Lance Munn

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Aberrant vascular architecture in tumors and its importance in drug-based therapies
    Lance L Munn
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Drug Discov Today 8:396-403. 2003
  2. pmc Particulate nature of blood determines macroscopic rheology: a 2-D lattice Boltzmann analysis
    Chenghai Sun
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Biophys J 88:1635-45. 2005
  3. ncbi request reprint PDGF and microvessel wall remodeling in adult rat lung: imaging PDGF-AA and PDGF-Ralpha molecules in progenitor smooth muscle cells developing in experimental pulmonary hypertension
    Rosemary Jones
    Department of Anesthesia and Critical Care, Harvard Medical School, Massachusetts General Hospital, MGH East, Charlestown, MA 02129, USA
    Cell Tissue Res 326:759-69. 2006
  4. pmc Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model
    Rakesh K Jain
    E L Steele Lab for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Res 67:2729-35. 2007
  5. pmc Red blood cells initiate leukocyte rolling in postcapillary expansions: a lattice Boltzmann analysis
    Chenghai Sun
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Biophys J 85:208-22. 2003
  6. pmc Non-uniform plasma leakage affects local hematocrit and blood flow: implications for inflammation and tumor perfusion
    Chenghai Sun
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Ann Biomed Eng 35:2121-9. 2007
  7. pmc Blood cell interactions and segregation in flow
    Lance L Munn
    E L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, 100 Blossom St, COX 7, Boston, MA 02114, USA
    Ann Biomed Eng 36:534-44. 2008
  8. pmc Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models
    Dai Fukumura
    Edwin L Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Microcirculation 17:206-25. 2010
  9. ncbi request reprint Dissecting tumour pathophysiology using intravital microscopy
    Rakesh K Jain
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Nat Rev Cancer 2:266-76. 2002
  10. ncbi request reprint Lymphatic metastasis in the absence of functional intratumor lymphatics
    Timothy P Padera
    E L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, 100 Blossom Street, Boston, MA 02114, USA
    Science 296:1883-6. 2002

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Aberrant vascular architecture in tumors and its importance in drug-based therapies
    Lance L Munn
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Drug Discov Today 8:396-403. 2003
    ..However, as more is learned about the formation of tumor vasculature and how it differs from that in normal tissue, more effective and directed therapies to fight cancer might be developed...
  2. pmc Particulate nature of blood determines macroscopic rheology: a 2-D lattice Boltzmann analysis
    Chenghai Sun
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Biophys J 88:1635-45. 2005
    ..This powerful and flexible model can be used to predict blood flow properties in any vessel geometry and with any blood composition...
  3. ncbi request reprint PDGF and microvessel wall remodeling in adult rat lung: imaging PDGF-AA and PDGF-Ralpha molecules in progenitor smooth muscle cells developing in experimental pulmonary hypertension
    Rosemary Jones
    Department of Anesthesia and Critical Care, Harvard Medical School, Massachusetts General Hospital, MGH East, Charlestown, MA 02129, USA
    Cell Tissue Res 326:759-69. 2006
    ....
  4. pmc Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model
    Rakesh K Jain
    E L Steele Lab for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Res 67:2729-35. 2007
    ..Finally, decreased fluid convection into the peritumor tissue would decrease peritumor edema associated with brain tumors and ascites accumulation in the peritoneal or pleural cavity, a major complication with a number of malignancies...
  5. pmc Red blood cells initiate leukocyte rolling in postcapillary expansions: a lattice Boltzmann analysis
    Chenghai Sun
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Biophys J 85:208-22. 2003
    ..The model predicts that an optimal configuration of the trailing red blood cells is required to drive the white blood cell to the wall...
  6. pmc Non-uniform plasma leakage affects local hematocrit and blood flow: implications for inflammation and tumor perfusion
    Chenghai Sun
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Ann Biomed Eng 35:2121-9. 2007
    ..Normalization of tumor vessels by anti-angiogenic therapy may improve tumor perfusion via the first two mechanisms...
  7. pmc Blood cell interactions and segregation in flow
    Lance L Munn
    E L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, 100 Blossom St, COX 7, Boston, MA 02114, USA
    Ann Biomed Eng 36:534-44. 2008
    ..Here we summarize efforts in our lab to continue this tradition and to further our understanding of how blood cells interact with each other and with the blood vessel wall...
  8. pmc Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models
    Dai Fukumura
    Edwin L Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Microcirculation 17:206-25. 2010
    ..Administration of cytotoxic therapy during periods of vascular normalization has the potential to enhance treatment efficacy...
  9. ncbi request reprint Dissecting tumour pathophysiology using intravital microscopy
    Rakesh K Jain
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Nat Rev Cancer 2:266-76. 2002
    ..Intravital microscopy has provided unprecedented molecular, cellular, anatomical and functional insights into these barriers and has revealed new approaches to improved detection and treatment...
