Dariush Mozaffarian

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Trans fatty acids and cardiovascular disease
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 354:1601-13. 2006
  2. ncbi Plasma phospholipid trans fatty acids, fatal ischemic heart disease, and sudden cardiac death in older adults: the cardiovascular health study
    Rozenn N Lemaitre
    University of Washington, Cardiovascular Health Research Unit, Department of Medicine, 1730 Minor Ave, Suite 1360, Seattle, Washington 98101, USA
    Circulation 114:209-15. 2006
  3. ncbi Fish intake, contaminants, and human health: evaluating the risks and the benefits
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Mass 02115, USA
    JAMA 296:1885-99. 2006
  4. ncbi Fish intake and risk of incident heart failure
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    J Am Coll Cardiol 45:2015-21. 2005
  5. ncbi Association of plasma phospholipid long-chain omega-3 fatty acids with incident atrial fibrillation in older adults: the cardiovascular health study
    Jason H Y Wu
    Departments of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Circulation 125:1084-93. 2012
  6. ncbi Blood concentrations of individual long-chain n-3 fatty acids and risk of nonfatal myocardial infarction
    Qi Sun
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 88:216-23. 2008
  7. ncbi Mercury exposure and risk of cardiovascular disease in two U.S. cohorts
    Dariush Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    N Engl J Med 364:1116-25. 2011
  8. ncbi Interplay between different polyunsaturated fatty acids and risk of coronary heart disease in men
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    Circulation 111:157-64. 2005
  9. ncbi Fish intake and risk of incident atrial fibrillation
    Dariush Mozaffarian
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, and Department of Epidemiology, Harvard School of Public Health, Boston, Mass, USA
    Circulation 110:368-73. 2004
  10. ncbi Circulating palmitoleic acid and risk of metabolic abnormalities and new-onset diabetes
    Dariush Mozaffarian
    Division of Cardiovascular Medicine and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School and Epidemiology, University of Washington, Seattle, WA, USA
    Am J Clin Nutr 92:1350-8. 2010

Detail Information

Publications89

  1. ncbi Trans fatty acids and cardiovascular disease
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 354:1601-13. 2006
  2. ncbi Plasma phospholipid trans fatty acids, fatal ischemic heart disease, and sudden cardiac death in older adults: the cardiovascular health study
    Rozenn N Lemaitre
    University of Washington, Cardiovascular Health Research Unit, Department of Medicine, 1730 Minor Ave, Suite 1360, Seattle, Washington 98101, USA
    Circulation 114:209-15. 2006
    ..To extend these findings, we investigated the associations of plasma phospholipid trans fatty acids with fatal ischemic heart disease (IHD) and sudden cardiac death...
  3. ncbi Fish intake, contaminants, and human health: evaluating the risks and the benefits
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Mass 02115, USA
    JAMA 296:1885-99. 2006
    ..Fish (finfish or shellfish) may have health benefits and also contain contaminants, resulting in confusion over the role of fish consumption in a healthy diet...
  4. ncbi Fish intake and risk of incident heart failure
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    J Am Coll Cardiol 45:2015-21. 2005
    ..Our aim was to investigate the relation between fish consumption and incidence of congestive heart failure (CHF)...
  5. ncbi Association of plasma phospholipid long-chain omega-3 fatty acids with incident atrial fibrillation in older adults: the cardiovascular health study
    Jason H Y Wu
    Departments of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Circulation 125:1084-93. 2012
    ..Prior studies evaluating fish or n-3 PUFA consumption from dietary questionnaires and incident AF have been conflicting. Circulating levels of n-3 PUFAs provide an objective measurement of exposure...
  6. ncbi Blood concentrations of individual long-chain n-3 fatty acids and risk of nonfatal myocardial infarction
    Qi Sun
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 88:216-23. 2008
    ..Whereas dietary intake of long-chain n-3 fatty acids has been associated with risk of nonfatal myocardial infarction (MI), few studies have examined the relation for blood concentrations...
  7. ncbi Mercury exposure and risk of cardiovascular disease in two U.S. cohorts
    Dariush Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    N Engl J Med 364:1116-25. 2011
    ..Beneficial effects of the ingestion of fish and selenium may also modify such effects...
