Daniel J Needleman

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint Cellular allometry: the spindle in development and inheritance
    Daniel J Needleman
    Harvard University, 52 Oxford Street, Room 365 10, Cambridge, MA 02138, USA
    Curr Biol 19:R846-7. 2009
  2. pmc Fast microtubule dynamics in meiotic spindles measured by single molecule imaging: evidence that the spindle environment does not stabilize microtubules
    Daniel J Needleman
    School of Engineering and Applied Sciences, Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Mol Biol Cell 21:323-33. 2010
  3. doi request reprint Mitosis: taking the measure of spindle length
    Daniel J Needleman
    Harvard University, Cambridge, MA 02138, USA
    Curr Biol 20:R359-60. 2010
  4. doi request reprint Nucleation and transport organize microtubules in metaphase spindles
    Jan Brugués
    Department of Molecular and Cellular Biology and Center for Systems Biology, Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA
    Cell 149:554-64. 2012
  5. doi request reprint Plasmid segregation: is a total understanding within reach?
    Daniel J Needleman
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Biol 18:R212-4. 2008
  6. pmc Pin-hole array correlation imaging: highly parallel fluorescence correlation spectroscopy
    Daniel J Needleman
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA
    Biophys J 96:5050-9. 2009
  7. doi request reprint Quantitative characterization of filament dynamics by single-molecule lifetime measurements
    Leonid A Mirny
    Harvard MIT Division of Health Sciences and Technology, and Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Methods Cell Biol 95:583-600. 2010
  8. doi request reprint Automated identification of microtubules in cellular electron tomography
    Daniyar Nurgaliev
    Department of Physics, Harvard University, Cambridge, Massachusetts 01238, USA
    Methods Cell Biol 97:475-95. 2010

Collaborators

Detail Information

Publications8

  1. doi request reprint Cellular allometry: the spindle in development and inheritance
    Daniel J Needleman
    Harvard University, 52 Oxford Street, Room 365 10, Cambridge, MA 02138, USA
    Curr Biol 19:R846-7. 2009
    ..Recent studies have demonstrated a correlation between cell size and the behaviors of the cytoskeletal division machinery during embryogenesis, giving insight into how a core cellular process is modulated over the course of development...
  2. pmc Fast microtubule dynamics in meiotic spindles measured by single molecule imaging: evidence that the spindle environment does not stabilize microtubules
    Daniel J Needleman
    School of Engineering and Applied Sciences, Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Mol Biol Cell 21:323-33. 2010
    ..It follows that the key to understanding spindle morphogenesis will be to elucidate how nucleation is spatially controlled...
  3. doi request reprint Mitosis: taking the measure of spindle length
    Daniel J Needleman
    Harvard University, Cambridge, MA 02138, USA
    Curr Biol 20:R359-60. 2010
    ..Recent studies have investigated the mechanisms responsible for setting spindle length - and how spindle length changes over the course of development...
  4. doi request reprint Nucleation and transport organize microtubules in metaphase spindles
    Jan Brugués
    Department of Molecular and Cellular Biology and Center for Systems Biology, Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA
    Cell 149:554-64. 2012
    ....
  5. doi request reprint Plasmid segregation: is a total understanding within reach?
    Daniel J Needleman
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Biol 18:R212-4. 2008
    ..Recent in vitro and in vivo studies of the proteins responsible for the active partitioning of bacterial plasmids suggest that it will be possible to develop a quantitative, molecular understanding of this form of DNA segregation...
  6. pmc Pin-hole array correlation imaging: highly parallel fluorescence correlation spectroscopy
    Daniel J Needleman
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA
    Biophys J 96:5050-9. 2009
    ....
  7. doi request reprint Quantitative characterization of filament dynamics by single-molecule lifetime measurements
    Leonid A Mirny
    Harvard MIT Division of Health Sciences and Technology, and Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Methods Cell Biol 95:583-600. 2010
    ..Similar methods should prove useful in studying cytoskeletal filaments in other contexts in vitro and in vivo...
  8. doi request reprint Automated identification of microtubules in cellular electron tomography
    Daniyar Nurgaliev
    Department of Physics, Harvard University, Cambridge, Massachusetts 01238, USA
    Methods Cell Biol 97:475-95. 2010
    ..At present, the method could be used to assist the analysis of large-scale tomography reconstructions. With further improvements, it may be possible to reliably segment cellular tomograms without human intervention...