Matthias Nahrendorf

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions
    Matthias Nahrendorf
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Exp Med 204:3037-47. 2007
  2. pmc Therapeutic siRNA silencing in inflammatory monocytes in mice
    Florian Leuschner
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Biotechnol 29:1005-10. 2011
  3. pmc Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis
    Florian Leuschner
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, Boston, MA 02114, USA
    J Exp Med 209:123-37. 2012
  4. pmc In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation
    Peter Panizzi
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 17:1142-6. 2011
  5. pmc Monocyte and macrophage heterogeneity in the heart
    Matthias Nahrendorf
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Circ Res 112:1624-33. 2013
  6. pmc Monocyte-directed RNAi targeting CCR2 improves infarct healing in atherosclerosis-prone mice
    Maulik D Majmudar
    Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, Boston, MA 02114, USA
    Circulation 127:2038-46. 2013
  7. pmc Hybrid PET-optical imaging using targeted probes
    Matthias Nahrendorf
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 107:7910-5. 2010
  8. pmc Detection of macrophages in aortic aneurysms by nanoparticle positron emission tomography-computed tomography
    Matthias Nahrendorf
    Center for Systems Biology, 185 Cambridge St, Boston, MA 02114, USA
    Arterioscler Thromb Vasc Biol 31:750-7. 2011
  9. pmc Activatable magnetic resonance imaging agent reports myeloperoxidase activity in healing infarcts and noninvasively detects the antiinflammatory effects of atorvastatin on ischemia-reperfusion injury
    Matthias Nahrendorf
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Circulation 117:1153-60. 2008
  10. doi request reprint Transglutaminase activity in acute infarcts predicts healing outcome and left ventricular remodelling: implications for FXIII therapy and antithrombin use in myocardial infarction
    Matthias Nahrendorf
    Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Room 5406, Charlestown, MA 02129, USA
    Eur Heart J 29:445-54. 2008

Research Grants

  1. Imaging of Cardiac Transplant Rejection
    Matthias Nahrendorf; Fiscal Year: 2009
  2. Cluster Imaging of Emerging Biomarker Networks in Wound Healing
    Matthias Nahrendorf; Fiscal Year: 2009
  3. Imaging of Cardiac Transplant Rejection
    Matthias Nahrendorf; Fiscal Year: 2010
  4. Cluster Imaging of Emerging Biomarker Networks in Wound Healing
    Matthias Nahrendorf; Fiscal Year: 2010

Detail Information

Publications93

  1. pmc The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions
    Matthias Nahrendorf
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Exp Med 204:3037-47. 2007
    ....
  2. pmc Therapeutic siRNA silencing in inflammatory monocytes in mice
    Florian Leuschner
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Biotechnol 29:1005-10. 2011
    ....
  3. pmc Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis
    Florian Leuschner
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, Boston, MA 02114, USA
    J Exp Med 209:123-37. 2012
    ..We also detected rapid Mo kinetics in mice with stroke. These findings expand our knowledge of Mo/MΦ flux in acute inflammation and provide the groundwork for novel anti-inflammatory strategies for treating heart failure...
  4. pmc In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation
    Peter Panizzi
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 17:1142-6. 2011
    ..When endocarditis was induced with an S. aureus strain with genetic deletion of coagulases, survival of mice improved, highlighting the role of staphylocoagulase as a virulence factor...
  5. pmc Monocyte and macrophage heterogeneity in the heart
    Matthias Nahrendorf
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Circ Res 112:1624-33. 2013
    ..This review discusses current concepts of lineage relationships and crosstalk of systems, highlights open questions, and describes tools for studying monocyte and macrophage subsets in the murine and human heart...
  6. pmc Monocyte-directed RNAi targeting CCR2 improves infarct healing in atherosclerosis-prone mice
    Maulik D Majmudar
    Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, Boston, MA 02114, USA
    Circulation 127:2038-46. 2013
    ..We used dual-target positron emission tomography/magnetic resonance imaging of transglutaminase factor XIII (FXIII) and myeloperoxidase (MPO) activity to monitor how monocyte subset-targeted RNAi altered infarct inflammation and healing...
  7. pmc Hybrid PET-optical imaging using targeted probes
    Matthias Nahrendorf
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 107:7910-5. 2010
    ..The findings also suggest that FMT can serve as a surrogate modality for the screening and development of radionuclide-based imaging agents...
  8. pmc Detection of macrophages in aortic aneurysms by nanoparticle positron emission tomography-computed tomography
    Matthias Nahrendorf
    Center for Systems Biology, 185 Cambridge St, Boston, MA 02114, USA
    Arterioscler Thromb Vasc Biol 31:750-7. 2011
    ..We here aimed to develop and validate macrophage-targeted nanoparticles labeled with fluorine-18 ((18)F) for positron emission tomography-computed tomography (PET-CT) detection of inflammation in AAs...
