Research Topics
Genomes and Genes
Species | M A MittlemanSummaryAffiliation: Harvard University Country: USA Publications
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Publications
A 39-year-old woman with hypercholesterolemiaMurray A Mittleman
Harvard Medical School, Boston, Mass, USA
JAMA 296:319-26. 2006..Recommendations for her, her longer-term risk for CHD, and evidence for lipid-lowering therapies are discussed...
Triggering myocardial infarction by marijuanaM A Mittleman
Institute for the Prevention of Cardiovascular Disease, Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Circulation 103:2805-9. 2001..Smoking marijuana is known to have hemodynamic consequences, including a dose-dependent increase in heart rate, supine hypertension, and postural hypotension; however, whether it can trigger the onset of myocardial infarction is unknown...
The double-edged blade of recreational hockeyMurray A Mittleman
Institute for Prevention of Cardiovascular Disease, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
CMAJ 166:331-2. 2002
Epidemiologic perspective on the role of psychosocial factorsM A Mittleman
Beth Israel Deaconess Medical Center, Harvard Medical School, One Autumn Street, 5th Floor, Boston, MA 02215, USA
Ital Heart J 2:887-9. 2001....
Hypobetalipoproteinemia is associated with low levels of hemostatic risk factors in the Framingham offspring populationF K Welty
Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass, USA
Circulation 95:825-30. 1997..The aim of this study was to utilize subjects with hypobetalipoproteinemia to examine the relation between thrombotic potential and low levels of LDL cholesterol...
Increased particulate air pollution and the triggering of myocardial infarctionA Peters
Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
Circulation 103:2810-5. 2001..Further studies in other locations are needed to clarify the importance of this potentially preventable trigger of MI...
Prior alcohol consumption and mortality following acute myocardial infarctionK J Mukamal
Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, 330 Brookline Ave, LY 303, Boston, MA 02215, USA
JAMA 285:1965-70. 2001....
Hyperinsulinemia, hyperglycemia, and impaired hemostasis: the Framingham Offspring StudyJ B Meigs
General Medicine Division and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Institute for Prevention of Cardiovascular Disease, Boston 02114, USA
JAMA 283:221-8. 2000..Hyperinsulinemia associated with glucose intolerance may increase risk directly, or its effect could be mediated through impaired hemostatic function...
Heart failure and the risk of shocks in patients with implantable cardioverter defibrillators: results from the Triggers Of Ventricular Arrhythmias (TOVA) studyWilliam Whang
Cardiovascular Division, Bulfinch 001, Massachusetts General Hospital, 55 Fruit St, Boston, Mass 02114, USA
Circulation 109:1386-91. 2004..Left ventricular ejection fraction (LVEF) predicts device discharges in patients with implantable cardioverter-defibrillators (ICDs). The relationship between severity of congestive heart failure (CHF) and ICD discharges is less clear...
Impact of diabetes on long-term survival after acute myocardial infarction: comparability of risk with prior myocardial infarctionK J Mukamal
Division of General Medicine and Primary Care at the Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Diabetes Care 24:1422-7. 2001..To determine the effect of diabetes on long-term survival after acute myocardial infarction and to compare its effect with that of a previous myocardial infarction...
Increased risk of paroxysmal atrial fibrillation episodes associated with acute increases in ambient air pollutionDavid Q Rich
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Environ Health Perspect 114:120-3. 2006..CONCLUSIONS: Increased ambient O3 pollution was associated with increased risk of episodes of rapid ventricular response due to PAF, thereby suggesting that community air pollution may be a precipitant of these events...
Chronic obstructive pulmonary disease, asthma, and risk of type 2 diabetes in womenJamal S Rana
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
Diabetes Care 27:2478-84. 2004..Differences in the inflammation and cytokine profile between COPD and asthma might explain why COPD, but not asthma, is associated with increased risk of type 2 diabetes...
Dietary glycemic index, dietary glycemic load, and incidence of heart failure events: a prospective study of middle-aged and elderly womenEmily B Levitan
Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
J Am Coll Nutr 29:65-71. 2010..The authors therefore assessed whether dietary GI and GL were associated with rates of HF events...
Should we use a case-crossover design?M Maclure
Epidemiology Department, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Annu Rev Public Health 21:193-221. 2000....
