Michael A Myre
Affiliation: Harvard University
- Clues to γ-secretase, huntingtin and Hirano body normal function using the model organism Dictyostelium discoideumMichael A Myre
Molecular Neurogenetics Unit, Center for Human Genetic Research, Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
J Biomed Sci 19:41. 2012....
- Reduced amyloidogenic processing of the amyloid beta-protein precursor by the small-molecule Differentiation Inducing Factor-1Michael A Myre
Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Cell Signal 21:567-76. 2009..Our findings suggest that DIF-1 affects G0/G1-associated amyloidogenic processing of APP by a gamma-secretase-, proteasome- and calpain-insensitive pathway, and that this effect requires the presence of residue Thr668...
- Deficiency of huntingtin has pleiotropic effects in the social amoeba Dictyostelium discoideumMichael A Myre
Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America
PLoS Genet 7:e1002052. 2011..Thus, Dictyostelium provides a novel haploid organism model for genetic, cell biological, and biochemical studies to delineate the functions of the HD protein...