Matthias Nahrendorf

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. Nahrendorf M, Swirski F. Lifestyle effects on hematopoiesis and atherosclerosis. Circ Res. 2015;116:884-94 pubmed publisher
  2. Dutta P, Hoyer F, Grigoryeva L, Sager H, Leuschner F, Courties G, et al. Macrophages retain hematopoietic stem cells in the spleen via VCAM-1. J Exp Med. 2015;212:497-512 pubmed publisher
  3. Nahrendorf M, Swirski F. Innate immune cells in ischaemic heart disease: does myocardial infarction beget myocardial infarction?. Eur Heart J. 2016;37:868-72 pubmed publisher
    ..That blood leucocytosis closely associates with cardiovascular mortality provides a strong motivation to understand why and how organ ischaemia alters cellular immunity. ..
  4. Sager H, Hulsmans M, Lavine K, Moreira M, Heidt T, Courties G, et al. Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure. Circ Res. 2016;119:853-64 pubmed publisher
    ..4±2.4 versus 19.1±2%; P<0.05). Myocardial failure is influenced by an altered myeloid cell repertoire. ..
  5. Swirski F, Nahrendorf M. Cardioimmunology: the immune system in cardiac homeostasis and disease. Nat Rev Immunol. 2018;18:733-744 pubmed publisher
    ..Under some circumstances, immune cells can cause irreversible damage, contributing to heart failure. This Review focuses on the role of the immune system in the heart under both homeostatic and perturbed conditions. ..
  6. Herisson F, Frodermann V, Courties G, Rohde D, Sun Y, Vandoorne K, et al. Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration. Nat Neurosci. 2018;21:1209-1217 pubmed publisher
    ..These observations point to a direct local interaction between the brain and the skull bone marrow through the meninges. ..
  7. Schloss M, Nahrendorf M. Some Macrophages Are Softies. Immunity. 2018;49:199-201 pubmed publisher
    ..In this issue of Immunity, Lim et al. (2018) describe that aortic LYVE-1+ macrophages regulate steady-state arterial matrix content by interacting with smooth muscle cells and collagen. ..
  8. Courties G, Herisson F, Sager H, Heidt T, Ye Y, Wei Y, et al. Ischemic stroke activates hematopoietic bone marrow stem cells. Circ Res. 2015;116:407-17 pubmed publisher
    ..74±0.33, P=0.51). Ischemic stroke activates hematopoietic stem cells via increased sympathetic tone, leading to a myeloid bias of hematopoiesis and higher bone marrow output of inflammatory Ly6C(high) monocytes and neutrophils. ..
  9. Nahrendorf M. Myeloid cell contributions to cardiovascular health and disease. Nat Med. 2018;24:711-720 pubmed publisher
    ..Here I review how new clinical and preclinical data, often linking the cardiovascular, immune and other organ systems, propel conceptual advances to a point where cardiovascular immunotherapy appears within reach. ..

