Vitaly Napadow

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Neuroimaging acupuncture effects in the human brain
    Rupali P Dhond
    Massachusetts General Hospital Massachusetts Institute of Technology Harvard Medical School, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    J Altern Complement Med 13:603-16. 2007
  2. pmc Brain white matter microstructure is associated with susceptibility to motion-induced nausea
    V Napadow
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA 02129, USA
    Neurogastroenterol Motil 25:448-50, e303. 2013
  3. pmc The brain circuitry underlying the temporal evolution of nausea in humans
    Vitaly Napadow
    Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    Cereb Cortex 23:806-13. 2013
  4. pmc Evoked pain analgesia in chronic pelvic pain patients using respiratory-gated auricular vagal afferent nerve stimulation
    Vitaly Napadow
    Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA
    Pain Med 13:777-89. 2012
  5. pmc Decreased intrinsic brain connectivity is associated with reduced clinical pain in fibromyalgia
    Vitaly Napadow
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Arthritis Rheum 64:2398-403. 2012
  6. ncbi request reprint Patient characteristics for outpatient acupuncture in Beijing, China
    Vitaly Napadow
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA 02129, USA
    J Altern Complement Med 10:565-72. 2004
  7. pmc Time-variant fMRI activity in the brainstem and higher structures in response to acupuncture
    Vitaly Napadow
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neuroimage 47:289-301. 2009
  8. pmc Intrinsic brain connectivity in fibromyalgia is associated with chronic pain intensity
    Vitaly Napadow
    Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 Thirteenth Street 2301, Charlestown, MA 02129, USA
    Arthritis Rheum 62:2545-55. 2010
  9. ncbi request reprint Correlating acupuncture FMRI in the human brainstem with heart rate variability
    Vitaly Napadow
    Member IEEE, Massachusetts General Hospital, Department of Radiology, Boston, MA 02129 USA phone 617 724 3402 fax 617 726 7422 e mail
    Conf Proc IEEE Eng Med Biol Soc 5:4496-9. 2005
  10. pmc Hypothalamus and amygdala response to acupuncture stimuli in Carpal Tunnel Syndrome
    V Napadow
    Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States
    Pain 130:254-66. 2007

Detail Information

Publications40

  1. ncbi request reprint Neuroimaging acupuncture effects in the human brain
    Rupali P Dhond
    Massachusetts General Hospital Massachusetts Institute of Technology Harvard Medical School, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    J Altern Complement Med 13:603-16. 2007
    ..In this review, we will summarize data from acupuncture neuroimaging research and discuss how these findings contribute to current hypotheses of acupuncture action...
  2. pmc Brain white matter microstructure is associated with susceptibility to motion-induced nausea
    V Napadow
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA 02129, USA
    Neurogastroenterol Motil 25:448-50, e303. 2013
    ....
  3. pmc The brain circuitry underlying the temporal evolution of nausea in humans
    Vitaly Napadow
    Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    Cereb Cortex 23:806-13. 2013
    ....
  4. pmc Evoked pain analgesia in chronic pelvic pain patients using respiratory-gated auricular vagal afferent nerve stimulation
    Vitaly Napadow
    Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA
    Pain Med 13:777-89. 2012
    ..The dorsal medullary vagal system operates in tune with respiration, and we propose that supplying vagal afferent stimulation gated to the exhalation phase of respiration can optimize t-VNS...
  5. pmc Decreased intrinsic brain connectivity is associated with reduced clinical pain in fibromyalgia
    Vitaly Napadow
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Arthritis Rheum 64:2398-403. 2012
    ....
  6. ncbi request reprint Patient characteristics for outpatient acupuncture in Beijing, China
    Vitaly Napadow
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA 02129, USA
    J Altern Complement Med 10:565-72. 2004
    ..This study quantifies and compares patient characteristics in outpatient acupuncture...
  7. pmc Time-variant fMRI activity in the brainstem and higher structures in response to acupuncture
    Vitaly Napadow
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neuroimage 47:289-301. 2009
    ..Our protocol also demonstrates a fMRI approach to study habituation and other time-variant phenomena over longer time durations...
