Kenneth Jay Mukamal

..We sought to derive and validate a cardiovascular disease (CVD) prediction algorithm for older adults with diabetes, and evaluate the incremental benefit of adding novel circulating biomarkers and measures of subclinical atherosclerosis...

..We sought to determine whether this process might be associated with appendicitis...

..Cohort studies have suggested little effect of coffee consumption on risk of acute myocardial infarction. The effect of coffee consumption on prognosis after myocardial infarction is uncertain...

..The relationship of marijuana use with coronary heart disease, including prognosis among patients with coronary heart disease, is uncertain...

..01). Alcohol consumption of 1-13 drinks per week in older adults may be associated with lower risk of LEAD, but heavier drinking is not associated with lower risk...

..The effects of black tea consumption on cardiovascular risk factors have been inconsistent in previous randomized trials, all of which have been limited to a few weeks duration...

..Whether alcohol intake is associated with concentrations of interleukin-6 (IL-6) and serum amyloid P (SAP) is uncertain...

..Whether this variation influences risk of infection, and hence whether CRP has anti-infective activity in humans, is uncertain...

..Body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) has been linked to depression and the risk of suicide attempts and deaths in conflicting directions...

..Previous studies have found inconsistent relationships of alcohol consumption with risk of hip fracture, and the importance of bone mineral density and risk of falls in mediating such a relationship has not been determined...

..Counseling for alcohol use is of proven utility, but whether disparities in provision of counseling exist is uncertain...

..The lower costs associated with moderate drinking were most apparent among participants with cardiovascular disease (CVD) and for hospitalization costs for CVD among healthy participants. Former drinkers had the highest costs...

..The relationship of alcohol consumption with risk of atrial fibrillation (AF) is inconsistent in previous studies, and its relationship with prognosis of AF is undetermined...

..The relationship of moderate alcohol use and health remains controversial and uncertain. How physicians and patients react to this uncertainty is unknown...

..Recommendations regarding moderate drinking must be individualized to reflect the potentially competing effects of alcohol on several chronic diseases...

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..The aim of this study was to determine the association of alcohol consumption and cardiovascular mortality in the U.S. population...

..To determine whether angiotensin-converting enzyme (ACE) inhibitors and other antihypertensives are associated with risk of pneumonia...

..Body mass index (BMI) has been linked with both increased and decreased risk of suicide attempts and deaths...

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..Previous studies of genetic variants of paraoxonase 1 (PON1) and coronary heart disease (CHD) have been conflicting and the modifying effects of lifestyle factors that affect PON1 activity are uncertain...

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..The roles of weather conditions and air pollution as triggers of headache have been inconsistent in previous, generally small studies...

..In some cases, risk factors were actually greater with heavier BMI. Further study of the relationship of BMI and suicide may yield novel modifiable risk factors that could cause or prevent this important cause of death...

..Individuals who die from suicide commonly have consumed alcohol immediately beforehand, often in large quantities. However, prospective cohort data on regular alcohol use as a risk factor for suicide are lacking...

..We previously found preliminary evidence that tea consumption may also be associated with lower risk of infarct-related ventricular arrhythmias...

..Moderate drinkers have a lower risk of mortality after myocardial infarction (MI). Although binge drinking has been associated with a higher risk of MI in some studies, its relation to prognosis after MI is uncertain...

..The association of light to moderate alcohol consumption with risk of ischemic stroke remains uncertain, as are the roles of potentially mediating factors and modification by apolipoprotein E (apoE) genotype...

..The relationship of the full range of alcohol consumption with risk of incident atrial fibrillation has been inconsistent in previous, mainly case-control studies...

..Alcohol intake has been associated with lower platelet activity; however, few large-scale studies have included women, and to our knowledge, the relationship of alcohol intake with measures of platelet activation has not been studied...

..The association of light to moderate alcohol consumption with risk for ischemic stroke remains controversial, as do the roles of beverage type and drinking pattern...

..Previous studies have generally suggested no effect of coffee consumption on the risk of acute myocardial infarction. The effect of coffee consumption on prognosis after acute myocardial infarction is uncertain...