Height is not associated with long-term survival after acute myocardial infarctionK J Mukamal
Divisions of General Medicine and Primary Care and Cardiology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Am Heart J 142:852-6. 2001..Studies show an inverse association between height and risk of myocardial infarction. How height affects survival after acute myocardial infarction is uncertain...
Lack of effect of recent alcohol consumption on the course of acute myocardial infarctionK J Mukamal
Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Am Heart J 138:926-33. 1999..We sought to determine whether recent alcohol consumption alters the course or complications of acute myocardial infarction...
Driving and implantable cardioverter-defibrillator shocks for ventricular arrhythmias: results from the TOVA studyChristine M Albert
Center for Arrhythmia Prevention, Division of Preventive Medicine and Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts 02215 1204, USA
J Am Coll Cardiol 50:2233-40. 2007..This study examined the risk of implantable cardioverter-defibrillator (ICD) shocks for ventricular tachycardia (VT) or ventricular fibrillation (VF) associated with driving...
Obesity and the risk of death after acute myocardial infarctionJamal S Rana
Department of Medicine, Division of Cardiology, Boston, Mass, USA
Am Heart J 147:841-6. 2004..Whether weight reduction and secondary prevention strategies would reverse this effect in obese population remains to be seen...
Acute changes in vascular function among welders exposed to metal-rich particulate matterShona C Fang
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
Epidemiology 19:217-25. 2008..To investigate the role of vascular function, we assessed levels of the augmentation index (a correlate of arterial stiffness) after short-term exposure to welding-derived fine particulate matter (PM2.5)...
Triggering of myocardial infarction by cocaineM A Mittleman
Institute for Prevention of Cardiovascular Disease, Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Circulation 99:2737-41. 1999..However, the magnitude of the increase in risk of acute myocardial infarction immediately after cocaine use remains unknown...
Increased risk of congestive heart failure among infarctions with nighttime onsetK J Mukamal
Department of Medicine, Divisions of General Medicine and Primary Care and Cardiology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Am Heart J 140:438-42. 2000..Further research may clarify whether this reflects differences in the pathophysiologic characteristics of infarction or the quality of medical care provided for daytime and nighttime infarctions...
Association of short-term ambient air pollution concentrations and ventricular arrhythmiasDavid Q Rich
Department of Environmental Health, Harvard School of Public Health, 401 Park Drive, Boston, MA 02215, USA
Am J Epidemiol 161:1123-32. 2005..These results confirm previous findings and suggest that matching of pollution periods to arrhythmias is important in detecting such associations...
Candidate genes for respiratory disease associated with markers of inflammation and endothelial dysfunction in elderly menElissa H Wilker
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, United States
Atherosclerosis 206:480-5. 2009..We hypothesized that candidate genes selected for a study of asthma and chronic obstructive pulmonary disorder (COPD) are associated with markers of systemic inflammation and endothelial dysfunction in an aging population...
Intervening on risk factors for coronary heart disease: an application of the parametric g-formulaSarah L Taubman
National Bureau of Economic Research, Cambridge, MA, USA
Int J Epidemiol 38:1599-611. 2009..This work represents the first large-scale application of the parametric g-formula in an epidemiologic cohort study...
Cardiovascular safety update of Tadalafil: retrospective analysis of data from placebo-controlled and open-label clinical trials of Tadalafil with as needed, three times-per-week or once-a-day dosingRobert A Kloner
The Heart Institute, Good Samaritan Hospital, Cardiovascular Division, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Am J Cardiol 97:1778-84. 2006..In this clinical trial population of men with erectile dysfunction, tadalafil was not associated with an increased risk for serious cardiovascular adverse events...
Prevalent cocaine use and myocardial infarctionStella Aslibekyan
Department of Epidemiology, Harvard School of Public Health, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Am J Cardiol 102:966-9. 2008..In conclusion, these data support a substantial association between cocaine use and MI; the temporal trend in cocaine use may increase the occurrence of MI, particularly in younger populations...
Depression as a predictor for appropriate shocks among patients with implantable cardioverter-defibrillators: results from the Triggers of Ventricular Arrhythmias (TOVA) studyWilliam Whang
Cardiovascular Division, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
J Am Coll Cardiol 45:1090-5. 2005..We sought to examine the relationship between symptoms of depression and shock-treated ventricular arrhythmias among implantable cardioverter-defibrillator (ICD) patients...