  8. pmc Intrinsic brain connectivity in fibromyalgia is associated with chronic pain intensity
    Vitaly Napadow
    Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 Thirteenth Street 2301, Charlestown, MA 02129, USA
    Arthritis Rheum 62:2545-55. 2010
    ..The objective of this study was to investigate the degree of connectivity between multiple brain networks in patients with FM, as well as how activity in these networks correlates with the level of spontaneous pain...
  9. ncbi request reprint Correlating acupuncture FMRI in the human brainstem with heart rate variability
    Vitaly Napadow
    Member IEEE, Massachusetts General Hospital, Department of Radiology, Boston, MA 02129 USA phone 617 724 3402 fax 617 726 7422 e mail
    Conf Proc IEEE Eng Med Biol Soc 5:4496-9. 2005
    ..The correlation of time-varying fMRI response with physiological parameters may provide insight into connections between acupuncture modulation of the autonomic nervous system and neuroprocessing...
  10. pmc Hypothalamus and amygdala response to acupuncture stimuli in Carpal Tunnel Syndrome
    V Napadow
    Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States
    Pain 130:254-66. 2007
    ..This is the first evidence suggesting that chronic pain patients respond to acupuncture differently than HC, through a coordinated limbic network including the hypothalamus and amygdala...
  11. ncbi request reprint Neurobiological correlates of acupuncture: November 17-18, 2005
    Vitaly Napadow
    Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, USA
    J Altern Complement Med 12:931-5. 2006
    ....
  12. ncbi request reprint Automated brainstem co-registration (ABC) for MRI
    Vitaly Napadow
    Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA
    Neuroimage 32:1113-9. 2006
    ..The use of easily available and validated tools (AFNI and FSL) for this method should ease adoption by other investigators interested in brainstem data group analysis...
  13. ncbi request reprint Somatosensory cortical plasticity in carpal tunnel syndrome treated by acupuncture
    Vitaly Napadow
    Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Hum Brain Mapp 28:159-71. 2007
    ..Acupuncture, a somatosensory conditioning stimulus, shows promise in inducing beneficial cortical plasticity manifested by more focused digital representations...
  14. ncbi request reprint Somatosensory cortical plasticity in carpal tunnel syndrome--a cross-sectional fMRI evaluation
    Vitaly Napadow
    Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA
    Neuroimage 31:520-30. 2006
    ..Our results are consistent with Hebbian plasticity mechanisms, as our cohort of CTS patients had predominant paresthesias, which produce more temporally coherent afferent signaling from affected digits...
  15. pmc Brain correlates of autonomic modulation: combining heart rate variability with fMRI
    Vitaly Napadow
    MGH MIT HMS Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02119, USA
    Neuroimage 42:169-77. 2008
    ..Our approach should be optimized and applied to study the human brain correlates of autonomic modulation for various stimuli in both physiological and pathological states...
  16. pmc Brain correlates of phasic autonomic response to acupuncture stimulation: an event-related fMRI study
    Vitaly Napadow
    Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts Department of Radiology, Logan College of Chiropractic, Chesterfield, Missouri
    Hum Brain Mapp 34:2592-606. 2013
    ....
  17. pmc Acupuncture mobilizes the brain's default mode and its anti-correlated network in healthy subjects
    Kathleen K S Hui
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 13th St, Charlestown, MA 02129, USA
    Brain Res 1287:84-103. 2009
    ..Our results suggest that acupuncture mobilizes the anti-correlated functional networks of the brain to mediate its actions, and that the effect is dependent on the psychophysical response...
  18. pmc Spatio-temporal mapping cortical neuroplasticity in carpal tunnel syndrome
    Rupali P Dhond
    Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Brain 135:3062-73. 2012
    ..These temporal magnetoencephalography measures are novel markers of neuroplasticity in carpal tunnel syndrome and could be used to study central changes that may occur following clinical intervention...
  19. pmc Brain encoding of acupuncture sensation--coupling on-line rating with fMRI
    Vitaly Napadow
    MGH HMS MIT Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA
    Neuroimage 47:1055-65. 2009
    ..Hence, acupuncture may function as a somatosensory-guided mind-body therapy...
