Constance M Moore

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Brain-to-serum lithium ratio and age: an in vivo magnetic resonance spectroscopy study
    Constance M Moore
    Brain Imaging Center, Consolidated Department of Psychiatry, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Am J Psychiatry 159:1240-2. 2002
  2. ncbi Choline, myo-inositol and mood in bipolar disorder: a proton magnetic resonance spectroscopic imaging study of the anterior cingulate cortex
    C M Moore
    Brain Imaging Center, McLean Hospital, Belmont, MA, USA
    Bipolar Disord 2:207-16. 2000
  3. ncbi Glutamine and glutamate levels in children and adolescents with bipolar disorder: a 4.0-T proton magnetic resonance spectroscopy study of the anterior cingulate cortex
    Constance M Moore
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    J Am Acad Child Adolesc Psychiatry 46:524-34. 2007
  4. pmc Mania, glutamate/glutamine and risperidone in pediatric bipolar disorder: a proton magnetic resonance spectroscopy study of the anterior cingulate cortex
    Constance M Moore
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    J Affect Disord 99:19-25. 2007
  5. ncbi Topiramate raises anterior cingulate cortex glutamine levels in healthy men; a 4.0 T magnetic resonance spectroscopy study
    Constance M Moore
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, and Consolidated Department of Psychiatry, Harvard Medical School, Boston, MA 02114, USA
    Psychopharmacology (Berl) 188:236-43. 2006
  6. ncbi Differences in brain chemistry in children and adolescents with attention deficit hyperactivity disorder with and without comorbid bipolar disorder: a proton magnetic resonance spectroscopy study
    Constance M Moore
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    Am J Psychiatry 163:316-8. 2006
  7. ncbi Mesial temporal lobe Cho to Cr(PCr) ratio asymmetry in chronic schizophrenics
    Constance M Moore
    Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Schizophr Res 57:35-42. 2002
  8. doi Brain lithium, N-acetyl aspartate and myo-inositol levels in older adults with bipolar disorder treated with lithium: a lithium-7 and proton magnetic resonance spectroscopy study
    Brent P Forester
    Geriatric Psychiatry Research Program, McLean Hospital, Belmont, MA 02478, USA
    Bipolar Disord 10:691-700. 2008
  9. ncbi White matter abnormalities in children with and at risk for bipolar disorder
    Jean A Frazier
    Department of Psychiatry, Harvard Medical School, Boston, USA
    Bipolar Disord 9:799-809. 2007
  10. doi Brain lithium levels and effects on cognition and mood in geriatric bipolar disorder: a lithium-7 magnetic resonance spectroscopy study
    Brent P Forester
    Geriatric Psychiatry Research Program, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Am J Geriatr Psychiatry 17:13-23. 2009