  10. ncbi request reprint Lymphatic metastasis in the absence of functional intratumor lymphatics
    Timothy P Padera
    E L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, 100 Blossom Street, Boston, MA 02114, USA
    Science 296:1883-6. 2002
    ..These findings suggest that the functional lymphatics in the tumor margin alone are sufficient for lymphatic metastasis and should be targeted therapeutically...
  11. pmc PDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment
    Emmanuelle di Tomaso
    E L Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 4:e5123. 2009
    ..Here we tested the hypothesis that Platelet Derived Growth Factor-C (PDGF-C), an isoform of the PDGF family, affects GBM progression independent of VEGF pathway and hinders anti-VEGF therapy...
  12. ncbi request reprint Mosaic tumor vessels: cellular basis and ultrastructure of focal regions lacking endothelial cell markers
    Emmanuelle di Tomaso
    Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Cancer Res 65:5740-9. 2005
    ..More than 80% of the defects lacked immunoreactivity for multiple basement membrane proteins...
  13. ncbi request reprint Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases
    Frank Winkler
    E L Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Boston, MA 02114, USA
    Cancer Cell 6:553-63. 2004
    ..During the normalization window, but not before or after it, VEGFR2 blockade increases pericyte coverage of brain tumor vessels via upregulation of Ang1 and degrades their pathologically thick basement membrane via MMP activation...
  14. pmc Micro-environmental mechanical stress controls tumor spheroid size and morphology by suppressing proliferation and inducing apoptosis in cancer cells
    Gang Cheng
    Edwin L Steele Laboratory of Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 4:e4632. 2009
    ....
  15. pmc Simultaneous measurement of RBC velocity, flux, hematocrit and shear rate in vascular networks
    Walid S Kamoun
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Methods 7:655-60. 2010
    ..Furthermore, we show that subpopulations of vessels, classified by functional parameters, exist in and around a tumor and in normal brain tissue...
  16. pmc Angiopoietin-2 interferes with anti-VEGFR2-induced vessel normalization and survival benefit in mice bearing gliomas
    Sung Suk Chae
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Clin Cancer Res 16:3618-27. 2010
    ..Here, we used an orthotopic glioma model to test the hypothesis that Ang-2 is an additional target for improving the efficacy of current anti-VEGF therapies in glioma patients...
  17. ncbi request reprint A mathematical model of the contribution of endothelial progenitor cells to angiogenesis in tumors: implications for antiangiogenic therapy
    Brian R Stoll
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Blood 102:2555-61. 2003
    ..The model offers new insight into tumor angiogenesis with implications for the rational design of antiangiogenic therapy...
  18. pmc Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging
    Benjamin J Vakoc
    Wellman Center for Photomedicine, Department of Dermatology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, USA
    Nat Med 15:1219-23. 2009
    ....
  19. pmc Red blood cells augment leukocyte rolling in a virtual blood vessel
    Cristiano Migliorini
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Biophys J 83:1834-41. 2002
    ..This novel approach can be applied to a large number of biological and industrial problems involving the complex flow of particulate suspensions...
  20. ncbi request reprint Solid stress generated by spheroid growth estimated using a linear poroelasticity model small star, filled
    Tiina Roose
    Steele Laboratory for Tumor Biology, Massachusetts General Hospital and Harvard Medical School, Department of Radiation Oncology, 100 Blossom Street, COX 7, Boston, MA 02114 2617, USA
    Microvasc Res 66:204-12. 2003
    ..This leads to the interesting possibility that cell size could be a direct indicator of solid stress level inside the tumors in clinical setting...
  21. pmc Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer
    Christopher G Willett
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Nat Med 10:145-7. 2004
    ..These data indicate that VEGF blockade has a direct and rapid antivascular effect in human tumors...
  22. ncbi request reprint Differential transplantability of tumor-associated stromal cells
    Dan G Duda
    E L Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Res 64:5920-4. 2004
    ..These studies of tumor tissue transplantation provide a platform for exploring the role of epithelial-stromal interactions in studies of tumor heterogeneity and drug resistance...
  23. pmc Paradoxical effects of PDGF-BB overexpression in endothelial cells on engineered blood vessels in vivo
    Patrick Au
    Department of RadiationOncology, Edwin L Steele Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Am J Pathol 175:294-302. 2009
    ..These results suggest a potential negative interaction between angiogenic growth factors and vascular cells; their use in combination should be carefully tested in vivo for such opposing effects...
  24. pmc Antibody-directed effector cell therapy of tumors: analysis and optimization using a physiologically based pharmacokinetic model
    Stuart W Friedrich
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Neoplasia 4:449-63. 2002
    ..Our results suggest that the design of the BFA is critical and the binding constants of the antigen and lymphocyte binding epitopes need to be optimized for successful therapy...