  9. pmc Activatable magnetic resonance imaging agent reports myeloperoxidase activity in healing infarcts and noninvasively detects the antiinflammatory effects of atorvastatin on ischemia-reperfusion injury
    Matthias Nahrendorf
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Circulation 117:1153-60. 2008
    ..We hypothesized that MPO imaging could be used to measure inflammatory responses after myocardial ischemia locally and noninvasively in a murine model...
  10. doi request reprint Transglutaminase activity in acute infarcts predicts healing outcome and left ventricular remodelling: implications for FXIII therapy and antithrombin use in myocardial infarction
    Matthias Nahrendorf
    Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Room 5406, Charlestown, MA 02129, USA
    Eur Heart J 29:445-54. 2008
    ..Here we assess the impact of transglutaminase-modulating therapies on healing and evolution of heart failure using a novel, non-invasive molecular imaging technique...
  11. pmc MR-optical imaging of cardiovascular molecular targets
    Matthias Nahrendorf
    Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, MA, USA
    Basic Res Cardiol 103:87-94. 2008
    ..We discuss strengths and limitations of respective imaging technologies, and comment on the potential of multi-modality imaging approaches...
  12. pmc 18F-4V for PET-CT imaging of VCAM-1 expression in atherosclerosis
    Matthias Nahrendorf
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02124, USA
    JACC Cardiovasc Imaging 2:1213-22. 2009
    ....
  13. pmc Nanoparticle PET-CT detects rejection and immunomodulation in cardiac allografts
    Takuya Ueno
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Circ Cardiovasc Imaging 6:568-73. 2013
    ..Macrophages predominate among the inflammatory cells in rejecting allografts. These innate immune cells, in addition to allospecific T cells, can damage cardiomyocytes directly...
  14. pmc Myeloperoxidase-rich Ly-6C+ myeloid cells infiltrate allografts and contribute to an imaging signature of organ rejection in mice
    Filip K Swirski
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 120:2627-34. 2010
    ..Thus, MPO imaging represents a potential alternative to the current invasive clinical standard by which transplants are monitored...
  15. pmc Molecular MRI of cardiomyocyte apoptosis with simultaneous delayed-enhancement MRI distinguishes apoptotic and necrotic myocytes in vivo: potential for midmyocardial salvage in acute ischemia
    David E Sosnovik
    Center for Molecular Imaging Research, The Cardiology Division, Martinos Center for Biomedical Imaging, and the Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston Mass, USA
    Circ Cardiovasc Imaging 2:460-7. 2009
    ..The technique uses the annexin-based nanoparticle AnxCLIO-Cy5.5 (apoptosis) and simultaneous delayed-enhancement imaging with a novel gadolinium chelate, Gd-DTPA-NBD (necrosis)...
  16. pmc Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosis
    Peter Panizzi
    Center for Systems Biology, Simches Research Building, Massachusetts General Hospital and Harvard Medical School Boston, Massachusetts 02114, USA
    J Am Coll Cardiol 55:1629-38. 2010
    ..The aim of this study was to test whether blood monocytosis in mice with atherosclerosis affects infarct healing...
  17. pmc Angiotensin-converting enzyme inhibition prevents the release of monocytes from their splenic reservoir in mice with myocardial infarction
    Florian Leuschner
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, USA
    Circ Res 107:1364-73. 2010
    ..Monocytes recruited to ischemic myocardium originate from a reservoir in the spleen, and the release from their splenic niche relies on angiotensin (Ang) II signaling...
  18. pmc Identification of splenic reservoir monocytes and their deployment to inflammatory sites
    Filip K Swirski
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Science 325:612-6. 2009
    ..These observations uncover a role for the spleen as a site for storage and rapid deployment of monocytes and identify splenic monocytes as a resource that the body exploits to regulate inflammation...
  19. ncbi request reprint Dual channel optical tomographic imaging of leukocyte recruitment and protease activity in the healing myocardial infarct
    Matthias Nahrendorf
    Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, USA
    Circ Res 100:1218-25. 2007
    ..Spectrally resolved imaging agents allow for simultaneous assesment of key processes of in vivo cellular functions. Specifically, we show that in vivo FMT detects impaired healing in FXIII-/- mice...
  20. pmc Angiotensin II drives the production of tumor-promoting macrophages
    Virna Cortez-Retamozo
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Immunity 38:296-308. 2013
    ..These findings indicate that AngII acts upstream of a potent macrophage amplification program and that tumors can remotely exploit the hormone's pathway to stimulate cancer-promoting immunity...
