Hongmei Nan

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Missense polymorphisms in matrix metalloproteinase genes and skin cancer risk
    Hongmei Nan
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 17:3551-7. 2008
  2. pmc Genetic variants in pigmentation genes, pigmentary phenotypes, and risk of skin cancer in Caucasians
    Hongmei Nan
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Int J Cancer 125:909-17. 2009
  3. pmc Interaction between p53 codon 72 polymorphism and melanocortin 1 receptor variants on suntan response and cutaneous melanoma risk
    H Nan
    Department of Epidemiology, Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
    Br J Dermatol 159:314-21. 2008
  4. pmc A functional SNP in the MDM2 promoter, pigmentary phenotypes, and risk of skin cancer
    Hongmei Nan
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
    Cancer Causes Control 20:171-9. 2009
  5. pmc Genome-wide association study of tanning phenotype in a population of European ancestry
    Hongmei Nan
    Channing Laboratory, Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Invest Dermatol 129:2250-7. 2009
  6. pmc Genetic variants in telomere-maintaining genes and skin cancer risk
    Hongmei Nan
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Hum Genet 129:247-53. 2011
  7. pmc Genetic variants in FGFR2 and FGFR4 genes and skin cancer risk in the Nurses' Health Study
    Hongmei Nan
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    BMC Cancer 9:172. 2009
  8. pmc A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation
    Jiali Han
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 4:e1000074. 2008
  9. pmc Genome-wide association study identifies novel alleles associated with risk of cutaneous basal cell carcinoma and squamous cell carcinoma
    Hongmei Nan
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Hum Mol Genet 20:3718-24. 2011
  10. pmc Genome-wide association study identifies nidogen 1 (NID1) as a susceptibility locus to cutaneous nevi and melanoma risk
    Hongmei Nan
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Hum Mol Genet 20:2673-9. 2011

