Rachael Lee Neve

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi A new wrestler in the battle between alpha- and beta-secretases for cleavage of APP
    Rachael L Neve
    Department of Psychiatry, Harvard Medical School, MRC 223, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Trends Neurosci 26:461-3. 2003
  2. ncbi The cell cycle as a therapeutic target for Alzheimer's disease
    Rachael L Neve
    Department of Psychiatry, MRC 223, Harvard Medical School and McLean Hospital, Belmont, MA 02478, USA
    Pharmacol Ther 111:99-113. 2006
  3. ncbi Use of herpes virus amplicon vectors to study brain disorders
    Rachael L Neve
    Harvard Medical School, MA, USA
    Biotechniques 39:381-91. 2005
  4. pmc Dysfunction of amyloid precursor protein signaling in neurons leads to DNA synthesis and apoptosis
    Rachael L Neve
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
    Biochim Biophys Acta 1772:430-7. 2007
  5. doi Alzheimer's disease sends the wrong signals--a perspective
    Rachael L Neve
    McLean Hospital, Belmont, MA 02478, USA
    Amyloid 15:1-4. 2008
  6. pmc APP-BP1 inhibits Abeta42 levels by interacting with Presenilin-1
    Yuzhi Chen
    Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Mol Neurodegener 2:3. 2007
  7. ncbi cis-acting regulatory elements in the GAP-43 mRNA 3'-untranslated region can function in trans to suppress endogenous GAP-43 gene expression
    R L Neve
    Department of Genetics, Harvard Medical School, McLean Hospital, Belmont, MA 02178, USA
    Brain Res Mol Brain Res 65:52-60. 1999
  8. ncbi Alzheimer's disease: a dysfunction of the amyloid precursor protein(1)
    R L Neve
    Department of Psychiatry, Harvard Medical School, MRC 223 McLean Hospital, 115 Mill St, 02478, Belmont, MA, USA
    Brain Res 886:54-66. 2000
  9. pmc Down syndrome fibroblast model of Alzheimer-related endosome pathology: accelerated endocytosis promotes late endocytic defects
    Anne M Cataldo
    Laboratory for Molecular Neuropathology, Mailman Research Center, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
    Am J Pathol 173:370-84. 2008
  10. ncbi Rab5 mediates an amyloid precursor protein signaling pathway that leads to apoptosis
    Daphna Laifenfeld
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Neurosci 27:7141-53. 2007

Research Grants

  1. MOLECULAR MECHANISMS UNDERLYING GAP-43 FUNCTION
    Rachael Neve; Fiscal Year: 2001
  2. APP-BP1, The Cell Cycle, and Alzheimer Disease
    Rachael Neve; Fiscal Year: 2007

