Research Topics
| M M MurraySummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
Platelet-rich plasma alone is not sufficient to enhance suture repair of the ACL in skeletally immature animals: an in vivo studyMartha M Murray
Department of Orthopaedic Surgery, Children s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
J Orthop Res 27:639-45. 2009..Use of PRP alone to supplement suture repair of the ACL is ineffective in this animal model...
Collagen-platelet rich plasma hydrogel enhances primary repair of the porcine anterior cruciate ligamentMartha M Murray
Department of Orthopaedic Surgery, Children s Hospital Boston, 300 Longwood Avenue, Harvard Medical School, Boston, Massachusetts 02115, USA
J Orthop Res 25:81-91. 2007..Further studies to determine the long-term effect of primary repair enhancement are needed...- Use of a collagen-platelet rich plasma scaffold to stimulate healing of a central defect in the canine ACLMartha M Murray
Department of Orthopaedic Surgery, Children s Hospital of Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
J Orthop Res 24:820-30. 2006..02). Placement of a collagen-PRP bridging scaffold in a central ACL defect can stimulate healing of the ACL histologically and biomechanically... - The effect of thrombin on ACL fibroblast interactions with collagen hydrogelsM M Murray
Department of Orthopaedic Surgery, Children s Hospital of Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
J Orthop Res 24:508-15. 2006..Use of low concentrations of thrombin (10.5 IU/mL) may be beneficial in applications where a faster set time and enhanced cell migration are desirable and the gel mechanical strength is of secondary importance... - Current status and potential of primary ACL repairMartha M Murray
Department of Orthopaedic Surgery, Children s Hospital of Boston, Hunnewell 2, 300 Longwood Avenue, Boston, MA 02115, USA
Clin Sports Med 28:51-61. 2009..Subsequent work in this area may lead to the development of a novel approach to treat this important injury... - Bone-to-bone fixation enhances functional healing of the porcine anterior cruciate ligament using a collagen-platelet compositeMartha M Murray
Department of Orthopaedic Surgery, Children s Hospital Boston, Boston, Massachusetts 02115, USA
Arthroscopy 26:S49-57. 2010.... - The effect of skeletal maturity on functional healing of the anterior cruciate ligamentMartha M Murray
Department of Orthopaedic Surgery, Children s Hospital Boston, Hunnewell 2, 300 Longwood Avenue, Boston, MA 02115, USA
J Bone Joint Surg Am 92:2039-49. 2010..In this study, we hypothesized that skeletally immature animals have improved functional healing compared with skeletally mature animals... - Delay of 2 or 6 weeks adversely affects the functional outcome of augmented primary repair of the porcine anterior cruciate ligamentElise M Magarian
Department of Orthopaedic Surgery, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Sports Med 38:2528-34. 2010..Previous studies have evaluated this approach at the time of anterior cruciate ligament disruption... - Enhanced histologic repair in a central wound in the anterior cruciate ligament with a collagen-platelet-rich plasma scaffoldMartha M Murray
Department of Orthopaedic Surgery, Children s Hospital Boston, Harvard Medical School, 300 Longwood Ave, Boston, Massachusetts 02115, USA
J Orthop Res 25:1007-17. 2007..This study supports the hypothesis that premature scaffold failure may play a key role in the normally expected failure of the ACL to heal after injury... - Migration of cells from human anterior cruciate ligament explants into collagen-glycosaminoglycan scaffoldsM M Murray
Department of Orthopaedic Surgery, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Orthop Res 18:557-64. 2000.... 
