D Mozaffarian

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Processing of meats and cardiovascular risk: time to focus on preservatives
    Renata Micha
    Departments of Epidemiology and Nutrition, Harvard School of Public Health, 665 Huntington Ave, Bldg 2 319, Boston, MA 02115, USA
    BMC Med 11:136. 2013
  2. pmc Plasma phospholipid long-chain ω-3 fatty acids and total and cause-specific mortality in older adults: a cohort study
    Dariush Mozaffarian
    Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Ann Intern Med 158:515-25. 2013
  3. pmc trans-Palmitoleic acid, other dairy fat biomarkers, and incident diabetes: the Multi-Ethnic Study of Atherosclerosis (MESA)
    Dariush Mozaffarian
    Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 97:854-61. 2013
  4. doi request reprint Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events
    Dariush Mozaffarian
    Division of Cardiovascular Medicine and Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Am Coll Cardiol 58:2047-67. 2011
  5. pmc Fish oil and postoperative atrial fibrillation: the Omega-3 Fatty Acids for Prevention of Post-operative Atrial Fibrillation (OPERA) randomized trial
    Dariush Mozaffarian
    Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    JAMA 308:2001-11. 2012
  6. pmc Mercury exposure and risk of hypertension in US men and women in 2 prospective cohorts
    Dariush Mozaffarian
    Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Hypertension 60:645-52. 2012
  7. pmc (n-3) fatty acids and cardiovascular health: are effects of EPA and DHA shared or complementary?
    Dariush Mozaffarian
    Division of Cardiovascular Medicine and Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
    J Nutr 142:614S-625S. 2012
  8. pmc Association of plasma phospholipid long-chain ω-3 fatty acids with incident atrial fibrillation in older adults: the cardiovascular health study
    Jason H Y Wu
    Departments of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Circulation 125:1084-93. 2012
  9. pmc Saturated fat and cardiometabolic risk factors, coronary heart disease, stroke, and diabetes: a fresh look at the evidence
    Renata Micha
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Lipids 45:893-905. 2010
  10. ncbi request reprint Fish and n-3 fatty acids for the prevention of fatal coronary heart disease and sudden cardiac death
    Dariush Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Department of Epidemiology and Nutrition, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 87:1991S-6S. 2008

Research Grants

  1. Mercury, Selenium, and Risk of Cardiovascular Disease in Women and Men
    Dariush Mozaffarian; Fiscal Year: 2010
  2. Fatty Acids and Major Cardiovascular Outcomes
    Dariush Mozaffarian; Fiscal Year: 2009
  3. Mercury, Selenium and Risk of Cardiovascular Disease in Women and Men
    Dariush Mozaffarian; Fiscal Year: 2009
  4. Fatty Acids and Major Cardiovascular Outcomes
    Dariush Mozaffarian; Fiscal Year: 2007
  5. Fatty Acids and Cardiovascular Health
    Dariush Mozaffarian; Fiscal Year: 2007
  6. Mercury, Selenium, and Risk of Cardiovascular Disease in Women and Men
    Dariush Mozaffarian; Fiscal Year: 2007
  7. Fatty Acids and Major Cardiovascular Outcomes
    Dariush Mozaffarian; Fiscal Year: 2010

Collaborators

Detail Information

Publications91

  1. pmc Processing of meats and cardiovascular risk: time to focus on preservatives
    Renata Micha
    Departments of Epidemiology and Nutrition, Harvard School of Public Health, 665 Huntington Ave, Bldg 2 319, Boston, MA 02115, USA
    BMC Med 11:136. 2013
    ..See related research article here http://www.biomedcentral.com/1741-7015/11/63...
  2. pmc Plasma phospholipid long-chain ω-3 fatty acids and total and cause-specific mortality in older adults: a cohort study
    Dariush Mozaffarian
    Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Ann Intern Med 158:515-25. 2013
    ....
  3. pmc trans-Palmitoleic acid, other dairy fat biomarkers, and incident diabetes: the Multi-Ethnic Study of Atherosclerosis (MESA)
    Dariush Mozaffarian
    Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 97:854-61. 2013
    ..Emerging evidence suggests that trans-palmitoleate (trans 16:1n-7), a fatty acid in dairy and also partially hydrogenated oils, may be associated with a more favorable metabolic profile and less incident diabetes...
