M M Murray

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Platelet-rich plasma alone is not sufficient to enhance suture repair of the ACL in skeletally immature animals: an in vivo study
    Martha M Murray
    Department of Orthopaedic Surgery, Children s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Orthop Res 27:639-45. 2009
  2. ncbi request reprint Collagen-platelet rich plasma hydrogel enhances primary repair of the porcine anterior cruciate ligament
    Martha M Murray
    Department of Orthopaedic Surgery, Children s Hospital Boston, 300 Longwood Avenue, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Orthop Res 25:81-91. 2007
  3. ncbi request reprint Use of a collagen-platelet rich plasma scaffold to stimulate healing of a central defect in the canine ACL
    Martha M Murray
    Department of Orthopaedic Surgery, Children s Hospital of Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Orthop Res 24:820-30. 2006
  4. ncbi request reprint The effect of thrombin on ACL fibroblast interactions with collagen hydrogels
    M M Murray
    Department of Orthopaedic Surgery, Children s Hospital of Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Orthop Res 24:508-15. 2006
  5. pmc Current status and potential of primary ACL repair
    Martha M Murray
    Department of Orthopaedic Surgery, Children s Hospital of Boston, Hunnewell 2, 300 Longwood Avenue, Boston, MA 02115, USA
    Clin Sports Med 28:51-61. 2009
  6. pmc Bone-to-bone fixation enhances functional healing of the porcine anterior cruciate ligament using a collagen-platelet composite
    Martha M Murray
    Department of Orthopaedic Surgery, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Arthroscopy 26:S49-57. 2010
  7. pmc The effect of skeletal maturity on functional healing of the anterior cruciate ligament
    Martha M Murray
    Department of Orthopaedic Surgery, Children s Hospital Boston, Hunnewell 2, 300 Longwood Avenue, Boston, MA 02115, USA
    J Bone Joint Surg Am 92:2039-49. 2010
  8. pmc Delay of 2 or 6 weeks adversely affects the functional outcome of augmented primary repair of the porcine anterior cruciate ligament
    Elise M Magarian
    Department of Orthopaedic Surgery, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Sports Med 38:2528-34. 2010
  9. ncbi request reprint Enhanced histologic repair in a central wound in the anterior cruciate ligament with a collagen-platelet-rich plasma scaffold
    Martha M Murray
    Department of Orthopaedic Surgery, Children s Hospital Boston, Harvard Medical School, 300 Longwood Ave, Boston, Massachusetts 02115, USA
    J Orthop Res 25:1007-17. 2007
  10. ncbi request reprint Migration of cells from human anterior cruciate ligament explants into collagen-glycosaminoglycan scaffolds
    M M Murray
    Department of Orthopaedic Surgery, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Orthop Res 18:557-64. 2000

Research Grants

  1. A Novel Mechanism for Intra-articular Nonunion
    Martha M Murray; Fiscal Year: 2010
  2. A Novel Mechanism for Intra-articular Nonunion
    Martha Murray; Fiscal Year: 2007
  3. The Effect of Age on Functional ACL Healing
    Martha Murray; Fiscal Year: 2007
  4. Enhanced Primary Repair of Ligament Injuries
    Martha Murray; Fiscal Year: 2007
  5. The Effect of Age on Functional ACL Healing
    Martha M Murray; Fiscal Year: 2010

