selection of active surveillance, adherence to NCCN Guidelines and minimization of overtreatment in patients with very-low-risk prostate cancer. ..
  48. doi Hormonal therapy or external-beam radiation with brachytherapy and the risk of death from prostate cancer in men with intermediate risk prostate cancer
    Jonathan E Rosenberg
    Lank Center for Genitourinary Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Clin Genitourin Cancer 10:21-5. 2012
    ..To determine whether external-beam radiotherapy (EBRT) improves disease control compared with supplemental androgen suppression therapy (AST) in men with intermediate-risk prostate cancer who are being treated with brachytherapy...
  49. pmc Fatty acid synthase polymorphisms, tumor expression, body mass index, prostate cancer risk, and survival
    Paul L Nguyen
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    J Clin Oncol 28:3958-64. 2010
    ..We examined whether common germline single nucleotide polymorphisms (SNPs) in the FASN gene affect prostate cancer (PCa) risk or PCa-specific mortality and whether these effects vary by body mass index (BMI)...
  50. doi Stepwise approach for nerve sparing without countertraction during robot-assisted radical prostatectomy: technique and outcomes
    Keith J Kowalczyk
    Division of Urologic Surgery, Brigham and Women s Faulkner Hospital, Harvard Medical School, Boston, MA 02130, USA
    Eur Urol 60:536-47. 2011
    ..However, the impact of active assistant/surgeon neurovascular bundle (NVB) countertraction on sexual function outcomes has not been studied or quantified...
  51. doi Predicting the risk of pelvic node involvement among men with prostate cancer in the contemporary era
    Paul L Nguyen
    Harvard Radiation Oncology Program, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 74:104-9. 2009
    ..We examined the accuracy of this formula in contemporary patients...
  52. doi Cancer control and complications of salvage local therapy after failure of radiotherapy for prostate cancer: a systematic review
    Arti Parekh
    Department of Radiation Oncology, Dana Farber Brigham and Women s Cancer Center, Harvard Medical School, Boston, MA 02115, USA
    Semin Radiat Oncol 23:222-34. 2013
    ..We found 5-year biochemical control rates to be similar across treatments, in the range of 52%-56%, although patient selection and definition of failure was variable. Toxicity profiles were also distinct between local salvage modalities...
  53. ncbi The impact of pathology review on treatment recommendations for patients with adenocarcinoma of the prostate
    Paul L Nguyen
    Department of Radiation Oncology, Brigham and Women s Hospital, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Urol Oncol 22:295-9. 2004
    ..2%, but was changed from intermediate or high risk to low risk in only 0.9%. Genitourinary pathology review would have changed management in approximately 10% of men, mainly in the direction of combined therapy over monotherapy...
  54. doi Hospital volume, utilization, costs and outcomes of robot-assisted laparoscopic radical prostatectomy
    Hua yin Yu
    Division of Urology, Lank Center for Genitourinary Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    J Urol 187:1632-7. 2012
    ....
  55. doi Utilization and expense of adjuvant cancer therapies following radical prostatectomy
    Stephen B Williams
    Division of Urologic Surgery, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Cancer 117:4846-54. 2011
    ..We sought to identify the costs of adjuvant therapies following radical prostatectomy (RP) and factors associated with their receipt...
  56. pmc Interfractional variations in the setup of pelvic bony anatomy and soft tissue, and their implications on the delivery of proton therapy for localized prostate cancer
    Alexei Trofimov
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 80:928-37. 2011
    ....
  57. doi Recommendations for post-prostatectomy radiation therapy in the United States before and after the presentation of randomized trials
    Karen E Hoffman
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Urol 185:116-20. 2011
    ....
  58. ncbi Comparative effectiveness of robot-assisted and open radical prostatectomy in the postdissemination era
    Giorgio Gandaglia
    Giorgio Gandaglia, Pierre I Karakiewicz, and Maxine Sun, Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Quebec, Canada Giorgio Gandaglia and Francesco Montorsi, Urological Research Institute, Vita Salute San Raffaele University, Milan, Italy Jesse D Sammon and Mani Menon, Vattikuti Urology Institute, Henry Ford Health System, Detroit, MI Steven L Chang, Toni K Choueiri, Adam S Kibel, Ramdev Konijeti, Paul L Nguyen, and Quoc Dien Trinh, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA Jim C Hu, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA Simon P Kim, Yale University, New Haven, CT and Shyam Sukumar, University of Minnesota, Minneapolis, MN
    J Clin Oncol 32:1419-26. 2014
    ....