  21. pmc Myocardial infarction accelerates atherosclerosis
    Partha Dutta
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 487:325-9. 2012
    ..The progenitors then seeded the spleen, yielding a sustained boost in monocyte production. These observations provide new mechanistic insight into atherogenesis and provide a novel therapeutic opportunity to mitigate disease progression...
  22. pmc Hybrid in vivo FMT-CT imaging of protease activity in atherosclerosis with customized nanosensors
    Matthias Nahrendorf
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Arterioscler Thromb Vasc Biol 29:1444-51. 2009
    ....
  23. ncbi request reprint Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo
    Elena Aikawa
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, 149 13th St, Room 5420, Charlestown, MA 02129, USA
    Circulation 116:2841-50. 2007
    ..Arterial calcification is associated with cardiovascular events; however, mechanisms of calcification in atherosclerosis remain obscure...
  24. pmc Molecular MRI detects low levels of cardiomyocyte apoptosis in a transgenic model of chronic heart failure
    David E Sosnovik
    Center for Molecular Imaging Research, The Cardiology Division, and Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Masss, USA
    Circ Cardiovasc Imaging 2:468-75. 2009
    ..The myocardium in heart failure, however, is characterized by very low levels of CM apoptosis and normal vascular permeability, factors thought to preclude the use of molecular MRI...
  25. pmc Extramedullary hematopoiesis generates Ly-6C(high) monocytes that infiltrate atherosclerotic lesions
    Clinton S Robbins
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Simches Research Bldg, 185 Cambridge St, Boston, MA 02114, USA
    Circulation 125:364-74. 2012
    ..Here, we hypothesized that the bone marrow outsources the production of Ly-6C(high) monocytes during atherosclerosis...
  26. pmc Local proliferation dominates lesional macrophage accumulation in atherosclerosis
    Clinton S Robbins
    1 Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA 2 Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada 3 Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada 4 Department of Immunology, University of Toronto, Toronto, Ontario, Canada 5
    Nat Med 19:1166-72. 2013
    ..Our study reveals macrophage proliferation as a key event in atherosclerosis and identifies macrophage self-renewal as a therapeutic target for cardiovascular disease. ..
  27. pmc Polymeric nanoparticle PET/MR imaging allows macrophage detection in atherosclerotic plaques
    Maulik D Majmudar
    Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, Boston, MA 02114, USA
    Circ Res 112:755-61. 2013
    ..05). Conclusions: Hybrid PET/MRI with a 13-nm DNP enables noninvasive assessment of inflammation in experimental atherosclerotic plaques and reports on therapeutic efficacy of anti-inflammatory therapy...
  28. pmc PET/MRI of inflammation in myocardial infarction
    Won Woo Lee
    Center for Systems Biology, Massachusetts General Hospital, Boston, USA
    J Am Coll Cardiol 59:153-63. 2012
    ..The aim of this study was to explore post-myocardial infarction (MI) myocardial inflammation...
  29. pmc Origins of tumor-associated macrophages and neutrophils
    Virna Cortez-Retamozo
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 109:2491-6. 2012
    ..The present study sheds light on the origins of TAMs and TANs, and positions the spleen as an important extramedullary site, which can continuously supply growing tumors with these cells...
  30. ncbi request reprint Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease
    Elena Aikawa
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Mass 02129, USA
    Circulation 115:377-86. 2007
    ..Visualizing early changes in valvular cell functions in vivo may predict the future risk and identify therapeutic targets for prevention of aortic valve stenosis...
  31. pmc Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosis
    Matthias Nahrendorf
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Circulation 117:379-87. 2008
    ....
  32. pmc Molecular imaging of innate immune cell function in transplant rejection
    Thomas Christen
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 119:1925-32. 2009
    ..Yet, which macrophage functions may provide useful markers for detecting parenchymal rejection remains uncertain...
  33. pmc Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction
    Lior Zangi
    1 Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA 2 Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA 3 Department of Cardiology, Children s Hospital Boston, Boston, Massachusetts, USA 4 Immune Disease Institute and Program in Cellular and Molecular Medicine, Children s Hospital Boston, Boston, Massachusetts, USA 5 Boston and Harvard Stem Cell Institute, Cambridge, Massachusetts, USA 6
    Nat Biotechnol 31:898-907. 2013
    ..Our results suggest that modRNA is a versatile approach for expressing paracrine factors as cell fate switches to control progenitor cell fate and thereby enhance long-term organ repair. ..
  34. pmc Vasculitis: molecular imaging by targeting the inflammatory enzyme myeloperoxidase
    Henry S Su
    Center for Molecular Imaging Research, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Radiology 262:181-90. 2012
    ..To determine if a molecular imaging approach targeting the highly oxidative enzyme myeloperoxidase (MPO) can help noninvasively identify and confirm sites of vascular wall inflammation in a murine model of vasculitis...
