DAVID BRANCH MOODY

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Mycobacterium tuberculosis pks12 produces a novel polyketide presented by CD1c to T cells
    Isamu Matsunaga
    Div of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, One Jimmy Fund Way, Smith 514A, Boston, MA 02115, USA
    J Exp Med 200:1559-69. 2004
  2. pmc CD1c tetramers detect ex vivo T cell responses to processed phosphomycoketide antigens
    Dalam Ly
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Exp Med 210:729-41. 2013
  3. pmc Ultralong C100 mycolic acids support the assignment of Segniliparus as a new bacterial genus
    Sunhee Hong
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e39017. 2012
  4. pmc CD1b tetramers bind αβ T cell receptors to identify a mycobacterial glycolipid-reactive T cell repertoire in humans
    Anne G Kasmar
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 208:1741-7. 2011
  5. pmc Mincle is a long sought receptor for mycobacterial cord factor
    Isamu Matsunaga
    Laboratory of Cell Regulation, Department of Viral Oncology, Institute for Virus Research, Kyoto University, Sakyo ku Kyoto 606 8507, Japan
    J Exp Med 206:2865-8. 2009
  6. ncbi request reprint TLR gateways to CD1 function
    D Branch Moody
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 7:811-7. 2006
  7. ncbi request reprint CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection
    D B Moody
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 404:884-8. 2000
  8. ncbi request reprint Anatomy of CD1-lipid antigen complexes
    D Branch Moody
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Smith Building, Room 514, 1 Jimmy Fund Way, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 5:387-99. 2005
  9. ncbi request reprint Polyisoprenyl glycolipids as targets of CD1-mediated T cell responses
    D B Moody
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell Mol Life Sci 58:1461-74. 2001
  10. ncbi request reprint Intracellular pathways of CD1 antigen presentation
    D Branch Moody
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, 1 Jimmy Fund Way, Boston, Massachusetts 02114, USA
    Nat Rev Immunol 3:11-22. 2003