  8. ncbi Interplay between different polyunsaturated fatty acids and risk of coronary heart disease in men
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    Circulation 111:157-64. 2005
    ..Additionally, seafood-based, long-chain n-3 PUFAs may modify the effects of plant-based, intermediate-chain n-3 PUFAs. However, the interactions of these PUFAs in relation to CHD risk are not well established...
  9. ncbi Fish intake and risk of incident atrial fibrillation
    Dariush Mozaffarian
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, and Department of Epidemiology, Harvard School of Public Health, Boston, Mass, USA
    Circulation 110:368-73. 2004
    ..Although effects of fish intake, including potential antiarrhythmic effects, may favorably influence risk of AF, relationships between fish intake and AF incidence have not been evaluated...
  10. ncbi Circulating palmitoleic acid and risk of metabolic abnormalities and new-onset diabetes
    Dariush Mozaffarian
    Division of Cardiovascular Medicine and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School and Epidemiology, University of Washington, Seattle, WA, USA
    Am J Clin Nutr 92:1350-8. 2010
    ..Animal experiments suggest that circulating palmitoleic acid (cis-16:1n-7) from adipocyte de novo fatty acid synthesis may directly regulate insulin resistance and metabolic dysregulation...
  11. ncbi Egg consumption and risk of type 2 diabetes in older adults
    Luc Djousse
    Division of Aging, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    Am J Clin Nutr 92:422-7. 2010
    ..Type 2 diabetes (T2D) remains an important public health issue in the United States. There are limited and inconsistent data on the association between egg consumption and fasting glucose or incident diabetes...
  12. ncbi Nonesterified fatty acids and risk of sudden cardiac death in older adults
    Luc Djousse
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School and Boston Veterans Affairs Healthcare System, Boston, MA 02120, USA
    Circ Arrhythm Electrophysiol 5:273-8. 2012
    ..Although nonesterified fatty acids (NEFA) have been positively associated with coronary heart disease risk factors, limited and inconsistent data are available on the relation between NEFA and sudden cardiac death...
  13. ncbi Circulating long-chain ?-3 fatty acids and incidence of congestive heart failure in older adults: the cardiovascular health study: a cohort study
    Dariush Mozaffarian
    Brigham and Women s Hospital, Harvard Medical School, and Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Ann Intern Med 155:160-70. 2011
    ..Circulating fatty acid concentrations provide objective biomarkers of exposure...
  14. ncbi Dietary fish and omega-3 fatty acid consumption and heart rate variability in US adults
    Dariush Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    Circulation 117:1130-7. 2008
    ..We hypothesized that habitual consumption of fish and marine omega-3 fatty acids would be associated with more favorable HRV, elucidating electrophysiological influences and supporting effects on clinical risk...
  15. ncbi Fish consumption and stroke risk in elderly individuals: the cardiovascular health study
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Harvard School of Public Health, Boston, MA, USA
    Arch Intern Med 165:200-6. 2005
    ..Additionally, such relationships have not been specifically evaluated in the elderly, in whom disease burden may be high and diet less influential...
  16. ncbi Omega-3 fatty acids and incident type 2 diabetes: a systematic review and meta-analysis
    Jason H Y Wu
    Department of Epidemiology, Harvard School of Public Health, Boston, 665 Huntington Ave, Kresge Building 913, Boston MA 02115, USA
    Br J Nutr 107:S214-27. 2012
    ..Reasons for potential heterogeneity of effects, which could include true biologic heterogeneity, publication bias, or chance, deserve further investigation...
  17. ncbi Optimal dietary habits for the prevention of stroke
    Eric L Ding
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Semin Neurol 26:11-23. 2006
    ..Further research is needed regarding the possible effects of other major dietary factors on stroke risk...
  18. ncbi Fatty acids in the de novo lipogenesis pathway and risk of coronary heart disease: the Cardiovascular Health Study
    Jason H Y Wu
    Division of Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am J Clin Nutr 94:431-8. 2011
    ..DNL could affect coronary heart disease (CHD) or sudden cardiac arrest (SCA) via generation of specific fatty acids. Whether these fatty acids are prospectively associated with SCA or other CHD events is unknown...
  19. ncbi Changes in diet and lifestyle and long-term weight gain in women and men
    Dariush Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    N Engl J Med 364:2392-404. 2011
    ..Specific dietary and other lifestyle behaviors may affect the success of the straightforward-sounding strategy "eat less and exercise more" for preventing long-term weight gain...