  4. doi request reprint Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events
    Dariush Mozaffarian
    Division of Cardiovascular Medicine and Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Am Coll Cardiol 58:2047-67. 2011
    ..National and international guidelines have converged on consistent recommendations for the general population to consume at least 250 mg/day of long-chain n-3 PUFA or at least 2 servings/week of oily fish...
  5. pmc Fish oil and postoperative atrial fibrillation: the Omega-3 Fatty Acids for Prevention of Post-operative Atrial Fibrillation (OPERA) randomized trial
    Dariush Mozaffarian
    Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    JAMA 308:2001-11. 2012
    ..A few small trials have evaluated whether long-chain n-3-polyunsaturated fatty acids (PUFAs) reduce postoperative AF, with mixed results...
  6. pmc Mercury exposure and risk of hypertension in US men and women in 2 prospective cohorts
    Dariush Mozaffarian
    Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Hypertension 60:645-52. 2012
    ..5-fold higher than the reference dose...
  7. pmc (n-3) fatty acids and cardiovascular health: are effects of EPA and DHA shared or complementary?
    Dariush Mozaffarian
    Division of Cardiovascular Medicine and Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
    J Nutr 142:614S-625S. 2012
    ....
  8. pmc Association of plasma phospholipid long-chain ω-3 fatty acids with incident atrial fibrillation in older adults: the cardiovascular health study
    Jason H Y Wu
    Departments of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Circulation 125:1084-93. 2012
    ..Prior studies evaluating fish or n-3 PUFA consumption from dietary questionnaires and incident AF have been conflicting. Circulating levels of n-3 PUFAs provide an objective measurement of exposure...
  9. pmc Saturated fat and cardiometabolic risk factors, coronary heart disease, stroke, and diabetes: a fresh look at the evidence
    Renata Micha
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Lipids 45:893-905. 2010
    ....
  10. ncbi request reprint Fish and n-3 fatty acids for the prevention of fatal coronary heart disease and sudden cardiac death
    Dariush Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Department of Epidemiology and Nutrition, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 87:1991S-6S. 2008
    ....
  11. doi request reprint Metabolic syndrome and mortality in older adults: the Cardiovascular Health Study
    Dariush Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, and Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Arch Intern Med 168:969-78. 2008
    ..In addition, few studies have compared the predictive utility of MetS to that of its individual risk factors...
  12. ncbi request reprint Trans fatty acids and cardiovascular risk: a unique cardiometabolic imprint?
    Dariush Mozaffarian
    Departments of Nutrition and Epidemiology, Harvard School of Public Health, 665 Huntington Avenue, Building 2 319, Boston, MA 02115, USA
    Curr Atheroscler Rep 9:486-93. 2007
    ....
  13. doi request reprint Dietary fish and omega-3 fatty acid consumption and heart rate variability in US adults
    Dariush Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    Circulation 117:1130-7. 2008
    ..We hypothesized that habitual consumption of fish and marine omega-3 fatty acids would be associated with more favorable HRV, elucidating electrophysiological influences and supporting effects on clinical risk...
  14. ncbi request reprint Commentary: Ruminant trans fatty acids and coronary heart disease--cause for concern?
    Dariush Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Int J Epidemiol 37:182-4. 2008
  15. ncbi request reprint Fish, n-3 fatty acids, and cardiovascular haemodynamics
    Dariush Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    J Cardiovasc Med (Hagerstown) 8:S23-6. 2007
    ..These haemodynamic effects could in part account for clinical benefits of fish or fish oil intake, including lower risk of cardiac death and possibly ischaemic stroke, heart failure, cognitive decline, and nonfatal coronary events...
  16. ncbi request reprint Incidence of new-onset diabetes and impaired fasting glucose in patients with recent myocardial infarction and the effect of clinical and lifestyle risk factors
    Dariush Mozaffarian
    Department of Medicine, Harvard Medical School and Harvard School of Public Health, Boston, MA 02115, USA
    Lancet 370:667-75. 2007
    ..We set out to estimate this incidence and investigate whether lifestyle factors such as dietary habits might alter this risk...
