Research Topics
| Vitaly NapadowSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Neuroimaging acupuncture effects in the human brainRupali P Dhond
Massachusetts General Hospital Massachusetts Institute of Technology Harvard Medical School, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
J Altern Complement Med 13:603-16. 2007..In this review, we will summarize data from acupuncture neuroimaging research and discuss how these findings contribute to current hypotheses of acupuncture action...
The brain circuitry underlying the temporal evolution of nausea in humansVitaly Napadow
Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
Cereb Cortex 23:806-13. 2013....- Evoked pain analgesia in chronic pelvic pain patients using respiratory-gated auricular vagal afferent nerve stimulationVitaly Napadow
Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA
Pain Med 13:777-89. 2012..The dorsal medullary vagal system operates in tune with respiration, and we propose that supplying vagal afferent stimulation gated to the exhalation phase of respiration can optimize t-VNS... - Decreased intrinsic brain connectivity is associated with reduced clinical pain in fibromyalgiaVitaly Napadow
Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
Arthritis Rheum 64:2398-403. 2012.... - Patient characteristics for outpatient acupuncture in Beijing, ChinaVitaly Napadow
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA 02129, USA
J Altern Complement Med 10:565-72. 2004..This study quantifies and compares patient characteristics in outpatient acupuncture. SETTING/DESIGN: Prospective primary source evidence was gathered at two prominent outpatient acupuncture clinics in Beijing, China (n = 563, n = 233)... - Intrinsic brain connectivity in fibromyalgia is associated with chronic pain intensityVitaly Napadow
Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 Thirteenth Street 2301, Charlestown, MA 02129, USA
Arthritis Rheum 62:2545-55. 2010..The objective of this study was to investigate the degree of connectivity between multiple brain networks in patients with FM, as well as how activity in these networks correlates with the level of spontaneous pain... - Time-variant fMRI activity in the brainstem and higher structures in response to acupunctureVitaly Napadow
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
Neuroimage 47:289-301. 2009..Our protocol also demonstrates a fMRI approach to study habituation and other time-variant phenomena over longer time durations... - Brain correlates of autonomic modulation: combining heart rate variability with fMRIVitaly Napadow
MGH MIT HMS Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02119, USA
Neuroimage 42:169-77. 2008..Our approach should be optimized and applied to study the human brain correlates of autonomic modulation for various stimuli in both physiological and pathological states... - Correlating acupuncture FMRI in the human brainstem with heart rate variabilityVitaly Napadow
Member IEEE, Massachusetts General Hospital, Department of Radiology, Boston, MA 02129 USA phone 617 724 3402 fax 617 726 7422 e mail
Conf Proc IEEE Eng Med Biol Soc 5:4496-9. 2005..The correlation of time-varying fMRI response with physiological parameters may provide insight into connections between acupuncture modulation of the autonomic nervous system and neuroprocessing... - Hypothalamus and amygdala response to acupuncture stimuli in Carpal Tunnel SyndromeV Napadow
Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States
Pain 130:254-66. 2007..This is the first evidence suggesting that chronic pain patients respond to acupuncture differently than HC, through a coordinated limbic network including the hypothalamus and amygdala... - Somatosensory cortical plasticity in carpal tunnel syndrome--a cross-sectional fMRI evaluationVitaly Napadow
Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA
Neuroimage 31:520-30. 2006..Our results are consistent with Hebbian plasticity mechanisms, as our cohort of CTS patients had predominant paresthesias, which produce more temporally coherent afferent signaling from affected digits... - Somatosensory cortical plasticity in carpal tunnel syndrome treated by acupunctureVitaly Napadow
Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA
Hum Brain Mapp 28:159-71. 2007..Acupuncture, a somatosensory conditioning stimulus, shows promise in inducing beneficial cortical plasticity manifested by more focused digital representations... - Automated brainstem co-registration (ABC) for MRIVitaly Napadow
Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA
Neuroimage 32:1113-9. 2006..The use of easily available and validated tools (AFNI and FSL) for this method should ease adoption by other investigators interested in brainstem data group analysis... - Neurobiological correlates of acupuncture: November 17-18, 2005Vitaly Napadow
Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, USA
J Altern Complement Med 12:931-5. 2006.... 
