ANNA contact MOORE

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Combined small interfering RNA therapy and in vivo magnetic resonance imaging in islet transplantation
    Ping Wang
    Molecular Imaging Laboratory, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 60:565-71. 2011
  2. pmc Molecular imaging: a promising tool to monitor islet transplantation
    Ping Wang
    Molecular Imaging Laboratory, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USA
    J Transplant 2011:202915. 2011
  3. pmc Non-conjugated small molecule FRET for differentiating monomers from higher molecular weight amyloid beta species
    Chongzhao Ran
    Molecular Imaging Laboratory, Department of Radiology, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Charlestown, Massachusetts, United States of America
    PLoS ONE 6:e19362. 2011
  4. pmc A theranostic small interfering RNA nanoprobe protects pancreatic islet grafts from adoptively transferred immune rejection
    Ping Wang
    Molecular Imaging Laboratory, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 61:3247-54. 2012
  5. ncbi request reprint Molecular imaging of stem cell transplantation for neurodegenerative diseases
    Ping Wang
    Molecular Imaging Laboratory, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, 02129, USA
    Curr Pharm Des 18:4426-40. 2012
  6. pmc Advances in beta-cell imaging
    Anna Moore
    Molecular Imaging Laboratory, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Charlestown, MA 02129, USA
    Eur J Radiol 70:254-7. 2009
  7. ncbi request reprint Human transferrin receptor gene as a marker gene for MR imaging
    A Moore
    Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Bldg 149, 13th St, Rm 5419, Charlestown, MA 02129, USA
    Radiology 221:244-50. 2001
  8. ncbi request reprint In vivo targeting of underglycosylated MUC-1 tumor antigen using a multimodal imaging probe
    Anna Moore
    Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Cancer Res 64:1821-7. 2004
  9. ncbi request reprint Noninvasive in vivo measurement of beta-cell mass in mouse model of diabetes
    A Moore
    Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Diabetes 50:2231-6. 2001
  10. ncbi request reprint Tracking the recruitment of diabetogenic CD8+ T-cells to the pancreas in real time
    Anna Moore
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Building 149, 13th Street, Room 2301, Charlestown, MA 02129, USA
    Diabetes 53:1459-66. 2004

