Andrew W Murray

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Don't make me mad, Bub!
    Andrew W Murray
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Dev Cell 22:1123-5. 2012
  2. ncbi request reprint Journey to the centre of the cell
    A W Murray
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nat Cell Biol 2:E130-1. 2000
  3. ncbi request reprint Recycling the cell cycle: cyclins revisited
    Andrew W Murray
    Department of Molecular and Cellular Biology, Biological Laboratories, Harvard University, Cambridge, MA 02138, USA
    Cell 116:221-34. 2004
  4. ncbi request reprint Can sequencing shed light on cell cycling?
    A W Murray
    Center for Genomics Research, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 409:844-6. 2001
  5. pmc Whither genomics?
    A W Murray
    Department of Physiology, University of California San Francisco, CA 94143, USA
    Genome Biol 1:COMMENT003. 2000
  6. ncbi request reprint Anaphase inactivation of the spindle checkpoint
    William J Palframan
    Department of Molecular and Cellular Biology, Biological Laboratories, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Science 313:680-4. 2006
  7. pmc Reduced Mad2 expression keeps relaxed kinetochores from arresting budding yeast in mitosis
    Erin L Barnhart
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Mol Biol Cell 22:2448-57. 2011
  8. pmc Mad2 and Mad3 cooperate to arrest budding yeast in mitosis
    Derek T C Lau
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Curr Biol 22:180-90. 2012
  9. ncbi request reprint Budding yeast mitotic chromosomes have an intrinsic bias to biorient on the spindle
    Vahan B Indjeian
    Department of Molecular and Cellular Biology, Harvard University, Massachusetts 02138, USA
    Curr Biol 17:1837-46. 2007
  10. ncbi request reprint A small-molecule inhibitor of Mps1 blocks the spindle-checkpoint response to a lack of tension on mitotic chromosomes
    Russell K Dorer
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Curr Biol 15:1070-6. 2005

Research Grants

  1. FEEDBACK CONTROL OF THE CELL CYCLE
    Andrew W Murray; Fiscal Year: 2010
  2. SISTER CHROMATID LINKAGE AND SEPARATION
    Andrew Murray; Fiscal Year: 2000
  3. Modular biology: experiment, theory and computation
    Andrew Murray; Fiscal Year: 2007
  4. FEEDBACK CONTROL OF THE CELL CYCLE
    Andrew Murray; Fiscal Year: 2007
  5. Sixth International Conference on Systems Biology (ICSB 2005)
    Andrew Murray; Fiscal Year: 2005
  6. SISTER CHROMATID LINKAGE AND SEPARATION
    Andrew Murray; Fiscal Year: 2004