  20. ncbi Fish consumption and risk of major chronic disease in men
    Jyrki K Virtanen
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 88:1618-25. 2008
    ..Higher n-6 fatty acid consumption has also been hypothesized to reduce the health benefits of n-3 fatty acids in fish...
  21. ncbi Trans-palmitoleic acid, metabolic risk factors, and new-onset diabetes in U.S. adults: a cohort study
    Dariush Mozaffarian
    Brigham and Women s Hospital, Harvard Medical School, and Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Ann Intern Med 153:790-9. 2010
    ..Trans-palmitoleate (trans-16:1n-7) represents a distinctly exogenous source of 16:1n-7, unconfounded by endogenous synthesis or its determinants, that may be uniquely informative...
  22. ncbi Long-chain omega-3 fatty acids, fish intake, and the risk of type 2 diabetes mellitus
    Manas Kaushik
    Departments of Nutrition, Harvard Medical School and Brigham and Women s Hospital, Boston, MA, USA
    Am J Clin Nutr 90:613-20. 2009
    ..The role of long-chain omega-3 (n-3) fatty acids (LCFAs) in the development of T2DM remains unresolved. Objective: We examined the association between dietary LCFAs and incidence of T2DM in 3 prospective cohorts of women and men...
  23. ncbi Endogenous red blood cell membrane fatty acids and sudden cardiac arrest
    Rozenn N Lemaitre
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA
    Metabolism 59:1029-34. 2010
    ..Further work is needed to investigate if conditions that favor de novo fatty acid synthesis, such as high-carbohydrate/low-fat diets, might also increase the risk of SCA...
  24. ncbi trans fatty acids and systemic inflammation in heart failure
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Clin Nutr 80:1521-5. 2004
    ..trans fatty acid (TFA) intake increases systemic inflammation in healthy persons. However, the effect in patients with established heart disease is unknown...
  25. ncbi Cardiac benefits of fish consumption may depend on the type of fish meal consumed: the Cardiovascular Health Study
    Dariush Mozaffarian
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Wash, USA
    Circulation 107:1372-7. 2003
    ..Few studies have examined associations of fish consumption with ischemic heart disease (IHD) risk among older adults or how different types of fish meals relate to IHD risk...
  26. ncbi (n-3) fatty acids and cardiovascular health: are effects of EPA and DHA shared or complementary?
    Dariush Mozaffarian
    Division of Cardiovascular Medicine and Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
    J Nutr 142:614S-625S. 2012
    ....
  27. ncbi Circulating and dietary ?-linolenic acid and incidence of congestive heart failure in older adults: the Cardiovascular Health Study
    Rozenn N Lemaitre
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, 98101, USA
    Am J Clin Nutr 96:269-74. 2012
    ..Few studies have evaluated the association between the n-3 fatty acid ?-linolenic acid (ALA) and the incidence of congestive heart failure (CHF)...
  28. ncbi Intake of total trans, trans-18:1, and trans-18:2 fatty acids and risk of sudden cardiac death in women
    Stephanie E Chiuve
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am Heart J 158:761-7. 2009
    ....
  29. ncbi The effects of atorvastatin (10 mg) on systemic inflammation in heart failure
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 96:1699-704. 2005
    ..In conclusion, short-term atorvastatin therapy reduced the levels of several important inflammatory markers in patients with HF...
  30. ncbi Mercury Exposure and Risk of Hypertension in US Men and Women in 2 Prospective Cohorts
    Dariush Mozaffarian
    665 Huntington Ave, Building 2 319, Boston, MA 02115
    Hypertension 60:645-52. 2012
    ..5-fold higher than the reference dose...
  31. ncbi Trans fatty acids and cardiovascular risk: a unique cardiometabolic imprint?
    Dariush Mozaffarian
    Departments of Nutrition and Epidemiology, Harvard School of Public Health, 665 Huntington Avenue, Building 2 319, Boston, MA 02115, USA
    Curr Atheroscler Rep 9:486-93. 2007
    ....
  32. ncbi Fish, n-3 fatty acids, and cardiovascular haemodynamics
    Dariush Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    J Cardiovasc Med (Hagerstown) 8:S23-6. 2007
    ..These haemodynamic effects could in part account for clinical benefits of fish or fish oil intake, including lower risk of cardiac death and possibly ischaemic stroke, heart failure, cognitive decline, and nonfatal coronary events...