  17. ncbi request reprint Prediction of mode of death in heart failure: the Seattle Heart Failure Model
    Dariush Mozaffarian
    Harvard Medical School and Harvard School of Public Health, Boston, Mass, USA
    Circulation 116:392-8. 2007
    ..Prediction of mode of death may facilitate decisions about specific medications or devices...
  18. ncbi request reprint JELIS, fish oil, and cardiac events
    Dariush Mozaffarian
    Department of Medicine, Harvard Medical School and Harvard School of Public Health, Boston, MA 02115, USA
    Lancet 369:1062-3. 2007
  19. ncbi request reprint Consumption of trans fats and estimated effects on coronary heart disease in Iran
    D Mozaffarian
    The Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Eur J Clin Nutr 61:1004-10. 2007
    ..To investigate the consumption of industrial trans-fatty acids (TFAs) in Iranian homes and the proportion of coronary heart disease (CHD) events in Iran attributable to such intake...
  20. doi request reprint Beyond established and novel risk factors: lifestyle risk factors for cardiovascular disease
    Dariush Mozaffarian
    Division of Cardiovascular Medicine and Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Circulation 117:3031-8. 2008
  21. pmc Physical activity and incidence of atrial fibrillation in older adults: the cardiovascular health study
    Dariush Mozaffarian
    Division of Cardiovascular Medicine and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    Circulation 118:800-7. 2008
    ..Vigorous exertion and endurance training have been reported to increase atrial fibrillation (AF). Associations of habitual light or moderate activity with AF incidence have not been evaluated...
  22. pmc Lifestyle risk factors and new-onset diabetes mellitus in older adults: the cardiovascular health study
    Dariush Mozaffarian
    Divisions of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard School of Public Health, 665 Huntington Ave, Bldg 2 319, Boston, MA 02115, USA
    Arch Intern Med 169:798-807. 2009
    ..The objective of this study was to determine how lifestyle factors, assessed in combination, relate to new-onset diabetes in a broad and relatively unselected population of older adults...
  23. pmc Circulating long-chain ω-3 fatty acids and incidence of congestive heart failure in older adults: the cardiovascular health study: a cohort study
    Dariush Mozaffarian
    Brigham and Women s Hospital, Harvard Medical School, and Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Ann Intern Med 155:160-70. 2011
    ..Circulating fatty acid concentrations provide objective biomarkers of exposure...
  24. pmc The ω-3 Fatty Acids for Prevention of Post-Operative Atrial Fibrillation trial--rationale and design
    Dariush Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am Heart J 162:56-63.e3. 2011
    ....
  25. pmc Changes in diet and lifestyle and long-term weight gain in women and men
    Dariush Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    N Engl J Med 364:2392-404. 2011
    ..Specific dietary and other lifestyle behaviors may affect the success of the straightforward-sounding strategy "eat less and exercise more" for preventing long-term weight gain...
  26. pmc Mercury exposure and risk of cardiovascular disease in two U.S. cohorts
    Dariush Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    N Engl J Med 364:1116-25. 2011
    ..Beneficial effects of the ingestion of fish and selenium may also modify such effects...
  27. pmc Trans-palmitoleic acid, metabolic risk factors, and new-onset diabetes in U.S. adults: a cohort study
    Dariush Mozaffarian
    Brigham and Women s Hospital, Harvard Medical School, and Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Ann Intern Med 153:790-9. 2010
    ..Trans-palmitoleate (trans-16:1n-7) represents a distinctly exogenous source of 16:1n-7, unconfounded by endogenous synthesis or its determinants, that may be uniquely informative...
  28. pmc Circulating palmitoleic acid and risk of metabolic abnormalities and new-onset diabetes
    Dariush Mozaffarian
    Division of Cardiovascular Medicine and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School and Epidemiology, University of Washington, Seattle, WA, USA
    Am J Clin Nutr 92:1350-8. 2010
    ..Animal experiments suggest that circulating palmitoleic acid (cis-16:1n-7) from adipocyte de novo fatty acid synthesis may directly regulate insulin resistance and metabolic dysregulation...
