Jorge Mora

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi T cell mediated cerebral hemorrhages and microhemorrhages during passive Aβ immunization in APPPS1 transgenic mice
    Melanie Meyer-Luehmann
    MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Department of Neurology, Alzheimer s Disease Research Laboratory, 02129 Charlestown, MA USA
    Mol Neurodegener 6:22. 2011
  2. ncbi Homing imprinting and immunomodulation in the gut: role of dendritic cells and retinoids
    J Rodrigo Mora
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Inflamm Bowel Dis 14:275-89. 2008
  3. ncbi Role of retinoic acid in the imprinting of gut-homing IgA-secreting cells
    J Rodrigo Mora
    Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, GRJ 815, Boston, MA 02114, USA
    Semin Immunol 21:28-35. 2009
  4. ncbi Reciprocal and dynamic control of CD8 T cell homing by dendritic cells from skin- and gut-associated lymphoid tissues
    J Rodrigo Mora
    The CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 201:303-16. 2005
  5. ncbi Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells
    J Rodrigo Mora
    The Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 424:88-93. 2003
  6. ncbi Retinoic acid: an educational "vitamin elixir" for gut-seeking T cells
    J Rodrigo Mora
    The CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Immunity 21:458-60. 2004
  7. ncbi Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells
    J Rodrigo Mora
    CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Science 314:1157-60. 2006
  8. ncbi In vivo imaging of lymphocyte trafficking
    Cornelia Halin
    The CBR Institute for Biomedical Research and the Department of Pathology, Harvard Medical School, Boston, Massachusetts, 02115, USA
    Annu Rev Cell Dev Biol 21:581-603. 2005
  9. ncbi T-cell homing specificity and plasticity: new concepts and future challenges
    J Rodrigo Mora
    CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Trends Immunol 27:235-43. 2006
  10. ncbi Vitamin effects on the immune system: vitamins A and D take centre stage
    J Rodrigo Mora
    Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nat Rev Immunol 8:685-98. 2008

Research Grants

  1. Reassessing the Physiological Role of Gut-Specific Lymphocyte Homing: Implication
    Jorge Mora; Fiscal Year: 2009

Collaborators

Detail Information

Publications16

  1. ncbi T cell mediated cerebral hemorrhages and microhemorrhages during passive Aβ immunization in APPPS1 transgenic mice
    Melanie Meyer-Luehmann
    MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Department of Neurology, Alzheimer s Disease Research Laboratory, 02129 Charlestown, MA USA
    Mol Neurodegener 6:22. 2011
    ..Neuropathological investigations of patients who died after the trial showed clearance of amyloid pathology, but also a powerful immune response involving activated T cells probably underlying the negative effects of the immunization...
  2. ncbi Homing imprinting and immunomodulation in the gut: role of dendritic cells and retinoids
    J Rodrigo Mora
    Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Inflamm Bowel Dis 14:275-89. 2008
    ..Harnessing these mechanisms could offer novel, effective, and more specific therapeutic strategies in IBD...
  3. ncbi Role of retinoic acid in the imprinting of gut-homing IgA-secreting cells
    J Rodrigo Mora
    Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, GRJ 815, Boston, MA 02114, USA
    Semin Immunol 21:28-35. 2009
    ..Here, we discuss the role of RA in the imprinting of gut-homing ASC and the evidence linking RA with the generation of intestinal IgA-ASCs...
  4. ncbi Reciprocal and dynamic control of CD8 T cell homing by dendritic cells from skin- and gut-associated lymphoid tissues
    J Rodrigo Mora
    The CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 201:303-16. 2005
    ..Memory T cells remain responsive to these signals, allowing for dynamic migratory reprogramming by skin- and gut-associated DC...
  5. ncbi Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells
    J Rodrigo Mora
    The Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 424:88-93. 2003
    ..These findings establish that Peyer's patch dendritic cells imprint gut-homing specificity on T cells, and thus license effector/memory cells to access anatomical sites most likely to contain their cognate antigen...
  6. ncbi Retinoic acid: an educational "vitamin elixir" for gut-seeking T cells
    J Rodrigo Mora
    The CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Immunity 21:458-60. 2004
    ..The mechanism for DC-dependent imprinting of gut specificity has remained unknown. New findings point to retinoic acid, which is uniquely produced by intestinal DC, but not by DC from other lymphoid organs...
  7. ncbi Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells
    J Rodrigo Mora
    CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Science 314:1157-60. 2006
    ..Thus, GALT-DC shape mucosal immunity by modulating B cell migration and effector activity through synergistically acting mediators...
  8. ncbi In vivo imaging of lymphocyte trafficking
    Cornelia Halin
    The CBR Institute for Biomedical Research and the Department of Pathology, Harvard Medical School, Boston, Massachusetts, 02115, USA
    Annu Rev Cell Dev Biol 21:581-603. 2005
    ....
  9. ncbi T-cell homing specificity and plasticity: new concepts and future challenges
    J Rodrigo Mora
    CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Trends Immunol 27:235-43. 2006
    ....
  10. ncbi Vitamin effects on the immune system: vitamins A and D take centre stage
    J Rodrigo Mora
    Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nat Rev Immunol 8:685-98. 2008
    ..Finally, we discuss the clinical potential of vitamin A and D metabolites for modulating tissue-specific immune responses and for preventing and/or treating inflammation and autoimmunity...
  11. ncbi Aberrant activation of integrin alpha4beta7 suppresses lymphocyte migration to the gut
    Eun Jeong Park
    CBR Institute for Biomedical Research, Boston, Massachusetts 02115, USA
    J Clin Invest 117:2526-38. 2007
    ..Our results underscore the importance of a proper balance in the adhesion and de-adhesion of the alpha4beta7 integrin, both for lymphocyte trafficking to the gut and for colitis progression...
  12. ncbi In vivo imaging of leukocyte trafficking in blood vessels and tissues
    Thorsten R Mempel
    The CBR Institute for Biomedical Research and the Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Immunol 16:406-17. 2004
    ....
  13. ncbi Imprinting of CCR9 on CD4 T cells requires IL-4 signaling on mesenteric lymph node dendritic cells
    Raul Elgueta
    Departamento de Biologia, Facultad de Ciencias, Universidad de Chile, Santiago, Chile
    J Immunol 180:6501-7. 2008
    ..Thus, besides the direct effect of RA on T cell gut tropism, our results show that the induction of a gut-homing phenotype on CD4(+) T cells is also influenced by the effect of IL-4 on gut-associated DC...
  14. ncbi Dendritic cell migration and lymphocyte homing imprinting
    Eduardo J Villablanca
    Cancer Gene Therapy Unit, Scientific Institute H San Raffaele, San Raffaele, Milan, Italy
    Histol Histopathol 23:897-910. 2008
    ..Finally, we discuss how dysregulation of these signals may play a key role in disease...
  15. ncbi Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
    Cheng Ming Sun
    Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:1775-85. 2007
    ..Together, these data demonstrate that the intestinal immune system has evolved a self-contained strategy to promote T reg cell neoconversion...
  16. ncbi Dendritic cells and the mode of action of anticalcineurinic drugs: an integrating hypothesis
    Alberto Fierro
    Clinica Las Condes, Transplantation Unit, Santiago, Chile
    Nephrol Dial Transplant 18:467-8; discussion 469-70. 2003

Research Grants1

  1. Reassessing the Physiological Role of Gut-Specific Lymphocyte Homing: Implication
    Jorge Mora; Fiscal Year: 2009
    ..It would also offer a simple method for boosting intestinal immune responses for vaccination purposes, such as in infections by Salmonella, rotavirus, and HIV. ..