  33. ncbi Cereal fiber and whole-grain intake are associated with reduced progression of coronary-artery atherosclerosis in postmenopausal women with coronary artery disease
    Arja T Erkkilä
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am Heart J 150:94-101. 2005
    ..The aim was to examine the association between intakes of total fiber and fiber from different dietary sources and progression of coronary-artery atherosclerosis among women with established CAD...
  34. ncbi Red and processed meat consumption and risk of incident coronary heart disease, stroke, and diabetes mellitus: a systematic review and meta-analysis
    Renata Micha
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Circulation 121:2271-83. 2010
    ..Effects of meat intake on these different outcomes, as well as of red versus processed meat, may also vary...
  35. ncbi Trans-fatty acids and sudden cardiac death
    Rozenn N Lemaitre
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, USA
    Atheroscler Suppl 7:13-5. 2006
    ..While further studies are needed to investigate possible effects of trans-18:2 on arrhythmia, it would be prudent to limit dietary intake of trans-18:2...
  36. ncbi Effects of dietary fats versus carbohydrates on coronary heart disease: a review of the evidence
    Dariush Mozaffarian
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Curr Atheroscler Rep 7:435-45. 2005
    ....
  37. ncbi Non-communicable diseases in sub-Saharan Africa: what we know now
    Shona Dalal
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Int J Epidemiol 40:885-901. 2011
    ....
  38. ncbi Dietary fish and n-3 fatty acid intake and cardiac electrocardiographic parameters in humans
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Am Coll Cardiol 48:478-84. 2006
    ..We evaluated the association between dietary fish intake and several cardiac electrocardiographic parameters in humans relevant to arrhythmic risk...
  39. ncbi Measures of adiposity and future risk of ischemic stroke and coronary heart disease in older men and women
    Jorge R Kizer
    Department of Medicine, Weill Medical College of Cornell University, New York, New York, USA
    Am J Epidemiol 173:10-25. 2011
    ..Whether these differences translate to better risk prediction will require meta-analytical approaches, as will determination of prognostic cutpoints...
  40. ncbi Fish and n-3 fatty acids for the prevention of fatal coronary heart disease and sudden cardiac death
    Dariush Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Department of Epidemiology and Nutrition, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 87:1991S-6S. 2008
    ....
  41. ncbi Metabolic syndrome and mortality in older adults: the Cardiovascular Health Study
    Dariush Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, and Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Arch Intern Med 168:969-78. 2008
    ..In addition, few studies have compared the predictive utility of MetS to that of its individual risk factors...
  42. ncbi Consumption and health effects of trans fatty acids: a review
    Shyam Mohan Teegala
    Harvard School of Public Health, Department of Epidemiology, 665 Huntington Ave, Boston, MA, USA
    J AOAC Int 92:1250-7. 2009
    ..Both individual- and policy-level initiatives to decrease TFA consumption should continue, particularly in population subgroups and in developing nations with high consumption of partially hydrogenated vegetable oils...
  43. ncbi The preventable causes of death in the United States: comparative risk assessment of dietary, lifestyle, and metabolic risk factors
    Goodarz Danaei
    Harvard School of Public Health, Boston, MA, USA
    PLoS Med 6:e1000058. 2009
    ....
  44. ncbi Saturated fat and cardiometabolic risk factors, coronary heart disease, stroke, and diabetes: a fresh look at the evidence
    Renata Micha
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Lipids 45:893-905. 2010
    ....
  45. ncbi Dietary fats, carbohydrate, and progression of coronary atherosclerosis in postmenopausal women
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Harvard School of Public Health, Boston, Massachusetts, USA
    Am J Clin Nutr 80:1175-84. 2004
    ..The influence of diet on atherosclerotic progression is not well established, particularly in postmenopausal women, in whom risk factors for progression may differ from those for men...
  46. ncbi Lifestyle risk factors and new-onset diabetes mellitus in older adults: the cardiovascular health study
    Dariush Mozaffarian
    Divisions of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard School of Public Health, 665 Huntington Ave, Bldg 2 319, Boston, MA 02115, USA
    Arch Intern Med 169:798-807. 2009
    ..The objective of this study was to determine how lifestyle factors, assessed in combination, relate to new-onset diabetes in a broad and relatively unselected population of older adults...