  35. pmc Monocyte subset dynamics in human atherosclerosis can be profiled with magnetic nano-sensors
    Moritz Wildgruber
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 4:e5663. 2009
    ....
  36. ncbi request reprint Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo
    David E Sosnovik
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Circulation 115:1384-91. 2007
    ....
  37. pmc Ly-6Chigh monocytes depend on Nr4a1 to balance both inflammatory and reparative phases in the infarcted myocardium
    Ingo Hilgendorf
    From the Center for Systems Biology I H, L M S G, C W, B G C, Y I, M N, R W, F K S and Department of Cardiology T C T, M S C, Massachusetts General Hospital, Boston Department of Gastroenterology, Hepatology, and Infectious Diseases, University of Duesseldorf, Duesseldorf, Germany T A W H Department of Medicine R L and Cardiovascular Division, Department of Medicine P L, Brigham and Women s Hospital, Boston, MA Department of Cardiology and Angiology I, University Heart Center Freiburg, Freiburg, Germany A Z Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, CA C C H and Department of Systems Biology, Harvard Medical School, Boston, MA R W
    Circ Res 114:1611-22. 2014
    ....
  38. pmc In vivo silencing of the transcription factor IRF5 reprograms the macrophage phenotype and improves infarct healing
    Gabriel Courties
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts
    J Am Coll Cardiol 63:1556-66. 2014
    ..The aim of this study was to test whether silencing of the transcription factor interferon regulatory factor 5 (IRF5) in cardiac macrophages improves infarct healing and attenuates post-myocardial infarction (MI) remodeling...
  39. pmc Fluorescence tomography of rapamycin-induced autophagy and cardioprotection in vivo
    Howard H Chen
    Martinos Center for Biomedical Imaging, Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Circ Cardiovasc Imaging 6:441-7. 2013
    ..The impact of autophagy in the heart, however, remains unclear in part because of the inability to noninvasively image this process in living animals...
  40. pmc Mapping molecular agents distributions in whole mice hearts using born-normalized optical projection tomography
    Claudio Vinegoni
    Center for System Biology, Massachusetts General Hospital and Harvard Medical School, Richard B Simches Research Center, Boston, Massachusetts, United States of America
    PLoS ONE 7:e34427. 2012
    ..We observed extensive monocyte recruitment within and around the infarcted areas and discovered that monocytes were also extensively recruited into non-ischemic myocardium, beyond that of injured tissue, such as the septum...
  41. pmc Oxazine conjugated nanoparticle detects in vivo hypochlorous acid and peroxynitrite generation
    Peter Panizzi
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge St, Boston, Massachusetts 02114, USA
    J Am Chem Soc 131:15739-44. 2009
    ..Fluorescence reflectance imaging and microscopic fluorescence imaging in mouse hearts after myocardial infarction showed probe release into neutrophil-rich ischemic areas, making this ROS/RNS sensor a novel prognostic indicator...
  42. ncbi request reprint Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis
    Matthias Nahrendorf
    Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, USA
    Circulation 114:1504-11. 2006
    ....
  43. pmc Normalized Born ratio for fluorescence optical projection tomography
    Claudio Vinegoni
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Opt Lett 34:319-21. 2009
    ..We use the algorithm to three-dimensionally reconstruct and characterize a fluorescein isothiocyanate containing absorptive phantom and an infarcted mouse heart previously injected with a fluorescent molecular probe...
  44. pmc Real-time assessment of inflammation and treatment response in a mouse model of allergic airway inflammation
    Virna Cortez-Retamozo
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Invest 118:4058-66. 2008
    ..Both fluorescence-mediated tomography and fiberoptic bronchoscopy techniques have the potential to be translated into the clinic...
  45. ncbi request reprint Cellular imaging of inflammation in atherosclerosis using magnetofluorescent nanomaterials
    Farouc A Jaffer
    Harvard Medical School, Charlestown, MA 02129, USA
    Mol Imaging 5:85-92. 2006
    ..To better understand their cellular targeting and imaging capabilities in atherosclerosis, we investigated prototypical dextran-coated near-infrared fluorescent MFNPs in the apolipoprotein E-deficient (apo E-/-) mouse model...
  46. pmc High-resolution imaging of murine myocardial infarction with delayed-enhancement cine micro-CT
    Matthias Nahrendorf
    Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, MA, USA
    Am J Physiol Heart Circ Physiol 292:H3172-8. 2007
    ..This efficient imaging tool is a valuable addition to the current phenotyping armamentarium and will allow rapid testing of novel drugs and cell-based interventions in murine models...
  47. pmc Innate response activator B cells protect against microbial sepsis
    Philipp J Rauch
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Science 335:597-601. 2012
    ..These observations enrich our understanding of innate immunity, position IRA B cells as gatekeepers of bacterial infection, and identify new treatment avenues for infectious diseases...