  29. pmc Effects on coronary heart disease of increasing polyunsaturated fat in place of saturated fat: a systematic review and meta-analysis of randomized controlled trials
    Dariush Mozaffarian
    Division of Cardiovascular Medicine and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Med 7:e1000252. 2010
    ..Additionally, some public health groups recommend lowering or limiting polyunsaturated fat (PUFA) consumption, a major potential replacement for SFA...
  30. pmc Fish, mercury, selenium and cardiovascular risk: current evidence and unanswered questions
    Dariush Mozaffarian
    Division of Cardiovascular Medicine and Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Int J Environ Res Public Health 6:1894-916. 2009
    ..The relevant current unanswered questions and directions of further research are summarized...
  31. doi request reprint Health effects of trans-fatty acids: experimental and observational evidence
    D Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Eur J Clin Nutr 63:S5-21. 2009
    ..As part of the World Health Organization (WHO) Scientific Update on TFA, we reviewed the evidence for effects of TFA consumption on coronary heart disease (CHD)...
  32. doi request reprint Quantitative effects on cardiovascular risk factors and coronary heart disease risk of replacing partially hydrogenated vegetable oils with other fats and oils
    D Mozaffarian
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Eur J Clin Nutr 63:S22-33. 2009
    ..We performed quantitative estimates of CHD effects if a person's PHVO consumption were to be replaced with alternative fats and oils based on (1) randomized dietary trials and (2) prospective observational studies...
  33. ncbi request reprint Fish intake, contaminants, and human health: evaluating the risks and the benefits
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Mass 02115, USA
    JAMA 296:1885-99. 2006
    ..Fish (finfish or shellfish) may have health benefits and also contain contaminants, resulting in confusion over the role of fish consumption in a healthy diet...
  34. ncbi request reprint Dietary fish and n-3 fatty acid intake and cardiac electrocardiographic parameters in humans
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Am Coll Cardiol 48:478-84. 2006
    ..We evaluated the association between dietary fish intake and several cardiac electrocardiographic parameters in humans relevant to arrhythmic risk...
  35. pmc Dietary fats, carbohydrate, and progression of coronary atherosclerosis in postmenopausal women
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Harvard School of Public Health, Boston, Massachusetts, USA
    Am J Clin Nutr 80:1175-84. 2004
    ..The influence of diet on atherosclerotic progression is not well established, particularly in postmenopausal women, in whom risk factors for progression may differ from those for men...
  36. ncbi request reprint Effects of dietary fats versus carbohydrates on coronary heart disease: a review of the evidence
    Dariush Mozaffarian
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Curr Atheroscler Rep 7:435-45. 2005
    ....
  37. pmc trans fatty acids and systemic inflammation in heart failure
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Clin Nutr 80:1521-5. 2004
    ..trans fatty acid (TFA) intake increases systemic inflammation in healthy persons. However, the effect in patients with established heart disease is unknown...
  38. ncbi request reprint Intake of tuna or other broiled or baked fish versus fried fish and cardiac structure, function, and hemodynamics
    Dariush Mozaffarian
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 97:216-22. 2006
    ..These findings suggest potential specific physiologic mechanisms that may, in part, account for the effects of fish intake on cardiovascular health...
  39. ncbi request reprint Effect of fish oil on heart rate in humans: a meta-analysis of randomized controlled trials
    Dariush Mozaffarian
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Circulation 112:1945-52. 2005
    ..The effect of fish oil on heart rate (HR), a major risk factor for sudden death, is not well established. We calculated this effect in a meta-analysis of randomized, double-blind, placebo-controlled trials in humans...
  40. ncbi request reprint Trans fatty acids and cardiovascular disease
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 354:1601-13. 2006
  41. ncbi request reprint The effects of atorvastatin (10 mg) on systemic inflammation in heart failure
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 96:1699-704. 2005
    ..In conclusion, short-term atorvastatin therapy reduced the levels of several important inflammatory markers in patients with HF...
  42. pmc Interplay between different polyunsaturated fatty acids and risk of coronary heart disease in men
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    Circulation 111:157-64. 2005
    ..Additionally, seafood-based, long-chain n-3 PUFAs may modify the effects of plant-based, intermediate-chain n-3 PUFAs. However, the interactions of these PUFAs in relation to CHD risk are not well established...