Storage conditions do not have detrimental effect on allograft collagen or scaffold performanceE L Abreu
Department of Orthopaedic Surgery, Children s Hospital of Boston, 300 Longwood Ave, Enders 1022, Boston, MA 02115, USA
Cell Tissue Bank 10:333-40. 2009..In conclusion, this study suggests that freezing or refrigeration for 1 week does not appear to have any detrimental effect on the mechanical properties and biologic performance of the collagen within allografts...- Histological changes in the human anterior cruciate ligament after ruptureM M Murray
Department of Orthopaedic Surgery, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Bone Joint Surg Am 82:1387-97. 2000..The primary objective of this study was to determine the location and the characteristics of the alpha-smooth muscle actin-containing myofibroblast-like cells that appear in the human anterior cruciate ligament following rupture... - The migration of cells from the ruptured human anterior cruciate ligament into collagen-glycosaminoglycan regeneration templates in vitroM M Murray
Department of Orthopaedic Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
Biomaterials 22:2393-402. 2001..Moreover, the ACL-derived cells can express a contractile actin isoform and can contract a CG analog of extracellular matrix... - Injection temperature significantly affects in vitro and in vivo performance of collagen-platelet scaffoldsM P Palmer
Department of Orthopaedic Surgery, Children s Hospital Boston, 300 Longwood Avenue, Enders 1022, Boston, Massachusetts 02115, USA
J Orthop Res 27:964-71. 2009.... - Immature animals have higher cellular density in the healing anterior cruciate ligament than adolescent or adult animalsAshley N Mastrangelo
Department of Orthopaedic Surgery, Children s Hospital of Boston, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
J Orthop Res 28:1100-6. 2010..Animal age had a significant effect on the density of cells populating the ACL wound site. Whether this observed cellular difference has an effect on the later biomechanical function of the repaired ACL requires further study... - Collagen-platelet composite enhances biomechanical and histologic healing of the porcine anterior cruciate ligamentShilpa M Joshi
Department of, Orthopaedic Surgery, Children s Hospital Boston, Boston, MA 02115, USA
Am J Sports Med 37:2401-10. 2009..Furthermore, large-animal models have recently shown that 1-month functional ACL healing is augmented after suture repair when a bioactive scaffold is placed in the tear site... - Collagen density significantly affects the functional properties of an engineered provisional scaffoldEduardo L Abreu
Department of Orthopaedic Surgery, Children s Hospital of Boston, Boston, MA 02115, USA
J Biomed Mater Res A 93:150-7. 2010..These studies suggest that the collagen density may be able to significantly influence the function of collagen-platelet hydrogels used as substitute provisional scaffolds... - The effect of skeletal maturity on the regenerative function of intrinsic ACL cellsAshley N Mastrangelo
Department of Orthopaedic Surgery, Enders 1020, 300 Longwood Avenue, Children s Hospital, Boston, Boston, Machusetts 02115, USA
J Orthop Res 28:644-51. 2010..These experiments suggest that skeletal maturity may influence the biologic repair capacity of intrinsic ACL cells... - Fibrin concentration affects ACL fibroblast proliferation and collagen synthesisPatrick Vavken
Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
Knee 18:42-6. 2011..To enhance cell behavior and thus clinical results fibrin applications should build on physiologic or sub-physiologic concentrations, and those with higher concentrations, such as currently available sealants, should be used cautiously... - Age dependence of expression of growth factor receptors in porcine ACL fibroblastsPatrick Vavken
Sports Medicine Research Laboratory, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
J Orthop Res 28:1107-12. 2010..These findings suggest that the decrease in growth factor receptor expression as a likely reason for reduced PRP action with increasing age... - Increased blood lead levels in an adolescent girl from a retained bullet. A case reportSusan T Mahan
Department of Orthopaedic Surgery, Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
J Bone Joint Surg Am 88:2726-9. 2006 - TRITON-X is most effective among three decellularization agents for ACL tissue engineeringPatrick Vavken
Sports Medicine Research Laboratory, Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Enders 1016, Boston, Massachusetts 02115, USA
J Orthop Res 27:1612-8. 2009..Porcine ACL tissue after decellularization with TRITON-X could be successfully reseeded with human ACL fibroblasts as demonstrated by steady DNA content and increasing pro-collagen expression... - Platelets, but not erythrocytes, significantly affect cytokine release and scaffold contraction in a provisional scaffold modelMay Jacobson
CBR Institute for Biomedical Research, Harvard Medical School, Boston, Massachusetts, USA