  48. pmc 18F labeled nanoparticles for in vivo PET-CT imaging
    Neal K Devaraj
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, Massachusetts 02114, USA
    Bioconjug Chem 20:397-401. 2009
    ..The presence of 18F dramatically lowers the detection threshold of the nanoparticles, while the facile conjugation chemistry provides a simple platform for rapid and efficient nanoparticle labeling...
  49. pmc Selective factor XIIa inhibition attenuates silent brain ischemia: application of molecular imaging targeting coagulation pathway
    John W Chen
    Center for Systems Biology, Boston, Massachusetts 02114, USA
    JACC Cardiovasc Imaging 5:1127-38. 2012
    ..The purpose of this study was use molecular imaging targeting coagulation pathway and inflammation to better understand the pathophysiology of silent brain ischemia (SBI) and monitor the effects of factor XIIa inhibition...
  50. pmc High throughput transmission optical projection tomography using low cost graphics processing unit
    Claudio Vinegoni
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA
    Opt Express 17:22320-32. 2009
    ..By implementing the GPU we have obtained a 300 fold performance enhancement in comparison to a CPU workstation implementation. This enables to obtain on-the-fly reconstructions enabling for high throughput imaging...
  51. ncbi request reprint Monocyte subset dynamics in human atherosclerosis can be profiled with magnetic nano-sensors
    Moritz Wildgruber
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 4:e5663. 2009
    ....
  52. pmc Unbiased discovery of in vivo imaging probes through in vitro profiling of nanoparticle libraries
    Kimberly A Kelly
    Center for Molecular Imaging, Massachusetts General Hospital, Harvard Medical School, 149 13th St, Rm 5420, Charlestown, MA 02129, USA
    Integr Biol (Camb) 1:311-7. 2009
    ..Overall, this work presents a generalizable approach to the unbiased discovery of in vivo imaging probes, and may guide the further development of novel endothelial imaging probes...
  53. pmc Real-time in vivo imaging of the beating mouse heart at microscopic resolution
    Sungon Lee
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Richard B Simches Research Center, 185 Cambridge Street, Boston 02114, USA
    Nat Commun 3:1054. 2012
    ..The generic method could be adapted to other moving organs and thus broadly facilitate in vivo microscopic investigations...
  54. pmc Regulation of monocyte functional heterogeneity by miR-146a and Relb
    Martin Etzrodt
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Cell Rep 1:317-24. 2012
    ....
  55. pmc 89Zr-labeled dextran nanoparticles allow in vivo macrophage imaging
    Edmund J Keliher
    Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, United States
    Bioconjug Chem 22:2383-9. 2011
    ..It is likely that the material described, which allows the visualization of macrophage biology in vivo, will likewise be useful for a multitude of human applications...
  56. pmc Intraoperative near-infrared fluorescent cholangiography (NIRFC) in mouse models of bile duct injury
    Jose Luiz Figueiredo
    Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
    World J Surg 34:336-43. 2010
    ....
  57. pmc Innate response activator B cells aggravate atherosclerosis by stimulating T helper-1 adaptive immunity
    Ingo Hilgendorf
    Center for Systems Biology, Massachusetts General Hospital, Boston I H, I T, L M S G, C S R, G F W, Y I, C W, H Y L, M N, R W, F K S Department of Internal Medicine VI, Infectious Diseases, Immunology Rheumatology, Pneumology, University Hospital of Innsbruck, Innsbruck, Austria I T Toronto General Research Institute, University Health Network, Toronto, ON, Canada C S R, N D Department of Medicine, University of California, San Diego, La Jolla A G, J L W Department of Gastroenterology, Hepatology and Infectious Diseases, University of Duesseldorf, Duesseldorf, Germany T A W H Department of Cardiology and Angiology I, University Heart Center Freiburg, Freiburg, Germany C W, A Z Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, USA
    Circulation 129:1677-87. 2014
    ..Innate response activator (IRA) B cells are a recently described population of granulocyte macrophage colony-stimulating factor-secreting cells of hitherto unknown function in atherosclerosis...
  58. pmc Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis
    Georg F Weber
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 Department of Visceral, Thoracic and Vascular Surgery, Medizinische Fakultät Carl Gustav Carus, Technische Universitat Dresden, 01307 Dresden, Germany
    J Exp Med 211:1243-56. 2014
    ..The study describes a previously unrecognized GM-CSF-IgM axis and positions IRA B cells as orchestrators of protective IgM immunity. ..