  47. ncbi Incidence of new-onset diabetes and impaired fasting glucose in patients with recent myocardial infarction and the effect of clinical and lifestyle risk factors
    Dariush Mozaffarian
    Department of Medicine, Harvard Medical School and Harvard School of Public Health, Boston, MA 02115, USA
    Lancet 370:667-75. 2007
    ..We set out to estimate this incidence and investigate whether lifestyle factors such as dietary habits might alter this risk...
  48. ncbi Trans-fatty acids and nonlipid risk factors
    Sarah K Wallace
    Department of Epidemiology, Harvard School of Public Health, Division of Cardiovascular Medicine and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Building 2 315, Boston, MA 02115, USA
    Curr Atheroscler Rep 11:423-33. 2009
    ..These nonlipid effects also explain why TFA consumption may adversely impact other non-CHD diseases and end points...
  49. ncbi Intake of tuna or other broiled or baked fish versus fried fish and cardiac structure, function, and hemodynamics
    Dariush Mozaffarian
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 97:216-22. 2006
    ..These findings suggest potential specific physiologic mechanisms that may, in part, account for the effects of fish intake on cardiovascular health...
  50. ncbi Commentary: Ruminant trans fatty acids and coronary heart disease--cause for concern?
    Dariush Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
    Int J Epidemiol 37:182-4. 2008
  51. ncbi Systematic review and meta-analysis of methotrexate use and risk of cardiovascular disease
    Renata Micha
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Am J Cardiol 108:1362-70. 2011
    ..81, 95% CI 0.74 to 0.89). In conclusion, methotrexate use is associated with a lower risk for CVD in patients with chronic inflammation. These findings suggest that a direct treatment of inflammation may reduce CVD risk...
  52. ncbi Does alpha-linolenic acid intake reduce the risk of coronary heart disease? A review of the evidence
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA
    Altern Ther Health Med 11:24-30; quiz 31, 79. 2005
    ..Presently, the weight of the evidence favors recommendations for modest dietary consumption of ALA (2 to 3 g per day) for the primary and secondary prevention of CHD...
  53. ncbi Trans-Fatty Acid consumption and heart rate variability in 2 separate cohorts of older and younger adults
    Luísa Soares-Miranda
    Department of Epidemiology, Harvard School of Public Health, Boston, MA
    Circ Arrhythm Electrophysiol 5:728-38. 2012
    ..Trans-18:1 consumption is associated with more favorable HRV indices in older adults. Our results support the need to investigate potential HRV-related mechanisms, whereby trans-18:2 may increase arrhythmic risk...
  54. ncbi Effects on coronary heart disease of increasing polyunsaturated fat in place of saturated fat: a systematic review and meta-analysis of randomized controlled trials
    Dariush Mozaffarian
    Division of Cardiovascular Medicine and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Med 7:e1000252. 2010
    ..Additionally, some public health groups recommend lowering or limiting polyunsaturated fat (PUFA) consumption, a major potential replacement for SFA...
  55. ncbi Trans fatty acids - effects on systemic inflammation and endothelial function
    Dariush Mozaffarian
    The Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Atheroscler Suppl 7:29-32. 2006
    ..Further study is indicated to define these effects of TFA and the implications of such effects for cardiovascular health...
  56. ncbi Fish, mercury, selenium and cardiovascular risk: current evidence and unanswered questions
    Dariush Mozaffarian
    Division of Cardiovascular Medicine and Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Int J Environ Res Public Health 6:1894-916. 2009
    ..The relevant current unanswered questions and directions of further research are summarized...
  57. ncbi Physical activity and incidence of atrial fibrillation in older adults: the cardiovascular health study
    Dariush Mozaffarian
    Division of Cardiovascular Medicine and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    Circulation 118:800-7. 2008
    ..Vigorous exertion and endurance training have been reported to increase atrial fibrillation (AF). Associations of habitual light or moderate activity with AF incidence have not been evaluated...
  58. ncbi JELIS, fish oil, and cardiac events
    Dariush Mozaffarian
    Department of Medicine, Harvard Medical School and Harvard School of Public Health, Boston, MA 02115, USA
    Lancet 369:1062-3. 2007
  59. ncbi Prediction of mode of death in heart failure: the Seattle Heart Failure Model
    Dariush Mozaffarian
    Harvard Medical School and Harvard School of Public Health, Boston, Mass, USA
    Circulation 116:392-8. 2007
    ..Prediction of mode of death may facilitate decisions about specific medications or devices...
