Thomas A Munro

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Standard protecting groups create potent and selective kappa opioids: salvinorin B alkoxymethyl ethers
    Thomas A Munro
    Mailman Research Center, McLean Hospital, Belmont, MA 02478, USA
    Bioorg Med Chem 16:1279-86. 2008
  2. pmc Selective κ opioid antagonists nor-BNI, GNTI and JDTic have low affinities for non-opioid receptors and transporters
    Thomas A Munro
    McLean Hospital, Belmont, Massachusetts, United States of America Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, United States of America School of Chemistry and Bio21 Institute, University of Melbourne, Parkville, Australia
    PLoS ONE 8:e70701. 2013
  3. pmc Modification of the furan ring of salvinorin A: identification of a selective partial agonist at the kappa opioid receptor
    Cecile Beguin
    Mailman Research Center, McLean Hospital, Belmont, MA 02478, USA
    Bioorg Med Chem 17:1370-80. 2009
  4. pmc Long-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity
    Thomas A Munro
    McLean Hospital, Belmont, MA and Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    BMC Pharmacol 12:5. 2012
  5. pmc Salvinorin B meth-oxy-methyl ether
    Thomas A Munro
    McLean Hospital, Belmont, MA, USA Harvard Medical School, Department of Psychiatry, Boston, MA, USA
    Acta Crystallogr Sect E Struct Rep Online 68:o3225-6. 2012
  6. ncbi request reprint N-methylacetamide analog of salvinorin A: a highly potent and selective kappa-opioid receptor agonist with oral efficacy
    Cecile Beguin
    Department of Psychiatry, McLean Hospital, MRC 322A, 115 Mill Street, Belmont, MA 02478, USA
    J Pharmacol Exp Ther 324:188-95. 2008
  7. pmc Studies toward the pharmacophore of salvinorin A, a potent kappa opioid receptor agonist
    Thomas A Munro
    School of Chemistry, The University of Melbourne, Victoria, 3010, Australia
    J Med Chem 48:345-8. 2005
  8. ncbi request reprint Divinatorins A-C, new neoclerodane diterpenoids from the controlled sage Salvia divinorum
    Andrea K Bigham
    Department of Microbiology and Immunology, School of Chemistry, The University of Melbourne, Victoria, 3010, Australia
    J Nat Prod 66:1242-4. 2003
  9. ncbi request reprint Salvinorins D-F, new neoclerodane diterpenoids from Salvia divinorum, and an improved method for the isolation of salvinorin A
    Thomas A Munro
    School of Chemistry, The University of Melbourne, Victoria, 3010, Australia
    J Nat Prod 66:703-5. 2003
  10. ncbi request reprint Confirmation of the NMR assignments of salvinorin A
    Thomas A Munro
    Magn Reson Chem 45:801. 2007

Collaborators

Detail Information

Publications11

  1. pmc Standard protecting groups create potent and selective kappa opioids: salvinorin B alkoxymethyl ethers
    Thomas A Munro
    Mailman Research Center, McLean Hospital, Belmont, MA 02478, USA
    Bioorg Med Chem 16:1279-86. 2008
    ..These protecting groups may prove useful in related work not only by enabling the use of harsher synthetic conditions, but potentially by optimizing the potency of the products...
  2. pmc Selective κ opioid antagonists nor-BNI, GNTI and JDTic have low affinities for non-opioid receptors and transporters
    Thomas A Munro
    McLean Hospital, Belmont, Massachusetts, United States of America Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, United States of America School of Chemistry and Bio21 Institute, University of Melbourne, Parkville, Australia
    PLoS ONE 8:e70701. 2013
    ..The transient effects of these compounds differ, suggesting that some of them may be mediated by other targets...
  3. pmc Modification of the furan ring of salvinorin A: identification of a selective partial agonist at the kappa opioid receptor
    Cecile Beguin
    Mailman Research Center, McLean Hospital, Belmont, MA 02478, USA
    Bioorg Med Chem 17:1370-80. 2009
    ..Finally, substitution of oxadiazoles for the furan ring abolished affinity for the KOPR. None of the compounds displayed any KOPR antagonism or any affinity for mu or delta opioid receptors...
  4. pmc Long-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity
    Thomas A Munro
    McLean Hospital, Belmont, MA and Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    BMC Pharmacol 12:5. 2012
    ..Recent evidence suggests, instead, that they induce prolonged desensitization of the κ opioid receptor...
  5. pmc Salvinorin B meth-oxy-methyl ether
    Thomas A Munro
    McLean Hospital, Belmont, MA, USA Harvard Medical School, Department of Psychiatry, Boston, MA, USA
    Acta Crystallogr Sect E Struct Rep Online 68:o3225-6. 2012
    ..This structure may prove useful in evaluating models of the activated κ-opioid receptor...
  6. ncbi request reprint N-methylacetamide analog of salvinorin A: a highly potent and selective kappa-opioid receptor agonist with oral efficacy
    Cecile Beguin
    Department of Psychiatry, McLean Hospital, MRC 322A, 115 Mill Street, Belmont, MA 02478, USA
    J Pharmacol Exp Ther 324:188-95. 2008
    ....
  7. pmc Studies toward the pharmacophore of salvinorin A, a potent kappa opioid receptor agonist
    Thomas A Munro
    School of Chemistry, The University of Melbourne, Victoria, 3010, Australia
    J Med Chem 48:345-8. 2005
    ..Other salvinorins showed negligible binding affinity at the KOR. None of the compounds bound to mu or delta opioid receptors...
  8. ncbi request reprint Divinatorins A-C, new neoclerodane diterpenoids from the controlled sage Salvia divinorum
    Andrea K Bigham
    Department of Microbiology and Immunology, School of Chemistry, The University of Melbourne, Victoria, 3010, Australia
    J Nat Prod 66:1242-4. 2003
    ..Neither the crude extract nor 7-9 displayed antimicrobial activity...
  9. ncbi request reprint Salvinorins D-F, new neoclerodane diterpenoids from Salvia divinorum, and an improved method for the isolation of salvinorin A
    Thomas A Munro
    School of Chemistry, The University of Melbourne, Victoria, 3010, Australia
    J Nat Prod 66:703-5. 2003
    ..A simplified isolation method using chromatography on activated carbon also gave improved yields of the controlled substance salvinorin A (1) and of salvinorin C (3)...
  10. ncbi request reprint Confirmation of the NMR assignments of salvinorin A
    Thomas A Munro
    Magn Reson Chem 45:801. 2007
  11. pmc Autoxidation of salvinorin A under basic conditions
    Thomas A Munro
    School of Chemistry, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Victoria, 3010, Australia
    J Org Chem 70:10057-61. 2005
    ..A general method for identifying salvinorin 8-epimers by TLC is also presented...