  59. pmc Endoscopic time-lapse imaging of immune cells in infarcted mouse hearts
    Keehoon Jung
    Department of Dermatology, Harvard Medical School, Massachusetts General Hospital, 65 Landsdowne Street, Cambridge, MA 02139, USA
    Circ Res 112:891-9. 2013
    ..High-resolution imaging of the heart in vivo is challenging owing to the difficulty in accessing the heart and the tissue motion caused by the heartbeat...
  60. pmc Behavior of endogenous tumor-associated macrophages assessed in vivo using a functionalized nanoparticle
    Antoine Leimgruber
    Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Neoplasia 11:459-68, 2 p following 468. 2009
    ..Noninvasive imaging can also be used to monitor TAM-depleting regimen quantitatively. Thus, AMTA680 or related cell-targeting agents represent appropriate injectable vehicles for in vivo analysis of the tumor microenvironment...
  61. pmc Does FXIII deficiency impair wound healing after myocardial infarction?
    Matthias Nahrendorf
    Medizinische Klinik und Poliklinik I, Universitat Wurzburg, Germany Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America
    PLoS ONE 1:e48. 2006
    ..Here we would like to share our initial clinical experiences with strikingly similar observations in patients with this grave disease, and compare these observations to experimental findings...
  62. ncbi request reprint Molecular imaging of myocardial infarction
    Farouc A Jaffer
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    J Mol Cell Cardiol 41:921-33. 2006
    ....
  63. pmc In vivo imaging of T cell delivery to tumors after adoptive transfer therapy
    Mikael J Pittet
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 104:12457-61. 2007
    ....
  64. pmc Imaging macrophage development and fate in atherosclerosis and myocardial infarction
    Filip K Swirski
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Immunol Cell Biol 91:297-303. 2013
    ..Here, we explore how various imaging modalities, from intravital microscopy in mice to organ-level imaging in patients, are contributing to our understanding of macrophages and their progenitors in cardiovascular disease...
  65. ncbi request reprint Molecular magnetic resonance imaging in cardiovascular medicine
    David E Sosnovik
    Center for Molecular Imaging Research, Massachusetts General Hospital, 149 13th St, Charlestown, MA 02129, USA
    Circulation 115:2076-86. 2007
  66. ncbi request reprint In vivo phage display selection yields atherosclerotic plaque targeted peptides for imaging
    Kimberly A Kelly
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, 149, 13th Street, Rm 5404, Charlestown, MA 02129, USA
    Mol Imaging Biol 8:201-7. 2006
    ..Atherosclerosis is a leading cause of morbidity and mortality in the Western world, yet specific imaging agents to detect and map inflammatory plaques are still lacking...
  67. doi request reprint Imaging macrophages with nanoparticles
    Ralph Weissleder
    1 Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, USA 2 Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA 3 Department of Radiology, Massachusetts General Hospital, 32 Fruit Street, Boston, Massachusetts 02114, USA
    Nat Mater 13:125-38. 2014
    ..New in vivo imaging clinical tools for noninvasive macrophage quantification are thus ultimately expected to become relevant to predicting patients' clinical outcome, defining treatment options and monitoring responses to therapy. ..
  68. pmc Cardiovascular molecular imaging: the road ahead
    Maulik D Majmudar
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Nucl Med 53:673-6. 2012
    ..This review addresses recent work on radionuclide imaging of cardiovascular inflammation, infection, and infarct healing. We further discuss opportunities provided by multimodality approaches such as PET/MRI and PET/optical imaging...
  69. doi request reprint Science to practice: how will myocardial inflammation be imaged with MR imaging?
    David E Sosnovik
    Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Radiology 264:309-11. 2012
    ..The approach described by Naresh et al adds a valuable tool to the preclinical molecular imaging armamentarium...
  70. pmc Magnetic nanoparticles for MR imaging: agents, techniques and cardiovascular applications
    David E Sosnovik
    Center for Molecular Imaging Research, Massachusetts General Hospital, 149 13th Street, Charlestown, MA, 02129, USA
    Basic Res Cardiol 103:122-30. 2008
    ..First generation MNP are already in clinical use and second generation agents, with longer blood half lives, are likely to be approved for routine clinical use in the near future...
  71. pmc Targeted imaging of myocardial damage
    David E Sosnovik
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, MA 02129, USA
    Nat Clin Pract Cardiovasc Med 5:S63-70. 2008
    ..The use of targeted imaging agents in the myocardium has the potential to provide valuable insights into the pathophysiology of myocardial injury and to facilitate the development of novel therapeutic strategies...
  72. pmc Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure
    Filip K Swirski
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA
    Science 339:161-6. 2013
    ..Leukocytes (white blood cells) are important participants at the various stages of cardiovascular disease progression and complication. This Review will discuss leukocyte function in atherosclerosis, MI, and heart failure...