  60. ncbi Cereal, fruit, and vegetable fiber intake and the risk of cardiovascular disease in elderly individuals
    Dariush Mozaffarian
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Wash, USA
    JAMA 289:1659-66. 2003
    ..Additionally, the influence of dietary habits on risk may be less pronounced in elderly persons, when atherosclerosis is more advanced. However, few data address the influence of diet on CVD risk in this population...
  61. ncbi Lifestyles of older adults: can we influence cardiovascular risk in older adults?
    Dariush Mozaffarian
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Geriatr Cardiol 13:153-60. 2004
    ..Clinical practice and public health implications, gaps in knowledge, and future research directions are summarized...
  62. ncbi Beyond established and novel risk factors: lifestyle risk factors for cardiovascular disease
    Dariush Mozaffarian
    Division of Cardiovascular Medicine and Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
    Circulation 117:3031-8. 2008
  63. ncbi Dietary intake of trans fatty acids and systemic inflammation in women
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am J Clin Nutr 79:606-12. 2004
    ..Systemic inflammation may be involved in the pathogenesis of such conditions; however, relations between TFA intake and systemic inflammation are not well established...
  64. ncbi Meta-analysis: travel and risk for venous thromboembolism
    Divay Chandra
    Harvard School of Public Health, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Ann Intern Med 151:180-90. 2009
    ....
  65. ncbi Food sources of individual plasma phospholipid trans fatty acid isomers: the Cardiovascular Health Study
    Renata Micha
    Division of Cardiovascular Medicine, University of Washington, Seattle, WA, USA
    Am J Clin Nutr 91:883-93. 2010
    ..However, multiple TFA isomers exist, each with potentially different health effects. Different food sources of these specific TFA isomers are not well established...
  66. ncbi Promise of improving metabolic and lifestyle risk in practice
    Dariush Mozaffarian
    Division of Cardiovascular Medicine and Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. dmozaff
    Lancet 371:1973-4. 2008
  67. ncbi Effect of fish oil on heart rate in humans: a meta-analysis of randomized controlled trials
    Dariush Mozaffarian
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Circulation 112:1945-52. 2005
    ..The effect of fish oil on heart rate (HR), a major risk factor for sudden death, is not well established. We calculated this effect in a meta-analysis of randomized, double-blind, placebo-controlled trials in humans...
  68. ncbi The ?-3 Fatty Acids for Prevention of Post-Operative Atrial Fibrillation trial--rationale and design
    Dariush Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am Heart J 162:56-63.e3. 2011
    ....
  69. ncbi n-3 Polyunsaturated fatty acids, fatal ischemic heart disease, and nonfatal myocardial infarction in older adults: the Cardiovascular Health Study
    Rozenn N Lemaitre
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle 98101, USA
    Am J Clin Nutr 77:319-25. 2003
    ....
  70. ncbi Omega-3 Fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events
    Dariush Mozaffarian
    Division of Cardiovascular Medicine and Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts
    J Am Coll Cardiol 58:2047-67. 2011
    ..National and international guidelines have converged on consistent recommendations for the general population to consume at least 250 mg/day of long-chain n-3 PUFA or at least 2 servings/week of oily fish...
  71. ncbi Electron-beam computed tomography for coronary calcium: a useful test to screen for coronary heart disease?
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass, USA
    JAMA 294:2897-901. 2005
  72. ncbi Trans fatty acids: effects on metabolic syndrome, heart disease and diabetes
    Renata Micha
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Nat Rev Endocrinol 5:335-44. 2009
    ..Nevertheless, the documented adverse effects of TFAs underscore their potential to cause harm and the importance of policy measures to minimize consumption of industrially produced TFAs...
  73. ncbi Statin therapy is associated with lower mortality among patients with severe heart failure
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 93:1124-9. 2004
    ..52, 95% confidence interval 0.30 to 0.89). Although this observational study does not prove causality, further investigation of potential benefits of statins in patients with severe heart failure appears warranted...
  74. ncbi Elevated serum alanine aminotransferase activity and calculated risk of coronary heart disease in the United States
    George N Ioannou
    Research Enhancement Award Program, Department of Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Hepatology 43:1145-51. 2006
    ..This association is more prominent in women...