  59. doi Low rate of clinician-scored gynecomastia induced by 6 months of combined androgen blockade in a randomized trial: Implications for prophylactic breast irradiation
    Amar U Kishan
    Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts
    Pract Radiat Oncol 2:172-8. 2012
    ..To determine the incidence and predictors of clinician-scored gynecomastia induced by 6 months of combined androgen blockade (CAB) in a randomized trial...
  60. pmc A single nucleotide polymorphism in inflammatory gene RNASEL predicts outcome after radiation therapy for localized prostate cancer
    Jonathan D Schoenfeld
    Harvard Radiation Oncology Program, Boston, Massachusetts, USA
    Clin Cancer Res 19:1612-9. 2013
    ..To study associations between single nucleotide polymorphisms (SNP) in Ribonuclease L (RNASEL), a gene implicated in inflammation and prostate cancer risk, and outcomes after radiation therapy...
  61. doi Patient-reported quality of life during radiation treatment for localized prostate cancer: results from a prospective phase II trial
    Ronald C Chen
    Department of Radiation Oncology and Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC 27599 7512, USA
    BJU Int 110:1690-5. 2012
    ....
  62. ncbi Quantifying the impact of seminal vesicle invasion identified using endorectal magnetic resonance imaging on PSA outcome after radiation therapy for patients with clinically localized prostate cancer
    Paul L Nguyen
    Department of Radiation Oncology, Brigham and Women s Hospital, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Int J Radiat Oncol Biol Phys 59:400-5. 2004
    ....
  63. doi Prostate cancer screening in men 75 years old or older: an assessment of self-reported health status and life expectancy
    Karen E Hoffman
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Urol 183:1798-802. 2010
    ..In this study we evaluated the influence of health status and life expectancy on prostate specific antigen screening in older men in the United States before the 2008 United States Preventive Services Task Force guidelines...
  64. ncbi High-dose external beam radiation for localized prostate cancer: current status and future challenges
    Paul L Nguyen
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Cancer J 13:295-301. 2007
    ....
  65. doi Thermal ablation vs surgery for localized kidney cancer: a Surveillance, Epidemiology, and End Results (SEER) database analysis
    Toni K Choueiri
    Dana Farber Cancer Institute, Boston, MA 02115, USA
    Urology 78:93-8. 2011
    ....
  66. ncbi Barriers to the implementation of surveillance for stage I testicular seminoma
    Nils D Arvold
    Harvard Radiation Oncology Program, Harvard Medical School, Boston, Massachusetts, USA
    Int J Radiat Oncol Biol Phys 84:383-9. 2012
    ..Because studies suggest that radiation oncologists in the United States continue to recommend RT for these patients, we sought to identify factors associated with management recommendations...
  67. pmc Prediagnostic body-mass index, plasma C-peptide concentration, and prostate cancer-specific mortality in men with prostate cancer: a long-term survival analysis
    Jing Ma
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Lancet Oncol 9:1039-47. 2008
    ..We assessed the effect of prediagnostic BMI and plasma C-peptide concentration (reflecting insulin secretion) on prostate cancer-specific mortality after diagnosis...
  68. doi Congestive heart failure risk in patients with breast cancer treated with bevacizumab
    Toni K Choueiri
    Dana Farber Cancer Institute, 44 Binney St Dana 1230, Boston MA 02115, USA
    J Clin Oncol 29:632-8. 2011
    ..We performed an up-to-date, comprehensive meta-analysis to determine the risk of serious CHF in patients with breast cancer receiving bevacizumab...