  73. ncbi request reprint Cardiac MRI in mice at 9.4 Tesla with a transmit-receive surface coil and a cardiac-tailored intensity-correction algorithm
    David E Sosnovik
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Magn Reson Imaging 26:279-87. 2007
    ..To evaluate the use of a transmit-receive surface (TRS) coil and a cardiac-tailored intensity-correction algorithm for cardiac MRI in mice at 9.4 Tesla (9.4T)...
  74. ncbi request reprint Magnetic resonance imaging of cardiomyocyte apoptosis with a novel magneto-optical nanoparticle
    David E Sosnovik
    Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Magn Reson Med 54:718-24. 2005
    ..1 versus 1.1, P<0.01). This study thus demonstrates the feasibility of obtaining high-resolution MR images of cardiomyocyte apoptosis in vivo with the novel nanoparticle, AnxCLIO-Cy5.5...
  75. doi request reprint Science to practice: will magnetic guidance of microbubbles play a role in clinical molecular imaging?
    Matthias Nahrendorf
    Center for Systems Biology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Radiology 260:309-10. 2011
    ....
  76. ncbi request reprint The ins and outs of inflammatory cells in atheromata
    Filip K Swirski
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Cell Metab 15:135-6. 2012
    ..Recent work in Nature Immunology (van Gils et al., 2012) demonstrates that the neuroimmune guidance cue netrin-1 can retain macrophages in atherosclerotic lesions, thus promoting atherosclerosis...
  77. pmc Molecular imaging of coronary atherosclerosis and myocardial infarction: considerations for the bench and perspectives for the clinic
    Florian Leuschner
    Center for Systems Biology, 185 Cambridge St, Boston, MA 02114, USA
    Circ Res 108:593-606. 2011
    ..Practical considerations stress the potential of fluorescence imaging for basic research and discuss hybrid protocols such as FMT-CT and PET-MRI...
  78. ncbi request reprint Multimodal functional cardiac MRI in creatine kinase-deficient mice reveals subtle abnormalities in myocardial perfusion and mechanics
    Matthias Nahrendorf
    Medizinische Klinik und Poliklinik 1, Universitat Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Am J Physiol Heart Circ Physiol 290:H2516-21. 2006
    ..The myocardium in CK-deficient mice is characterized by reduced perfusion and reduced maximal contraction velocity, suggesting that the myocardial hypertrophy seen in these mice cannot fully compensate for the absence of the CK system...
  79. pmc Factor XIII deficiency causes cardiac rupture, impairs wound healing, and aggravates cardiac remodeling in mice with myocardial infarction
    Matthias Nahrendorf
    Medizinische Klinik und Poliklinik I, Universitat Wurzburg, Wurzburg, Germany
    Circulation 113:1196-202. 2006
    ..We hypothesized that clotting factor XIII (FXIII), a transglutaminase involved in wound healing, may play an important role in MI given prior clinical and mouse model data...
  80. ncbi request reprint Effect of transmyocardial laser revascularization on myocardial perfusion and left ventricular remodeling after myocardial infarction in rats
    Matthias Nahrendorf
    Physikalisches Institut EP5, Universitat Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Radiology 225:487-93. 2002
    ..To monitor perfusion changes in remote myocardium caused by transmyocardial laser revascularization (TMLR) and to investigate the influence of TMLR on left ventricular morphology and function...
  81. ncbi request reprint Impact of hydroxymethylglutaryl coenzyme a reductase inhibition on left ventricular remodeling after myocardial infarction: an experimental serial cardiac magnetic resonance imaging study
    Matthias Nahrendorf
    Medizinische Universitatsklinik, University of Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    J Am Coll Cardiol 40:1695-700. 2002
    ....
  82. ncbi request reprint Time course of right ventricular remodeling in rats with experimental myocardial infarction
    Matthias Nahrendorf
    Department of Internal Medicine, 97080 Wurzburg, Germany
    Am J Physiol Heart Circ Physiol 284:H241-8. 2003
    ..Because RV wall stress was not increased after infarction, mechanical factors may not conclusively explain hypertrophy, which maintained balanced loading conditions for the RV even after large LV infarction...
  83. ncbi request reprint In vivo time-resolved quantitative motion mapping of the murine myocardium with phase contrast MRI
    Jörg U G Streif
    Physikalisches Institut, Lehrstuhl für Experimentelle Physik V Biophysik, Universitat Wurzburg, Am Hubland, Wurzburg, Germany
    Magn Reson Med 49:315-21. 2003
    ..Areas with myocardial infarction were clearly segmented and showed a motion velocity which was significantly reduced. In conclusion, the method is an accurate technique for the assessment of murine myocardial motion in vivo...