  43. ncbi request reprint Trans fatty acids - effects on systemic inflammation and endothelial function
    Dariush Mozaffarian
    The Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Atheroscler Suppl 7:29-32. 2006
    ..Further study is indicated to define these effects of TFA and the implications of such effects for cardiovascular health...
  44. pmc Fish consumption and stroke risk in elderly individuals: the cardiovascular health study
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Harvard School of Public Health, Boston, MA, USA
    Arch Intern Med 165:200-6. 2005
    ..Additionally, such relationships have not been specifically evaluated in the elderly, in whom disease burden may be high and diet less influential...
  45. ncbi request reprint Electron-beam computed tomography for coronary calcium: a useful test to screen for coronary heart disease?
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    JAMA 294:2897-901. 2005
  46. pmc Fish intake and risk of incident atrial fibrillation
    Dariush Mozaffarian
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, and Department of Epidemiology, Harvard School of Public Health, Boston, Mass, USA
    Circulation 110:368-73. 2004
    ..Although effects of fish intake, including potential antiarrhythmic effects, may favorably influence risk of AF, relationships between fish intake and AF incidence have not been evaluated...
  47. ncbi request reprint n-3 Polyunsaturated fatty acids, fatal ischemic heart disease, and nonfatal myocardial infarction in older adults: the Cardiovascular Health Study
    Rozenn N Lemaitre
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle 98101, USA
    Am J Clin Nutr 77:319-25. 2003
    ....
  48. ncbi request reprint Blood concentrations of individual long-chain n-3 fatty acids and risk of nonfatal myocardial infarction
    Qi Sun
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 88:216-23. 2008
    ..Whereas dietary intake of long-chain n-3 fatty acids has been associated with risk of nonfatal myocardial infarction (MI), few studies have examined the relation for blood concentrations...
  49. ncbi request reprint Fish intake is associated with a reduced progression of coronary artery atherosclerosis in postmenopausal women with coronary artery disease
    Arja T Erkkilä
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA HNRCA, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Am J Clin Nutr 80:626-32. 2004
    ..However, limited data exist on the effect of fish intake on actual measures of progression of coronary artery atherosclerosis...
  50. ncbi request reprint Optimal dietary habits for the prevention of stroke
    Eric L Ding
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Semin Neurol 26:11-23. 2006
    ..Further research is needed regarding the possible effects of other major dietary factors on stroke risk...
  51. pmc Fish consumption and risk of major chronic disease in men
    Jyrki K Virtanen
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 88:1618-25. 2008
    ..Higher n-6 fatty acid consumption has also been hypothesized to reduce the health benefits of n-3 fatty acids in fish...
  52. pmc Long-chain omega-3 fatty acids, fish intake, and the risk of type 2 diabetes mellitus
    Manas Kaushik
    Departments of Nutrition, Harvard Medical School and Brigham and Women s Hospital, Boston, MA, USA
    Am J Clin Nutr 90:613-20. 2009
    ..The role of long-chain omega-3 (n-3) fatty acids (LCFAs) in the development of T2DM remains unresolved. Objective: We examined the association between dietary LCFAs and incidence of T2DM in 3 prospective cohorts of women and men...
  53. ncbi request reprint The Seattle Heart Failure Model: prediction of survival in heart failure
    Wayne C Levy
    University of Washington, Seattle, WA 98177, USA
    Circulation 113:1424-33. 2006
    ....
  54. ncbi request reprint Statin therapy is associated with lower mortality among patients with severe heart failure
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 93:1124-9. 2004
    ..52, 95% confidence interval 0.30 to 0.89). Although this observational study does not prove causality, further investigation of potential benefits of statins in patients with severe heart failure appears warranted...
  55. doi request reprint Estimating the global and regional burden of suboptimal nutrition on chronic disease: methods and inputs to the analysis
    R Micha
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Eur J Clin Nutr 66:119-29. 2012
    ..The objective of this study was to develop systematic and comparable methods to quantitatively assess the impact of suboptimal dietary habits on CVD, diabetes and cancer burdens globally and in 21 world regions...