Collaborators

Detail Information

Publications51

  1. pmc Don't make me mad, Bub!
    Andrew W Murray
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Dev Cell 22:1123-5. 2012
    ..In this issue of Developmental Cell, Suijkerbuijk et al. (2012) provide evidence that Bub1 has duplicated and diverged many times during eukaryotic evolution, dividing the functions of its ancestor between the two duplicated copies...
  2. ncbi request reprint Journey to the centre of the cell
    A W Murray
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nat Cell Biol 2:E130-1. 2000
    ....
  3. ncbi request reprint Recycling the cell cycle: cyclins revisited
    Andrew W Murray
    Department of Molecular and Cellular Biology, Biological Laboratories, Harvard University, Cambridge, MA 02138, USA
    Cell 116:221-34. 2004
    ..I discuss how a cyclin/Cdk-based engine could have evolved to assume control of the cell cycle from other, older protein kinases...
  4. ncbi request reprint Can sequencing shed light on cell cycling?
    A W Murray
    Center for Genomics Research, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 409:844-6. 2001
    ..Disappointingly, we discovered a few novel cyclins and no new Cdks or components of the spindle checkpoint, and could shed little light on the organization of the cell cycle...
  5. pmc Whither genomics?
    A W Murray
    Department of Physiology, University of California San Francisco, CA 94143, USA
    Genome Biol 1:COMMENT003. 2000
    ....
  6. ncbi request reprint Anaphase inactivation of the spindle checkpoint
    William J Palframan
    Department of Molecular and Cellular Biology, Biological Laboratories, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Science 313:680-4. 2006
    ..Furthermore, expression of Mps1 in anaphase, or repression of the APC in anaphase, reactivates the spindle checkpoint. This APC-Mps1 feedback circuit allows cells to irreversibly inactivate the checkpoint during anaphase...
  7. pmc Reduced Mad2 expression keeps relaxed kinetochores from arresting budding yeast in mitosis
    Erin L Barnhart
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Mol Biol Cell 22:2448-57. 2011
    ..We conclude that cells need the normal Mad2:Mad1 ratio to respond to chromosomes that are not under tension...
  8. pmc Mad2 and Mad3 cooperate to arrest budding yeast in mitosis
    Derek T C Lau
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Curr Biol 22:180-90. 2012
    ..Despite numerous studies, we still do not understand how the checkpoint proteins coordinate with each other to inhibit APC(Cdc20) activity...
  9. ncbi request reprint Budding yeast mitotic chromosomes have an intrinsic bias to biorient on the spindle
    Vahan B Indjeian
    Department of Molecular and Cellular Biology, Harvard University, Massachusetts 02138, USA
    Curr Biol 17:1837-46. 2007
    ..After the spindle has been depolymerized and allowed to reform, budding yeast sgo1 mutants fail to biorient their sister chromatids and die as cells divide...
  10. ncbi request reprint A small-molecule inhibitor of Mps1 blocks the spindle-checkpoint response to a lack of tension on mitotic chromosomes
    Russell K Dorer
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Curr Biol 15:1070-6. 2005
    ..Our results demonstrate that Mps1 can be exploited as a target and that inhibiting the tension-sensitive branch of the spindle checkpoint may be a way of selectively killing cancer cells that display chromosomal instability...
  11. pmc The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast
    S Biggins
    Department of Physiology, University of California, San Francisco, California 94143 0444, USA
    Genes Dev 13:532-44. 1999
    ..Because aurora2 has been implicated in oncogenesis, defects in kinetochore function may contribute to genetic instability in human tumors...
  12. doi request reprint An in vitro assay for Cdc20-dependent mitotic anaphase-promoting complex activity from budding yeast
    Scott C Schuyler
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA
    Methods Mol Biol 545:271-85. 2009
    ..Here we outline a quantitative in vitro mitotic APC(Cdc20) assay that makes use of a highly active form of the APC that is purified from budding yeast cells arrested in mitosis...
  13. pmc Recruiting a microtubule-binding complex to DNA directs chromosome segregation in budding yeast
    Soni Lacefield
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nat Cell Biol 11:1116-20. 2009
    ..We conclude that tethering a single kinetochore protein to DNA triggers assembly of the complex structure that directs mitotic chromosome segregation...
  14. pmc Cdc28 activates exit from mitosis in budding yeast
    A D Rudner
    Department of Physiology, University of California, San Francisco, California 94143 0444, USA
    J Cell Biol 149:1361-76. 2000
    ..The defects of CDC28-VF suggest that Cdc28 activity is required to induce the metaphase to anaphase transition and initiate the transition from anaphase to G1 in budding yeast...
  15. pmc A novel yeast screen for mitotic arrest mutants identifies DOC1, a new gene involved in cyclin proteolysis
    L H Hwang
    Department of Physiology, University of California, San Francisco 94143 0444, USA
    Mol Biol Cell 8:1877-87. 1997
    ..Cdc26 associates in vivo with Doc1, Cdc16, Cdc23, and Cdc27. In addition, the majority of Doc1 cosediments at 20S with Cdc27 in a sucrose gradient, indicating that Cdc26 and Doc1 are components of the anaphase promoting complex...
  16. pmc High-resolution mutation mapping reveals parallel experimental evolution in yeast
    Ayellet V Segrè
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA
    PLoS Biol 4:e256. 2006
    ..Our results show an example of parallel adaptation caused by mutations in the same gene...
  17. ncbi request reprint The centromeric protein Sgo1 is required to sense lack of tension on mitotic chromosomes
    Vahan B Indjeian
    Department of Molecular and Cellular Biology, Biological Laboratories, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Science 307:130-3. 2005
    ....
  18. ncbi request reprint The spindle checkpoint rescues the meiotic segregation of chromosomes whose crossovers are far from the centromere
    Soni Lacefield
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nat Genet 39:1273-7. 2007
    ..The tether partially rescues the segregation of chromosomes that lack crossovers...