  84. ncbi request reprint Novel insights into LV remodeling after murine myocardial infarction by in vivo magnetic resonance tissue velocity mapping
    Frank Wiesmann
    Department of Medicine, University of Wuerzburg, Germany
    Int J Cardiovasc Imaging 20:289-91. 2004
  85. ncbi request reprint Effect of testosterone on post-myocardial infarction remodeling and function
    Matthias Nahrendorf
    Medical University Hospital Wuerzburg, Josef Schneider Strasse 2, 97080 Wuerzburg, Germany
    Cardiovasc Res 57:370-8. 2003
    ..Moreover, testosterone (T) treatment is increasingly used in elderly males. Therefore, we examined effects of chronic anabolic T administration on left ventricular (LV) remodeling after myocardial infarction (MI)...
  86. doi request reprint Diversity of denizens of the atherosclerotic plaque: not all monocytes are created equal
    Peter Libby
    Circulation 117:3168-70. 2008
  87. ncbi request reprint Chronic coronary artery stenosis induces impaired function of remote myocardium: MRI and spectroscopy study in rat
    Matthias Nahrendorf
    Physikalisches Institut, Universitat Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Am J Physiol Heart Circ Physiol 285:H2712-21. 2003
    ..Function of the remote region was affected as well. The fusion of PCr metabolite maps and the coronary angiogram may help to assess coronary morphology and resulting metabolic changes simultaneously...
  88. ncbi request reprint Microvascular adaptation to coronary stenosis in the rat heart in vivo: a serial magnetic resonance imaging study
    Christiane Waller
    Medizinische Universitatsklinik, Wurzburg, Germany
    Microvasc Res 66:173-82. 2003
    ..RBV remains constant in order to maintain blood supply. These functional changes reflect adaptive processes that may compensate for ischemic tissue loss...
  89. ncbi request reprint Creatine kinase knockout mice show left ventricular hypertrophy and dilatation, but unaltered remodeling post-myocardial infarction
    Matthias Nahrendorf
    Medizinische Universitätsklinik Würzburg, Universitat Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Cardiovasc Res 65:419-27. 2005
    ..Our hypothesis was that ablation of CK isoenzymes leads to cardiac hypertrophy, impaired function, and aggravation of left ventricular remodeling post-myocardial infarction...
  90. ncbi request reprint In vivo assessment of absolute perfusion and intracapillary blood volume in the murine myocardium by spin labeling magnetic resonance imaging
    Jörg U G Streif
    Physikalisches Institut, Lehrstuhl für Experimentelle Physik V Biophysik, Universitat Wurzburg, Am Hubland, 97074 Wurzburg, Germany
    Magn Reson Med 53:584-92. 2005
    ....
  91. ncbi request reprint Volume catheter parallel conductance varies between end-systole and end-diastole
    Chia Ling Wei
    Department of Electrical Engineering, National Cheng Kung University, No 1 University Road, Tainan 70101, Taiwan
    IEEE Trans Biomed Eng 54:1480-9. 2007
    ..Finally, we propose a new method to determine the instantaneous myocardial contribution to the measured left ventricular admittance that does not require saline injection or other intervention to calibrate...
  92. ncbi request reprint Assessment of cardiovascular apoptosis in the isolated rat heart by magnetic resonance molecular imaging
    Karl Heinz Hiller
    Universität Wuerzburg, Germany
    Mol Imaging 5:115-21. 2006
    ....
  93. ncbi request reprint The estrogen receptor-alpha agonist 16alpha-LE2 inhibits cardiac hypertrophy and improves hemodynamic function in estrogen-deficient spontaneously hypertensive rats
    Theo Pelzer
    Department of Medicine, University of Wurzburg, Josef Schneider Str 2, D 97080 Wurzburg, Germany
    Cardiovasc Res 67:604-12. 2005
    ..Therefore, we analyzed myocardial hypertrophy as well as cardiac function and gene expression in ovariectomized, spontaneously hypertensive rats (SHR) treated with the subtype-selective ERalpha agonist 16alpha-LE2 or 17beta-estradiol...

Research Grants4

  1. Imaging of Cardiac Transplant Rejection
    Matthias Nahrendorf; Fiscal Year: 2009
    ..We will first investigate and then exploit the role of macrophages, increasingly appreciated to contribute to rejection, as imaging targets. The approach will be tested in several therapy trials. ..
  2. Cluster Imaging of Emerging Biomarker Networks in Wound Healing
    Matthias Nahrendorf; Fiscal Year: 2009
    ....
  3. Imaging of Cardiac Transplant Rejection
    Matthias Nahrendorf; Fiscal Year: 2010
    ..We will first investigate and then exploit the role of macrophages, increasingly appreciated to contribute to rejection, as imaging targets. The approach will be tested in several therapy trials. ..
  4. Cluster Imaging of Emerging Biomarker Networks in Wound Healing
    Matthias Nahrendorf; Fiscal Year: 2010
    ....