Collaborators

Detail Information

Publications30

  1. pmc Mycobacterium tuberculosis pks12 produces a novel polyketide presented by CD1c to T cells
    Isamu Matsunaga
    Div of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, One Jimmy Fund Way, Smith 514A, Boston, MA 02115, USA
    J Exp Med 200:1559-69. 2004
    ..These studies establish the genetic and enzymatic basis for a previously unknown type of polyketide, designated mycoketide, which contains a lipidic pathogen-associated molecular pattern...
  2. pmc CD1c tetramers detect ex vivo T cell responses to processed phosphomycoketide antigens
    Dalam Ly
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Exp Med 210:729-41. 2013
    ..Furthermore, PM-loaded CD1c tetramers detect fresh human T cells from peripheral blood, demonstrating a polyclonal response to PM antigens in humans ex vivo...
  3. pmc Ultralong C100 mycolic acids support the assignment of Segniliparus as a new bacterial genus
    Sunhee Hong
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e39017. 2012
    ..Therefore, these new and unexpected extremes of mycolic acid chemical structure raise questions about the modes of mycolic acid packing and folding into a membrane...
  4. pmc CD1b tetramers bind αβ T cell receptors to identify a mycobacterial glycolipid-reactive T cell repertoire in humans
    Anne G Kasmar
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 208:1741-7. 2011
    ..CD1b tetramers detect a natural CD1b-restricted T cell repertoire ex vivo with unexpected features, opening a new investigative path to study the human CD1 system...
  5. pmc Mincle is a long sought receptor for mycobacterial cord factor
    Isamu Matsunaga
    Laboratory of Cell Regulation, Department of Viral Oncology, Institute for Virus Research, Kyoto University, Sakyo ku Kyoto 606 8507, Japan
    J Exp Med 206:2865-8. 2009
    ....
  6. ncbi request reprint TLR gateways to CD1 function
    D Branch Moody
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 7:811-7. 2006
    ....
  7. ncbi request reprint CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection
    D B Moody
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 404:884-8. 2000
    ....
  8. ncbi request reprint Anatomy of CD1-lipid antigen complexes
    D Branch Moody
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Smith Building, Room 514, 1 Jimmy Fund Way, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 5:387-99. 2005
    ....
  9. ncbi request reprint Polyisoprenyl glycolipids as targets of CD1-mediated T cell responses
    D B Moody
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell Mol Life Sci 58:1461-74. 2001
    ....
  10. ncbi request reprint Intracellular pathways of CD1 antigen presentation
    D Branch Moody
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, 1 Jimmy Fund Way, Boston, Massachusetts 02114, USA
    Nat Rev Immunol 3:11-22. 2003
    ..Here, we summarize evidence supporting the hypothesis that CD1 proteins use separate, but parallel, pathways to survey endosomal compartments differentially for lipid antigens...
  11. ncbi request reprint T cell activation by lipopeptide antigens
    D Branch Moody
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Smith Building Room 514, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Science 303:527-31. 2004
    ..These studies identify a means of intracellular pathogen detection and identify lipopeptides as a biochemical class of antigens for T cells, which, like conventional peptides, have a potential for marked structural diversity...
  12. pmc CD1b-mediated T cell recognition of a glycolipid antigen generated from mycobacterial lipid and host carbohydrate during infection
    D B Moody
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 192:965-76. 2000
    ....
  13. ncbi request reprint Lipid length controls antigen entry into endosomal and nonendosomal pathways for CD1b presentation
    D Branch Moody
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Nat Immunol 3:435-42. 2002
    ....
  14. pmc Role of lipid trimming and CD1 groove size in cellular antigen presentation
    Tan Yun Cheng
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    EMBO J 25:2989-99. 2006
    ..Lipids are loaded in an intact form, so that they likely protrude through a portal near the bottom of the groove, which represents an escape hatch for long lipids from mycobacterial pathogens...
  15. ncbi request reprint Apolipoprotein-mediated pathways of lipid antigen presentation
    Peter van den Elzen
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 437:906-10. 2005
    ..Thus, the immune system has co-opted a component of lipid metabolism to develop immunological responses to lipid antigens...
  16. pmc pH-dependent interdomain tethers of CD1b regulate its antigen capture
    Miguel Relloso
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital and Harvard Medical School, Smith Building Room 514, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Immunity 28:774-86. 2008
    ..We propose that ionic tethers act as molecular switches that respond to pH fluxes during endosomal recycling and regulate the conformation of the CD1 heavy chain to control the size and rate of antigens captured...
  17. ncbi request reprint CD1a and CD1c activate intrathyroidal T cells during Graves' disease and Hashimoto's thyroiditis
    Carme Roura-Mir
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 174:3773-80. 2005
    ....
  18. pmc Synthesis of dideoxymycobactin antigens presented by CD1a reveals T cell fine specificity for natural lipopeptide structures
    David C Young
    Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 284:25087-96. 2009
    ..Therefore, we conclude that T cells show precise specificity for both arms of the peptide, which are predicted to lie at the CD1a-T cell receptor interface...
  19. pmc Serum lipids regulate dendritic cell CD1 expression and function
    David S Leslie
    Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Immunology 125:289-301. 2008
    ....
  20. pmc CD1c presentation of synthetic glycolipid antigens with foreign alkyl branching motifs
    Annemieke de Jong
    Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Smith Building Room 538, One Jimmy Fund Way, Boston, MA 02115, USA
    Chem Biol 14:1232-42. 2007
    ..Therefore, the preferential recognition of branched lipids may represent a new lipid-based pathogen-associated molecular pattern...
  21. ncbi request reprint T-cell recognition of glycolipids presented by CD1 proteins
    David C Young
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Smith Building Room 514, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Glycobiology 16:103R-112R. 2006
    ..These findings provide a previously unrecognized mechanism by which the cellular immune system can recognize alterations in many types of carbohydrate structures...
  22. pmc CD1d-restricted T cell activation by nonlipidic small molecules
    Ildiko Van Rhijn
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:13578-83. 2004
    ..These studies provide evidence for noninvariant CD1d-restricted T cells in humans and identify the complete molecular structure of a nonlipidic small molecule that activates T cells through an alphabeta TCR...
  23. ncbi request reprint Sorting out self and microbial lipid antigens for CD1
    Carme Roura-Mir
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Smith Building Room 514, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Microbes Infect 5:1137-48. 2003
    ..Therefore, the endosomal network may represent a depot for concentrating and then selectively presenting exogenous foreign lipid antigens to T cells...
  24. pmc CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids
    Ildiko Van Rhijn
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 206:1409-22. 2009
    ..Thus, although certain antigens require antigen processing in lysosomes, others are destroyed there, providing a hypothesis for the evolutionary conservation of large CD1 families containing isoforms that survey early endosomal pathways...
  25. ncbi request reprint Mycobacterium tuberculosis regulates CD1 antigen presentation pathways through TLR-2
    Carme Roura-Mir
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 175:1758-66. 2005
    ..These dual activation signals may represent a system for selectively promoting the presentation of exogenous foreign lipids by those myeloid APCs, which come into direct contact with pathogens...
  26. ncbi request reprint The surprising diversity of lipid antigens for CD1-restricted T cells
    D Branch Moody
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Adv Immunol 89:87-139. 2006
    ..These studies lead to a broader view of the natural function of alphabeta T cells, which involves recognition of both cellular proteins and lipids...
  27. pmc The evolved functions of CD1 during infection
    Anne Kasmar
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Curr Opin Immunol 21:397-403. 2009
    ..Viewed from the perspective that CD1 is a diverse gene family that activates several of classes of T cells, new insights into lipid loading and infection response are emerging...
  28. pmc CD1a-autoreactive T cells are a normal component of the human αβ T cell repertoire
    Annemieke de Jong
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 11:1102-9. 2010
    ..The strong and frequent responses among genetically diverse donors define CD1a-autoreactive cells as a normal part of the human T cell repertoire and CD1a as a target of the T(H)22 subset of helper T cells...
  29. pmc Mycobacterium tuberculosis SigM positively regulates Esx secreted protein and nonribosomal peptide synthetase genes and down regulates virulence-associated surface lipid synthesis
    Sahadevan Raman
    Division of Infectious Diseases, Children s Hospital, Boston, MA 02115, USA
    J Bacteriol 188:8460-8. 2006
    ..These findings demonstrate that SigM positively and negatively regulates cell surface and secreted molecules that are likely to function in host-pathogen interactions...
  30. pmc Mycobacterial Esx-3 is required for mycobactin-mediated iron acquisition
    M Sloan Siegrist
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:18792-7. 2009
    ..Mycobacteria thus require a specialized secretion system for acquiring iron from siderophores...