Collaborators

Detail Information

Publications35

  1. pmc Platelet-rich plasma alone is not sufficient to enhance suture repair of the ACL in skeletally immature animals: an in vivo study
    Martha M Murray
    Department of Orthopaedic Surgery, Children s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Orthop Res 27:639-45. 2009
    ..Use of PRP alone to supplement suture repair of the ACL is ineffective in this animal model...
  2. ncbi request reprint Collagen-platelet rich plasma hydrogel enhances primary repair of the porcine anterior cruciate ligament
    Martha M Murray
    Department of Orthopaedic Surgery, Children s Hospital Boston, 300 Longwood Avenue, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Orthop Res 25:81-91. 2007
    ..Further studies to determine the long-term effect of primary repair enhancement are needed...
  3. ncbi request reprint Use of a collagen-platelet rich plasma scaffold to stimulate healing of a central defect in the canine ACL
    Martha M Murray
    Department of Orthopaedic Surgery, Children s Hospital of Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Orthop Res 24:820-30. 2006
    ..02). Placement of a collagen-PRP bridging scaffold in a central ACL defect can stimulate healing of the ACL histologically and biomechanically...
  4. ncbi request reprint The effect of thrombin on ACL fibroblast interactions with collagen hydrogels
    M M Murray
    Department of Orthopaedic Surgery, Children s Hospital of Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Orthop Res 24:508-15. 2006
    ..Use of low concentrations of thrombin (10.5 IU/mL) may be beneficial in applications where a faster set time and enhanced cell migration are desirable and the gel mechanical strength is of secondary importance...
  5. pmc Current status and potential of primary ACL repair
    Martha M Murray
    Department of Orthopaedic Surgery, Children s Hospital of Boston, Hunnewell 2, 300 Longwood Avenue, Boston, MA 02115, USA
    Clin Sports Med 28:51-61. 2009
    ..Subsequent work in this area may lead to the development of a novel approach to treat this important injury...
  6. pmc Bone-to-bone fixation enhances functional healing of the porcine anterior cruciate ligament using a collagen-platelet composite
    Martha M Murray
    Department of Orthopaedic Surgery, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Arthroscopy 26:S49-57. 2010
    ....
  7. pmc The effect of skeletal maturity on functional healing of the anterior cruciate ligament
    Martha M Murray
    Department of Orthopaedic Surgery, Children s Hospital Boston, Hunnewell 2, 300 Longwood Avenue, Boston, MA 02115, USA
    J Bone Joint Surg Am 92:2039-49. 2010
    ..In this study, we hypothesized that skeletally immature animals have improved functional healing compared with skeletally mature animals...
  8. pmc Delay of 2 or 6 weeks adversely affects the functional outcome of augmented primary repair of the porcine anterior cruciate ligament
    Elise M Magarian
    Department of Orthopaedic Surgery, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Sports Med 38:2528-34. 2010
    ..Previous studies have evaluated this approach at the time of anterior cruciate ligament disruption...
  9. ncbi request reprint Enhanced histologic repair in a central wound in the anterior cruciate ligament with a collagen-platelet-rich plasma scaffold
    Martha M Murray
    Department of Orthopaedic Surgery, Children s Hospital Boston, Harvard Medical School, 300 Longwood Ave, Boston, Massachusetts 02115, USA
    J Orthop Res 25:1007-17. 2007
    ..This study supports the hypothesis that premature scaffold failure may play a key role in the normally expected failure of the ACL to heal after injury...
  10. ncbi request reprint Migration of cells from human anterior cruciate ligament explants into collagen-glycosaminoglycan scaffolds
    M M Murray
    Department of Orthopaedic Surgery, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Orthop Res 18:557-64. 2000
    ....
  11. doi request reprint Mesenchymal stem cells from the retropatellar fat pad and peripheral blood stimulate ACL fibroblast migration, proliferation, and collagen gene expression
    B L Proffen
    Department of Orthopaedic Surgery, Children s Hospital Boston, Boston, MA 02115, USA
    Connect Tissue Res 54:14-21. 2013
    ..This was not seen for the PBMCs. Thus, the effects of MSCs on in situ ACL fibroblasts were found to be source dependent, and the choice of MSC source should take into account the different performance characteristic of each type of MSC...
  12. pmc Injection temperature significantly affects in vitro and in vivo performance of collagen-platelet scaffolds
    M P Palmer
    Department of Orthopaedic Surgery, Children s Hospital Boston, 300 Longwood Avenue, Enders 1022, Boston, Massachusetts 02115, USA
    J Orthop Res 27:964-71. 2009
    ....
  13. doi request reprint Storage conditions do not have detrimental effect on allograft collagen or scaffold performance
    E L Abreu
    Department of Orthopaedic Surgery, Children s Hospital of Boston, 300 Longwood Ave, Enders 1022, Boston, MA 02115, USA
    Cell Tissue Bank 10:333-40. 2009
