Research Topics
Species | George MutterSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
The spectrum of endometrial pathology induced by progesterone receptor modulatorsGeorge L Mutter
Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
Mod Pathol 21:591-8. 2008..The panel has designated these changes as PRM-associated endometrial changes (PAEC). Additional follow-up studies will be needed to fully define their natural history and relationship to specific agents and administration regimens...- Squamous morules are functionally inert elements of premalignant endometrial neoplasiaMing Chieh Lin
Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
Mod Pathol 22:167-74. 2009..Even isolated morules should be carefully followed, however, to exclude a coexisting undersampled, or occult, glandular lesion... - Endometrial intraepithelial neoplasia (EIN): will it bring order to chaos? The Endometrial Collaborative GroupG L Mutter
Harvard Medical School, Division of Women s and Perinatal Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
Gynecol Oncol 76:287-90. 2000..Implementation of this proposal will bring diagnostic terminology into agreement with current concepts of premalignant endometrial disease and facilitate more uniform patient management... - Biopsy histomorphometry predicts uterine myoinvasion by endometrial carcinoma: a Gynecologic Oncology Group studyGeorge L Mutter
Department of Pathology, BDivision of Women s and Perinatal Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
Hum Pathol 39:866-74. 2008.... - Comparison of frozen and RNALater solid tissue storage methods for use in RNA expression microarraysGeorge L Mutter
Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
BMC Genomics 5:88. 2004..frozen vs. 24 or 72 hours RNALater), and random background (duplicates). The dataset was randomly permuted to define a baseline pattern of ANOVA test statistic values against which the observed results could be interpreted... - Benign endometrial hyperplasia sequence and endometrial intraepithelial neoplasiaGeorge L Mutter
Department of Pathology at Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Int J Gynecol Pathol 26:103-14. 2007.... - Diagnosis of premalignant endometrial diseaseG L Mutter
Department of Pathology, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
J Clin Pathol 55:326-31. 2002..Specialised molecular and morphometric analyses have been extremely useful in redefining clinically relevant premalignant endometrial disease, but translation to improved patient care requires the informed participation of pathologists... - Global expression changes of constitutive and hormonally regulated genes during endometrial neoplastic transformationG L Mutter
Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Gynecol Oncol 83:177-85. 2001..We used large-scale messenger RNA expression analysis to discover genes that distinguish neoplastic transformation and examine the patterns of tumor expression of those genes which are normally regulated during the menstrual cycle... - Molecular identification of latent precancers in histologically normal endometriumG L Mutter
Department of Pathology, Brigham and Women s Hospital, 75Francis Street, Boston, MA 02115, USA
Cancer Res 61:4311-4. 2001..Histopathology of PTEN-null glands is initially unremarkable, but with progression, they form distinctive high-density clusters. These data are consistent with a progression model in which initial mutation is not rate limiting... - Changes in endometrial PTEN expression throughout the human menstrual cycleG L Mutter
Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Clin Endocrinol Metab 85:2334-8. 2000.... - Altered PTEN expression as a diagnostic marker for the earliest endometrial precancersG L Mutter
Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
J Natl Cancer Inst 92:924-30. 2000..Testing the hypothesis that altered PTEN function precedes the appearance of endometrial adenocarcinoma has been difficult, however, partly because of uncertainties in precancer diagnosis... - K-ras mutations appear in the premalignant phase of both microsatellite stable and unstable endometrial carcinogenesisG L Mutter
Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
Mol Pathol 52:257-62. 1999..The distribution of k-ras mutations in microsatellite stable and unstable premalignant lesions was studied to determine whether this gene is implicated in both tumorigenic pathways... - Molecular pathogenesis of uterine smooth muscle tumors from transcriptional profilingBradley J Quade
Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Genes Chromosomes Cancer 40:97-108. 2004..These genes define a tumor signature for uterine smooth muscle neoplasia, and they suggest that the molecular pathways in leiomyoma and leiomyosarcoma are distinct... - Endometrial changes from short-term therapy with CDB-4124, a selective progesterone receptor modulatorOlga B Ioffe
Department of Pathology, University of Maryland, Baltimore, MD, USA
Mod Pathol 22:450-9. 2009..Knowledge of the constellation of endometrial changes associated with this agent and other progesterone receptor modulators, including cystic architecture and mixed non-physiologic epithelial changes will prevent misdiagnosis... - Molecular and pathologic aspects of endometrial carcinogenesisJonathan L Hecht
Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
J Clin Oncol 24:4783-91. 2006..This article reviews the genetic aspects of endometrial carcinogenesis and progression. We will define the precursor lesion of type I endometrioid cancer and the role of genetics and estrogen in its progression... - Prediction of endometrial carcinoma by subjective endometrial intraepithelial neoplasia diagnosisJonathan L Hecht
Department of Pathology, Beth Israel Hospital, Boston, MA 02115, USA
Mod Pathol 18:324-30. 2005.... - Histologic and immunohistochemical decision-making in endometrial adenocarcinomaLesley Lomo
Department of Pathology, Division of Women s and Perinatal Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
Mod Pathol 21:937-42. 2008..Because p53 is an important marker for endometrial adenocarcinoma outcome, and cannot be predicted in advance in indeterminate cases, p53 immunostaining should be employed in cases with observer disagreement in a binary system... - Evidence for a latent precursor (p53 signature) that may precede serous endometrial intraepithelial carcinomaElke A Jarboe
Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
Mod Pathol 22:345-50. 2009..The significance of p53 signatures in benign conditions (polyps) remains to be determined. The role of the p53 signature in early serous neoplasia is discussed... - Estradiol-induced hyperplasia in endometrial biopsies from women on hormone replacement therapyThomas C Wright
Department of Pathology, Columbia University Presbiterian Medical Center, New York, New York 10032, USA
Am J Surg Pathol 26:1269-75. 2002 - Hertig and beyond: a systematic and practical approach to the endometrial biopsyChristopher P Crum
Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Adv Anat Pathol 10:301-18. 2003..Algorithms for the laboratory management of cyclic changes, dysfunctional bleeding, and mixed-pattern endometria are provided, as are pitfalls in interpretation and exclusion of neoplasia... - Involution of PTEN-null endometrial glands with progestin therapyWenxin Zheng
Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA
Gynecol Oncol 92:1008-13. 2004..This effect occurs among PTEN-null glands having a variety of histopathologic presentations... - Joint loss of PAX2 and PTEN expression in endometrial precancers and cancerNicolas M Monte
Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Cancer Res 70:6225-32. 2010..Loss of function of both genes in an overlapping distribution characterizes the clinical emergence of a premalignant lesion which is carried forward to carcinoma... - Secretory cell outgrowth, PAX2 and serous carcinogenesis in the Fallopian tubeEleanor Y Chen
Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
J Pathol 222:110-6. 2010.... - Coexisting intraepithelial serous carcinomas of the endometrium and fallopian tube: frequency and potential significanceElke A Jarboe
Department of Pathology, Division of Women s and Perinatal Pathology, Brigham and Women s Hospital, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
Int J Gynecol Pathol 28:308-15. 2009.... - Biomarkers in diagnostic obstetric and gynecologic pathology: a reviewMarisa R Nucci
Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachussetts 02115, USA
Adv Anat Pathol 10:55-68. 2003.... - Identification of differentially expressed genes in high-density oligonucleotide arrays accounting for the quantification limits of the technologyMahlet G Tadesse
Department of Statistics, Texas A and M University, College Station, Texas, USA
Biometrics 59:542-54. 2003..We examine the performance of our proposed method on simulated data, then present a detailed case study of an endometrial cancer dataset... - Risk of subsequent endometrial carcinoma associated with endometrial intraepithelial neoplasia classification of endometrial biopsiesJames V Lacey
Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852 7234, USA