  56. ncbi request reprint Usefulness of relative lymphocyte count as an independent predictor of death/urgent transplant in heart failure
    Kier V Huehnergarth
    Department of Internal Medicine, University of Washington, Seattle, Washington 98195, USA
    Am J Cardiol 95:1492-5. 2005
    ..There was only a borderline inverse association with cortisol levels during evening hours...
  57. ncbi request reprint Cardiac benefits of fish consumption may depend on the type of fish meal consumed: the Cardiovascular Health Study
    Dariush Mozaffarian
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Wash, USA
    Circulation 107:1372-7. 2003
    ..Few studies have examined associations of fish consumption with ischemic heart disease (IHD) risk among older adults or how different types of fish meals relate to IHD risk...
  58. ncbi request reprint Does alpha-linolenic acid intake reduce the risk of coronary heart disease? A review of the evidence
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, USA
    Altern Ther Health Med 11:24-30; quiz 31, 79. 2005
    ..Presently, the weight of the evidence favors recommendations for modest dietary consumption of ALA (2 to 3 g per day) for the primary and secondary prevention of CHD...
  59. ncbi request reprint Anemia predicts mortality in severe heart failure: the prospective randomized amlodipine survival evaluation (PRAISE)
    Dariush Mozaffarian
    Veterans Affairs Puget Sound Health Care System, 1660 South Columbian Way, MS 152, Seattle, WA 98108, USA
    J Am Coll Cardiol 41:1933-9. 2003
    ..Our aim was to examine the relationships between serum hematocrit (Hct) and risk of all-cause mortality among patients with severe heart failure (HF)...
  60. ncbi request reprint Lifestyles of older adults: can we influence cardiovascular risk in older adults?
    Dariush Mozaffarian
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Geriatr Cardiol 13:153-60. 2004
    ..Clinical practice and public health implications, gaps in knowledge, and future research directions are summarized...
  61. pmc Intake of total trans, trans-18:1, and trans-18:2 fatty acids and risk of sudden cardiac death in women
    Stephanie E Chiuve
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am Heart J 158:761-7. 2009
    ....
  62. pmc Endogenous red blood cell membrane fatty acids and sudden cardiac arrest
    Rozenn N Lemaitre
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA
    Metabolism 59:1029-34. 2010
    ..Further work is needed to investigate if conditions that favor de novo fatty acid synthesis, such as high-carbohydrate/low-fat diets, might also increase the risk of SCA...
  63. pmc Food sources of individual plasma phospholipid trans fatty acid isomers: the Cardiovascular Health Study
    Renata Micha
    Division of Cardiovascular Medicine, University of Washington, Seattle, WA, USA
    Am J Clin Nutr 91:883-93. 2010
    ..However, multiple TFA isomers exist, each with potentially different health effects. Different food sources of these specific TFA isomers are not well established...
  64. pmc Red and processed meat consumption and risk of incident coronary heart disease, stroke, and diabetes mellitus: a systematic review and meta-analysis
    Renata Micha
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Circulation 121:2271-83. 2010
    ..Effects of meat intake on these different outcomes, as well as of red versus processed meat, may also vary...
  65. pmc Egg consumption and risk of type 2 diabetes in older adults
    Luc Djousse
    Division of Aging, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    Am J Clin Nutr 92:422-7. 2010
    ..Type 2 diabetes (T2D) remains an important public health issue in the United States. There are limited and inconsistent data on the association between egg consumption and fasting glucose or incident diabetes...
  66. ncbi request reprint Consumption and health effects of trans fatty acids: a review
    Shyam Mohan Teegala
    Harvard School of Public Health, Department of Epidemiology, 665 Huntington Ave, Boston, MA, USA
    J AOAC Int 92:1250-7. 2009
    ..Both individual- and policy-level initiatives to decrease TFA consumption should continue, particularly in population subgroups and in developing nations with high consumption of partially hydrogenated vegetable oils...
  67. ncbi request reprint Trans-fatty acids and nonlipid risk factors
    Sarah K Wallace
    Department of Epidemiology, Harvard School of Public Health, Division of Cardiovascular Medicine and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Building 2 315, Boston, MA 02115, USA
    Curr Atheroscler Rep 11:423-33. 2009
    ..These nonlipid effects also explain why TFA consumption may adversely impact other non-CHD diseases and end points...