  19. pmc Lesions in many different spindle components activate the spindle checkpoint in the budding yeast Saccharomyces cerevisiae
    K G Hardwick
    Department of Physiology, University of California, San Francisco, California 94143 0444, USA
    Genetics 152:509-18. 1999
    ..In contrast, the cell cycle arrest caused by mutations that induce DNA damage (cdc13), inactivate the cyclin proteolysis machinery (cdc16 and cdc23), or arrest cells in anaphase (cdc15) is independent of the spindle checkpoint...
  20. pmc Identification of xenopus CENP-A and an associated centromeric DNA repeat
    Nathaniel S Edwards
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Mol Biol Cell 16:1800-10. 2005
    ..Fluorescent in situ hybridization with Fcr1 probes stained most centromeres in cultured cells. By staining lampbrush chromosomes, we specifically identified the 11 (of 18) chromosomes that stain consistently with Fcr1 probes...
  21. pmc The speed of evolution and maintenance of variation in asexual populations
    Michael M Desai
    Department of Physics, Harvard University, Cambridge, MA 02138, USA
    Curr Biol 17:385-94. 2007
    ..We focus on the effects of such multiple mutations...
  22. pmc Mutation rates across budding yeast chromosome VI are correlated with replication timing
    Gregory I Lang
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA
    Genome Biol Evol 3:799-811. 2011
    ..This model is supported by the observation that eliminating translesion synthesis decreases this variation...
  23. ncbi request reprint Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption
    K G Hardwick
    Department of Physiology, University of California, San Francisco, CA 94143 0444, USA
    Science 273:953-6. 1996
    ..Ectopic activation of cell-cycle checkpoints might be used to exploit the differences in checkpoint status between normal and tumor cells and thus improve the selectivity of chemotherapy...
  24. ncbi request reprint Budding yeast Cdc20: a target of the spindle checkpoint
    L H Hwang
    Department of Physiology, University of California at San Francisco, San Francisco, CA 94143 0444, USA
    Science 279:1041-4. 1998
    ..Mutants in Cdc20 that were resistant to the spindle checkpoint no longer bound Mad proteins, suggesting that Cdc20 is the target of the spindle checkpoint...
  25. pmc Time-lapse microscopy reveals unique roles for kinesins during anaphase in budding yeast
    A F Straight
    Department of Physiology, School of Medicine, University of California San Francisco, San Francisco, California 94143, USA
    J Cell Biol 143:687-94. 1998
    ..The kip3Delta and kip1Delta mutants affect the duration of anaphase, but cin8Delta does not...
  26. pmc Phosphorylation by Cdc28 activates the Cdc20-dependent activity of the anaphase-promoting complex
    A D Rudner
    Department of Physiology, University of California, San Francisco, California 94143 0444, USA
    J Cell Biol 149:1377-90. 2000
    ..We show that, like cdc28 mutants, cdc5 mutants affect APC phosphorylation in vivo. However, although Cdc5 can phosphorylate Cdc16 and Cdc27 in vitro, this in vitro phosphorylation does not occur on in vivo sites of phosphorylation...
  27. ncbi request reprint The Xenopus chromokinesin Xkid is essential for metaphase chromosome alignment and must be degraded to allow anaphase chromosome movement
    H Funabiki
    Department of Physiology, University of California, San Francisco 94143, USA
    Cell 102:411-24. 2000
    ..We propose that Xkid provides the metaphase force that pushes chromosome arms toward the equator of the spindle and that its destruction is needed for anaphase chromosome movement...
  28. ncbi request reprint Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores
    R H Chen
    Department of Physiology, University of California, San Francisco, 94143, USA Chapel Hill, NC 27599, USA
    Science 274:242-6. 1996
    ..This study furthers understanding of the mechanism of cell cycle checkpoints in metazoa and provides a marker for studying the role of the spindle assembly checkpoint in the genetic instability of tumors...
  29. ncbi request reprint Lack of tension at kinetochores activates the spindle checkpoint in budding yeast
    B M Stern
    Department of Molecular and Cell Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Curr Biol 11:1462-7. 2001
    ..Because the spindle checkpoint is activated in these cells, we conclude that the absence of tension at the yeast kinetochore is sufficient to activate the spindle checkpoint in mitosis...
  30. doi request reprint A brief history of error
    Andrew W Murray
    Harvard University, Molecular and Cellular Biology, 52 Oxford Street, Northwest Science Building, Cambridge, Massachusetts 02138, USA
    Nat Cell Biol 13:1178-82. 2011
    ..This perspective will present a brief history summarizing what we know about the checkpoint, and a list of questions we must answer before we understand it...
  31. pmc Positive-feedback loops as a flexible biological module
    Nicholas T Ingolia
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Curr Biol 17:668-77. 2007
    ..Bistable behavior can result from positive feedback, but feedback loops can have other roles in signal transduction as well...
  32. pmc Estimating the per-base-pair mutation rate in the yeast Saccharomyces cerevisiae
    Gregory I Lang
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genetics 178:67-82. 2008
    ..44x10(-10) at CAN1) and we propose a definition for the effective target size of genes (the probability that a mutation inactivates the gene) that acknowledges that the mutation rate is nonuniform across the genome...
  33. pmc Members of the NAP/SET family of proteins interact specifically with B-type cyclins
    D R Kellogg
    Department of Physiology, University of California, San Francisco 94143 0444, USA
    J Cell Biol 130:661-73. 1995
    ..This protein is the Xenopus homolog of the human SET protein, which was previously identified as part of a putative oncogenic fusion protein (Von Lindern et al., 1992)...
  34. ncbi request reprint Genetic selection of peptide inhibitors of biological pathways
    T C Norman
    Department of Physiology, University of California, San Francisco, CA 94143 0444, USA
    Science 285:591-5. 1999
    ....
  35. pmc Improved use of a public good selects for the evolution of undifferentiated multicellularity
    John H Koschwanez
    FAS Center for Systems Biology and Department of Molecular and Cellular Biology, Harvard University, Cambridge, United States
