DAVID BRUCE MOUNT

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc The independent association between parathyroid hormone levels and hyperuricemia: a national population study
    Janet Y Hui
    The Clinical Epidemiology Unit, Boston University School of Medicine, 650 Albany Street, Suite 200, Boston, MA 02118, USA
    Arthritis Res Ther 14:R56. 2012
  2. doi request reprint Hyponatremia: case vignettes
    David B Mount
    Renal Division, Brigham and Women s Hospital and VA Boston Healthcare System, Harvard Medical School, Boston, MA 02215, USA
    Semin Nephrol 29:300-17. 2009
  3. doi request reprint The brain in hyponatremia: both culprit and victim
    David B Mount
    Renal Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Semin Nephrol 29:196-215. 2009
  4. ncbi request reprint The SLC26 gene family of multifunctional anion exchangers
    David B Mount
    Renal Divisions, VA Boston Healthcare System and Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Pflugers Arch 447:710-21. 2004
  5. ncbi request reprint Renal urate transport
    David B Mount
    Harvard Medical School, Boston, MA, USA
    Rheum Dis Clin North Am 32:313-31, vi. 2006
  6. ncbi request reprint Molecular physiology of mammalian K(+)-Cl- cotransporters
    Adriana Mercado
    Renal Division, West Roxbury VA Medical Center, Boston, MA, USA
    Adv Exp Med Biol 559:29-41. 2004
  7. ncbi request reprint Renal physiology of SLC26 anion exchangers
    Aleksandra Sindic
    Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, and Renal Division, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Curr Opin Nephrol Hypertens 16:484-90. 2007
  8. ncbi request reprint A C-terminal domain in KCC2 confers constitutive K+-Cl- cotransport
    Adriana Mercado
    Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Biol Chem 281:1016-26. 2006
  9. ncbi request reprint NH2-terminal heterogeneity in the KCC3 K+-Cl- cotransporter
    Adriana Mercado
    Renal Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Physiol Renal Physiol 289:F1246-61. 2005
  10. pmc Mortality after hospitalization with mild, moderate, and severe hyponatremia
    Sushrut S Waikar
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Am J Med 122:857-65. 2009

Research Grants

Collaborators

Detail Information

Publications13

  1. pmc The independent association between parathyroid hormone levels and hyperuricemia: a national population study
    Janet Y Hui
    The Clinical Epidemiology Unit, Boston University School of Medicine, 650 Albany Street, Suite 200, Boston, MA 02118, USA
    Arthritis Res Ther 14:R56. 2012
    ..We evaluated the potential population impact of PTH on serum uric acid (SUA) levels by using a nationally representative sample of United States adults...
  2. doi request reprint Hyponatremia: case vignettes
    David B Mount
    Renal Division, Brigham and Women s Hospital and VA Boston Healthcare System, Harvard Medical School, Boston, MA 02215, USA
    Semin Nephrol 29:300-17. 2009
    ..We present five clinical scenarios of patients with hyponatremia. These discussions reinforce concepts reviewed elsewhere in this issue of Seminars in Nephrology and/or emphasize specific causes and management issues...
  3. doi request reprint The brain in hyponatremia: both culprit and victim
    David B Mount
    Renal Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Semin Nephrol 29:196-215. 2009
    ..This review summarizes recent advances in the understanding of osmoreception in the brain, the CNS response to acute and chronic hyponatremia, and the pathophysiology of ODS...
  4. ncbi request reprint The SLC26 gene family of multifunctional anion exchangers
    David B Mount
    Renal Divisions, VA Boston Healthcare System and Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Pflugers Arch 447:710-21. 2004
    ....
  5. ncbi request reprint Renal urate transport
    David B Mount
    Harvard Medical School, Boston, MA, USA
    Rheum Dis Clin North Am 32:313-31, vi. 2006
    ..Relevant developments in the molecular and renal physiology of urate homeostasis are reviewed...
  6. ncbi request reprint Molecular physiology of mammalian K(+)-Cl- cotransporters
    Adriana Mercado
    Renal Division, West Roxbury VA Medical Center, Boston, MA, USA
    Adv Exp Med Biol 559:29-41. 2004
  7. ncbi request reprint Renal physiology of SLC26 anion exchangers
    Aleksandra Sindic
    Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, and Renal Division, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Curr Opin Nephrol Hypertens 16:484-90. 2007
    ..The aim of this review is to present recent studies on the molecular function of the Slc26 family and its role in renal physiology and pathophysiology...
  8. ncbi request reprint A C-terminal domain in KCC2 confers constitutive K+-Cl- cotransport
    Adriana Mercado
    Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Biol Chem 281:1016-26. 2006
    ....
  9. ncbi request reprint NH2-terminal heterogeneity in the KCC3 K+-Cl- cotransporter
    Adriana Mercado
    Renal Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Physiol Renal Physiol 289:F1246-61. 2005
    ..Basolateral swelling-activated K(+)-Cl(-) cotransport mediated by KCC3 likely functions in cell volume regulation during the transepithelial transport of both salt and solutes by the proximal tubule...
  10. pmc Mortality after hospitalization with mild, moderate, and severe hyponatremia
    Sushrut S Waikar
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Am J Med 122:857-65. 2009
    ..Hyponatremia is the most common electrolyte abnormality in hospitalized individuals...
  11. pmc Seizure sensitivity is ameliorated by targeted expression of K+-Cl- cotransporter function in the mushroom body of the Drosophila brain
    Daria S Hekmat-Scafe
    Renal Division, VA Boston Healthcare System, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genetics 184:171-83. 2010
    ..We show that kcc(DHS1) seizure sensitivity in MB neurons acts via a weakening of chemical synaptic inhibition by GABAergic transmission and suggest that this is due to disruption of intracellular Cl(-) gradients in MB neurons...
  12. doi request reprint Genetics of gout
    Hyon K Choi
    Section of Rheumatology and the Clinical Epidemiology Unit, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Curr Opin Rheumatol 22:144-51. 2010
    ..This review provides an update on recent findings with regards to the genetics of hyperuricemia and gout, including recent data from genome-wide association studies (GWAS)...
  13. doi request reprint Roles of the cation-chloride cotransporters in neurological disease
    Kristopher T Kahle
    Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Nat Clin Pract Neurol 4:490-503. 2008
    ..CCCs represent attractive therapeutic targets in neurological disorders the pathogenesis of which involves deranged cellular chloride homoestasis...

Research Grants9

  1. MOLECULAR PHYSIOLOGY OF RENAL K+/ CL- COTRANSPORTERS
    David Mount; Fiscal Year: 2003
    ..Functional studies of these co-transporters will determine which intracellular amino acids determine the volume sensitivity of KCC3 and KCC4 and which transmembrane amino acids determine cation affinity. ..
  2. Molecular Physiology of Renal K-Cl Cotransporters
    David Mount; Fiscal Year: 2007
    ..abstract_text> ..