    ..In conclusion, this study suggests that freezing or refrigeration for 1 week does not appear to have any detrimental effect on the mechanical properties and biologic performance of the collagen within allografts...
  14. ncbi request reprint The migration of cells from the ruptured human anterior cruciate ligament into collagen-glycosaminoglycan regeneration templates in vitro
    M M Murray
    Department of Orthopaedic Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
    Biomaterials 22:2393-402. 2001
    ..Moreover, the ACL-derived cells can express a contractile actin isoform and can contract a CG analog of extracellular matrix...
  15. ncbi request reprint Histological changes in the human anterior cruciate ligament after rupture
    M M Murray
    Department of Orthopaedic Surgery, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Bone Joint Surg Am 82:1387-97. 2000
    ..The primary objective of this study was to determine the location and the characteristics of the alpha-smooth muscle actin-containing myofibroblast-like cells that appear in the human anterior cruciate ligament following rupture...
  16. pmc Immature animals have higher cellular density in the healing anterior cruciate ligament than adolescent or adult animals
    Ashley N Mastrangelo
    Department of Orthopaedic Surgery, Children s Hospital of Boston, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Orthop Res 28:1100-6. 2010
    ..Animal age had a significant effect on the density of cells populating the ACL wound site. Whether this observed cellular difference has an effect on the later biomechanical function of the repaired ACL requires further study...
  17. pmc Collagen-platelet composite enhances biomechanical and histologic healing of the porcine anterior cruciate ligament
    Shilpa M Joshi
    Department of, Orthopaedic Surgery, Children s Hospital Boston, Boston, MA 02115, USA
    Am J Sports Med 37:2401-10. 2009
    ..Furthermore, large-animal models have recently shown that 1-month functional ACL healing is augmented after suture repair when a bioactive scaffold is placed in the tear site...
  18. pmc Age dependence of expression of growth factor receptors in porcine ACL fibroblasts
    Patrick Vavken
    Sports Medicine Research Laboratory, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Orthop Res 28:1107-12. 2010
    ..These findings suggest that the decrease in growth factor receptor expression as a likely reason for reduced PRP action with increasing age...
  19. pmc The effect of skeletal maturity on the regenerative function of intrinsic ACL cells
    Ashley N Mastrangelo
    Department of Orthopaedic Surgery, Enders 1020, 300 Longwood Avenue, Children s Hospital, Boston, Boston, Machusetts 02115, USA
    J Orthop Res 28:644-51. 2010
    ..These experiments suggest that skeletal maturity may influence the biologic repair capacity of intrinsic ACL cells...
  20. pmc Collagen density significantly affects the functional properties of an engineered provisional scaffold
    Eduardo L Abreu
    Department of Orthopaedic Surgery, Children s Hospital of Boston, Boston, MA 02115, USA
    J Biomed Mater Res A 93:150-7. 2010
    ..These studies suggest that the collagen density may be able to significantly influence the function of collagen-platelet hydrogels used as substitute provisional scaffolds...
  21. pmc Fibrin concentration affects ACL fibroblast proliferation and collagen synthesis
    Patrick Vavken
    Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    Knee 18:42-6. 2011
    ..To enhance cell behavior and thus clinical results fibrin applications should build on physiologic or sub-physiologic concentrations, and those with higher concentrations, such as currently available sealants, should be used cautiously...
  22. pmc TRITON-X is most effective among three decellularization agents for ACL tissue engineering
    Patrick Vavken
    Sports Medicine Research Laboratory, Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Enders 1016, Boston, Massachusetts 02115, USA
    J Orthop Res 27:1612-8. 2009
    ..Porcine ACL tissue after decellularization with TRITON-X could be successfully reseeded with human ACL fibroblasts as demonstrated by steady DNA content and increasing pro-collagen expression...
  23. ncbi request reprint Increased blood lead levels in an adolescent girl from a retained bullet. A case report
    Susan T Mahan
    Department of Orthopaedic Surgery, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
    J Bone Joint Surg Am 88:2726-9. 2006
  24. pmc Platelets, but not erythrocytes, significantly affect cytokine release and scaffold contraction in a provisional scaffold model
    May Jacobson
    CBR Institute for Biomedical Research, Harvard Medical School, Boston, Massachusetts, USA
    Wound Repair Regen 16:370-8. 2008
    ..Therefore, while platelets may be an important regulator of repair processes after injury, it is less likely that erythrocytes have a similar function...
  25. doi request reprint Translational studies in anterior cruciate ligament repair
    Patrick Vavken
    Sports Medicine Research Laboratory, Department of Orthopedic Surgery, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Tissue Eng Part B Rev 16:5-11. 2010