    elife 2:e00367. 2013
    ..Our study shows that combining rational design with experimental evolution can help evaluate hypotheses about evolutionary strategies. DOI:http://dx.doi.org/10.7554/eLife.00367.001...
  36. pmc Sucrose utilization in budding yeast as a model for the origin of undifferentiated multicellularity
    John H Koschwanez
    FAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts, United States of America
    PLoS Biol 9:e1001122. 2011
    ..We propose that the prior use of public goods led to selection for the incomplete cell separation that first produced multicellularity...
  37. ncbi request reprint Ploidy controls the success of mutators and nature of mutations during budding yeast evolution
    Dawn A Thompson
    Molecular and Cellular Biology Department, 16 Divinity Ave, Harvard University, Cambridge, MA 02138, USA
    Curr Biol 16:1581-90. 2006
    ..Mismatch repair defective and nonmutator strains were competed during adaptation to four laboratory environments (rich medium, low glucose, high salt, and a nonfermentable carbon source)...
  38. ncbi request reprint The ups and downs of modeling the cell cycle
    Nicholas T Ingolia
    Department of Molecular and Cellular Biology, Biological Laboratories, Harvard University, Cambridge, Massachusetts 02138, USA
    Curr Biol 14:R771-7. 2004
    ..These include asking how the various elaborations of the basic oscillator affect the robustness of the system and how cells monitor their size and use this information to control the cell cycle...
  39. pmc Rapid expansion and functional divergence of subtelomeric gene families in yeasts
    Chris A Brown
    Faculty of Arts and Sciences Center for Systems Biology, Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA
    Curr Biol 20:895-903. 2010
    ..However, most genome sequences do not contain assembled subtelomeric sequences, and, as a result, subtelomeres are often overlooked in comparative genomics...
  40. pmc Spo13 protects meiotic cohesin at centromeres in meiosis I
    Marion A Shonn
    Department of Molecular and Cell Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genes Dev 16:1659-71. 2002
    ..Overexpressing the mitotic cohesin, Scc1/Mcd1, does not substitute for Rec8, suggesting that the combined actions of Spo13 and Rec8 are important for preventing sister centromere separation in meiosis I...
  41. pmc NAP1 acts with Clb1 to perform mitotic functions and to suppress polar bud growth in budding yeast
    D R Kellogg
    Department of Physiology, University of California, San Francisco 94143 0444, USA
    J Cell Biol 130:675-85. 1995
    ....
  42. pmc The spindle checkpoint of budding yeast depends on a tight complex between the Mad1 and Mad2 proteins
    R H Chen
    Department of Physiology, University of California, San Francisco, San Francisco, California 94143 0444, USA
    Mol Biol Cell 10:2607-18. 1999
    ..Deletion and mutational analysis of both proteins indicate that association of Mad2p with Mad1p is critical for checkpoint function and for hyperphosphorylation of Mad1p...
  43. pmc Selective sweeps in growing microbial colonies
    Kirill S Korolev
    FAS Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA
    Phys Biol 9:026008. 2012
    ..Spatial sector patterns therefore provide an alternative fitness assay to the commonly used liquid culture fitness assays...
  44. ncbi request reprint Spindle checkpoint component Mad2 contributes to biorientation of homologous chromosomes
    Marion A Shonn
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02130, USA
    Curr Biol 13:1979-84. 2003
    ....
  45. ncbi request reprint Experimental evolution of mating discrimination in budding yeast
    Jun Yi Leu
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Ave, Room 3000, Cambridge, Massachusetts 02138, USA
    Curr Biol 16:280-6. 2006
    ..Genetic analysis indicates that multiple mutations have accumulated to produce the altered mating preference. Our results show that subtle details of mating behavior can play an important role in the evolution of reproductive isolation...
  46. ncbi request reprint Sister chromatid cohesion in mitosis
    S Biggins
    513 Parnassus Avenue, Box 0444, Department of Physiology, University of California, San Francisco, San Francisco, California 94143 0444, USA
    Curr Opin Genet Dev 9:230-6. 1999
    ..Proteins that induce and regulate the separation of sister chromatids have also been recently identified. (This review is an updated version of one that was published in Current Opinion in Cell Biology 1998, 10:769-775.)..
  47. pmc Mad1p, a phosphoprotein component of the spindle assembly checkpoint in budding yeast
    K G Hardwick
    Department of Physiology, University of California, San Francisco 94143 0444, USA
    J Cell Biol 131:709-20. 1995
    ..We discuss the possible functions of Mad1p at this cell cycle checkpoint...
  48. ncbi request reprint Signal transduction. History matters
    Nicholas T Ingolia
    Department of Molecular and Cellular Biology and Bauer Center for Genomics Research, Harvard University, Cambridge, MA 02138, USA
    Science 297:948-9. 2002
  49. ncbi request reprint The spindle assembly checkpoint
    A D Rudner
    Department of Physiology, Box 0444, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0444, USA
    Curr Opin Cell Biol 8:773-80. 1996
    ..Checkpoint components reside on kinetochores of chromosomes and show changes in phosphorylation and localization as cells proceed through mitosis. Adaptation to prolonged checkpoint arrest can occur by inhibitory phosphorylation of Cdc2...
  50. pmc Genes involved in sister chromatid separation and segregation in the budding yeast Saccharomyces cerevisiae
    S Biggins
    Department of Physiology, University of California, San Francisco, 94143, USA
    Genetics 159:453-70. 2001
    ..We also report an initial characterization of phenotypes associated with the SMT3/SUMO gene and the isolation of WSS1, a high-copy smt3 suppressor...
  51. pmc Mutation of YCS4, a budding yeast condensin subunit, affects mitotic and nonmitotic chromosome behavior
    Needhi Bhalla
    Department of Cell Biology and Physiology, University of California, San Francisco, San Francisco, California 94143, USA
    Mol Biol Cell 13:632-45. 2002
    ..Taken together, our data suggest that there are mitotic as well as nonmitotic chromosomal abnormalities associated with loss of condensin function in budding yeast...

