Genomes and Genes
Nishit K Mukhopadhyay
Affiliation: Harvard University
- Unraveling androgen receptor interactomes by an array-based method: discovery of proto-oncoprotein c-Rel as a negative regulator of androgen receptorNishit K Mukhopadhyay
Molecular Urology Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Exp Cell Res 312:3782-95. 2006..In summary, we have identified several new partners of AR by using the TF-TF array method and have provided the first evidence of a functional role for c-Rel in androgen-responsive human prostate cancer cells...
- The zinc finger protein ras-responsive element binding protein-1 is a coregulator of the androgen receptor: implications for the role of the Ras pathway in enhancing androgenic signaling in prostate cancerNishit K Mukhopadhyay
Department of Urology Surgery, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
Mol Endocrinol 21:2056-70. 2007..Collectively, our data for the first time identify RREB-1 as a repressor of AR and further implicate the Ras/MAPK kinase pathway as a likely antagonist of the inhibitory effects of RREB-1 on androgenic signaling...
- Cholesterol sensitivity of endogenous and myristoylated AktRosalyn M Adam
Urological Diseases Research Center, Children s Hospital Boston, Boston, Massachusetts 02115, USA
Cancer Res 67:6238-46. 2007....
- Heterogeneous nuclear ribonucleoprotein K is a novel regulator of androgen receptor translationNishit K Mukhopadhyay
Urological Diseases Research Center, Department of Urology, Children s Hospital Boston, Boston, MA 02115, USA
Cancer Res 69:2210-8. 2009..HnRNP-K is the first protein identified that directly interacts with and regulates the AR translational apparatus...
- Activation of focal adhesion kinase in human lung cancer cells involves multiple and potentially parallel signaling eventsNishit K Mukhopadhyay
Division of Thoracic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, 02115, USA
J Cell Mol Med 9:387-97. 2005..Collectively, this report defines the existence of multiple and potentially parallel Coll IV/beta1-integrin mediated signaling events in Calu-1 cells, which involve FAK, ERKs, and PKC...
- Phosphoinositide 3-kinase-independent non-genomic signals transit from the androgen receptor to Akt1 in membrane raft microdomainsBekir Cinar
Urological Diseases Research Center, Departments of Urology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 282:29584-93. 2007..Our results indicate that cholesterol-rich membrane microdomains play a role in transmitting non-genomic signals involving androgen and the Akt pathway in prostate cancer cells...
- Effectiveness of trichostatin A as a potential candidate for anticancer therapy in non-small-cell lung cancerNishit K Mukhopadhyay
Division of Thoracic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Ann Thorac Surg 81:1034-42. 2006....
- Transit of hormonal and EGF receptor-dependent signals through cholesterol-rich membranesMichael R Freeman
Urological Diseases Research Center, Department of Urology, Children s Hospital Boston, Boston, MA 02115, United States
Steroids 72:210-7. 2007..Understanding the manner in which these pathways converge within cholesterol-rich membranes may present new avenues for therapeutic intervention in hormone-dependent cancers...
- Rapid preparation of nuclei-depleted detergent-resistant membrane fractions suitable for proteomics analysisRosalyn M Adam
Urological Diseases Research Center, Children s Hospital Boston and Department of Surgery, Harvard Medical School, Boston, MA 02115, USA
BMC Cell Biol 9:30. 2008..To address these issues, we have modified a published differential detergent extraction method to enable rapid DRM isolation that minimizes nuclear contamination and yields fractions compatible with mass spectrometry...
- Cloning and functional characterization of the murine mastermind-like 1 (Maml1) geneLizi Wu
Department of Medical Oncology, Mayer 540, Dana Farber Cancer Institute, Brigham and Women s Hospital and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
Gene 328:153-65. 2004..There seems to be close correlation of the spatial and temporal expression among Maml1, Notch1 and Hes1 in the central nervous system (CNS) during early development, implicating a role for the Maml1 gene in neurogenesis...
- Integrin-dependent protein tyrosine phosphorylation is a key regulatory event in collagen-IV-mediated adhesion and proliferation of human lung tumor cell line, Calu-1Nishit K Mukhopadhyay
Division of Thoracic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Ann Thorac Surg 78:450-7. 2004..During invasion, tumor cells attach to the basement membrane protein, collagen type IV, degrade it, migrate through blood vessels, and adhere to extracellular matrix proteins...