Stevens S Negus

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Effects of GABA agonists and GABA-A receptor modulators on cocaine discrimination in rhesus monkeys
    S S Negus
    Alcohol and Drug Abuse Research Center, Harvard Medical School McLean Hospital, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 152:398-407. 2000
  2. ncbi request reprint Monoamine releasers with varying selectivity for dopamine/norepinephrine versus serotonin release as candidate "agonist" medications for cocaine dependence: studies in assays of cocaine discrimination and cocaine self-administration in rhesus mo
    S S Negus
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478 9106, USA
    J Pharmacol Exp Ther 320:627-36. 2007
  3. pmc Preclinical assessment of candidate analgesic drugs: recent advances and future challenges
    S S Negus
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, 115 Mill St, Belmont, MA 02478 9106, USA
    J Pharmacol Exp Ther 319:507-14. 2006
  4. pmc Some implications of receptor theory for in vivo assessment of agonists, antagonists and inverse agonists
    S Stevens Negus
    Alcohol and Drug Abuse Research Center, 115 Mill Street, McLean Hospital, Harvard Medical School, Belmont, MA, United States
    Biochem Pharmacol 71:1663-70. 2006
  5. ncbi request reprint Choice between heroin and food in nondependent and heroin-dependent rhesus monkeys: effects of naloxone, buprenorphine, and methadone
    S Stevens Negus
    Alcohol and Drug Abuse Research Center, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02178 9106, USA
    J Pharmacol Exp Ther 317:711-23. 2006
  6. ncbi request reprint Effects of punishment on choice between cocaine and food in rhesus monkeys
    S Stevens Negus
    Alcohol and Drug Abuse Research Center, Harvard Medical School McLean Hospital, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 181:244-52. 2005
  7. ncbi request reprint Interactions between the reinforcing effects of cocaine and heroin in a drug-vs-food choice procedure in rhesus monkeys: a dose-addition analysis
    S Stevens Negus
    Alcohol and Drug Abuse Research Center, Harvard Medical School, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 180:115-24. 2005
  8. ncbi request reprint Effects of chronic methadone treatment on cocaine- and food-maintained responding under second-order, progressive-ratio and concurrent-choice schedules in rhesus monkeys
    S Stevens Negus
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478 9106, USA
    Drug Alcohol Depend 74:297-309. 2004
  9. ncbi request reprint Effects of the kappa opioid agonist U50,488 and the kappa opioid antagonist nor-binaltorphimine on choice between cocaine and food in rhesus monkeys
    S Stevens Negus
    Alcohol and Drug Abuse Research Center Harvard Medical School, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 176:204-13. 2004
  10. ncbi request reprint Sex differences in thermal nociception and prostaglandin-induced thermal hypersensitivity in rhesus monkeys
    S Stevens Negus
    Alcohol and Drug Abuse Research Center, Harvard Medical School McLean Hospital, Belmont, MA 02478, USA
    J Pain 5:92-103. 2004