Research Grants24

  1. Remodeling of the M. tuberculosis cell wall during infection
    David Moody; Fiscal Year: 2009
    ..Identification of the genes, enzymes and cell wall lipids that mediate adaptation to growth in tissues provides the information necessary to achieve this goal. ..
  2. T cell response to CDI-restricted lipids in tuberculosis
    David Moody; Fiscal Year: 2001
    ....
  3. CD1 presentation of self glycolipids and lipopeptides to T cells
    David Moody; Fiscal Year: 2007
    ....
  4. Remodeling of the M. tuberculosis cell wall during infection
    David Moody; Fiscal Year: 2007
    ..Identification of the genes, enzymes and cell wall lipids that mediate adaptation to growth in tissues provides the information necessary to achieve this goal. ..
  5. T-Cell response to CD1-restricted lipids in Tuberculosis
    David Moody; Fiscal Year: 2009
    ..abstract_text> ..
  6. CD1 presentation of self glycolipids and lipopeptides to T cells
    David Moody; Fiscal Year: 2009
    ....
  7. T-Cell response to CD1-restricted lipids in Tuberculosis
    DAVID BRANCH MOODY; Fiscal Year: 2010
    ..abstract_text> ..
  8. CD1 presentation of self glycolipids and lipopeptides to T cells
    DAVID BRANCH MOODY; Fiscal Year: 2010
    ....
  9. T-Cell response to CD1-restricted lipids in Tuberculosis
    David Moody; Fiscal Year: 2007
    ....
  10. Remodeling of the M. tuberculosis cell wall during infection
    David Moody; Fiscal Year: 2006
    ..Identification of the genes, enzymes and cell wall lipids that mediate adaptation to growth in tissues provides the information necessary to achieve this goal. ..
  11. CD1c presentation of self glycolipids to T cells
    David Moody; Fiscal Year: 2002
    ..These studies will define the molecular features of natural self and foreign dolichyl glycolipids that control the separate processes of binding to CD1c and activation of T cells. ..
  12. T cell response to CDI-restricted lipids in tuberculosis
    David Moody; Fiscal Year: 2002
    ....
  13. T cell response to CDI-restricted lipids in tuberculosis
    David Moody; Fiscal Year: 2003
    ....
  14. CD1c presentation of self glycolipids to T cells
    David Moody; Fiscal Year: 2003
    ..These studies will define the molecular features of natural self and foreign dolichyl glycolipids that control the separate processes of binding to CD1c and activation of T cells. ..
  15. T cell response to CDI-restricted lipids in tuberculosis
    David Moody; Fiscal Year: 2004
    ....
  16. CD1c presentation of self glycolipids to T cells
    David Moody; Fiscal Year: 2004
    ..These studies will define the molecular features of natural self and foreign dolichyl glycolipids that control the separate processes of binding to CD1c and activation of T cells. ..
  17. T cell response to CDI-restricted lipids in tuberculosis
    David Moody; Fiscal Year: 2005
    ....
  18. CD1c presentation of self glycolipids to T cells
    David Moody; Fiscal Year: 2005
    ..These studies will define the molecular features of natural self and foreign dolichyl glycolipids that control the separate processes of binding to CD1c and activation of T cells. ..
  19. T-Cell response to CD1-restricted lipids in Tuberculosis
    David Moody; Fiscal Year: 2006
    ....
  20. CD1c presentation of self glycolipids to T cells
    David Moody; Fiscal Year: 2006
    ..These studies will define the molecular features of natural self and foreign dolichyl glycolipids that control the separate processes of binding to CD1c and activation of T cells. ..
  21. Remodeling of the M. tuberculosis cell wall during infection
    DAVID BRANCH MOODY; Fiscal Year: 2010
    ..Identification of the genes, enzymes and cell wall lipids that mediate adaptation to growth in tissues provides the information necessary to achieve this goal. ..