  25. pmc Edema control by cediranib, a vascular endothelial growth factor receptor-targeted kinase inhibitor, prolongs survival despite persistent brain tumor growth in mice
    Walid S Kamoun
    Edwin L Steele Laboratory, Department of Radiation Oncology, Stephen E and Catherine Pappas Center for Neuro Oncology, and AA Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Clin Oncol 27:2542-52. 2009
    ..Our goal was to determine whether alleviation of edema by anti-VEGF agents alone could increase survival in mice...
  26. pmc In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts
    Jean Y Perentes
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Boston, Massachusetts 02114, USA
    Nat Methods 6:143-5. 2009
    ..We show that the matrix-modifying hormone relaxin increased tumor-associated fibroblast (TAF) interaction with collagen fibers by stimulating beta1-integrin activity, which is necessary for fiber remodeling by matrix metalloproteinases...
  27. ncbi request reprint Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors
    Robert B Campbell
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Cancer Res 62:6831-6. 2002
    ..Our results suggest that optimizing physicochemical properties of liposomes that exploit physiological features of tumors and control the intratumor distribution of these drug carriers should improve vascular-specific delivery...
  28. ncbi request reprint Differential gene expression in metastasizing cells shed from kidney tumors
    Maximilian Bockhorn
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 64:2469-73. 2004
    ..Furthermore, resistance to apoptosis may enhance metastasis in the higher metastatic tumor...
  29. ncbi request reprint Lack of telopeptides in fibrillar collagen I promotes the invasion of a metastatic breast tumor cell line
    Zoe N Demou
    Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Cancer Res 65:5674-82. 2005
    ..Thus, the higher RhoA activity of MDA-MB-435S cells in telopeptide-free collagen enhances the changes in cellular morphodynamics associated with motility and invasion...
  30. pmc NO mediates mural cell recruitment and vessel morphogenesis in murine melanomas and tissue-engineered blood vessels
    Satoshi Kashiwagi
    Edwin L Steele Laboratory, Department of Radiation Oncology, and Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    J Clin Invest 115:1816-27. 2005
    ..These data indicate that endothelial cell-derived NO induces mural cell recruitment as well as subsequent morphogenesis and stabilization of angiogenic vessels...
  31. pmc Biomimetic autoseparation of leukocytes from whole blood in a microfluidic device
    Sergey S Shevkoplyas
    Visual and Circulatory Biophysics Laboratory, Department of Biomedical Engineering, Boston University, 36 Cummington Street, Boston, MA 02215, USA
    Anal Chem 77:933-7. 2005
    ..Its integration into microanalytical devices that require leukocyte enrichment will enable accelerated transition of these devices into the field for point-of-care clinical testing...
  32. pmc Diffusion of particles in the extracellular matrix: the effect of repulsive electrostatic interactions
    Triantafyllos Stylianopoulos
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Biophys J 99:1342-9. 2010
    ..Taken together, we conclude that optimal particles for delivery to tumors should be initially cationic to target the tumor vessels and then change to neutral charge after exiting the blood vessels...
  33. pmc Active versus passive mechanisms in metastasis: do cancer cells crawl into vessels, or are they pushed?
    Maximilian Bockhorn
    Department of General, Visceral and Transplantation Surgery, University Hospital Essen, Germany
    Lancet Oncol 8:444-8. 2007
    ..We discuss the evidence for and against this passive-shedding hypothesis and the implications for future treatments...
  34. ncbi request reprint Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients
    Christopher G Willett
    J Clin Oncol 23:8136-9. 2005

Research Grants12

  1. Microfluidic Device for Isolating Rare Blood Cells
    Lance Munn; Fiscal Year: 2007
    ..When fully-developed, this technology will be a necessary and integral component of any microfluidic device analyzing nucleated blood cell populations by eliminating the need for preliminary blood processing steps. ..
  2. Blood rheology, cell adhesion and endothelial activation
    Lance Munn; Fiscal Year: 2007
    ..A combination of in vivo experiments and mathematical modeling will be used to assess the combination of fluid forces and vessel geometries that lead to atherosclerotic lesions. ..
  3. Blood Rheology and Leukocyte Mechanics
    Lance Munn; Fiscal Year: 2005
    ..The unique combination of experimental and theoretical approaches will form the basis of my independent scientific career. ..
  4. CELL-SURFACE ADHESION--INFLUENCE OF BLOOD RHEOLOGY
    Lance Munn; Fiscal Year: 2003
    ....
  5. Flow-based remodeling and function of tumor vasculature
    Lance L Munn; Fiscal Year: 2010
    ..We will apply a mathematical model to determine how changes in vessel leakiness and network structure individually influence oxygen and drug delivery throughout tumor. ..