Research Topics
| Constance M MooreSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Brain-to-serum lithium ratio and age: an in vivo magnetic resonance spectroscopy studyConstance M Moore
Brain Imaging Center, Consolidated Department of Psychiatry, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Am J Psychiatry 159:1240-2. 2002..The authors' goal was to determine if there is an association between brain-to-serum lithium ratios and age...- Choline, myo-inositol and mood in bipolar disorder: a proton magnetic resonance spectroscopic imaging study of the anterior cingulate cortexC M Moore
Brain Imaging Center, McLean Hospital, Belmont, MA, USA
Bipolar Disord 2:207-16. 2000..We wished to determine the relationship between anterior cingulate cortex choline and myo-inositol levels, assessed using proton magnetic resonance spectroscopic imaging (MRSI), and mood state in subjects with bipolar disorder... - Glutamine and glutamate levels in children and adolescents with bipolar disorder: a 4.0-T proton magnetic resonance spectroscopy study of the anterior cingulate cortexConstance M Moore
Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
J Am Acad Child Adolesc Psychiatry 46:524-34. 2007..We hypothesized that unmedicated children with BPD would have reduced glutamine and glutamate levels compared with HCSs and medicated children with BPD... 
Mania, glutamate/glutamine and risperidone in pediatric bipolar disorder: a proton magnetic resonance spectroscopy study of the anterior cingulate cortexConstance M Moore
Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
J Affect Disord 99:19-25. 2007..In this study, we hypothesized that the children with BPD in need of treatment would have lower Glx/Cr compared with the children with BPD being stably treated with risperidone...- Topiramate raises anterior cingulate cortex glutamine levels in healthy men; a 4.0 T magnetic resonance spectroscopy studyConstance M Moore
Brain Imaging Center, McLean Hospital, Belmont, MA 02478, and Consolidated Department of Psychiatry, Harvard Medical School, Boston, MA 02114, USA
Psychopharmacology (Berl) 188:236-43. 2006..In particular, topiramate has been shown to increase occipital cortex GABA levels, as measured using proton magnetic resonance spectroscopy (MRS)... - Differences in brain chemistry in children and adolescents with attention deficit hyperactivity disorder with and without comorbid bipolar disorder: a proton magnetic resonance spectroscopy studyConstance M Moore
Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
Am J Psychiatry 163:316-8. 2006.... - Mesial temporal lobe Cho to Cr(PCr) ratio asymmetry in chronic schizophrenicsConstance M Moore
Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Schizophr Res 57:35-42. 2002..No such correlations were noted on the right side. No significant difference was found between Cho/Cr(PCr) in the left temporal lobe or in the right temporal lobe of the schizophrenia subjects vs. the control group... 
Brain lithium, N-acetyl aspartate and myo-inositol levels in older adults with bipolar disorder treated with lithium: a lithium-7 and proton magnetic resonance spectroscopy studyBrent P Forester
Geriatric Psychiatry Research Program, McLean Hospital, Belmont, MA 02478, USA
Bipolar Disord 10:691-700. 2008..We investigated the relationship between brain lithium levels and the metabolites N-acetyl aspartate (NAA) and myo-inositol (myo-Ino) in the anterior cingulate cortex of a group of older adults with bipolar disorder (BD)...- White matter abnormalities in children with and at risk for bipolar disorderJean A Frazier
Department of Psychiatry, Harvard Medical School, Boston, USA
Bipolar Disord 9:799-809. 2007..To more fully examine this possibility, we scanned children with DSM-IV BPD and compared them to healthy peers and children at risk for BPD (AR-BPD), defined as having a first-degree relative with the disorder... - Brain lithium levels and effects on cognition and mood in geriatric bipolar disorder: a lithium-7 magnetic resonance spectroscopy studyBrent P Forester
Geriatric Psychiatry Research Program, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Am J Geriatr Psychiatry 17:13-23. 2009..In addition, the authors investigated the association between brain lithium and serum lithium with frontal lobe functioning and mood in a subgroup of older subjects... - Brain biochemical effects of methylphenidate treatment using proton magnetic spectroscopy in youth with attention-deficit hyperactivity disorder: a controlled pilot studyPaul Hammerness
Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, 02138, USA
CNS Neurosci Ther 18:34-40. 2012.... - Galantamine-ER for cognitive dysfunction in bipolar disorder and correlation with hippocampal neuronal viability: a proof-of-concept studyDan V Iosifescu
The Bipolar Clinic and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
CNS Neurosci Ther 15:309-19. 2009..Many subjects with bipolar disorder experience significant cognitive dysfunction, even when euthymic, but few studies assess biological correlates of or treatment strategies for cognitive dysfunction... - Combined diffusion tensor imaging and transverse relaxometry in early-onset bipolar disorderAtilla Gönenç
Harvard Medical School and the Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
J Am Acad Child Adolesc Psychiatry 49:1260-8. 2010..The objective of the present work was to examine T2 abnormalities in children with unmodified DSM-IV-TR bipolar disorder (BD) in bilateral cingulate-paracingulate (CPC) white matter... - Diagnostic and sex effects on limbic volumes in early-onset bipolar disorder and schizophreniaJean A Frazier
Department of Psychiatry, Harvard Medical School, Massachusetts, USA
Schizophr Bull 34:37-46. 2008..The limbic structures in early-onset schizophrenia-spectrum illness (SZ) and bipolar disorder (BPD) were studied to discern patterns associated with diagnosis and sex... - Phosphorous31 magnetic resonance spectroscopy after total sleep deprivation in healthy adult menCynthia M Dorsey
Sleep Disorders Center, Behavioral Psychopharmacology Research Laboratory, McLean Hospital, Harvard Medical School, Belmont 02478, USA
Sleep 26:573-7. 2003..To investigate chemical changes in the brains of healthy adults after sleep deprivation and recovery sleep, using phosphorous magnetic resonance spectroscopy... - Lithium-induced alterations in nucleoside triphosphate levels in human brain: a proton-decoupled 31P magnetic resonance spectroscopy studyAysegul Yildiz
Dokuz Eylul Medical School, Department of Psychiatry, Izmir, Turkey
Psychiatry Res 138:51-9. 2005..The theoretical relevance of the lithium-induced alterations on brain high-energy phosphates to the lithium-induced modifications of neuroplasticity is discussed...
Research Grants
- Magnetic Resonance Spectroscopy in Affective IllnessCONSTANCE MOORE; Fiscal Year: 2005..Decreased caudate nucleus beta-NTP will be associated with depression. An increase in caudate nucleus PME will occur as a result of lithium treatment. ..