Research Grants11

  1. FEEDBACK CONTROL OF THE CELL CYCLE
    Andrew W Murray; Fiscal Year: 2010
    ..This project uses brewer's yeast to understand how cells normally keep track of their chromosomes and how mutations can wreck the tracking machinery. ..
  2. SISTER CHROMATID LINKAGE AND SEPARATION
    Andrew Murray; Fiscal Year: 2000
    ..This information will be directly relevant to understanding the generation of aneuploidy seen in Down syndrome and tumor progression. ..
  3. Modular biology: experiment, theory and computation
    Andrew Murray; Fiscal Year: 2007
    ..abstract_text> ..
  4. FEEDBACK CONTROL OF THE CELL CYCLE
    Andrew Murray; Fiscal Year: 2007
    ..These inhibitors will be useful as research tools in organisms that lack sophisticated genetics, will identify new components of the checkpoint, and mavrenresent a novel class of chemotherapeutic agents. ..
  5. Sixth International Conference on Systems Biology (ICSB 2005)
    Andrew Murray; Fiscal Year: 2005
    ..The speakers and contributors will include experimental biologists, chemists, computer scientists, physicists, engineers, and mathematicians. ..
  6. SISTER CHROMATID LINKAGE AND SEPARATION
    Andrew Murray; Fiscal Year: 2004
    ..This information will be directly relevant to understanding how aneuploidy is generated in Down syndrome and tumor progression. ..