More Information

Publications26

  1. Ye Y, Calcagno C, Binderup T, Courties G, Keliher E, Wojtkiewicz G, et al. Imaging Macrophage and Hematopoietic Progenitor Proliferation in Atherosclerosis. Circ Res. 2015;117:835-45 pubmed publisher
    ..18)F-FLT positron emission tomography imaging may serve as an imaging biomarker for cell proliferation in plaque and hematopoietic activity in individuals with atherosclerosis. ..
  2. Nahrendorf M, Sosnovik D, Chen J, Panizzi P, Figueiredo J, Aikawa E, et al. Activatable magnetic resonance imaging agent reports myeloperoxidase activity in healing infarcts and noninvasively detects the antiinflammatory effects of atorvastatin on ischemia-reperfusion injury. Circulation. 2008;117:1153-60 pubmed publisher
    ..This approach allows noninvasive evaluation of the inflammatory response to ischemia and has the potential to guide the development of novel cardioprotective therapies. ..
  3. Nahrendorf M, Sosnovik D, French B, Swirski F, Bengel F, Sadeghi M, et al. Multimodality cardiovascular molecular imaging, Part II. Circ Cardiovasc Imaging. 2009;2:56-70 pubmed publisher
  4. Nahrendorf M, Sosnovik D, Weissleder R. MR-optical imaging of cardiovascular molecular targets. Basic Res Cardiol. 2008;103:87-94 pubmed publisher
    ..We discuss strengths and limitations of respective imaging technologies, and comment on the potential of multi-modality imaging approaches. ..
  5. Davis R, Brannen A, Hossain M, MONSMA S, Bock P, Nahrendorf M, et al. Complete genome of Staphylococcus aureus Tager 104 provides evidence of its relation to modern systemic hospital-acquired strains. BMC Genomics. 2016;17:179 pubmed publisher
    ..Tager 104 represents an early-branching ancestor of certain hospital-acquired strains. Combined with its earlier isolation date and limited content of MGE, Tager 104 can serve as a viable reference for future comparative genome studies. ..
  6. Dutta P, Hoyer F, Sun Y, Iwamoto Y, Tricot B, Weissleder R, et al. E-Selectin Inhibition Mitigates Splenic HSC Activation and Myelopoiesis in Hypercholesterolemic Mice With Myocardial Infarction. Arterioscler Thromb Vasc Biol. 2016;36:1802-8 pubmed publisher
    ..Inhibiting E-selectin attenuated inflammation in atherosclerotic plaques, likely by reducing leukocyte recruitment into plaques and by mitigating hematopoietic stem and progenitor cell activation in the spleen of mice with MI. ..
  7. Hulsmans M, Sager H, Roh J, Valero Muñoz M, Houstis N, Iwamoto Y, et al. Cardiac macrophages promote diastolic dysfunction. J Exp Med. 2018;215:423-440 pubmed publisher
    ..Deletion of IL-10 in macrophages improves diastolic function. These data imply expansion and phenotypic changes of cardiac macrophages as therapeutic targets for cardiac fibrosis leading to diastolic dysfunction. ..
  8. Hulsmans M, Sam F, Nahrendorf M. Monocyte and macrophage contributions to cardiac remodeling. J Mol Cell Cardiol. 2016;93:149-55 pubmed publisher
    ..Finally, we highlight their potential role as therapeutic targets. ..
  9. Honold L, Nahrendorf M. Resident and Monocyte-Derived Macrophages in Cardiovascular Disease. Circ Res. 2018;122:113-127 pubmed publisher
    ..Here, we discuss the ontogeny, function, and interplay of tissue-resident and monocyte-derived macrophages in various organs contributing to the development and progression of cardiovascular disease. ..
  10. Dutta P, Sager H, Stengel K, Naxerova K, Courties G, Saez B, et al. Myocardial Infarction Activates CCR2(+) Hematopoietic Stem and Progenitor Cells. Cell Stem Cell. 2015;16:477-87 pubmed publisher
    ..Together, these data provide insights into regulation of emergency hematopoiesis after ischemic injury and identify potential therapeutic targets to modulate leukocyte output after MI. ..
  11. Sager H, Heidt T, Hulsmans M, Dutta P, Courties G, Sebas M, et al. Targeting Interleukin-1β Reduces Leukocyte Production After Acute Myocardial Infarction. Circulation. 2015;132:1880-90 pubmed publisher
    ..The presented insight into post-MI bone marrow activation identifies a mechanistic target for muting inflammation in the ischemically damaged heart. ..
  12. Heidt T, Courties G, Dutta P, Sager H, Sebas M, Iwamoto Y, et al. Differential contribution of monocytes to heart macrophages in steady-state and after myocardial infarction. Circ Res. 2014;115:284-95 pubmed publisher
    ..These data correspond with previous studies on tissue-resident macrophages and raise important questions on the fate and function of macrophages during the development of heart failure. ..
  13. Nahrendorf M, Swirski F. Monocyte and macrophage heterogeneity in the heart. Circ Res. 2013;112:1624-33 pubmed publisher
    ..This review discusses current concepts of lineage relationships and crosstalk of systems, highlights open questions, and describes tools for studying monocyte and macrophage subsets in the murine and human heart...
  14. Majmudar M, Keliher E, Heidt T, Leuschner F, Truelove J, Sena B, et al. Monocyte-directed RNAi targeting CCR2 improves infarct healing in atherosclerosis-prone mice. Circulation. 2013;127:2038-46 pubmed publisher
    ..05). CCR2-targeted RNAi reduced recruitment of Ly-6C(high) monocytes, attenuated infarct inflammation, and curbed post-MI left ventricular remodeling. ..
  15. Courties G, Heidt T, Sebas M, Iwamoto Y, Jeon D, Truelove J, et al. In vivo silencing of the transcription factor IRF5 reprograms the macrophage phenotype and improves infarct healing. J Am Coll Cardiol. 2014;63:1556-66 pubmed publisher
    ..05). This work identified a new therapeutic avenue to augment resolution of inflammation in healing infarcts by macrophage phenotype manipulation. This therapeutic concept may be used to attenuate post-MI remodeling and heart failure. ..
  16. Vandoorne K, Nahrendorf M. Multiparametric Imaging of Organ System Interfaces. Circ Cardiovasc Imaging. 2017;10: pubmed publisher
    ..As the opportunities provided by imaging expand, mapping interconnected systems will help us decipher the complexity of cardiovascular disease and monitor novel therapeutic strategies. ..
  17. Hulsmans M, Clauss S, Xiao L, Aguirre A, King K, Hanley A, et al. Macrophages Facilitate Electrical Conduction in the Heart. Cell. 2017;169:510-522.e20 pubmed publisher
    ..In the Cd11bDTR mouse, macrophage ablation induces progressive atrioventricular block. These observations implicate macrophages in normal and aberrant cardiac conduction. ..