Collaborators

Detail Information

Publications26

  1. pmc Combined small interfering RNA therapy and in vivo magnetic resonance imaging in islet transplantation
    Ping Wang
    Molecular Imaging Laboratory, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 60:565-71. 2011
    ..We expect that treatment with the probe would result in significantly better survival of transplanted islets, which could be monitored by in vivo magnetic resonance imaging (MRI)...
  2. pmc Molecular imaging: a promising tool to monitor islet transplantation
    Ping Wang
    Molecular Imaging Laboratory, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USA
    J Transplant 2011:202915. 2011
    ..Here, we highlight the use of combined imaging and therapeutic interventions in islet transplantation and the in vivo monitoring of stem cells differentiation into insulin-producing cells...
  3. pmc Non-conjugated small molecule FRET for differentiating monomers from higher molecular weight amyloid beta species
    Chongzhao Ran
    Molecular Imaging Laboratory, Department of Radiology, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Charlestown, Massachusetts, United States of America
    PLoS ONE 6:e19362. 2011
    ..However, fast and cheap methods for these specific aims are still lacking...
  4. pmc A theranostic small interfering RNA nanoprobe protects pancreatic islet grafts from adoptively transferred immune rejection
    Ping Wang
    Molecular Imaging Laboratory, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 61:3247-54. 2012
    ....
  5. ncbi request reprint Molecular imaging of stem cell transplantation for neurodegenerative diseases
    Ping Wang
    Molecular Imaging Laboratory, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, 02129, USA
    Curr Pharm Des 18:4426-40. 2012
    ..We discuss current challenges and perspectives of these techniques and encompass updated information such as theranostic imaging and optogenetics in stem cell-based treatment of neurodegenerative diseases...
  6. pmc Advances in beta-cell imaging
    Anna Moore
    Molecular Imaging Laboratory, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Charlestown, MA 02129, USA
    Eur J Radiol 70:254-7. 2009
    ..This review will focus on employment of state-of-the-art in vivo imaging methods to estimate and evaluate beta-cell mass in animal models of diabetes...
  7. ncbi request reprint Human transferrin receptor gene as a marker gene for MR imaging
    A Moore
    Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Bldg 149, 13th St, Rm 5419, Charlestown, MA 02129, USA
    Radiology 221:244-50. 2001
    ..To quantitate and characterize the expression of an engineered human transferrin receptor (ETR) as a marker gene by using magnetic resonance (MR) imaging...
  8. ncbi request reprint In vivo targeting of underglycosylated MUC-1 tumor antigen using a multimodal imaging probe
    Anna Moore
    Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Cancer Res 64:1821-7. 2004
    ..We expect that this probe has a potential to greatly aid in screening prospective patients for early cancer detection and in monitoring the efficacy of drug therapy...
  9. ncbi request reprint Noninvasive in vivo measurement of beta-cell mass in mouse model of diabetes
    A Moore
    Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Diabetes 50:2231-6. 2001
    ..The results from this study set the route for further development of imaging probes for measuring BCM that would aid in diagnosis and treatment of diabetic patients in the clinic...
  10. ncbi request reprint Tracking the recruitment of diabetogenic CD8+ T-cells to the pancreas in real time
    Anna Moore
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Building 149, 13th Street, Room 2301, Charlestown, MA 02129, USA
    Diabetes 53:1459-66. 2004
    ..This study demonstrates the feasibility of visualizing the presence of ongoing autoimmune responses noninvasively...
  11. ncbi request reprint MRI of insulitis in autoimmune diabetes
    Anna Moore
    Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Magn Reson Med 47:751-8. 2002
    ..The results from this study could potentially lead to detection of immune infiltration during diabetes formation in vivo, which would be one of the earliest parameters of disease development...
  12. pmc Non-invasive detection of transplanted pancreatic islets
    Z Medarova
    Molecular Imaging Program, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
    Diabetes Obes Metab 10:88-97. 2008
    ..In addition, we will critically look into limitations and obstacles currently present on the way to successful clinical implementation of this approach...
  13. doi request reprint Effects of glucose toxicity and islet purity on in vivo magnetic resonance imaging of transplanted pancreatic islets
    Natalia V Evgenov
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Transplantation 85:1091-8. 2008
    ..To fully interpret the imaging data, it is critical to investigate factors normally present during clinical transplantation and influencing MRI of transplanted islets...
  14. doi request reprint In vivo imaging of a diabetogenic CD8+ T cell response during type 1 diabetes progression
    Zdravka Medarova
    Massachusetts General Hospital Massachusetts Institute of Technology Harvard Medical School Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Boston Massachusetts 02129, USA
    Magn Reson Med 59:712-20. 2008
    ..Antigen/MHC-coupled nanoparticles represent a promising new avenue for noninvasive imaging of lymphocyte inflammation in organ-specific autoimmunity and transplantation...
  15. ncbi request reprint Magnetic resonance imaging of the pancreas and pancreatic tumors in a mouse orthotopic model of human cancer
    Jan Grimm
    Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA
    Int J Cancer 106:806-11. 2003
    ..MR serves as a noninvasive high-resolution image modality to monitor murine pancreas as well as size, growth and even areas of heterogeneity in orthotopic pancreatic tumors...
  16. doi request reprint Enhanced tumor MR imaging with gadolinium-loaded polychelating polymer-containing tumor-targeted liposomes
    Suna Erdogan
    Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA
    J Magn Reson Imaging 27:574-80. 2008
    ....
  17. ncbi request reprint In vivo imaging of immune rejection in transplanted pancreatic islets
    Natalia V Evgenov
    Molecular Imaging Laboratory, Department of Radiology, Massachusetts General Hospital Massachusetts Institute of Technology Harvard Medical School, Charlestown, MA 02129, USA
    Diabetes 55:2419-28. 2006
    ..We believe that this agent, in combination with our preclinical model of islet transplantation, will facilitate the transition of imaging immune rejection to clinical trials...
  18. ncbi request reprint In vivo imaging of tumor response to therapy using a dual-modality imaging strategy
    Zdravka Medarova
    Molecular Imaging Laboratory, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA
    Int J Cancer 118:2796-802. 2006
    ....
  19. ncbi request reprint In vivo imaging of islet transplantation
    Natalia V Evgenov
    Molecular Imaging Laboratory, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital Harvard Medical School, Room 2301, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA
    Nat Med 12:144-8. 2006
    ..We anticipate that the information obtained in this study would ultimately result in the ability to detect and monitor islet engraftment in humans, which would greatly aid the clinical management of this disease...
  20. ncbi request reprint Imaging beta-cell death with a near-infrared probe
    Zdravka Medarova
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital Harvard Medical School, Charlestown, MA 02129, USA
    Diabetes 54:1780-8. 2005
    ....
  21. ncbi request reprint Detection of lymph node metastases by contrast-enhanced MRI in an experimental model
    Patrick Wunderbaldinger
    Center of Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Magn Reson Med 47:292-7. 2002
    ..0112 +/- 0.0061) was different from micrometastatic nodes (0.179 +/- 0.080, P < 0.00046) and nodes bearing small metastases (0.723 +/- 0.269, P < 0.00013), with high degrees of significance...
  22. ncbi request reprint Synthesis and application of a water-soluble near-infrared dye for cancer detection using optical imaging
    Wellington Pham
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Bioconjug Chem 16:735-40. 2005
    ..The in vivo optical imaging showed potential and broad applications of this dye in developing molecular-based beacons for cancer detection...
  23. ncbi request reprint Synthesis and testing of beta-cell-specific streptozotocin-derived near-infrared imaging probes
    Chongzhao Ran
    Molecular Imaging Laboratory, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, 13th Street, Building 149, Room 2301, Charlestown MA 02129, USA
    Angew Chem Int Ed Engl 46:8998-9001. 2007
  24. ncbi request reprint Noninvasive magnetic resonance imaging of microvascular changes in type 1 diabetes
    Zdravka Medarova
    Molecular Imaging Laboratory, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital Harvard Medical School, Room 2301, Bldg 149, 13th St, Charlestown, MA 02129, USA
    Diabetes 56:2677-82. 2007
    ..Consequently, the ability to noninvasively monitor the dynamics of the pancreatic microvasculature would aid in early diagnosis and permit the assessment, design, and optimization of individualized therapeutic intervention strategies...
  25. ncbi request reprint Crossing the blood-brain barrier: a potential application of myristoylated polyarginine for in vivo neuroimaging
    Wellington Pham
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, 02129, USA
    Neuroimage 28:287-92. 2005
    ..We conclude that this approach can be used for the delivery of imaging probes and potentially targeted therapeutics across the BBB...
  26. ncbi request reprint In vivo multimodal imaging of transplanted pancreatic islets
    Zdravka Medarova
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    Nat Protoc 1:429-35. 2006
    ..This information would be essential not only for the long-term monitoring of graft function but also for the design of improved transplantation and immunomodulatory methods...