  20. doi request reprint Disrupted brain circuitry for pain-related reward/punishment in fibromyalgia
    Marco L Loggia
    Massachusetts General Hospital, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts
    Arthritis Rheumatol 66:203-12. 2014
    ..This study was undertaken to investigate potential dysregulation of the neural circuitry underlying cognitive and hedonic aspects of the subjective experience of pain, such as anticipation of pain and anticipation of pain relief...
  21. pmc Sustained deep-tissue pain alters functional brain connectivity
    Jieun Kim
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA, USA
    Pain 154:1343-51. 2013
    ..Furthermore, increased connectivity between S1/M1 and both sensory and affective processing areas may be an important contribution to interindividual differences in pain sensitivity...
  22. pmc Default mode network connectivity encodes clinical pain: an arterial spin labeling study
    Marco L Loggia
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School HMS, Boston, MA, USA
    Pain 154:24-33. 2013
    ..Our results support the use of arterial spin labeling to evaluate clinical pain, and the use of resting DMN connectivity as a potential neuroimaging biomarker for chronic pain perception...
  23. pmc Disentangling linear and nonlinear brain responses to evoked deep tissue pain
    Marco L Loggia
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Pain 153:2140-51. 2012
    ..Future studies should apply a similar approach using innocuous stimuli of multiple intensities to evaluate whether the response profiles reported here can also be generalized to nonpainful somatosensory processing...
  24. pmc Static and dynamic autonomic response with increasing nausea perception
    Lauren T LaCount
    Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 Thirteenth St, 2301, Charlestown, MA 02129, USA
    Aviat Space Environ Med 82:424-33. 2011
    ..Nausea is a commonly occurring symptom typified by epigastric discomfort with urge to vomit. The relationship between autonomic nervous system (ANS) outflow and increasing nausea perception is not fully understood...
  25. pmc Characterization of the "deqi" response in acupuncture
    Kathleen K S Hui
    Athinoula A, Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    BMC Complement Altern Med 7:33. 2007
    ....
  26. pmc Differences in cortical response to acupressure and electroacupuncture stimuli
    Thomas Witzel
    Harvard Medical School, Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    BMC Neurosci 12:73. 2011
    ..We used whole head magnetoencephalography (MEG) to map S1 brain response during 15 minutes of electroacupuncture (EA) and acupressure (AP). We further assessed how brain response changed during the course of stimulation...
  27. ncbi request reprint The integrated response of the human cerebro-cerebellar and limbic systems to acupuncture stimulation at ST 36 as evidenced by fMRI
    Kathleen K S Hui
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Room 2301, Charlestown, MA 02129, USA
    Neuroimage 27:479-96. 2005
    ..The study provides preliminary evidence for an integrated response of the human cerebro-cerebellar and limbic systems to acupuncture stimulation at ST 36 that correlates with the psychophysical response...
  28. pmc Acupuncture modulates resting state connectivity in default and sensorimotor brain networks
    Rupali P Dhond
    MGH MIT HMS Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Boston, MA 02129, USA
    Pain 136:407-18. 2008
    ..This modulation and sympathovagal response may relate to acupuncture analgesia and other potential therapeutic effects...
  29. ncbi request reprint Effects of electroacupuncture versus manual acupuncture on the human brain as measured by fMRI
    Vitaly Napadow
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Hum Brain Mapp 24:193-205. 2005
    ....
  30. ncbi request reprint A systematic study of acupuncture practice: acupoint usage in an outpatient setting in Beijing, China
    Vitaly Napadow
    Athinoula A Martinos Imaging Center, Massachusetts General Hospital, Boston, MA, USA
    Complement Ther Med 12:209-16. 2004
    ....
  31. pmc The status and future of acupuncture mechanism research
    Vitaly Napadow
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charleston, MA 02129, USA
    J Altern Complement Med 14:861-9. 2008
    ..Iterative testing, expanding, and perhaps merging of such models will potentially lead to an incremental understanding of the effects of manual and electrical stimulation of acupuncture needles that is solidly rooted in physiology...
  32. pmc Spatiotemporal mapping the neural correlates of acupuncture with MEG
    Rupali P Dhond
    MGH MIT HMS Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
    J Altern Complement Med 14:679-88. 2008
    ..Thus, MEG provides excellent spatiotemporal characterization of the somatosensory component of acupuncture, and future studies can contrast derived brain response parameters in healthy controls with those found in a diseased state...
