Nishit K Mukhopadhyay

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Unraveling androgen receptor interactomes by an array-based method: discovery of proto-oncoprotein c-Rel as a negative regulator of androgen receptor
    Nishit K Mukhopadhyay
    Molecular Urology Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Exp Cell Res 312:3782-95. 2006
  2. ncbi The zinc finger protein ras-responsive element binding protein-1 is a coregulator of the androgen receptor: implications for the role of the Ras pathway in enhancing androgenic signaling in prostate cancer
    Nishit K Mukhopadhyay
    Department of Urology Surgery, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Mol Endocrinol 21:2056-70. 2007
  3. ncbi Cholesterol sensitivity of endogenous and myristoylated Akt
    Rosalyn M Adam
    Urological Diseases Research Center, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Cancer Res 67:6238-46. 2007
  4. pmc Heterogeneous nuclear ribonucleoprotein K is a novel regulator of androgen receptor translation
    Nishit K Mukhopadhyay
    Urological Diseases Research Center, Department of Urology, Children s Hospital Boston, Boston, MA 02115, USA
    Cancer Res 69:2210-8. 2009
  5. ncbi Activation of focal adhesion kinase in human lung cancer cells involves multiple and potentially parallel signaling events
    Nishit K Mukhopadhyay
    Division of Thoracic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, 02115, USA
    J Cell Mol Med 9:387-97. 2005
  6. ncbi Phosphoinositide 3-kinase-independent non-genomic signals transit from the androgen receptor to Akt1 in membrane raft microdomains
    Bekir Cinar
    Urological Diseases Research Center, Departments of Urology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 282:29584-93. 2007
  7. ncbi Effectiveness of trichostatin A as a potential candidate for anticancer therapy in non-small-cell lung cancer
    Nishit K Mukhopadhyay
    Division of Thoracic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Ann Thorac Surg 81:1034-42. 2006
  8. pmc Transit of hormonal and EGF receptor-dependent signals through cholesterol-rich membranes
    Michael R Freeman
    Urological Diseases Research Center, Department of Urology, Children s Hospital Boston, Boston, MA 02115, United States
    Steroids 72:210-7. 2007
  9. pmc Rapid preparation of nuclei-depleted detergent-resistant membrane fractions suitable for proteomics analysis
    Rosalyn M Adam
    Urological Diseases Research Center, Children s Hospital Boston and Department of Surgery, Harvard Medical School, Boston, MA 02115, USA
    BMC Cell Biol 9:30. 2008
  10. ncbi Cloning and functional characterization of the murine mastermind-like 1 (Maml1) gene
    Lizi Wu
    Department of Medical Oncology, Mayer 540, Dana Farber Cancer Institute, Brigham and Women s Hospital and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Gene 328:153-65. 2004

Detail Information

Publications11

  1. ncbi Unraveling androgen receptor interactomes by an array-based method: discovery of proto-oncoprotein c-Rel as a negative regulator of androgen receptor
    Nishit K Mukhopadhyay
    Molecular Urology Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Exp Cell Res 312:3782-95. 2006
    ..In summary, we have identified several new partners of AR by using the TF-TF array method and have provided the first evidence of a functional role for c-Rel in androgen-responsive human prostate cancer cells...
  2. ncbi The zinc finger protein ras-responsive element binding protein-1 is a coregulator of the androgen receptor: implications for the role of the Ras pathway in enhancing androgenic signaling in prostate cancer
    Nishit K Mukhopadhyay
    Department of Urology Surgery, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Mol Endocrinol 21:2056-70. 2007
    ..Collectively, our data for the first time identify RREB-1 as a repressor of AR and further implicate the Ras/MAPK kinase pathway as a likely antagonist of the inhibitory effects of RREB-1 on androgenic signaling...
  3. ncbi Cholesterol sensitivity of endogenous and myristoylated Akt
    Rosalyn M Adam
    Urological Diseases Research Center, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Cancer Res 67:6238-46. 2007
    ....
  4. pmc Heterogeneous nuclear ribonucleoprotein K is a novel regulator of androgen receptor translation
    Nishit K Mukhopadhyay
    Urological Diseases Research Center, Department of Urology, Children s Hospital Boston, Boston, MA 02115, USA
    Cancer Res 69:2210-8. 2009
    ..HnRNP-K is the first protein identified that directly interacts with and regulates the AR translational apparatus...
  5. ncbi Activation of focal adhesion kinase in human lung cancer cells involves multiple and potentially parallel signaling events
    Nishit K Mukhopadhyay
    Division of Thoracic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, 02115, USA
    J Cell Mol Med 9:387-97. 2005
    ..Collectively, this report defines the existence of multiple and potentially parallel Coll IV/beta1-integrin mediated signaling events in Calu-1 cells, which involve FAK, ERKs, and PKC...
  6. ncbi Phosphoinositide 3-kinase-independent non-genomic signals transit from the androgen receptor to Akt1 in membrane raft microdomains
    Bekir Cinar
    Urological Diseases Research Center, Departments of Urology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 282:29584-93. 2007
    ..Our results indicate that cholesterol-rich membrane microdomains play a role in transmitting non-genomic signals involving androgen and the Akt pathway in prostate cancer cells...
  7. ncbi Effectiveness of trichostatin A as a potential candidate for anticancer therapy in non-small-cell lung cancer
    Nishit K Mukhopadhyay
    Division of Thoracic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Ann Thorac Surg 81:1034-42. 2006
    ....
  8. pmc Transit of hormonal and EGF receptor-dependent signals through cholesterol-rich membranes
    Michael R Freeman
    Urological Diseases Research Center, Department of Urology, Children s Hospital Boston, Boston, MA 02115, United States
    Steroids 72:210-7. 2007
    ..Understanding the manner in which these pathways converge within cholesterol-rich membranes may present new avenues for therapeutic intervention in hormone-dependent cancers...
  9. pmc Rapid preparation of nuclei-depleted detergent-resistant membrane fractions suitable for proteomics analysis
    Rosalyn M Adam
    Urological Diseases Research Center, Children s Hospital Boston and Department of Surgery, Harvard Medical School, Boston, MA 02115, USA
    BMC Cell Biol 9:30. 2008
    ..To address these issues, we have modified a published differential detergent extraction method to enable rapid DRM isolation that minimizes nuclear contamination and yields fractions compatible with mass spectrometry...
  10. ncbi Cloning and functional characterization of the murine mastermind-like 1 (Maml1) gene
    Lizi Wu
    Department of Medical Oncology, Mayer 540, Dana Farber Cancer Institute, Brigham and Women s Hospital and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Gene 328:153-65. 2004
    ..There seems to be close correlation of the spatial and temporal expression among Maml1, Notch1 and Hes1 in the central nervous system (CNS) during early development, implicating a role for the Maml1 gene in neurogenesis...
  11. ncbi Integrin-dependent protein tyrosine phosphorylation is a key regulatory event in collagen-IV-mediated adhesion and proliferation of human lung tumor cell line, Calu-1
    Nishit K Mukhopadhyay
    Division of Thoracic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Ann Thorac Surg 78:450-7. 2004
    ..During invasion, tumor cells attach to the basement membrane protein, collagen type IV, degrade it, migrate through blood vessels, and adhere to extracellular matrix proteins...