Venkatesh Murthy

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Synaptic vesicles
    William J Tyler
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Curr Biol 14:R294-7. 2004
  2. pmc Calcium dynamics during fertilization in C. elegans
    A D Samuel
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA
    BMC Dev Biol 1:8. 2001
  3. ncbi request reprint Optical detection of synaptic vesicle exocytosis and endocytosis
    V N Murthy
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Curr Opin Neurobiol 9:314-20. 1999
  4. doi request reprint Olfactory maps in the brain
    Venkatesh N Murthy
    Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA
    Annu Rev Neurosci 34:233-58. 2011
  5. ncbi request reprint Cell biology of the presynaptic terminal
    Venkatesh N Murthy
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Annu Rev Neurosci 26:701-28. 2003
  6. pmc Dynamics of dendritic calcium transients evoked by quantal release at excitatory hippocampal synapses
    V N Murthy
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 97:901-6. 2000
  7. ncbi request reprint Synaptic gain control and homeostasis
    Juan Burrone
    Department of Molecular and Cellular Biology, 16 Divinity Avenue, Harvard University, Cambridge, MA 02138, USA
    Curr Opin Neurobiol 13:560-7. 2003
  8. ncbi request reprint Multiple forms of synaptic plasticity triggered by selective suppression of activity in individual neurons
    Juan Burrone
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 420:414-8. 2002
  9. ncbi request reprint Synaptic activity of the AFD neuron in Caenorhabditis elegans correlates with thermotactic memory
    Aravinthan D T Samuel
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Neurosci 23:373-6. 2003
  10. pmc Real-time imaging of Rab3a and Rab5a reveals differential roles in presynaptic function
    Erin N Star
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    J Physiol 569:103-17. 2005

Research Grants

  1. SYNAPTIC VESICLE TRAFFICKING IN HIPPOCAMPAL SYNAPSES
    Venkatesh Murthy; Fiscal Year: 2007
  2. SYNAPTIC VESICLE TRAFFICKING IN HIPPOCAMPAL SYNAPSES
    Venkatesh N Murthy; Fiscal Year: 2010
  3. Optogenetic studies of mouse olfaction
    Venkatesh N Murthy; Fiscal Year: 2011