  33. doi request reprint The brain circuitry mediating antipruritic effects of acupuncture
    Vitaly Napadow
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
    Cereb Cortex 24:873-82. 2014
    ..Understanding brain circuitry underlying itch reduction following acupuncture and related neuromodulatory therapies will significantly impact the development and applicability of novel therapies to reduce an itch. ..
  34. doi request reprint Pregabalin rectifies aberrant brain chemistry, connectivity, and functional response in chronic pain patients
    Richard E Harris
    Assistant Professor, Research Specialist, Professor, Chronic Pain and Fatigue Research Center, Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan Assistant Professor, Research Fellow, Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts Senior Director, Director, Pfizer Incorporated, Groton, Connecticut Professor, Department of Radiology, Division of Neuroradiology, University of Michigan, and Department of Diagnostic Radiology, Clinical Sciences Lund, Lund University, Lund, Sweden Assistant Professor, Department of Radiology, Division of Neuroradiology, University of Michigan, and Ann Arbor VA Healthcare System Assistant Professor, Department of Radiology, Division of Neuroradiology, University of Michigan Associate Professor, Department of Neurology, Bergmannsheil, Berufsgenossenschaftliche Universitätsklinik, Ruhr Universitat Bochum, Bochum, Germany
    Anesthesiology 119:1453-64. 2013
    ..However, human brain neuroimaging techniques enable the assessment of functional and neurochemical alterations in patients experiencing chronic pain and how these factors may dynamically change with pharmacologic treatment...
  35. doi request reprint Acupuncture de qi, from qualitative history to quantitative measurement
    Jian Kong
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Altern Complement Med 13:1059-70. 2007
    ....
  36. pmc Neural correlates of chronic low back pain measured by arterial spin labeling
    Ajay D Wasan
    Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    Anesthesiology 115:364-74. 2011
    ..Arterial spin labeling is a perfusion-based imaging technique allowing the absolute quantification of regional cerebral blood flow, which is a surrogate measure of neuronal activity...
  37. pmc Do the neural correlates of acupuncture and placebo effects differ?
    Rupali P Dhond
    MGH MIT HMS Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    Pain 128:8-12. 2007
  38. doi request reprint Frequency-dependent relationship between resting-state functional magnetic resonance imaging signal power and head motion is localized within distributed association networks
    Jieun Kim
    1 Department of Radiology, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts
    Brain Connect 4:30-9. 2014
    ..Hence, head motion significantly affects rs-fMRI power and great care must be taken when assigning a diagnostic marker for clinical populations known to present with greater head motion...
  39. pmc The missing link: enhanced functional connectivity between amygdala and visceroceptive cortex in migraine
    Nouchine Hadjikhani
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, MA, USA
    Cephalalgia 33:1264-8. 2013
    ..The role of CSD and amygdala connectivity in migraine without aura (MwoA) is less clear and may differentiate migraine from other chronic pain disorders...
  40. pmc S1 is associated with chronic low back pain: a functional and structural MRI study
    Jian Kong
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, Harvard Medical School, 120 2nd Ave, Room 101, Charlestown, MA 02129, USA
    Mol Pain 9:43. 2013
    ..Our results provide evidence of structural plasticity co-localized with areas exhibiting FC changes in S1 in cLBP patients...

Research Grants5

  1. Exploring Neurocircuitry of Acupuncture Action with fMRI
    Vitaly Napadow; Fiscal Year: 2007
    ..The goals of this study are to understand the neurobiology of acupuncture action and promote the development of this ancient healing technique into evidence-based medicine. ..
  2. Brain Plasticity in Carpal Tunnel Syndrome and its Response to Acupuncture
    Vitaly Napadow; Fiscal Year: 2009
    ....
  3. Brain Plasticity in Carpal Tunnel Syndrome and its Response to Acupuncture
    Vitaly Napadow; Fiscal Year: 2009
    ..This grant will assess changes in brain activity and cortical disinhibition that accompany the dysfunction in the wrist, as well as how acupuncture might modify both local nerve health and brain function to help treat CTS patients. ..
  4. Brain Plasticity in Carpal Tunnel Syndrome and its Response to Acupuncture
    Vitaly Napadow; Fiscal Year: 2010
    ....