..To evaluate several aspects of the relationship between alcohol use and coronary heart disease in older adults, including beverage type, mediating factors, and type of outcome...

..Although moderate drinking has been associated with lower mortality among patients after myocardial infarction, its relationship with prognosis and graft obstruction among patients with coronary artery bypass grafts is unknown...

..75; 95% confidence interval, 0.57 to 0.99; p for trend 0.02), with similar findings among men, women, whites, and blacks...

..Although moderate drinking has been associated with lower mortality among patients with coronary heart disease, its safety among patients taking common cardiac medications is unknown...

..Whether the association of alcohol consumption and cardiovascular disease is the product of confounding and the degree to which this concern applies to other behaviors are unclear...

..These findings support the hypothesis that inflammation contributes to the etiology of AF...

..Heavy drinking has been associated with several cancers, including melanoma and basal cell carcinoma...

..We studied whether alcohol consumption is inversely associated with risk for coronary heart disease in men who report consistently favorable lifestyle behaviors...

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..Whether weight reduction and secondary prevention strategies would reverse this effect in obese population remains to be seen...

..To estimate the prevalence of problem drinking and related risk behaviors among adults with diabetes and eye disease in the United States...

..However, data on the association between alcohol consumption and CVD among individuals with hypertension are scarce...

..We sought to investigate whether a polymorphism in the alcohol dehydrogenase 1c (ADH1C) gene modifies the association between alcohol consumption and type 2 diabetes...

..Inconsistency in observation of such an effect in patients with diabetes in the past may well have been due to difference in the duration of diabetes and thus the variable extent of underlying autonomic dysfunction...

..This study examines whether obesity accelerates atherogenic progression or adverse outcomes after coronary artery bypass graft (CABG) surgery...

..The association of alcohol use with atherosclerosis is inconsistent in previous studies...

..Nonetheless, the risks and benefits of alcohol use remain complex, even among patients with CHD, and no simple recommendation regarding alcohol consumption can be made for all patients...

..Type 2 diabetes (T2D) remains an important public health issue in the United States. There are limited and inconsistent data on the association between egg consumption and fasting glucose or incident diabetes...

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..Alcohol consumption has been associated with complex changes in cerebral vasculature and structure in older adults. How alcohol consumption affects the incidence of dementia is less clear...

..Although moderate drinking confers a decreased risk of myocardial infarction, the roles of the drinking pattern and type of beverage remain unclear...

..Further research is needed to determine how these associations interact to influence overall brain function...

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..Some herbal supplements may contain lead...

..The association of acculturation and cardiovascular risk factor control among populations with high proportions of immigrants has not been well studied...

..However, in placebo-controlled trials the incidence of muscle pain is most often similar for placebo and active control groups...

..To provide deeper insight into the role of natural variation in this gene, we investigated the association between the LPL S447X variant with lipids and risk of coronary heart disease (CHD) in 3 independent, prospective studies...

..We examined whether obesity's association with novel cardiovascular risk factors such as C-reactive protein (CRP) also varies by race and ethnicity...

..However, few studies have comprehensively examined six common single-nucleotide polymorphisms (SNPs) in the CRP gene, haplotypes, and plasma CRP levels with risk of coronary heart disease (CHD)...

..We suggest specific strategies that clinician-educators, investigators, administrative leaders, and medical schools might use to foster collaboration...

..We sought to determine the relation of alcohol intake and systemic inflammation in a population-based sample of older adults...

..Saphenous vein grafts are common among patients with a history of coronary artery bypass graft (CABG) surgery. Chronic kidney disease (CKD) is an established cardiovascular risk factor, but its role in graft disease has not been evaluated...

..In conclusion, WBC count is associated with a graded increase in cardiovascular events in patients with coronary artery bypass grafts...

..These results may prove to have important biological, clinical, and public health implications for the care of CHD. ..

..Finally, we will examine how a derived dietary antioxidant score, based upon measured oxidative potential of specific foods using the ferric-reducing/antioxidant power method, is related to PAD. ..

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..Finally, we will examine how a derived dietary antioxidant score, based upon measured oxidative potential of specific foods using the ferric-reducing/antioxidant power method, is related to PAD. ..