Circadian variation in the onset of myocardial infarction: effect of duration of diabetesJamal S Rana
Department of Medicine, Division of Cardiology, Beth Israel Deaconess Medical Center, 1 Autumn Street, 5th Floor, Boston, MA 02215, USA
Diabetes 52:1464-8. 2003..Inconsistency in observation of such an effect in patients with diabetes in the past may well have been due to difference in the duration of diabetes and thus the variable extent of underlying autonomic dysfunction...
Air pollution and risk of stroke: underestimation of effect due to misclassification of time of event onsetR Peter Lokken
Department of Medicine, Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
Epidemiology 20:137-42. 2009..Epidemiologic studies linking ambient air pollution to the onset of acute cardiovascular events often rely on date of hospital admission for exposure assessment...
Circulating adhesion molecules after short-term exposure to particulate matter among weldersS C Fang
Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, FXB 103, Boston, MA 02115, USA
Occup Environ Med 67:11-6. 2010....
Alternative approaches to analytical designs in occupational injury epidemiologyM A Mittleman
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
Am J Ind Med 32:129-41. 1997..Finally, a variety of hybrid designs are discussed, including combinations of case-control, case-crossover, and cohort designs...
Alcohol consumption and hemostatic factors: analysis of the Framingham Offspring cohortK J Mukamal
Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Circulation 104:1367-73. 2001..Moderate alcohol consumers have lower rates of cardiovascular disease than abstainers. One proposed mechanism is a beneficial effect on hemostatic parameters, but previous studies have provided conflicting results...
Cardiovascular outcomes among sildenafil users: results of the International Men's Health StudyM A Mittleman
Cardiovascular Epidemiology Research Unit, Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Int J Clin Pract 62:367-73. 2008..To assess the incidence of serious cardiovascular disease (CVD) events [i.e. myocardial infarction (MI) and stroke] and all-cause mortality in men with erectile dysfunction (ED) who received prescriptions for sildenafil...
Tea consumption and infarct-related ventricular arrhythmias: the determinants of myocardial infarction onset studyKenneth J Mukamal
Beth Israel Deaconess Medical Center, Division of General Medicine and Primary Care Research Program, Brookline, MA 02446, USA
J Am Coll Nutr 25:472-9. 2006..We previously found preliminary evidence that tea consumption may also be associated with lower risk of infarct-related ventricular arrhythmias...
Prevalent rheumatoid arthritis and diabetes among NHANES III participants aged 60 and olderJulia F Simard
Department of Epidemiology, Harvard School of Public Health, and the Cardiovascular Epidemiology Research Unit, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
J Rheumatol 34:469-73. 2007..This study examines the cross-sectional association between prevalent rheumatoid arthritis (RA) and diabetes among noninstitutionalized US civilians aged >or= 60 years between 1988 and 1994...
Improvements in long-term mortality after myocardial infarction and increased use of cardiovascular drugs after discharge: a 10-year trend analysisSoko Setoguchi
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
J Am Coll Cardiol 51:1247-54. 2008..We sought to assess the relationship between increasing use of cardiovascular medications and trends in long-term prognosis after myocardial infarction (MI) in the elderly...
Obesity and C-reactive protein levels among white, black, and hispanic US adultsChristina C Wee
Division of General Medicine and Primary Care, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Obesity (Silver Spring) 16:875-80. 2008..We examined whether obesity's association with novel cardiovascular risk factors such as C-reactive protein (CRP) also varies by race and ethnicity...
Dietary glycemic index, dietary glycemic load, and cardiovascular disease in middle-aged and older Swedish menEmily B Levitan
Cardiovascular Epidemiology Research Unit, Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Am J Clin Nutr 85:1521-6. 2007..In women, dietary glycemic index (GI) and dietary glycemic load (GL) have been associated with cardiovascular disease; in men, however, the evidence for an association is weaker...
Alcohol consumption and risk and prognosis of atrial fibrillation among older adults: the Cardiovascular Health StudyKenneth J Mukamal
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
Am Heart J 153:260-6. 2007..The relationship of alcohol consumption with risk of atrial fibrillation (AF) is inconsistent in previous studies, and its relationship with prognosis of AF is undetermined...