Wound Repair Regen 16:370-8. 2008..Therefore, while platelets may be an important regulator of repair processes after injury, it is less likely that erythrocytes have a similar function... - Translational studies in anterior cruciate ligament repairPatrick Vavken
Sports Medicine Research Laboratory, Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
Tissue Eng Part B Rev 16:5-11. 2010.... - Strategies to improve anterior cruciate ligament healing and graft placementMark E Steiner
New England Baptist Hospital, Boston, Massachusetts, USA
Am J Sports Med 36:176-89. 2008..Although these biologic engineering strategies are currently experimental, they are projected for clinical application in the near future... - Activation of platelet-rich plasma using soluble type I collagenDuretti Fufa
Department of Orthopaedic Surgery, Harvard Medical School, Children s Hospital of Boston, Boston, MA 02115, USA
J Oral Maxillofac Surg 66:684-90. 2008..In this work, our hypothesis was that soluble type I collagen would be as effective as bovine thrombin in causing clotting of the PRP and stimulating growth factor release from the platelets and granulocytes... - Pathologic characteristics of the torn human meniscusMena Mesiha
Department of Orthopaedic Surgery, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
Am J Sports Med 35:103-12. 2007..Information that would help surgeons predict, preoperatively, or intraoperatively which torn menisci had few viable cells could be useful in deciding which patients might be at increased risk for retear and failure of surgical repair... - The presence of smooth muscle actin in fibroblasts in the torn human rotator cuffJ Premdas
Department of Orthopaedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
J Orthop Res 19:221-8. 2001..The results of the present study thus suggest that SMA-containing cells could contribute to the retraction of the torn ends of a ruptured rotator cuff and play an important role in healing... - Platelet activation by collagen provides sustained release of anabolic cytokinesSophia Harrison
Department of Orthopaedic Surgery, Children s Hospital of Boston, Massachusetts 02115, USA
Am J Sports Med 39:729-34. 2011..However, little is known about the effect of platelet activator choice on growth factor release kinetics... - Genome-wide expression analysis of intra- and extraarticular connective tissueRICHARD V PEARSE
Department of Genetics, Harvard Medical School, NRB 360, Boston, Massachusetts 02115, USA
J Orthop Res 27:427-34. 2009.... - Posterior periosteal disruption in Salter-Harris Type II fractures of the distal femur: evidence for a hyperextension mechanismSupika Kritsaneepaiboon
Department of Radiology, Section of Musculoskeletal Imaging, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
AJR Am J Roentgenol 193:W540-5. 2009.... - Can suture repair of ACL transection restore normal anteroposterior laxity of the knee? An ex vivo studyBraden C Fleming
Department of Orthopaedics, Warren Alpert Medical School of Brown University, CORO West, 1 Hoppin Street, Providence, Rhode Island 02903, USA
J Orthop Res 26:1500-5. 2008..Additional studies defining the changes in laxity with cyclic loading and in vivo healing are indicated... - In situ IGF-1 gene delivery to cells emerging from the injured anterior cruciate ligamentAndre F Steinert
Division of Gene Therapy, Orthopedic Center for Musculoskeletal Research, Orthopedic Clinic, König Ludwig Haus, Julius Maximilians University, Brettreichstrasse 11, D 97074 Wurzburg, Germany
Biomaterials 29:904-16. 2008..These data confirm the promise of using vector-laden hydrogels for the in situ delivery of genes to cells within damaged ligaments and suggest novel possibilities for the biological repair of the ACL... - The biomechanical response to doses of TGF-beta 2 in the healing rabbit medial collateral ligamentKurt P Spindler
Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, 2601 Jess Neely Drive, Nashville, TN 37212, USA
J Orthop Res 21:245-9. 2003..This study suggests the mechanical stiffness, but not the load at failure, of ligament scar can be significantly altered by the administration of TGF-beta 2...
Research Grants
- A Novel Mechanism for Intra-articular NonunionMartha M Murray; Fiscal Year: 2010....
- A Novel Mechanism for Intra-articular NonunionMartha Murray; Fiscal Year: 2007....
- The Effect of Age on Functional ACL HealingMartha Murray; Fiscal Year: 2007..New treatments are being developed, where the ligament is stimulated to heal instead of being replaced, and this project will enable us to determine whether children and adolescents will be good candidates for this new approach. ..
- Enhanced Primary Repair of Ligament InjuriesMartha Murray; Fiscal Year: 2007..In the third aim, the optimized scaffolds will be tested in an in vivo canine ACL non-union model. Information gained in each of these aims will serve to improve our understanding of mechanisms of ligament healing. ..
- The Effect of Age on Functional ACL HealingMartha M Murray; Fiscal Year: 2010..Success in this endeavor could improve the care of hundreds of thousands of adolescent and adult patients with ACL tears each year. ..