DAVID BRUCE MOUNT

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi The SLC26 gene family of multifunctional anion exchangers
    David B Mount
    Renal Divisions, VA Boston Healthcare System and Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Pflugers Arch 447:710-21. 2004
  2. ncbi Renal urate transport
    David B Mount
    Harvard Medical School, Boston, MA, USA
    Rheum Dis Clin North Am 32:313-31, vi. 2006
  3. ncbi The brain in hyponatremia: both culprit and victim
    David B Mount
    Renal Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Semin Nephrol 29:196-215. 2009
  4. ncbi Hyponatremia: case vignettes
    David B Mount
    Renal Division, Brigham and Women s Hospital and VA Boston Healthcare System, Harvard Medical School, Boston, MA 02215, USA
    Semin Nephrol 29:300-17. 2009
  5. ncbi Molecular physiology of mammalian K(+)-Cl- cotransporters
    Adriana Mercado
    Renal Division, West Roxbury VA Medical Center, Boston, MA, USA
    Adv Exp Med Biol 559:29-41. 2004
  6. ncbi Renal physiology of SLC26 anion exchangers
    Aleksandra Sindic
    Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, and Renal Division, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Curr Opin Nephrol Hypertens 16:484-90. 2007
  7. ncbi A C-terminal domain in KCC2 confers constitutive K+-Cl- cotransport
    Adriana Mercado
    Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Biol Chem 281:1016-26. 2006
  8. ncbi Seizure sensitivity is ameliorated by targeted expression of K+-Cl- cotransporter function in the mushroom body of the Drosophila brain
    Daria S Hekmat-Scafe
    Renal Division, VA Boston Healthcare System, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genetics 184:171-83. 2010
  9. ncbi Mortality after hospitalization with mild, moderate, and severe hyponatremia
    Sushrut S Waikar
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Am J Med 122:857-65. 2009
  10. ncbi Roles of the cation-chloride cotransporters in neurological disease
    Kristopher T Kahle
    Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Nat Clin Pract Neurol 4:490-503. 2008

Research Grants

  1. MOLECULAR PHYSIOLOGY OF RENAL K+/ CL- COTRANSPORTERS
    David Mount; Fiscal Year: 2003
  2. Molecular Physiology of Renal K-Cl Cotransporters
    David Mount; Fiscal Year: 2007

Collaborators

Detail Information

Publications12

  1. ncbi The SLC26 gene family of multifunctional anion exchangers
    David B Mount
    Renal Divisions, VA Boston Healthcare System and Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Pflugers Arch 447:710-21. 2004
    ....
  2. ncbi Renal urate transport
    David B Mount
    Harvard Medical School, Boston, MA, USA
    Rheum Dis Clin North Am 32:313-31, vi. 2006
    ..Relevant developments in the molecular and renal physiology of urate homeostasis are reviewed...
  3. ncbi The brain in hyponatremia: both culprit and victim
    David B Mount
    Renal Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Semin Nephrol 29:196-215. 2009
    ..This review summarizes recent advances in the understanding of osmoreception in the brain, the CNS response to acute and chronic hyponatremia, and the pathophysiology of ODS...
  4. ncbi Hyponatremia: case vignettes
    David B Mount
    Renal Division, Brigham and Women s Hospital and VA Boston Healthcare System, Harvard Medical School, Boston, MA 02215, USA
    Semin Nephrol 29:300-17. 2009
    ..We present five clinical scenarios of patients with hyponatremia. These discussions reinforce concepts reviewed elsewhere in this issue of Seminars in Nephrology and/or emphasize specific causes and management issues...
  5. ncbi Molecular physiology of mammalian K(+)-Cl- cotransporters
    Adriana Mercado
    Renal Division, West Roxbury VA Medical Center, Boston, MA, USA
    Adv Exp Med Biol 559:29-41. 2004
  6. ncbi Renal physiology of SLC26 anion exchangers
    Aleksandra Sindic
    Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, and Renal Division, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Curr Opin Nephrol Hypertens 16:484-90. 2007
    ..The aim of this review is to present recent studies on the molecular function of the Slc26 family and its role in renal physiology and pathophysiology...
  7. ncbi A C-terminal domain in KCC2 confers constitutive K+-Cl- cotransport
    Adriana Mercado
    Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Biol Chem 281:1016-26. 2006
    ....
  8. ncbi Seizure sensitivity is ameliorated by targeted expression of K+-Cl- cotransporter function in the mushroom body of the Drosophila brain
    Daria S Hekmat-Scafe
    Renal Division, VA Boston Healthcare System, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genetics 184:171-83. 2010
    ..We show that kcc(DHS1) seizure sensitivity in MB neurons acts via a weakening of chemical synaptic inhibition by GABAergic transmission and suggest that this is due to disruption of intracellular Cl(-) gradients in MB neurons...
  9. ncbi Mortality after hospitalization with mild, moderate, and severe hyponatremia
    Sushrut S Waikar
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Am J Med 122:857-65. 2009
    ..Hyponatremia is the most common electrolyte abnormality in hospitalized individuals...
  10. ncbi Roles of the cation-chloride cotransporters in neurological disease
    Kristopher T Kahle
    Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Nat Clin Pract Neurol 4:490-503. 2008
    ..CCCs represent attractive therapeutic targets in neurological disorders the pathogenesis of which involves deranged cellular chloride homoestasis...
  11. ncbi NH2-terminal heterogeneity in the KCC3 K+-Cl- cotransporter
    Adriana Mercado
    Renal Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Physiol Renal Physiol 289:F1246-61. 2005
    ..Basolateral swelling-activated K(+)-Cl(-) cotransport mediated by KCC3 likely functions in cell volume regulation during the transepithelial transport of both salt and solutes by the proximal tubule...
  12. ncbi Genetics of gout
    Hyon K Choi
    Section of Rheumatology and the Clinical Epidemiology Unit, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Curr Opin Rheumatol 22:144-51. 2010
    ..This review provides an update on recent findings with regards to the genetics of hyperuricemia and gout, including recent data from genome-wide association studies (GWAS)...

Research Grants9

  1. MOLECULAR PHYSIOLOGY OF RENAL K+/ CL- COTRANSPORTERS
    David Mount; Fiscal Year: 2003
    ..Functional studies of these co-transporters will determine which intracellular amino acids determine the volume sensitivity of KCC3 and KCC4 and which transmembrane amino acids determine cation affinity. ..
  2. Molecular Physiology of Renal K-Cl Cotransporters
    David Mount; Fiscal Year: 2007
    ..abstract_text> ..