    ....
  26. doi request reprint Strategies to improve anterior cruciate ligament healing and graft placement
    Mark E Steiner
    New England Baptist Hospital, Boston, Massachusetts, USA
    Am J Sports Med 36:176-89. 2008
    ..Although these biologic engineering strategies are currently experimental, they are projected for clinical application in the near future...
  27. pmc Activation of platelet-rich plasma using soluble type I collagen
    Duretti Fufa
    Department of Orthopaedic Surgery, Harvard Medical School, Children s Hospital of Boston, Boston, MA 02115, USA
    J Oral Maxillofac Surg 66:684-90. 2008
    ..In this work, our hypothesis was that soluble type I collagen would be as effective as bovine thrombin in causing clotting of the PRP and stimulating growth factor release from the platelets and granulocytes...
  28. ncbi request reprint Pathologic characteristics of the torn human meniscus
    Mena Mesiha
    Department of Orthopaedic Surgery, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Am J Sports Med 35:103-12. 2007
    ..Information that would help surgeons predict, preoperatively, or intraoperatively which torn menisci had few viable cells could be useful in deciding which patients might be at increased risk for retear and failure of surgical repair...
  29. ncbi request reprint The presence of smooth muscle actin in fibroblasts in the torn human rotator cuff
    J Premdas
    Department of Orthopaedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Orthop Res 19:221-8. 2001
    ..The results of the present study thus suggest that SMA-containing cells could contribute to the retraction of the torn ends of a ruptured rotator cuff and play an important role in healing...
  30. pmc Platelet activation by collagen provides sustained release of anabolic cytokines
    Sophia Harrison
    Department of Orthopaedic Surgery, Children s Hospital of Boston, Massachusetts 02115, USA
    Am J Sports Med 39:729-34. 2011
    ..However, little is known about the effect of platelet activator choice on growth factor release kinetics...
  31. pmc Genome-wide expression analysis of intra- and extraarticular connective tissue
    RICHARD V PEARSE
    Department of Genetics, Harvard Medical School, NRB 360, Boston, Massachusetts 02115, USA
    J Orthop Res 27:427-34. 2009
    ....
  32. doi request reprint Posterior periosteal disruption in Salter-Harris Type II fractures of the distal femur: evidence for a hyperextension mechanism
    Supika Kritsaneepaiboon
    Department of Radiology, Section of Musculoskeletal Imaging, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    AJR Am J Roentgenol 193:W540-5. 2009
    ....
  33. pmc Can suture repair of ACL transection restore normal anteroposterior laxity of the knee? An ex vivo study
    Braden C Fleming
    Department of Orthopaedics, Warren Alpert Medical School of Brown University, CORO West, 1 Hoppin Street, Providence, Rhode Island 02903, USA
    J Orthop Res 26:1500-5. 2008
    ..Additional studies defining the changes in laxity with cyclic loading and in vivo healing are indicated...
  34. ncbi request reprint In situ IGF-1 gene delivery to cells emerging from the injured anterior cruciate ligament
    Andre F Steinert
    Division of Gene Therapy, Orthopedic Center for Musculoskeletal Research, Orthopedic Clinic, König Ludwig Haus, Julius Maximilians University, Brettreichstrasse 11, D 97074 Wurzburg, Germany
    Biomaterials 29:904-16. 2008
    ..These data confirm the promise of using vector-laden hydrogels for the in situ delivery of genes to cells within damaged ligaments and suggest novel possibilities for the biological repair of the ACL...
  35. ncbi request reprint The biomechanical response to doses of TGF-beta 2 in the healing rabbit medial collateral ligament
    Kurt P Spindler
    Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, 2601 Jess Neely Drive, Nashville, TN 37212, USA
    J Orthop Res 21:245-9. 2003
    ..This study suggests the mechanical stiffness, but not the load at failure, of ligament scar can be significantly altered by the administration of TGF-beta 2...

Research Grants10

  1. A Novel Mechanism for Intra-articular Nonunion
    Martha M Murray; Fiscal Year: 2010
    ....
  2. A Novel Mechanism for Intra-articular Nonunion
    Martha Murray; Fiscal Year: 2007
    ....
  3. The Effect of Age on Functional ACL Healing
    Martha Murray; Fiscal Year: 2007
    ..New treatments are being developed, where the ligament is stimulated to heal instead of being replaced, and this project will enable us to determine whether children and adolescents will be good candidates for this new approach. ..
  4. Enhanced Primary Repair of Ligament Injuries
    Martha Murray; Fiscal Year: 2007
    ..In the third aim, the optimized scaffolds will be tested in an in vivo canine ACL non-union model. Information gained in each of these aims will serve to improve our understanding of mechanisms of ligament healing. ..
  5. The Effect of Age on Functional ACL Healing
    Martha M Murray; Fiscal Year: 2010
    ..Success in this endeavor could improve the care of hundreds of thousands of adolescent and adult patients with ACL tears each year. ..