  75. ncbi The perfect storm: obesity, adipocyte dysfunction, and metabolic consequences
    Sarah de Ferranti
    Department of Cardiology, Children s Hospital Boston, Boston, MA 02115, USA
    Clin Chem 54:945-55. 2008
    ....
  76. ncbi Low-fat diet and cardiovascular disease
    Dariush Mozaffarian
    JAMA 296:279-80; author reply 280-1. 2006
  77. ncbi The Seattle Heart Failure Model: prediction of survival in heart failure
    Wayne C Levy
    University of Washington, Seattle, WA 98177, USA
    Circulation 113:1424-33. 2006
    ....
  78. ncbi Validation of the Seattle Heart Failure Model in a community-based heart failure population and enhancement by adding B-type natriuretic peptide
    Heidi T May
    LDS Hospital, Intermountain Medical Center, Salt Lake City, Utah, USA
    Am J Cardiol 100:697-700. 2007
    ..02). In conclusion, the SHFM predicts survival in patients with HF in a hospital-based population, with areas under the curve similar to those from data on which models were initially fit...
  79. ncbi Anemia predicts mortality in severe heart failure: the prospective randomized amlodipine survival evaluation (PRAISE)
    Dariush Mozaffarian
    Veterans Affairs Puget Sound Health Care System, 1660 South Columbian Way, MS 152, Seattle, WA 98108, USA
    J Am Coll Cardiol 41:1933-9. 2003
    ..Our aim was to examine the relationships between serum hematocrit (Hct) and risk of all-cause mortality among patients with severe heart failure (HF)...
  80. ncbi Decreased carotenoid content in preaponeurotic orbital fat of patients with involutional ptosis
    A J Ahmadi
    Department of Ophthalmology, University of Washington, Seattle, WA 98195-6485, USA
    Ophthal Plast Reconstr Surg 21:46-51. 2005
    ..Further investigation of the potential role of orbital fat carotenoids in the development of involutional ptosis is warranted...
  81. ncbi Usefulness of relative lymphocyte count as an independent predictor of death/urgent transplant in heart failure
    Kier V Huehnergarth
    Department of Internal Medicine, University of Washington, Seattle, Washington 98195, USA
    Am J Cardiol 95:1492-5. 2005
    ..There was only a borderline inverse association with cortisol levels during evening hours...
  82. ncbi Conclusions and recommendations from the symposium, Beyond Cholesterol: Prevention and Treatment of Coronary Heart Disease with n-3 Fatty Acids
    Richard J Deckelbaum
    Institute of Human Nutrition, Department of Pediatrics, Columbia University Medical Center, New York, NY 10032, USA
    Am J Clin Nutr 87:2010S-2S. 2008
    ..Additional references for these conclusions can be found in the articles included in the supplement...
  83. ncbi Free fatty acids, cardiovascular mortality, and cardiometabolic stress
    Dariush Mozaffarian
    Eur Heart J 28:2699-700. 2007
  84. ncbi Anginal symptoms consistently predict total mortality among outpatients with coronary artery disease
    Dariush Mozaffarian
    Health Services Research and Development Center of Excellence, Veterans Affairs Puget Sound Health Care System, University of Washington, Seattle, Wash, USA
    Am Heart J 146:1015-22. 2003
    ....
  85. ncbi The fish story: a diet-heart hypothesis with clinical implications: n-3 polyunsaturated fatty acids, myocardial vulnerability, and sudden death
    David S Siscovick
    Circulation 107:2632-4. 2003
  86. ncbi In patients with heart failure elevated soluble TNF-receptor 1 is associated with higher risk of depression
    Alec J Moorman
    Department of Internal Medicine, Division of Cardiology, University of Washington, Seattle, Washington, USA
    J Card Fail 13:738-43. 2007
    ..In this cross-sectional study, we investigated whether systemic inflammation, as assessed by circulating levels of inflammatory cytokines, was associated with comorbid depression in patients with heart failure...
  87. ncbi Ruminant or industrial sources of trans fatty acids: public health issue or food label skirmish?
    Walter Willett
    Am J Clin Nutr 87:515-6. 2008
  88. ncbi Fish oil and prevention of atrial fibrillation
    Dariush Mozaffarian
    J Am Coll Cardiol 50:1513-4. 2007