Acupuncture mobilizes the brain's default mode and its anti-correlated network in healthy subjectsKathleen K S Hui
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 13th St, Charlestown, MA 02129, USA
Brain Res 1287:84-103. 2009..Our results suggest that acupuncture mobilizes the anti-correlated functional networks of the brain to mediate its actions, and that the effect is dependent on the psychophysical response...- Spatio-temporal mapping cortical neuroplasticity in carpal tunnel syndromeRupali P Dhond
Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Brain 135:3062-73. 2012..These temporal magnetoencephalography measures are novel markers of neuroplasticity in carpal tunnel syndrome and could be used to study central changes that may occur following clinical intervention... - Brain encoding of acupuncture sensation--coupling on-line rating with fMRIVitaly Napadow
MGH HMS MIT Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA
Neuroimage 47:1055-65. 2009..Hence, acupuncture may function as a somatosensory-guided mind-body therapy... - Disentangling linear and nonlinear brain responses to evoked deep tissue painMarco L Loggia
Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Pain 153:2140-51. 2012..Future studies should apply a similar approach using innocuous stimuli of multiple intensities to evaluate whether the response profiles reported here can also be generalized to nonpainful somatosensory processing... - Static and dynamic autonomic response with increasing nausea perceptionLauren T LaCount
Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 Thirteenth St, 2301, Charlestown, MA 02129, USA
Aviat Space Environ Med 82:424-33. 2011..Nausea is a commonly occurring symptom typified by epigastric discomfort with urge to vomit. The relationship between autonomic nervous system (ANS) outflow and increasing nausea perception is not fully understood... - Characterization of the "deqi" response in acupunctureKathleen K S Hui
Athinoula A, Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
BMC Complement Altern Med 7:33. 2007.... - Differences in cortical response to acupressure and electroacupuncture stimuliThomas Witzel
Harvard Medical School, Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
BMC Neurosci 12:73. 2011..We used whole head magnetoencephalography (MEG) to map S1 brain response during 15 minutes of electroacupuncture (EA) and acupressure (AP). We further assessed how brain response changed during the course of stimulation... - Acupuncture modulates resting state connectivity in default and sensorimotor brain networksRupali P Dhond
MGH MIT HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Boston, MA 02129, USA
Pain 136:407-18. 2008..This modulation and sympathovagal response may relate to acupuncture analgesia and other potential therapeutic effects... - Default mode network connectivity encodes clinical pain: an arterial spin labeling studyMarco L Loggia
Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School HMS, Boston, MA, USA
Pain 154:24-33. 2013..Our results support the use of arterial spin labeling to evaluate clinical pain, and the use of resting DMN connectivity as a potential neuroimaging biomarker for chronic pain perception... - The status and future of acupuncture mechanism researchVitaly Napadow
Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charleston, MA 02129, USA
J Altern Complement Med 14:861-9. 2008..Iterative testing, expanding, and perhaps merging of such models will potentially lead to an incremental understanding of the effects of manual and electrical stimulation of acupuncture needles that is solidly rooted in physiology... - The integrated response of the human cerebro-cerebellar and limbic systems to acupuncture stimulation at ST 36 as evidenced by fMRIKathleen K S Hui
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Room 2301, Charlestown, MA 02129, USA
Neuroimage 27:479-96. 2005..The study provides preliminary evidence for an integrated response of the human cerebro-cerebellar and limbic systems to acupuncture stimulation at ST 36 that correlates with the psychophysical response... - A systematic study of acupuncture practice: acupoint usage in an outpatient setting in Beijing, ChinaVitaly Napadow
Athinoula A. Martinos Imaging Center, Massachusetts General Hospital, Boston, MA, USA
Complement Ther Med 12:209-16. 2004.... - Effects of electroacupuncture versus manual acupuncture on the human brain as measured by fMRIVitaly Napadow
Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
Hum Brain Mapp 24:193-205. 2005.... - Spatiotemporal mapping the neural correlates of acupuncture with MEGRupali P Dhond
MGH MIT HMS Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
J Altern Complement Med 14:679-88. 2008..Thus, MEG provides excellent spatiotemporal characterization of the somatosensory component of acupuncture, and future studies can contrast derived brain response parameters in healthy controls with those found in a diseased state... - Acupuncture de qi, from qualitative history to quantitative measurementJian Kong
Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA 02129, USA
J Altern Complement Med 13:1059-70. 2007.... - Neural correlates of chronic low back pain measured by arterial spin labelingAjay D Wasan
Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, USA
Anesthesiology 115:364-74. 2011..Arterial spin labeling is a perfusion-based imaging technique allowing the absolute quantification of regional cerebral blood flow, which is a surrogate measure of neuronal activity... - Do the neural correlates of acupuncture and placebo effects differ?Rupali P Dhond
MGH MIT HMS Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
Pain 128:8-12. 2007
Research Grants
- Exploring Neurocircuitry of Acupuncture Action with fMRIVitaly Napadow; Fiscal Year: 2007..The goals of this study are to understand the neurobiology of acupuncture action and promote the development of this ancient healing technique into evidence-based medicine. ..
- Brain Plasticity in Carpal Tunnel Syndrome and its Response to AcupunctureVitaly Napadow; Fiscal Year: 2009....
- Brain Plasticity in Carpal Tunnel Syndrome and its Response to AcupunctureVitaly Napadow; Fiscal Year: 2009..This grant will assess changes in brain activity and cortical disinhibition that accompany the dysfunction in the wrist, as well as how acupuncture might modify both local nerve health and brain function to help treat CTS patients. ..
- Brain Plasticity in Carpal Tunnel Syndrome and its Response to AcupunctureVitaly Napadow; Fiscal Year: 2010....