A 6-month randomized pilot study of black tea and cardiovascular risk factorsKenneth J Mukamal
Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02446, USA
Am Heart J 154:724.e1-6. 2007..The effects of black tea consumption on cardiovascular risk factors have been inconsistent in previous randomized trials, all of which have been limited to a few weeks duration...
The prevalence of blood pressure and cholesterol monitoring in Boston among non-Hispanic blacks, Hispanics, and non-Hispanic whitesEileen M Stuart-Shor
Cardiovascular Epidemiology Research Unit, Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Ethn Dis 16:375-83. 2006..This study examines blood pressure and cholesterol monitoring among non-Hispanic Black, Hispanic, and non-Hispanic White subjects...
Chimney stove intervention to reduce long-term wood smoke exposure lowers blood pressure among Guatemalan womenJohn P McCracken
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02215, USA
Environ Health Perspect 115:996-1001. 2007..Given the evidence that ambient particles increase blood pressure, we hypothesized that the intervention would lower blood pressure...
Use of dietary supplements among United States adults with coronary artery disease and atherosclerotic risksCatherine Buettner
Division for Research and Education in Complementary and Integrative Medical Therapies, Harvard Medical School, Boston, Massachusetts, USA
Am J Cardiol 99:661-6. 2007..In conclusion, use of dietary supplements is common in those with CAD or CAD risks...
Beliefs, motivations, and opinions about moderate drinking: a cross-sectional surveyKenneth J Mukamal
Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Fam Med 40:188-95. 2008..The relationship of moderate alcohol use and health remains controversial and uncertain. How physicians and patients react to this uncertainty is unknown...
Residential exposure to traffic-related air pollution and survival after heart failureMercedes Medina-Ramón
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
Environ Health Perspect 116:481-5. 2008....
Alcohol and acute ischemic stroke onset: the stroke onset studyElizabeth Mostofsky
Cardiovascular Epidemiology Research Unit, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass 02215, USA
Stroke 41:1845-9. 2010....
Safety and effectiveness of bivalirudin in routine care of patients undergoing percutaneous coronary interventionJeremy A Rassen
Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
Eur Heart J 31:561-72. 2010..Trials have indicated that bivalirudin is non-inferior to heparin with respect to death and repeat revascularization and may decrease the risk of major bleeds. The use of bivalirudin in routine care has not been evaluated...
Adiposity and incidence of heart failure hospitalization and mortality: a population-based prospective studyEmily B Levitan
Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, Mass, USA
Circ Heart Fail 2:202-8. 2009..Obesity is associated with heart failure (HF) incidence. We examined the strength of the association of body mass index (BMI) with HF by age and joint associations of BMI and waist circumference (WC)...
Postural changes in blood pressure associated with interactions between candidate genes for chronic respiratory diseases and exposure to particulate matterElissa Wilker
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
Environ Health Perspect 117:935-40. 2009..Fine particulate matter [aerodynamic diameter </= 2.5 mum (PM(2.5))] has been associated with autonomic dysregulation...
Herbal supplement use and blood lead levels of United States adultsCatherine Buettner
Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
J Gen Intern Med 24:1175-82. 2009..Some herbal supplements may contain lead...
Fish consumption, marine omega-3 fatty acids, and incidence of heart failure: a population-based prospective study of middle-aged and elderly menEmily B Levitan
Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Harvard Medical School, 375 Longwood Avenue, Boston, MA 02215, USA
Eur Heart J 30:1495-500. 2009..We therefore conducted a population-based, prospective study of 39 367 middle-aged and older Swedish men...
Instrumental variables II: instrumental variable application-in 25 variations, the physician prescribing preference generally was strong and reduced covariate imbalanceJeremy A Rassen
Brigham and Women s Hospital, Boston, MA 02120, USA
J Clin Epidemiol 62:1233-41. 2009..As reduction in covariate imbalance may suggest increased IV validity, we sought to examine the covariate balance and instrument strength in 25 formulations of the PPP IV in two cohort studies...
Weather and air pollution as triggers of severe headachesKenneth J Mukamal
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Neurology 72:922-7. 2009..The roles of weather conditions and air pollution as triggers of headache have been inconsistent in previous, generally small studies...
