Daniel J Needleman

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint The Material Basis of Life
    Daniel Needleman
    Department of Molecular and Cellular Biology, School of Engineering and Applied Sciences, FAS Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA Electronic address
    Trends Cell Biol 25:713-6. 2015
  2. doi request reprint Determining physical principles of subcellular organization
    Dan Needleman
    School of Engineering and Applied Sciences, Department of Molecular and Cellular Biology, FAS Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA Electronic address
    Dev Cell 29:135-8. 2014
  3. doi request reprint Cellular allometry: the spindle in development and inheritance
    Daniel J Needleman
    Harvard University, 52 Oxford Street, Room 365 10, Cambridge, MA 02138, USA
    Curr Biol 19:R846-7. 2009
  4. pmc Fast microtubule dynamics in meiotic spindles measured by single molecule imaging: evidence that the spindle environment does not stabilize microtubules
    Daniel J Needleman
    School of Engineering and Applied Sciences, Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Mol Biol Cell 21:323-33. 2010
  5. doi request reprint Mitosis: taking the measure of spindle length
    Daniel J Needleman
    Harvard University, Cambridge, MA 02138, USA
    Curr Biol 20:R359-60. 2010
  6. doi request reprint Nucleation and transport organize microtubules in metaphase spindles
    Jan Brugués
    Department of Molecular and Cellular Biology and Center for Systems Biology, Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA
    Cell 149:554-64. 2012
  7. doi request reprint Quantitative characterization of filament dynamics by single-molecule lifetime measurements
    Leonid A Mirny
    Harvard MIT Division of Health Sciences and Technology, and Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Methods Cell Biol 95:583-600. 2010
  8. doi request reprint Plasmid segregation: is a total understanding within reach?
    Daniel J Needleman
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Biol 18:R212-4. 2008
  9. pmc Pin-hole array correlation imaging: highly parallel fluorescence correlation spectroscopy
    Daniel J Needleman
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA
    Biophys J 96:5050-9. 2009
  10. doi request reprint Scaling, selection, and evolutionary dynamics of the mitotic spindle
    Reza Farhadifar
    School of Engineering and Applied Sciences, Department of Molecular and Cellular Biology, FAS Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA Electronic address
    Curr Biol 25:732-40. 2015

Collaborators

  • Ryoma Ohi
  • Leonid A Mirny
  • Timothy Mitchison
  • Reza Farhadifar
  • Jan Brugués
  • Daniyar Nurgaliev
  • Charles F Baer
  • Marie Delattre
  • Erik C Andersen
  • Thomas Müller-Reichert
  • Aurore Cécile Valfort
  • Eric Mazur
  • Valeria Nuzzo
  • Timur Gatanov

Detail Information

Publications11

  1. doi request reprint The Material Basis of Life
    Daniel Needleman
    Department of Molecular and Cellular Biology, School of Engineering and Applied Sciences, FAS Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA Electronic address
    Trends Cell Biol 25:713-6. 2015
    ..Approaches from the physical sciences for studying collective properties may help with this difficult problem, but they must be adapted to account for the specific attributes of biological molecules. ..
  2. doi request reprint Determining physical principles of subcellular organization
    Dan Needleman
    School of Engineering and Applied Sciences, Department of Molecular and Cellular Biology, FAS Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA Electronic address
    Dev Cell 29:135-8. 2014
    ..One difficulty is that we lack an understanding of the physical principles of subcellular organization. Combining quantitative experiments with new theoretical insights may allow such principles to be developed. ..
  3. doi request reprint Cellular allometry: the spindle in development and inheritance
    Daniel J Needleman
    Harvard University, 52 Oxford Street, Room 365 10, Cambridge, MA 02138, USA
    Curr Biol 19:R846-7. 2009
    ..Recent studies have demonstrated a correlation between cell size and the behaviors of the cytoskeletal division machinery during embryogenesis, giving insight into how a core cellular process is modulated over the course of development...
  4. pmc Fast microtubule dynamics in meiotic spindles measured by single molecule imaging: evidence that the spindle environment does not stabilize microtubules
    Daniel J Needleman
    School of Engineering and Applied Sciences, Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Mol Biol Cell 21:323-33. 2010
    ..It follows that the key to understanding spindle morphogenesis will be to elucidate how nucleation is spatially controlled...
  5. doi request reprint Mitosis: taking the measure of spindle length
    Daniel J Needleman
    Harvard University, Cambridge, MA 02138, USA
    Curr Biol 20:R359-60. 2010
    ..Recent studies have investigated the mechanisms responsible for setting spindle length - and how spindle length changes over the course of development...
  6. doi request reprint Nucleation and transport organize microtubules in metaphase spindles
    Jan Brugués
    Department of Molecular and Cellular Biology and Center for Systems Biology, Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA
    Cell 149:554-64. 2012
    ....
  7. doi request reprint Quantitative characterization of filament dynamics by single-molecule lifetime measurements
    Leonid A Mirny
    Harvard MIT Division of Health Sciences and Technology, and Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Methods Cell Biol 95:583-600. 2010
    ..Similar methods should prove useful in studying cytoskeletal filaments in other contexts in vitro and in vivo...
  8. doi request reprint Plasmid segregation: is a total understanding within reach?
    Daniel J Needleman
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Biol 18:R212-4. 2008
    ..Recent in vitro and in vivo studies of the proteins responsible for the active partitioning of bacterial plasmids suggest that it will be possible to develop a quantitative, molecular understanding of this form of DNA segregation...
  9. pmc Pin-hole array correlation imaging: highly parallel fluorescence correlation spectroscopy
    Daniel J Needleman
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA
    Biophys J 96:5050-9. 2009
    ....
  10. doi request reprint Scaling, selection, and evolutionary dynamics of the mitotic spindle
    Reza Farhadifar
    School of Engineering and Applied Sciences, Department of Molecular and Cellular Biology, FAS Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA Electronic address
    Curr Biol 25:732-40. 2015
    ..Cellular structures such as the nucleus, Golgi, centrioles, and spindle show remarkable diversity between species, but the mechanisms that produce these variations in cell biology are not known...
  11. doi request reprint Automated identification of microtubules in cellular electron tomography
    Daniyar Nurgaliev
    Department of Physics, Harvard University, Cambridge, Massachusetts 01238, USA
    Methods Cell Biol 97:475-95. 2010
    ..At present, the method could be used to assist the analysis of large-scale tomography reconstructions. With further improvements, it may be possible to reliably segment cellular tomograms without human intervention...