  68. ncbi request reprint Meta-analysis: travel and risk for venous thromboembolism
    Divay Chandra
    Harvard School of Public Health, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Ann Intern Med 151:180-90. 2009
    ....
  69. pmc Dietary intake of trans fatty acids and systemic inflammation in women
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am J Clin Nutr 79:606-12. 2004
    ..Systemic inflammation may be involved in the pathogenesis of such conditions; however, relations between TFA intake and systemic inflammation are not well established...
  70. ncbi request reprint Fish intake and risk of incident heart failure
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    J Am Coll Cardiol 45:2015-21. 2005
    ..Our aim was to investigate the relation between fish consumption and incidence of congestive heart failure (CHF)...
  71. doi request reprint Promise of improving metabolic and lifestyle risk in practice
    Dariush Mozaffarian
    Division of Cardiovascular Medicine and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA dmozaff
    Lancet 371:1973-4. 2008
  72. ncbi request reprint Trans-fatty acids and sudden cardiac death
    Rozenn N Lemaitre
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, USA
    Atheroscler Suppl 7:13-5. 2006
    ..While further studies are needed to investigate possible effects of trans-18:2 on arrhythmia, it would be prudent to limit dietary intake of trans-18:2...
  73. ncbi request reprint Plasma phospholipid trans fatty acids, fatal ischemic heart disease, and sudden cardiac death in older adults: the cardiovascular health study
    Rozenn N Lemaitre
    University of Washington, Cardiovascular Health Research Unit, Department of Medicine, 1730 Minor Ave, Suite 1360, Seattle, Washington 98101, USA
    Circulation 114:209-15. 2006
    ..To extend these findings, we investigated the associations of plasma phospholipid trans fatty acids with fatal ischemic heart disease (IHD) and sudden cardiac death...
  74. pmc The preventable causes of death in the United States: comparative risk assessment of dietary, lifestyle, and metabolic risk factors
    Goodarz Danaei
    Harvard School of Public Health, Boston, MA, USA
    PLoS Med 6:e1000058. 2009
    ....
  75. pmc Trans fatty acids: effects on cardiometabolic health and implications for policy
    R Micha
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Prostaglandins Leukot Essent Fatty Acids 79:147-52. 2008
    ....
  76. doi request reprint Trans fatty acids: effects on metabolic syndrome, heart disease and diabetes
    Renata Micha
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Nat Rev Endocrinol 5:335-44. 2009
    ..Nevertheless, the documented adverse effects of TFAs underscore their potential to cause harm and the importance of policy measures to minimize consumption of industrially produced TFAs...
  77. pmc Association between adiposity in midlife and older age and risk of diabetes in older adults
    Mary L Biggs
    Department of Biostatistics, School of Public Health and Community Medicine, University of Washington, Seattle, WA, USA
    JAMA 303:2504-12. 2010
    ..Adiposity is a well-recognized risk factor for type 2 diabetes among young and middle-aged adults, but the relationship between body composition and type 2 diabetes is not well described among older adults...
  78. ncbi request reprint Decreased carotenoid content in preaponeurotic orbital fat of patients with involutional ptosis
    A J Ahmadi
    Department of Ophthalmology, University of Washington, Seattle, WA 98195 6485, USA
    Ophthal Plast Reconstr Surg 21:46-51. 2005
    ....
  79. ncbi request reprint Elevated serum alanine aminotransferase activity and calculated risk of coronary heart disease in the United States
    George N Ioannou
    Research Enhancement Award Program, Department of Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Hepatology 43:1145-51. 2006
    ..This association is more prominent in women...
  80. ncbi request reprint Anginal symptoms consistently predict total mortality among outpatients with coronary artery disease
    Dariush Mozaffarian
    Health Services Research and Development Center of Excellence, Veterans Affairs Puget Sound Health Care System, University of Washington, Seattle, Wash, USA
    Am Heart J 146:1015-22. 2003
    ....
  81. doi request reprint The perfect storm: obesity, adipocyte dysfunction, and metabolic consequences
    Sarah de Ferranti
    Department of Cardiology, Children s Hospital Boston, Boston, MA 02115, USA
    Clin Chem 54:945-55. 2008
    ....