Collaborators

Detail Information

Publications22

  1. ncbi A new wrestler in the battle between alpha- and beta-secretases for cleavage of APP
    Rachael L Neve
    Department of Psychiatry, Harvard Medical School, MRC 223, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Trends Neurosci 26:461-3. 2003
    ....
  2. ncbi The cell cycle as a therapeutic target for Alzheimer's disease
    Rachael L Neve
    Department of Psychiatry, MRC 223, Harvard Medical School and McLean Hospital, Belmont, MA 02478, USA
    Pharmacol Ther 111:99-113. 2006
    ..Drugs and peptides that can inhibit molecular steps leading to AD neurodegeneration by intervening in the activation of cell cycle re-entry in neurons represent an entirely new approach to the development of treatments for AD...
  3. ncbi Use of herpes virus amplicon vectors to study brain disorders
    Rachael L Neve
    Harvard Medical School, MA, USA
    Biotechniques 39:381-91. 2005
    ..The HSV amplicon virus is a user-friendly vector for the delivery of genes into neurons that has come of age for the study of brain function...
  4. pmc Dysfunction of amyloid precursor protein signaling in neurons leads to DNA synthesis and apoptosis
    Rachael L Neve
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
    Biochim Biophys Acta 1772:430-7. 2007
    ..In this article, we review the evidence that APP has the potential to activate aberrant neuronal cell cycle re-entry in AD, and we describe a signal transduction pathway that may mediate this abnormal activation of the cell cycle...
  5. doi Alzheimer's disease sends the wrong signals--a perspective
    Rachael L Neve
    McLean Hospital, Belmont, MA 02478, USA
    Amyloid 15:1-4. 2008
    ..Three recent papers highlight the potential importance of presenilin and APP signaling in the etiology of AD...
  6. pmc APP-BP1 inhibits Abeta42 levels by interacting with Presenilin-1
    Yuzhi Chen
    Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Mol Neurodegener 2:3. 2007
    ..Increased Abeta42/Abeta40 ratios trigger amyloid plaque formations in Alzheimer's disease (AD). APP binds to APP-BP1, but the biological consequence is not well understood...
  7. ncbi cis-acting regulatory elements in the GAP-43 mRNA 3'-untranslated region can function in trans to suppress endogenous GAP-43 gene expression
    R L Neve
    Department of Genetics, Harvard Medical School, McLean Hospital, Belmont, MA 02178, USA
    Brain Res Mol Brain Res 65:52-60. 1999
    ....
  8. ncbi Alzheimer's disease: a dysfunction of the amyloid precursor protein(1)
    R L Neve
    Department of Psychiatry, Harvard Medical School, MRC 223 McLean Hospital, 115 Mill St, 02478, Belmont, MA, USA
    Brain Res 886:54-66. 2000
    ....
  9. pmc Down syndrome fibroblast model of Alzheimer-related endosome pathology: accelerated endocytosis promotes late endocytic defects
    Anne M Cataldo
    Laboratory for Molecular Neuropathology, Mailman Research Center, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
    Am J Pathol 173:370-84. 2008
    ....
  10. ncbi Rab5 mediates an amyloid precursor protein signaling pathway that leads to apoptosis
    Daphna Laifenfeld
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Neurosci 27:7141-53. 2007
    ....
  11. pmc APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain
    Yuzhi Chen
    MRC 223, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
    J Cell Biol 163:27-33. 2003
    ..This translocation of APP-BP1 to lipid rafts is accompanied by a change in the subcellular localization of the ubiquitin-like protein NEDD8, which is activated by APP-BP1...
  12. ncbi ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosis
    Yuzhi Chen
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts, USA
    J Neurochem 85:801-9. 2003
    ....
  13. ncbi DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3
    Donna L McPhie
    Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, Massachusetts 02478, USA
    J Neurosci 23:6914-27. 2003
    ..These data suggest that a normal signaling pathway mediated by the interaction of APP, PAK3, and Go is constitutively activated in neurons by FAD mutations in APP and that this activation causes cell cycle entry and consequent apoptosis...
  14. ncbi Morphine acutely regulates opioid receptor trafficking selectively in dendrites of nucleus accumbens neurons
    Helena Haberstock-Debic
    Department of Psychiatry, University of California, San Francisco, San Francisco, California 94143 2140, USA
    J Neurosci 23:4324-32. 2003
    ....
  15. ncbi Viral-mediated gene transfer to study the behavioral correlates of CREB function in the nucleus accumbens of rats
    William A Carlezon
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, USA
    Methods Mol Med 79:331-50. 2003
  16. doi Role of GluR1 expression in nucleus accumbens neurons in cocaine sensitization and cocaine-seeking behavior
    Ryan K Bachtell
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Eur J Neurosci 27:2229-40. 2008
    ....
  17. doi Induction of activating transcription factors (ATFs) ATF2, ATF3, and ATF4 in the nucleus accumbens and their regulation of emotional behavior
    Thomas A Green
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 28:2025-32. 2008
    ....
  18. ncbi Induction of deltaFosB in the periaqueductal gray by stress promotes active coping responses
    Olivier Berton
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Neuron 55:289-300. 2007
    ..These results indicate that IS-induced accumulation of DeltaFosB in the vlPAG desensitizes substance P neurons enriched in this area and opposes behavioral despair by promoting active defense responses...
  19. ncbi Brain reward regulated by AMPA receptor subunits in nucleus accumbens shell
    Mark S Todtenkopf
    Behavioral Genetics, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Neurosci 26:11665-9. 2006
    ..These data suggest that GluR1 and GluR2 in the NAc shell play opposing roles in the regulation of motivated behavior...
  20. ncbi Role of cAMP response element-binding protein in the rat locus ceruleus: regulation of neuronal activity and opiate withdrawal behaviors
    Ming Hu Han
    Department of Psychiatry, Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 26:4624-9. 2006
    ....
  21. ncbi Antidepressant effect of the calcium-activated tyrosine kinase Pyk2 in the lateral septum
    Teige P Sheehan
    Department of Psychiatry, Division of Molecular Psychiatry, Yale University School of Medicine, Connecticut Mental Health Center, New Haven, Connecticut 06508, USA
    Biol Psychiatry 54:540-51. 2003
    ....
  22. pmc Essential role of the cAMP-cAMP response-element binding protein pathway in opiate-induced homeostatic adaptations of locus coeruleus neurons
    Jun Li Cao
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Proc Natl Acad Sci U S A 107:17011-6. 2010
    ....

Research Grants19

  1. MOLECULAR MECHANISMS UNDERLYING GAP-43 FUNCTION
    Rachael Neve; Fiscal Year: 2001
    ..The data obtained from the proposed studies will begin to provide unifying molecular mechanisms for the diverse functions in which GAP-43 is known to participate. ..
  2. APP-BP1, The Cell Cycle, and Alzheimer Disease
    Rachael Neve; Fiscal Year: 2007
    ..We will test whether these predictions are correct. ..