Research Topics
Species | DAVID BRANCH MOODYSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infectionD B Moody
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 404:884-8. 2000....- CD1b-mediated T cell recognition of a glycolipid antigen generated from mycobacterial lipid and host carbohydrate during infectionD B Moody
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Exp Med 192:965-76. 2000.... - Polyisoprenyl glycolipids as targets of CD1-mediated T cell responsesD B Moody
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Cell Mol Life Sci 58:1461-74. 2001.... - Lipid length controls antigen entry into endosomal and nonendosomal pathways for CD1b presentationD Branch Moody
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Nat Immunol 3:435-42. 2002.... - Intracellular pathways of CD1 antigen presentationD Branch Moody
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, 1 Jimmy Fund Way, Boston, Massachusetts 02114, USA
Nat Rev Immunol 3:11-22. 2003..Here, we summarize evidence supporting the hypothesis that CD1 proteins use separate, but parallel, pathways to survey endosomal compartments differentially for lipid antigens... - TLR gateways to CD1 functionD Branch Moody
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Immunol 7:811-7. 2006.... - T cell activation by lipopeptide antigensD Branch Moody
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Smith Building Room 514, 1 Jimmy Fund Way, Boston, MA 02115, USA
Science 303:527-31. 2004..These studies identify a means of intracellular pathogen detection and identify lipopeptides as a biochemical class of antigens for T cells, which, like conventional peptides, have a potential for marked structural diversity... - Anatomy of CD1-lipid antigen complexesD Branch Moody
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Smith Building, Room 514, 1 Jimmy Fund Way, Boston, Massachusetts 02115, USA
Nat Rev Immunol 5:387-99. 2005.... - Role of lipid trimming and CD1 groove size in cellular antigen presentationTan Yun Cheng
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
EMBO J 25:2989-99. 2006..Lipids are loaded in an intact form, so that they likely protrude through a portal near the bottom of the groove, which represents an escape hatch for long lipids from mycobacterial pathogens... - Apolipoprotein-mediated pathways of lipid antigen presentationPeter van den Elzen
Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 437:906-10. 2005..Thus, the immune system has co-opted a component of lipid metabolism to develop immunological responses to lipid antigens... - pH-dependent interdomain tethers of CD1b regulate its antigen captureMiguel Relloso
Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital and Harvard Medical School, Smith Building Room 514, 1 Jimmy Fund Way, Boston, MA 02115, USA
Immunity 28:774-86. 2008..We propose that ionic tethers act as molecular switches that respond to pH fluxes during endosomal recycling and regulate the conformation of the CD1 heavy chain to control the size and rate of antigens captured... - CD1a and CD1c activate intrathyroidal T cells during Graves' disease and Hashimoto's thyroiditisCarme Roura-Mir
Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 174:3773-80. 2005.... - Synthesis of dideoxymycobactin antigens presented by CD1a reveals T cell fine specificity for natural lipopeptide structuresDavid C Young
Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 284:25087-96. 2009..Therefore, we conclude that T cells show precise specificity for both arms of the peptide, which are predicted to lie at the CD1a-T cell receptor interface... - Mycobacterium tuberculosis pks12 produces a novel polyketide presented by CD1c to T cellsIsamu Matsunaga
Div of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, One Jimmy Fund Way, Smith 514A, Boston, MA 02115, USA
J Exp Med 200:1559-69. 2004..These studies establish the genetic and enzymatic basis for a previously unknown type of polyketide, designated mycoketide, which contains a lipidic pathogen-associated molecular pattern... - Serum lipids regulate dendritic cell CD1 expression and functionDavid S Leslie
Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Immunology 125:289-301. 2008.... - CD1c presentation of synthetic glycolipid antigens with foreign alkyl branching motifsAnnemieke de Jong
Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Smith Building Room 538, One Jimmy Fund Way, Boston, MA 02115, USA
Chem Biol 14:1232-42. 2007..Therefore, the preferential recognition of branched lipids may represent a new lipid-based pathogen-associated molecular pattern... - Sorting out self and microbial lipid antigens for CD1Carme Roura-Mir
Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Smith Building Room 514, 1 Jimmy Fund Way, Boston, MA 02115, USA
Microbes Infect 5:1137-48. 2003..Therefore, the endosomal network may represent a depot for concentrating and then selectively presenting exogenous foreign lipid antigens to T cells... - T-cell recognition of glycolipids presented by CD1 proteinsDavid C Young