  82. ncbi request reprint Validation of the Seattle Heart Failure Model in a community-based heart failure population and enhancement by adding B-type natriuretic peptide
    Heidi T May
    LDS Hospital, Intermountain Medical Center, Salt Lake City, Utah, USA
    Am J Cardiol 100:697-700. 2007
    ..02). In conclusion, the SHFM predicts survival in patients with HF in a hospital-based population, with areas under the curve similar to those from data on which models were initially fit...
  83. ncbi request reprint Low-fat diet and cardiovascular disease
    Dariush Mozaffarian
    JAMA 296:279-80; author reply 280-1. 2006
  84. ncbi request reprint Conclusions and recommendations from the symposium, Beyond Cholesterol: Prevention and Treatment of Coronary Heart Disease with n-3 Fatty Acids
    Richard J Deckelbaum
    Institute of Human Nutrition, Department of Pediatrics, Columbia University Medical Center, New York, NY 10032, USA
    Am J Clin Nutr 87:2010S-2S. 2008
    ..Additional references for these conclusions can be found in the articles included in the supplement...
  85. ncbi request reprint Cereal, fruit, and vegetable fiber intake and the risk of cardiovascular disease in elderly individuals
    Dariush Mozaffarian
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Wash, USA
    JAMA 289:1659-66. 2003
    ..Additionally, the influence of dietary habits on risk may be less pronounced in elderly persons, when atherosclerosis is more advanced. However, few data address the influence of diet on CVD risk in this population...
  86. ncbi request reprint The fish story: a diet-heart hypothesis with clinical implications: n-3 polyunsaturated fatty acids, myocardial vulnerability, and sudden death
    David S Siscovick
    Circulation 107:2632-4. 2003
  87. ncbi request reprint Cereal fiber and whole-grain intake are associated with reduced progression of coronary-artery atherosclerosis in postmenopausal women with coronary artery disease
    Arja T Erkkilä
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am Heart J 150:94-101. 2005
    ..The aim was to examine the association between intakes of total fiber and fiber from different dietary sources and progression of coronary-artery atherosclerosis among women with established CAD...
  88. ncbi request reprint In patients with heart failure elevated soluble TNF-receptor 1 is associated with higher risk of depression
    Alec J Moorman
    Department of Internal Medicine, Division of Cardiology, University of Washington, Seattle, Washington, USA
    J Card Fail 13:738-43. 2007
    ..In this cross-sectional study, we investigated whether systemic inflammation, as assessed by circulating levels of inflammatory cytokines, was associated with comorbid depression in patients with heart failure...
  89. ncbi request reprint Fish oil and prevention of atrial fibrillation
    Dariush Mozaffarian
    J Am Coll Cardiol 50:1513-4. 2007
  90. ncbi request reprint Free fatty acids, cardiovascular mortality, and cardiometabolic stress
    Dariush Mozaffarian
    Eur Heart J 28:2699-700. 2007
  91. ncbi request reprint Ruminant or industrial sources of trans fatty acids: public health issue or food label skirmish?
    Walter Willett
    Am J Clin Nutr 87:515-6. 2008

Research Grants12

  1. Mercury, Selenium, and Risk of Cardiovascular Disease in Women and Men
    Dariush Mozaffarian; Fiscal Year: 2010
    ....
  2. Fatty Acids and Major Cardiovascular Outcomes
    Dariush Mozaffarian; Fiscal Year: 2009
    ....
  3. Mercury, Selenium and Risk of Cardiovascular Disease in Women and Men
    Dariush Mozaffarian; Fiscal Year: 2009
    ....
  4. Fatty Acids and Major Cardiovascular Outcomes
    Dariush Mozaffarian; Fiscal Year: 2007
    ....
  5. Fatty Acids and Cardiovascular Health
    Dariush Mozaffarian; Fiscal Year: 2007
    ..End of Abstract) ..
  6. Mercury, Selenium, and Risk of Cardiovascular Disease in Women and Men
    Dariush Mozaffarian; Fiscal Year: 2007
    ....
  7. Fatty Acids and Major Cardiovascular Outcomes
    Dariush Mozaffarian; Fiscal Year: 2010
    ....