Research Grants25

  1. In Vivo Imaging of Autoimmune Attack in Type 1 Diabetes
    Anna Moore; Fiscal Year: 2002
    ..The proposed studies are a logical extension of the feasibility experiments, and if successful, a transition of this research would be tested in clinical trials. ..
  2. In-Vivo Imaging of Islet Transplantation
    Anna Moore; Fiscal Year: 2009
    ..These results will be directly correlated to MR studies on the same animals. We anticipate that if successful, these studies can be promptly translated into clinical trials. ..
  3. Pre-clinical in vivo imaging of islet transplantation in non-human primates
    Anna Moore; Fiscal Year: 2009
    ....
  4. Combined siRNA Therapy and In-vivo Imaging in Islet Transplantation
    Anna Moore; Fiscal Year: 2009
    ....
  5. Multi-Parameter Monitoring of Breast Cancer Progression and Therapeutic Response
    Anna Moore; Fiscal Year: 2009
    ..If successful, this study can further be translated into clinical applications, since related iron oxides have already been tested in clinical trials. ..
  6. Pre-clinical in vivo imaging of islet transplantation in non-human primates
    Anna Moore; Fiscal Year: 2010
    ....
  7. Combined siRNA Therapy and In-vivo Imaging in Islet Transplantation
    Anna Moore; Fiscal Year: 2010
    ....
  8. Multi-Parameter Monitoring of Breast Cancer Progression and Therapeutic Response
    ANNA contact MOORE; Fiscal Year: 2010
    ..If successful, this study can further be translated into clinical applications, since related iron oxides have already been tested in clinical trials. ..
  9. Imaging of Pancreatic Islet Vasculature: An Interdisciplinary Resource
    Anna Moore; Fiscal Year: 2007
    ....
  10. Pre-clinical in vivo imaging of islet transplantation in non-human primates
    Anna Moore; Fiscal Year: 2007
    ....
  11. In vivo imaging of diabetogenic cytotoxic T-lymphocytes
    Anna Moore; Fiscal Year: 2003
    ..The proposed studies are a logical extension of the feasibility experiments, and if successful, a transition of this research would be tested in clinical trials. ..
  12. In vivo imaging of diabetogenic cytotoxic T-lymphocytes
    Anna Moore; Fiscal Year: 2004
    ..The proposed studies are a logical extension of the feasibility experiments, and if successful, a transition of this research would be tested in clinical trials. ..
  13. Novel multi-modal probes for in vivo cancer imaging
    Anna Moore; Fiscal Year: 2004
    ..If successful, this study can be further translated into clinical applications since related iron oxides have already been tested in clinical trials. ..
  14. In vivo imaging of diabetogenic cytotoxic T-lymphocytes
    Anna Moore; Fiscal Year: 2005
    ..The proposed studies are a logical extension of the feasibility experiments, and if successful, a transition of this research would be tested in clinical trials. ..
  15. Labeling Human Pancreatic Islets for Multi-Modal Imaging
    Anna Moore; Fiscal Year: 2006
    ..If successful, this research can be further translated into human studies as similar imaging probes are already in clinical trials. ..
  16. In vivo imaging of diabetogenic cytotoxic T-lymphocytes
    Anna Moore; Fiscal Year: 2006
    ..The proposed studies are a logical extension of the feasibility experiments, and if successful, a transition of this research would be tested in clinical trials. ..
  17. In-Vivo Imaging of Islet Transplantation
    Anna Moore; Fiscal Year: 2006
    ..These results will be directly correlated to MR studies on the same animals. We anticipate that if successful, these studies can be promptly translated into clinical trials. ..
  18. In-Vivo Imaging of Islet Transplantation
    Anna Moore; Fiscal Year: 2007
    ..These results will be directly correlated to MR studies on the same animals. We anticipate that if successful, these studies can be promptly translated into clinical trials. ..
  19. In vivo Image Guided Cancer Therapy
    Anna Moore; Fiscal Year: 2007
    ..If successful, this study can further be translated into clinical applications, since related iron oxides have already been tested in clinical trials. ..
  20. Combined siRNA Therapy and In-vivo Imaging in Islet Transplantation
    Anna Moore; Fiscal Year: 2010
    ....