Detail Information

Publications19

  1. ncbi request reprint Effects of GABA agonists and GABA-A receptor modulators on cocaine discrimination in rhesus monkeys
    S S Negus
    Alcohol and Drug Abuse Research Center, Harvard Medical School McLean Hospital, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 152:398-407. 2000
    ..Dopaminergic systems thought to mediate the abuse-related effects of cocaine are under inhibitory control by GABAergic systems. These findings suggest that GABA agonists may attenuate some abuse-related effects of cocaine...
  2. ncbi request reprint Monoamine releasers with varying selectivity for dopamine/norepinephrine versus serotonin release as candidate "agonist" medications for cocaine dependence: studies in assays of cocaine discrimination and cocaine self-administration in rhesus mo
    S S Negus
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478 9106, USA
    J Pharmacol Exp Ther 320:627-36. 2007
    ....
  3. pmc Preclinical assessment of candidate analgesic drugs: recent advances and future challenges
    S S Negus
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, 115 Mill St, Belmont, MA 02478 9106, USA
    J Pharmacol Exp Ther 319:507-14. 2006
    ..Integration of these complementary approaches may improve the predictive validity of analgesic drug development...
  4. pmc Some implications of receptor theory for in vivo assessment of agonists, antagonists and inverse agonists
    S Stevens Negus
    Alcohol and Drug Abuse Research Center, 115 Mill Street, McLean Hospital, Harvard Medical School, Belmont, MA, United States
    Biochem Pharmacol 71:1663-70. 2006
    ..Studies with intermediate efficacy ligands may be especially helpful in this regard, because their effects are differentially influenced by endogenous agonist tone versus constitutive receptor tone...
  5. ncbi request reprint Choice between heroin and food in nondependent and heroin-dependent rhesus monkeys: effects of naloxone, buprenorphine, and methadone
    S Stevens Negus
    Alcohol and Drug Abuse Research Center, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02178 9106, USA
    J Pharmacol Exp Ther 317:711-23. 2006
    ..Moreover, this procedure may be useful for exploring mechanisms underlying withdrawal-associated increases in opiate reinforcement and for testing candidate medications...
  6. ncbi request reprint Effects of punishment on choice between cocaine and food in rhesus monkeys
    S Stevens Negus
    Alcohol and Drug Abuse Research Center, Harvard Medical School McLean Hospital, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 181:244-52. 2005
    ..Such studies may contribute to more rational use of punishment to control drug use...
  7. ncbi request reprint Interactions between the reinforcing effects of cocaine and heroin in a drug-vs-food choice procedure in rhesus monkeys: a dose-addition analysis
    S Stevens Negus
    Alcohol and Drug Abuse Research Center, Harvard Medical School, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 180:115-24. 2005
    ..Dose-addition analysis is a tool for the quantitative assessment of drug interactions, but this analysis has not been applied to evaluation of the reinforcing effects of cocaine and heroin...
  8. ncbi request reprint Effects of chronic methadone treatment on cocaine- and food-maintained responding under second-order, progressive-ratio and concurrent-choice schedules in rhesus monkeys
    S Stevens Negus
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478 9106, USA
    Drug Alcohol Depend 74:297-309. 2004
    ..These results provide little evidence to suggest that chronic methadone altered the reinforcing effects of cocaine; rather methadone appeared to non-selectively decrease rates of operant responding...
  9. ncbi request reprint Effects of the kappa opioid agonist U50,488 and the kappa opioid antagonist nor-binaltorphimine on choice between cocaine and food in rhesus monkeys
    S Stevens Negus
    Alcohol and Drug Abuse Research Center Harvard Medical School, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 176:204-13. 2004
    ....
  10. ncbi request reprint Sex differences in thermal nociception and prostaglandin-induced thermal hypersensitivity in rhesus monkeys
    S Stevens Negus
    Alcohol and Drug Abuse Research Center, Harvard Medical School McLean Hospital, Belmont, MA 02478, USA
    J Pain 5:92-103. 2004
    ..These results suggest that sex and gonadal hormone levels have only a minor influence on thermal nociception or thermal hypersensitivity in rhesus monkeys...
  11. ncbi request reprint Effects of chronic d-amphetamine treatment on cocaine- and food-maintained responding under a second-order schedule in rhesus monkeys
    S Stevens Negus
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Drug Alcohol Depend 70:39-52. 2003
    ....
  12. ncbi request reprint Effects of heroin and its metabolites on schedule-controlled responding and thermal nociception in rhesus monkeys: sensitivity to antagonism by quadazocine, naltrindole and beta-funaltrexamine
    S Stevens Negus
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, 115 Mill St, Belmont, MA 02178, USA
    Drug Alcohol Depend 70:17-27. 2003
    ..The in vivo apparent efficacy of heroin at mu receptors was similar to or only slightly greater than that of morphine...
  13. ncbi request reprint Effects of chronic d-amphetamine treatment on cocaine- and food-maintained responding under a progressive-ratio schedule in rhesus monkeys
    S Stevens Negus
    Alcohol and Drug Abuse Research Center, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 167:324-32. 2003
    ..d-Amphetamine is a candidate agonist medication for the treatment of cocaine dependence, and evaluation of d-amphetamine effects on abuse-related effects of cocaine in preclinical assays is warranted...
  14. ncbi request reprint Rapid assessment of choice between cocaine and food in rhesus monkeys: effects of environmental manipulations and treatment with d-amphetamine and flupenthixol
    S Stevens Negus
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478 9106, USA
    Neuropsychopharmacology 28:919-31. 2003
    ..Overall, these results suggest that this choice procedure may be useful for the evaluation of both environmental determinants of cocaine use and candidate pharmacotherapies for the treatment of cocaine abuse...
  15. ncbi request reprint Kappa opioid antagonist effects of the novel kappa antagonist 5'-guanidinonaltrindole (GNTI) in an assay of schedule-controlled behavior in rhesus monkeys
    S Stevens Negus
    Alcohol and Drug Abuse Research Center, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 163:412-9. 2002
    ..Receptor-selective antagonists are useful experimental tools for evaluation of opioid receptor-mediated processes. 5'-Guanidinonaltrindole (GNTI) was recently developed as a novel kappa-selective antagonist...
  16. ncbi request reprint Effects of gonadal steroid hormone treatments on opioid antinociception in ovariectomized rhesus monkeys
    Stevens S Negus
    Alcohol and Drug Abuse Research Center, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 159:275-83. 2002
    ..Sex differences have also been observed in the antinociceptive effects of opioid agonists. These findings suggest that gonadal hormones may modulate opioid antinociception...
  17. ncbi request reprint Effects of mu-opioid agonists on cocaine- and food-maintained responding and cocaine discrimination in rhesus monkeys: role of mu-agonist efficacy
    S Stevens Negus
    Alcohol and Drug Abuse Research Center of McLean Hospital at Harvard Medical School, Belmont, Massachusetts 02178 9106, USA
    J Pharmacol Exp Ther 300:1111-21. 2002
    ..These results suggest that low-efficacy mu-agonists may decrease cocaine self-administration to a greater degree and with fewer undesirable effects than high-efficacy mu-agonists...
  18. ncbi request reprint Lack of evidence for opioid tolerance or dependence in rhesus monkeys following high-dose anabolic-androgenic steroid administration
    S S Negus
    Alcohol and Drug Abuse Research Center Behavioral Science Laboratory, McLean Hospital Harvard Medical School, 115 Mill St, Belmont, MA 02478, USA
    Psychoneuroendocrinology 26:789-96. 2001
    ..These data do not support the hypothesis that high-dose AAS treatment enhances endogenous opioid activity in rhesus monkeys in a way that produces opioid tolerance or dependence...
  19. ncbi request reprint Overview of conference on preclinical abuse liability testing: current methods and future challenges
    Stevens S Negus
    McLean Hospital Harvard Medical School, Bellmont, MA 02478, USA
    Drug Alcohol Depend 92:301-6. 2008