  69. ncbi Results of whole-brain radiation as salvage of methotrexate failure for immunocompetent patients with primary CNS lymphoma
    Paul L Nguyen
    Massachusetts General Hospital, Department of Radiation Oncology, 100 Blossom St, Boston, MA 02114, USA
    J Clin Oncol 23:1507-13. 2005
    ..This study evaluates the efficacy and toxicity of whole-brain radiation therapy (WBRT) as salvage therapy for immunocompetent patients who failed initial high-dose methotrexate for primary CNS lymphoma (PCNSL)...
  70. doi Which patients with undetectable PSA levels 5 years after radical prostatectomy are still at risk of recurrence?--implications for a risk-adapted follow-up strategy
    Deborah A Ahove
    Smith College, Northhampton, Massachusetts, USA
    Urology 76:1201-5. 2010
    ..To determine the predictors of late prostate-specific antigen (PSA) failure among men with an undetectable PSA level 5 years after radical prostatectomy (RP)...
  71. doi Dosimetric quality and evolution of edema after low-dose-rate brachytherapy for small prostates: implications for the use of newer isotopes
    Konstantin A Kovtun
    Department of Radiation Oncology, Dana Farber Cancer Institute Brigham and Women s Hospital, Harvard Medical School, Boston, MA
    Brachytherapy 13:152-6. 2014
    ..To characterize prostate swelling and dosimetry in patients with small prostate volumes (PVs) undergoing brachytherapy...
  72. pmc Fatty acid synthase as a potential therapeutic target in cancer
    Richard Flavin
    Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Harvard Medical School, Brigham and Women s Hospital, Boston, MA, USA
    Future Oncol 6:551-62. 2010
    ..Furthermore, novel sources of FASN inhibitors, such as green tea and dietary soy, make both dietary manipulation and chemoprevention potential alternative modes of therapy in the future...
  73. doi Breast cancer subtype approximated by estrogen receptor, progesterone receptor, and HER-2 is associated with local and distant recurrence after breast-conserving therapy
    Paul L Nguyen
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA
    J Clin Oncol 26:2373-8. 2008
    ..To determine whether breast cancer subtype is associated with outcome after breast-conserving therapy (BCT) consisting of lumpectomy and radiation therapy...
  74. pmc Overexpression of fatty acid synthase is associated with palmitoylation of Wnt1 and cytoplasmic stabilization of beta-catenin in prostate cancer
    Michelangelo Fiorentino
    Department of Medical Oncology, Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Boston, MA, USA
    Lab Invest 88:1340-8. 2008
    ..001, Spearman's rho=0.33). We propose that cytoplasmic stabilization of beta-catenin through palmitoylation of Wnt-1 and subsequent activation of the pathway is a potential mechanism of FASN oncogenicity in prostate cancer...
  75. pmc Expanded prostate cancer index composite for clinical practice: development and validation of a practical health related quality of life instrument for use in the routine clinical care of patients with prostate cancer
    Peter Chang
    Division of Urology, Department of Surgery, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Urol 186:865-72. 2011
    ..Thus, we developed an instrument for this purpose...
  76. ncbi The effect of excessive anticoagulation on mortality and morbidity in hospitalized patients with anticoagulant-related major hemorrhage
    Sophia Koo
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Arch Intern Med 164:1557-60. 2004
    ..We aimed to determine the effect of excessive anticoagulation on morbidity and mortality in hospitalized patients with major anticoagulant-associated hemorrhage...
  77. doi Linear accelerator-based stereotactic radiosurgery for brainstem metastases: the Dana-Farber/Brigham and Women's Cancer Center experience
    Paul J Kelly
    Department of Radiation Oncology, Dana Farber Brigham and Women s Cancer Center, Boston, MA 02115, USA
    J Neurooncol 104:553-7. 2011
    ..6% at 1 year. RTOG grade 3 toxicities were recorded in two patients (ataxia, confusion). Linac-based SRS for small volume brainstem metastases using a median dose of 13 Gy is associated with acceptable local control and low morbidity...
  78. doi Targeting pelvic lymph nodes in men with intermediate- and high-risk prostate cancer despite two negative randomized trials
    Paul L Nguyen
    J Clin Oncol 26:2055-6; author reply 2056-7. 2008