Research Grants

Detail Information

Publications16

  1. ncbi Brain-to-serum lithium ratio and age: an in vivo magnetic resonance spectroscopy study
    Constance M Moore
    Brain Imaging Center, Consolidated Department of Psychiatry, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Am J Psychiatry 159:1240-2. 2002
    ..The authors' goal was to determine if there is an association between brain-to-serum lithium ratios and age...
  2. ncbi Choline, myo-inositol and mood in bipolar disorder: a proton magnetic resonance spectroscopic imaging study of the anterior cingulate cortex
    C M Moore
    Brain Imaging Center, McLean Hospital, Belmont, MA, USA
    Bipolar Disord 2:207-16. 2000
    ..We wished to determine the relationship between anterior cingulate cortex choline and myo-inositol levels, assessed using proton magnetic resonance spectroscopic imaging (MRSI), and mood state in subjects with bipolar disorder...
  3. ncbi Glutamine and glutamate levels in children and adolescents with bipolar disorder: a 4.0-T proton magnetic resonance spectroscopy study of the anterior cingulate cortex
    Constance M Moore
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    J Am Acad Child Adolesc Psychiatry 46:524-34. 2007
    ..We hypothesized that unmedicated children with BPD would have reduced glutamine and glutamate levels compared with HCSs and medicated children with BPD...
  4. pmc Mania, glutamate/glutamine and risperidone in pediatric bipolar disorder: a proton magnetic resonance spectroscopy study of the anterior cingulate cortex
    Constance M Moore
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    J Affect Disord 99:19-25. 2007
    ..In this study, we hypothesized that the children with BPD in need of treatment would have lower Glx/Cr compared with the children with BPD being stably treated with risperidone...
  5. ncbi Topiramate raises anterior cingulate cortex glutamine levels in healthy men; a 4.0 T magnetic resonance spectroscopy study
    Constance M Moore
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, and Consolidated Department of Psychiatry, Harvard Medical School, Boston, MA 02114, USA
    Psychopharmacology (Berl) 188:236-43. 2006
    ..In particular, topiramate has been shown to increase occipital cortex GABA levels, as measured using proton magnetic resonance spectroscopy (MRS)...
  6. ncbi Differences in brain chemistry in children and adolescents with attention deficit hyperactivity disorder with and without comorbid bipolar disorder: a proton magnetic resonance spectroscopy study
    Constance M Moore
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    Am J Psychiatry 163:316-8. 2006
    ....
  7. ncbi Mesial temporal lobe Cho to Cr(PCr) ratio asymmetry in chronic schizophrenics
    Constance M Moore
    Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Schizophr Res 57:35-42. 2002
    ..No such correlations were noted on the right side. No significant difference was found between Cho/Cr(PCr) in the left temporal lobe or in the right temporal lobe of the schizophrenia subjects vs. the control group...
  8. doi Brain lithium, N-acetyl aspartate and myo-inositol levels in older adults with bipolar disorder treated with lithium: a lithium-7 and proton magnetic resonance spectroscopy study
    Brent P Forester
    Geriatric Psychiatry Research Program, McLean Hospital, Belmont, MA 02478, USA
    Bipolar Disord 10:691-700. 2008
    ..We investigated the relationship between brain lithium levels and the metabolites N-acetyl aspartate (NAA) and myo-inositol (myo-Ino) in the anterior cingulate cortex of a group of older adults with bipolar disorder (BD)...
  9. ncbi White matter abnormalities in children with and at risk for bipolar disorder
    Jean A Frazier
    Department of Psychiatry, Harvard Medical School, Boston, USA
    Bipolar Disord 9:799-809. 2007
    ..To more fully examine this possibility, we scanned children with DSM-IV BPD and compared them to healthy peers and children at risk for BPD (AR-BPD), defined as having a first-degree relative with the disorder...
  10. doi Brain lithium levels and effects on cognition and mood in geriatric bipolar disorder: a lithium-7 magnetic resonance spectroscopy study
    Brent P Forester
    Geriatric Psychiatry Research Program, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Am J Geriatr Psychiatry 17:13-23. 2009
    ..In addition, the authors investigated the association between brain lithium and serum lithium with frontal lobe functioning and mood in a subgroup of older subjects...
  11. doi Brain biochemical effects of methylphenidate treatment using proton magnetic spectroscopy in youth with attention-deficit hyperactivity disorder: a controlled pilot study
    Paul Hammerness
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, 02138, USA
    CNS Neurosci Ther 18:34-40. 2012
    ....
  12. doi Galantamine-ER for cognitive dysfunction in bipolar disorder and correlation with hippocampal neuronal viability: a proof-of-concept study
    Dan V Iosifescu
    The Bipolar Clinic and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    CNS Neurosci Ther 15:309-19. 2009
    ..Many subjects with bipolar disorder experience significant cognitive dysfunction, even when euthymic, but few studies assess biological correlates of or treatment strategies for cognitive dysfunction...
  13. doi Combined diffusion tensor imaging and transverse relaxometry in early-onset bipolar disorder
    Atilla Gönenç
    Harvard Medical School and the Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    J Am Acad Child Adolesc Psychiatry 49:1260-8. 2010
    ..The objective of the present work was to examine T2 abnormalities in children with unmodified DSM-IV-TR bipolar disorder (BD) in bilateral cingulate-paracingulate (CPC) white matter...
  14. pmc Diagnostic and sex effects on limbic volumes in early-onset bipolar disorder and schizophrenia
    Jean A Frazier
    Department of Psychiatry, Harvard Medical School, Massachusetts, USA
    Schizophr Bull 34:37-46. 2008
    ..The limbic structures in early-onset schizophrenia-spectrum illness (SZ) and bipolar disorder (BPD) were studied to discern patterns associated with diagnosis and sex...
  15. ncbi Phosphorous31 magnetic resonance spectroscopy after total sleep deprivation in healthy adult men
    Cynthia M Dorsey
    Sleep Disorders Center, Behavioral Psychopharmacology Research Laboratory, McLean Hospital, Harvard Medical School, Belmont 02478, USA
    Sleep 26:573-7. 2003
    ..To investigate chemical changes in the brains of healthy adults after sleep deprivation and recovery sleep, using phosphorous magnetic resonance spectroscopy...
  16. ncbi Lithium-induced alterations in nucleoside triphosphate levels in human brain: a proton-decoupled 31P magnetic resonance spectroscopy study
    Aysegul Yildiz
    Dokuz Eylul Medical School, Department of Psychiatry, Izmir, Turkey
    Psychiatry Res 138:51-9. 2005
    ..The theoretical relevance of the lithium-induced alterations on brain high-energy phosphates to the lithium-induced modifications of neuroplasticity is discussed...

Research Grants4

  1. Magnetic Resonance Spectroscopy in Affective Illness
    CONSTANCE MOORE; Fiscal Year: 2005
    ..Decreased caudate nucleus beta-NTP will be associated with depression. An increase in caudate nucleus PME will occur as a result of lithium treatment. ..