J M Mullington

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Sleep loss reduces diurnal rhythm amplitude of leptin in healthy men
    J M Mullington
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Neuroendocrinol 15:851-4. 2003
  2. ncbi Sleep loss and inflammation
    Janet M Mullington
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Best Pract Res Clin Endocrinol Metab 24:775-84. 2010
  3. ncbi Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk
    Hans K Meier-Ewert
    Department of Cardiology, Lahey Clinic Medical Center, Burlington, Boston, Massachusetts, USA
    J Am Coll Cardiol 43:678-83. 2004
  4. ncbi Mediators of inflammation and their interaction with sleep: relevance for chronic fatigue syndrome and related conditions
    J M Mullington
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Ann N Y Acad Sci 933:201-10. 2001
  5. ncbi Elevated inflammatory markers in response to prolonged sleep restriction are associated with increased pain experience in healthy volunteers
    Monika Haack
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Sleep 30:1145-52. 2007
  6. ncbi Cardiovascular, inflammatory, and metabolic consequences of sleep deprivation
    Janet M Mullington
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School Division of Cardiology, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA
    Prog Cardiovasc Dis 51:294-302. 2009
  7. ncbi Activation of the prostaglandin system in response to sleep loss in healthy humans: potential mediator of increased spontaneous pain
    Monika Haack
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Pain 145:136-41. 2009
  8. ncbi Diurnal and sleep-wake dependent variations of soluble TNF- and IL-2 receptors in healthy volunteers
    Monika Haack
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, DA 779, Boston, MA 02215, USA
    Brain Behav Immun 18:361-7. 2004
  9. ncbi Sustained sleep restriction reduces emotional and physical well-being
    Monika Haack
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, East Campus, Dana 779, Boston, MA 02215, USA
    Pain 119:56-64. 2005
  10. ncbi The contribution of sleep to improvements in working memory scanning speed: a study of prolonged sleep restriction
    Melynda D Casement
    Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Biol Psychol 72:208-12. 2006

Research Grants

  1. Aging & the inflammatory, metabolic and autonomic response to sleep loss
    Janet Mullington; Fiscal Year: 2007
  2. Adiposity, BP & the inflammatory response to sleep loss
    Janet Mullington; Fiscal Year: 2006
  3. CHRONIC SLEEP RESTRICTION & HUMAN HOST RESPONSE
    Janet Mullington; Fiscal Year: 2004
  4. Aging & the inflammatory, metabolic and autonomic response to sleep loss
    Janet Mullington; Fiscal Year: 2009

Collaborators

Detail Information

Publications12

  1. ncbi Sleep loss reduces diurnal rhythm amplitude of leptin in healthy men
    J M Mullington
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Neuroendocrinol 15:851-4. 2003
    ..This finding provides evidence that sleep influences the nocturnal leptin profile, and may have implications for the understanding of the role of sleep in metabolic regulation and the aetiologies of obesity and the night eating syndrome...
  2. ncbi Sleep loss and inflammation
    Janet M Mullington
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Best Pract Res Clin Endocrinol Metab 24:775-84. 2010
    ..Although the mechanism of this altered inflammatory status in humans undergoing experimental sleep loss is unknown, it is likely that autonomic activation and metabolic changes play key roles...
  3. ncbi Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk
    Hans K Meier-Ewert
    Department of Cardiology, Lahey Clinic Medical Center, Burlington, Boston, Massachusetts, USA
    J Am Coll Cardiol 43:678-83. 2004
    ..We propose that sleep loss may be one of the ways that inflammatory processes are activated and contribute to the association of sleep complaints, short sleep duration, and cardiovascular morbidity observed in epidemiologic surveys...
  4. ncbi Mediators of inflammation and their interaction with sleep: relevance for chronic fatigue syndrome and related conditions
    J M Mullington
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Ann N Y Acad Sci 933:201-10. 2001
    ..The debilitating fatigue experienced in chronic fatigue syndrome and related diseases may also be related to altered cytokine profiles...
  5. ncbi Elevated inflammatory markers in response to prolonged sleep restriction are associated with increased pain experience in healthy volunteers
    Monika Haack
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Sleep 30:1145-52. 2007
    ..Sleep disturbances, pain, and inflammation co-occur in various medical conditions, but their interrelationships are poorly understood...
  6. ncbi Cardiovascular, inflammatory, and metabolic consequences of sleep deprivation
    Janet M Mullington
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School Division of Cardiology, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA
    Prog Cardiovasc Dis 51:294-302. 2009
    ..These studies show that insufficient sleep alters established cardiovascular risk factors in a direction that is known to increase the risk of cardiac morbidity...
  7. ncbi Activation of the prostaglandin system in response to sleep loss in healthy humans: potential mediator of increased spontaneous pain
    Monika Haack
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Pain 145:136-41. 2009
    ..Activation of the PGE2 system appears to be a potential mediator of increased spontaneous pain in response to insufficient sleep...
  8. ncbi Diurnal and sleep-wake dependent variations of soluble TNF- and IL-2 receptors in healthy volunteers
    Monika Haack
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, DA 779, Boston, MA 02215, USA
    Brain Behav Immun 18:361-7. 2004
    ..These diurnal variations in sTNF-Rs levels are consistent with the hypothesis that the TNF system plays a role in normal diurnal temperature regulation...
  9. ncbi Sustained sleep restriction reduces emotional and physical well-being
    Monika Haack
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, East Campus, Dana 779, Boston, MA 02215, USA
    Pain 119:56-64. 2005
    ..Prolonged curtailment of nocturnal sleep has been studied for its adverse effect on cognitive functioning and subjective tiredness, but relatively little is known about its effect on mood and physical symptoms...
  10. ncbi The contribution of sleep to improvements in working memory scanning speed: a study of prolonged sleep restriction
    Melynda D Casement
    Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Biol Psychol 72:208-12. 2006
    ..These results indicate that the efficiency of working memory scanning can improve with repeated practice given sufficient sleep, and that prolonged sleep restriction to 50% of habitual sleep prevents this improvement...
  11. ncbi Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality
    Kiichiro Yano
    Center for Vascular Biology Research, Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Exp Med 203:1447-58. 2006
    ..Adenovirus-mediated overexpression of VEGF but not PlGF exacerbated the lipopolysaccharide-mediated toxic effects. Together, these data support a pathophysiological role for VEGF in mediating the sepsis phenotype...
  12. ncbi The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation
    Hans P A Van Dongen
    Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, Department of Psychiatry, and Centerfor Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    Sleep 26:117-26. 2003
    ....

Research Grants13

  1. Aging & the inflammatory, metabolic and autonomic response to sleep loss
    Janet Mullington; Fiscal Year: 2007
    ..An additional metabolic challenge includes the fasting oral glucose test conducted at baseline and during the latter part of the vigil. ..
  2. Adiposity, BP & the inflammatory response to sleep loss
    Janet Mullington; Fiscal Year: 2006
    ..In screening data from this study we will also investigate the relationship between adiposity, cardiovascular fitness, C-reactive protein and habitual sleep duration and quality. ..
  3. CHRONIC SLEEP RESTRICTION & HUMAN HOST RESPONSE
    Janet Mullington; Fiscal Year: 2004
    ..This research will significantly enhance our understanding of the role of sleep in host protection and autonomic regulation, and have broad implications for health maintenance and illness prevention. ..
  4. Aging & the inflammatory, metabolic and autonomic response to sleep loss
    Janet Mullington; Fiscal Year: 2009
    ..An additional metabolic challenge includes the fasting oral glucose test conducted at baseline and during the latter part of the vigil. ..