Detail Information

Publications18

  1. pmc Missense polymorphisms in matrix metalloproteinase genes and skin cancer risk
    Hongmei Nan
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 17:3551-7. 2008
    ..No associations were found for other SNPs with skin cancer risk. This study provides evidence for the contribution of the MMP9 Arg668Gln to SCC development...
  2. pmc Genetic variants in pigmentation genes, pigmentary phenotypes, and risk of skin cancer in Caucasians
    Hongmei Nan
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Int J Cancer 125:909-17. 2009
    ..Our study provides evidence for the contribution of pigmentation genetic variants, in addition to the MC1R variants, to variation in human pigmentary phenotypes and possibly the development of skin cancer...
  3. pmc Interaction between p53 codon 72 polymorphism and melanocortin 1 receptor variants on suntan response and cutaneous melanoma risk
    H Nan
    Department of Epidemiology, Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
    Br J Dermatol 159:314-21. 2008
    ..The common p53 codon 72 polymorphism alters the protein's transcriptional activity, which may influence the UV radiation-induced tanning response...
  4. pmc A functional SNP in the MDM2 promoter, pigmentary phenotypes, and risk of skin cancer
    Hongmei Nan
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
    Cancer Causes Control 20:171-9. 2009
    ..05) than p53 Arg/Arg wild-type group (p, trend, 0.99; p, interaction, 0.07). These results provide evidence for the potential involvement of MDM2 SNP309 in pigmentary traits...
  5. pmc Genome-wide association study of tanning phenotype in a population of European ancestry
    Hongmei Nan
    Channing Laboratory, Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Invest Dermatol 129:2250-7. 2009
    ..Overall, these tanning ability-related loci are similar to the hair color-related loci previously reported in the GWAS of hair color...
  6. pmc Genetic variants in telomere-maintaining genes and skin cancer risk
    Hongmei Nan
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Hum Genet 129:247-53. 2011
    ..05). We did not observe significant associations for SCC or BCC risk. Our study provides evidence for the contribution of genetic variants in the telomere-maintaining genes to melanoma susceptibility...
  7. pmc Genetic variants in FGFR2 and FGFR4 genes and skin cancer risk in the Nurses' Health Study
    Hongmei Nan
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    BMC Cancer 9:172. 2009
    ..Overexpression of the FGFR4 protein has been linked to cutaneous melanoma progression. Previous studies reported associations between genetic variants in the FGFR2 and FGFR4 genes and development of various cancers...
  8. pmc A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation
    Jiali Han
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 4:e1000074. 2008
    ..The signals detected in a region around the MC1R gene were explained by MC1R red hair color alleles. Our results suggest that the IRF4 and SLC24A4 loci are associated with human hair color and skin pigmentation...
  9. pmc Genome-wide association study identifies novel alleles associated with risk of cutaneous basal cell carcinoma and squamous cell carcinoma
    Hongmei Nan
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Hum Mol Genet 20:3718-24. 2011
    ..21 (1.02-1.44); P= 0.03], were associated with an increased risk of SCC. These two variants were not associated with melanoma risk. We conclude that 6p25 and 13q32 are novel loci conferring susceptibility to non-melanoma skin cancer...
  10. pmc Genome-wide association study identifies nidogen 1 (NID1) as a susceptibility locus to cutaneous nevi and melanoma risk
    Hongmei Nan
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Hum Mol Genet 20:2673-9. 2011
    ..5 × 10(-6)) and in primary melanoma (P = 4.6 × 10(-4)) compared with the normal skin...
  11. pmc A germline variant in the interferon regulatory factor 4 gene as a novel skin cancer risk locus
    Jiali Han
    Clinical Research Program, Department of Dermatology, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 71:1533-9. 2011
    ..6 × 10(-3)). Given that the T allele was shown previously to be associated with increased expression of IRF4 locus, further studies are warranted to elucidate the role of the IRF4 gene in human pigmentation and skin cancer development...
  12. pmc ASIP genetic variants and the number of non-melanoma skin cancers
    Wen Lin
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Cancer Causes Control 22:495-501. 2011
    ..32; 95% CI, 1.07-1.63). The OR increased to 1.45(1.18-1.78) for those with 2-4 NMSCs and 1.84(1.34-2.53) for those with at least five. The findings suggest that ASIP locus is associated with the number of NMSCs...
  13. pmc Shorter telomeres associate with a reduced risk of melanoma development
    Hongmei Nan
    Channing Laboratory, Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 71:6758-63. 2011
    ..43 (95% CI: 0.28-0.68; P(trend), 0.0003). Unlike findings for other tumors, shorter telomeres were significantly associated with a decreased risk of melanoma in this study, suggesting a unique role of telomeres in melanoma development...
  14. pmc Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans
    Mingfeng Zhang
    Clinical Research Program, Department of Dermatology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Hum Mol Genet 22:2948-59. 2013
    ..0 × 10(-8); P = 6.6 × 10(-7) in the discovery set and P = 3.0 × 10(-3) in the replication set) and rs8015138 upstream of GNG2 (P = 6.6 × 10(-8); P = 5.3 × 10(-7) in the discovery set and P = 0.01 in the replication set). ..
  15. pmc Obesity-related genetic variants, human pigmentation, and risk of melanoma
    Xin Li
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Hum Genet 132:793-801. 2013
    ..But none of them was associated with obesity or in linkage disequilibrium with obesity-related variants. FTO locus may confer variation in human pigmentation and risk of melanoma, which may be independent of its effect on obesity...
  16. pmc Prospective study of alcohol consumption and the risk of colorectal cancer before and after folic acid fortification in the United States
    Hongmei Nan
    Division of Cancer Epidemiology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA
    Ann Epidemiol 23:558-63. 2013
    ..To evaluate the influence of alcohol consumption on the risk of colorectal cancer according to folic acid fortification period in the United States...
  17. pmc Phenotypic and tumor molecular characterization of colorectal cancer in relation to a susceptibility SMAD7 variant associated with survival
    Xabier Garcia-Albeniz
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Carcinogenesis 34:292-8. 2013
    ..These findings suggest that individuals with this SMAD7 variant that develop CRC are more probably to have tumors with greater invasiveness and methylation of RUNX3, which potentially contributes to their poorer observed survival...
  18. pmc Pre-diagnostic leukocyte genomic DNA methylation and the risk of colorectal cancer in women
    Hongmei Nan
    Division of Cancer Epidemiology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA
    PLoS ONE 8:e59455. 2013
    ..Abnormal one-carbon metabolism may lead to general genomic (global) hypomethylation, which may predispose an individual to the development of colorectal neoplasia...