Cancer 113:2073-81. 2008..The authors estimated progression risk associated with EIN among endometrial biopsies in a nested case-control study of EH progression... - PTEN expression in endometrial biopsies as a marker of progression to endometrial carcinomaJames V Lacey
Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA
Cancer Res 68:6014-20. 2008..Loss of PTEN expression in endometrial biopsies was neither associated with nor a sensitive and specific marker of subsequent progression to endometrial carcinoma... - Regression of latent endometrial precancers by progestin infiltrated intrauterine deviceAnne Ørbo
Department of Pathology, University of Tromso, Tromso, Norway
Cancer Res 66:5613-7. 2006.... - Combined total genome loss of heterozygosity scan of breast cancer stroma and epithelium reveals multiplicity of stromal targetsKoichi Fukino
Clinical Cancer Genetics Program, Division of Human Cancer Genetics, Department of Molecular Virology, Immunology, and Medical Genetics, School of Public Health, The Ohio State University, Columbus, Ohio, USA
Cancer Res 64:7231-6. 2004..Genetic alterations in stroma did not mimic those in epithelium, but they could play a different and parallel role in carcinogenesis and tumor progression, probably by modifying some features specific to breast cancer... - The molecular genetics and morphometry-based endometrial intraepithelial neoplasia classification system predicts disease progression in endometrial hyperplasia more accurately than the 1994 World Health Organization classification systemJan P Baak
Department of Pathology, Stavanger University Hospital, Stavanger, Norway
Cancer 103:2304-12. 2005.... - Lack of PTEN expression in endometrial intraepithelial neoplasia is correlated with cancer progressionJan Pieter Albert Baak
Department of Pathology, Stavanger University Hospital, Norway
Hum Pathol 36:555-61. 2005..Unless endometrial hyperplasias are stratified by histological morphometric D-Score, PTEN has a low positive predictive value... - Breast-cancer stromal cells with TP53 mutations and nodal metastasesAttila Patocs
Genomic Medicine Institute, Cleveland Clinic Foundation, Cleveland 44195, USA
N Engl J Med 357:2543-51. 2007..We hypothesized that mutational inactivation of the tumor-suppressor gene TP53 and genomic alterations in stromal cells of a tumor's microenvironment contribute to the clinical outcome... - Genomic instability within tumor stroma and clinicopathological characteristics of sporadic primary invasive breast carcinomaKoichi Fukino
Genomic Medicine Institute, Lerner Research Institute and Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
JAMA 297:2103-11. 2007..That genomic alterations occur in both the epithelium and stroma of sporadic breast cancers has been documented by several groups. However, whether these microenvironmental alterations relate to clinicopathological features is unknown... - p63 Coordinates anogenital modeling and epithelial cell differentiation in the developing female urogenital tractTan A Ince
Department of Pathology, Division of Women s and Perinatal Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Pathol 161:1111-7. 2002..The second is necessary for the generation of multipotential reserve cells in the cervix and may be operative in other epithelial stromal interactions integral to the emergence of uterine basal cells later in life... - Precancer: a conceptual working definition -- results of a Consensus ConferenceJules J Berman
Cancer Diagnosis Program, National Cancer Institute, NIH, Bethesda, MD, USA
Cancer Detect Prev 30:387-94. 2006..This manuscript reviews the proposed definition of precancers and suggests how pathologists, oncologists and cancer researchers may determine when these criteria are satisfied... - Total-genome analysis of BRCA1/2-related invasive carcinomas of the breast identifies tumor stroma as potential landscaper for neoplastic initiationFrank Weber
Genomic Medicine Institute, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195, USA
Am J Hum Genet 78:961-72. 2006....
Research Grants
- Biomarkers and Chemoprevention of Endometrial CancerGeorge Mutter; Fiscal Year: 2006..If successful, we will be able to rapidly implement a rational and effective strategy for early detection and chemoprevention of endometrial carcinoma. ..
- Hormonal modulation of latent endometrial precancersGeorge Mutter; Fiscal Year: 2007..If our hypothesis is confirmed, this project will establish biomarker-detectable preclinical disease as a surrogate marker for risk surveillance, and a potential target for cancer preventative therapies. ..