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Smith Building Room 514, 1 Jimmy Fund Way, Boston, MA 02115, USA
Glycobiology 16:103R-112R. 2006..These findings provide a previously unrecognized mechanism by which the cellular immune system can recognize alterations in many types of carbohydrate structures... - CD1d-restricted T cell activation by nonlipidic small moleculesIldiko Van Rhijn
Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, 1 Jimmy Fund Way, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 101:13578-83. 2004..These studies provide evidence for noninvariant CD1d-restricted T cells in humans and identify the complete molecular structure of a nonlipidic small molecule that activates T cells through an alphabeta TCR... - CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acidsIldiko Van Rhijn
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Exp Med 206:1409-22. 2009..Thus, although certain antigens require antigen processing in lysosomes, others are destroyed there, providing a hypothesis for the evolutionary conservation of large CD1 families containing isoforms that survey early endosomal pathways... - Mycobacterium tuberculosis regulates CD1 antigen presentation pathways through TLR-2Carme Roura-Mir
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Immunol 175:1758-66. 2005..These dual activation signals may represent a system for selectively promoting the presentation of exogenous foreign lipids by those myeloid APCs, which come into direct contact with pathogens... - The surprising diversity of lipid antigens for CD1-restricted T cellsD Branch Moody
Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Adv Immunol 89:87-139. 2006..These studies lead to a broader view of the natural function of alphabeta T cells, which involves recognition of both cellular proteins and lipids... - The evolved functions of CD1 during infectionAnne Kasmar
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Curr Opin Immunol 21:397-403. 2009..Viewed from the perspective that CD1 is a diverse gene family that activates several of classes of T cells, new insights into lipid loading and infection response are emerging... - Mycobacterium tuberculosis SigM positively regulates Esx secreted protein and nonribosomal peptide synthetase genes and down regulates virulence-associated surface lipid synthesisSahadevan Raman
Division of Infectious Diseases, Children s Hospital, Boston, MA 02115, USA
J Bacteriol 188:8460-8. 2006..These findings demonstrate that SigM positively and negatively regulates cell surface and secreted molecules that are likely to function in host-pathogen interactions... - Mycobacterial Esx-3 is required for mycobactin-mediated iron acquisitionM Sloan Siegrist
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 106:18792-7. 2009..Mycobacteria thus require a specialized secretion system for acquiring iron from siderophores... - CD1a-autoreactive T cells are a normal component of the human αβ T cell repertoireAnnemieke de Jong
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Nat Immunol 11:1102-9. 2010..The strong and frequent responses among genetically diverse donors define CD1a-autoreactive cells as a normal part of the human T cell repertoire and CD1a as a target of the T(H)22 subset of helper T cells...
Research Grants
- Remodeling of the M. tuberculosis cell wall during infectionDavid Moody; Fiscal Year: 2009..Identification of the genes, enzymes and cell wall lipids that mediate adaptation to growth in tissues provides the information necessary to achieve this goal. ..
- CD1 presentation of self glycolipids and lipopeptides to T cellsDavid Moody; Fiscal Year: 2007....
- Remodeling of the M. tuberculosis cell wall during infectionDavid Moody; Fiscal Year: 2007..Identification of the genes, enzymes and cell wall lipids that mediate adaptation to growth in tissues provides the information necessary to achieve this goal. ..
- CD1 presentation of self glycolipids and lipopeptides to T cellsDavid Moody; Fiscal Year: 2009....
- T-Cell response to CD1-restricted lipids in TuberculosisDAVID BRANCH MOODY; Fiscal Year: 2010..abstract_text> ..
- CD1 presentation of self glycolipids and lipopeptides to T cellsDAVID BRANCH MOODY; Fiscal Year: 2010....
- T-Cell response to CD1-restricted lipids in TuberculosisDavid Moody; Fiscal Year: 2007....
- T cell response to CDI-restricted lipids in tuberculosisDavid Moody; Fiscal Year: 2005....
- CD1c presentation of self glycolipids to T cellsDavid Moody; Fiscal Year: 2006..These studies will define the molecular features of natural self and foreign dolichyl glycolipids that control the separate processes of binding to CD1c and activation of T cells. ..
- Remodeling of the M. tuberculosis cell wall during infectionDAVID BRANCH MOODY; Fiscal Year: 2010..Identification of the genes, enzymes and cell wall lipids that mediate adaptation to growth in tissues provides the information necessary to achieve this goal. ..