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Synaptic vesicles
    William J Tyler
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Curr Biol 14:R294-7. 2004
  2. pmc Calcium dynamics during fertilization in C. elegans
    A D Samuel
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA
    BMC Dev Biol 1:8. 2001
    ..Motivated by the experimental possibilities inherent in using such a well-established model organism, we have characterized fertilization-induced calcium dynamics in C. elegans...
  3. ncbi request reprint Optical detection of synaptic vesicle exocytosis and endocytosis
    V N Murthy
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Curr Opin Neurobiol 9:314-20. 1999
    ..Sensitive detection of exocytosis and endocytosis at individual synapses has advanced our knowledge of synaptic vesicle trafficking...
  4. doi request reprint Olfactory maps in the brain
    Venkatesh N Murthy
    Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA
    Annu Rev Neurosci 34:233-58. 2011
    ..Experiments and theory that relate the properties of odorant receptors to the detailed wiring diagram of the downstream olfactory circuits and to behaviors they trigger may reveal the design principles that have emerged during evolution...
  5. ncbi request reprint Cell biology of the presynaptic terminal
    Venkatesh N Murthy
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Annu Rev Neurosci 26:701-28. 2003
    ..Focusing our attention on the presynaptic terminal, we review the current understanding of how synaptic morphology is maintained and then the mechanisms in synaptic vesicle exocytosis and recycling...
  6. pmc Dynamics of dendritic calcium transients evoked by quantal release at excitatory hippocampal synapses
    V N Murthy
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 97:901-6. 2000
    ....
  7. ncbi request reprint Synaptic gain control and homeostasis
    Juan Burrone
    Department of Molecular and Cellular Biology, 16 Divinity Avenue, Harvard University, Cambridge, MA 02138, USA
    Curr Opin Neurobiol 13:560-7. 2003
    ..Recent studies have shed light on what triggers homeostatic synaptic plasticity, whether or not it is distinct from other forms of synaptic plasticity and whether or not it occurs in the intact brain...
  8. ncbi request reprint Multiple forms of synaptic plasticity triggered by selective suppression of activity in individual neurons
    Juan Burrone
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 420:414-8. 2002
    ..Our results highlight the differences between global and selective suppression of activity, as well as those between early and late manipulation of activity...
  9. ncbi request reprint Synaptic activity of the AFD neuron in Caenorhabditis elegans correlates with thermotactic memory
    Aravinthan D T Samuel
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Neurosci 23:373-6. 2003
    ..This suggests that AFD encodes a direct comparison between T(amb) and T(cult)...
  10. pmc Real-time imaging of Rab3a and Rab5a reveals differential roles in presynaptic function
    Erin N Star
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    J Physiol 569:103-17. 2005
    ..We propose that while Rab3a preferentially associates with recycling synaptic vesicles and modulates their trafficking, Rab5a is largely excluded from recycling vesicles...
  11. pmc Inhibition of dynamin completely blocks compensatory synaptic vesicle endocytosis
    A Jamila Newton
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 103:17955-60. 2006
    ..In sum, our data indicate that dynamin is essential for all forms of compensatory synaptic vesicle endocytosis including any kiss-and-run events...
  12. pmc Synaptic vesicle recycling studied in transgenic mice expressing synaptopHluorin
    Zhiying Li
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 102:6131-6. 2005
    ..We conclude that, at presynaptic terminals in the hippocampus, most vesicles vacate release sites after exocytosis and are replaced by existing vesicles from the reserve pool, placing constraints on kiss-and-run recycling...
  13. ncbi request reprint Experience-dependent modification of primary sensory synapses in the mammalian olfactory bulb
    William J Tyler
    Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA
    J Neurosci 27:9427-38. 2007
    ..Such compensatory experience-dependent changes may represent a mechanism of sensory gain control...
  14. ncbi request reprint Rapid turnover of actin in dendritic spines and its regulation by activity
    Erin N Star
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Ave, Cambridge, Massachusetts 02138, USA
    Nat Neurosci 5:239-46. 2002
    ..Our studies provide new information on the kinetics of actin turnover in spines, its regulation by neural activity and the mechanisms involved in this regulation...
  15. doi request reprint Serotonergic modulation of odor input to the mammalian olfactory bulb
    Gabor C Petzold
    Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA
    Nat Neurosci 12:784-91. 2009
    ..Our data indicate that the serotonergic system regulates odor inputs in the olfactory bulb and suggest that behavioral states may alter odor processing at the earliest stages...
  16. pmc Nanowire transistor arrays for mapping neural circuits in acute brain slices
    Quan Qing
    Department of Chemistry and Chemical Biology, Center for Brain Science, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 107:1882-7. 2010
    ..Our demonstration of simultaneous high temporal and spatial resolution recording, as well as mapping of functional connectivity, suggest that NWFETs can become a powerful platform for studying neural circuits in the brain...
  17. pmc Contrasting short-term plasticity at two sides of the mitral-granule reciprocal synapse in the mammalian olfactory bulb
    Shelby B Dietz
    Graduate Program in Neuroscience, Harvard Medical School, Boston, MA, USA
    J Physiol 569:475-88. 2005
    ..The observed short-term plasticity could enable mitral cells to overcome autoinhibition and increase action potential propagation along lateral dendrites by burst firing...
  18. ncbi request reprint Studying vesicle cycling in presynaptic terminals using the genetically encoded probe synaptopHluorin
    Juan Burrone
    MRC Center for Developmental Neurobiology, King s College London, London SE1 1UL, UK
    Nat Protoc 1:2970-8. 2006
    ..This technique can be easily adapted to study different classes of synapses from wild-type and mutant mice. Once cultured neurons expressing synaptopHluorin are available, the whole procedure should take about 2 h...

Research Grants11

  1. SYNAPTIC VESICLE TRAFFICKING IN HIPPOCAMPAL SYNAPSES
    Venkatesh Murthy; Fiscal Year: 2007
    ..Since synaptic transmission is adversely affected in many disorders of the nervous system, a better understanding of synaptic release mechanisms will provide a rational basis for treatment. ..
  2. SYNAPTIC VESICLE TRAFFICKING IN HIPPOCAMPAL SYNAPSES
    Venkatesh N Murthy; Fiscal Year: 2010
    ..These experiments will elucidate fundamental presynaptic mechanisms of vesicle traffic in GABAergic synapses and how they are altered by activity. ..
  3. Optogenetic studies of mouse olfaction
    Venkatesh N Murthy; Fiscal Year: 2011
    ..More generally, our studies also have direct implications for human health, since olfactory deficits have also been strongly associated with aging and some neurological diseases such as Alzheimer's. ..