Consistency with the DASH diet and incidence of heart failureEmily B Levitan
Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, 375 Longwood Avenue, Boston, MA 02215, USA
Arch Intern Med 169:851-7. 2009..We hypothesized that diets consistent with the DASH diet would be associated with a lower incidence of heart failure (HF)...
Hematologic parameters, atherosclerotic progression, and prognosis in patients with previous coronary artery bypass grafting (from the Post CABG Trial)Kenneth J Mukamal
Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA, USA
Am J Cardiol 103:328-32. 2009..In conclusion, WBC count is associated with a graded increase in cardiovascular events in patients with coronary artery bypass grafts...
Instrumental variable analysis for estimation of treatment effects with dichotomous outcomesJeremy A Rassen
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Boston, MA 02120, USA
Am J Epidemiol 169:273-84. 2009..Generalized method of moments estimation produced substantially the same results as the 2-stage logistic method. Few substantive differences among the methods were observed, despite their reliance on distinct assumptions...
Disparities in myocardial infarction case fatality rates among the elderly: the 20-year Medicare experienceGregory A Wellenius
Department of Medicine, Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Am Heart J 156:483-90. 2008..Accordingly, we sought to assess long-term temporal trends in mortality after hospitalization for MI and to assess whether these trends differ by sex, race, or age in a cohort of elderly patients...
The relationship between obesity and atherosclerotic progression and prognosis among patients with coronary artery bypass grafts the effect of aggressive statin therapyChristina C Wee
Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
J Am Coll Cardiol 52:620-5. 2008..This study examines whether obesity accelerates atherogenic progression or adverse outcomes after coronary artery bypass graft (CABG) surgery...
Perinatal factors and adult-onset lupusJulia F Simard
Department of Epidemiology, Harvard University School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
Arthritis Rheum 59:1155-61. 2008..Therefore, we evaluated the role of birth weight, being breastfed, and preterm birth on the incidence of SLE in participants in the Nurses' Health Study (NHS) and the Nurses' Health Study II (NHSII)...
Prevalence of musculoskeletal pain and statin useCatherine Buettner
Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
J Gen Intern Med 23:1182-6. 2008..However, in placebo-controlled trials the incidence of muscle pain is most often similar for placebo and active control groups...
A prospective study of floor surface, shoes, floor cleaning and slipping in US limited-service restaurant workersSantosh K Verma
Center for Injury Epidemiology, Liberty Mutual Research Institute for Safety, Hopkinton, Massachusetts, USA
Occup Environ Med 68:279-85. 2011..This study examined the association between floor surface characteristics, slip-resistant shoes, floor cleaning frequency and the risk of slipping in limited-service restaurant workers...
Renal dysfunction increases the risk of saphenous vein graft occlusion: results from the Post-CABG trialGregory A Wellenius
Cardiovascular Epidemiology Research Unit, Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Deaconess 306, Boston, MA 02215, USA
Atherosclerosis 193:414-20. 2007..Saphenous vein grafts are common among patients with a history of coronary artery bypass graft (CABG) surgery. Chronic kidney disease (CKD) is an established cardiovascular risk factor, but its role in graft disease has not been evaluated...
Optimal referent selection strategies in case-crossover studies: a settled issueMurray A Mittleman
Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, and the Department of Medicine, Harvard School of Medicine, Boston, MA 02215, USA
Epidemiology 16:715-6. 2005
Alcohol use and risk of ischemic stroke among older adults: the cardiovascular health studyKenneth J Mukamal
Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
Stroke 36:1830-4. 2005..The association of light to moderate alcohol consumption with risk of ischemic stroke remains uncertain, as are the roles of potentially mediating factors and modification by apolipoprotein E (apoE) genotype...
Evaluation of acute risk for myocardial infarction in men treated with sildenafil citrateMurray A Mittleman
Cardiovascular Epidemiology Research Unit, Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
Am J Cardiol 96:443-6. 2005....
Roles of drinking pattern and type of alcohol consumed in coronary heart disease in menKenneth J Mukamal
Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
N Engl J Med 348:109-18. 2003..Although moderate drinking confers a decreased risk of myocardial infarction, the roles of the drinking pattern and type of beverage remain unclear...
Prospective study of alcohol consumption and risk of dementia in older adultsKenneth J Mukamal
Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, 330 Brookline Ave, RO 114, Boston, Mass 02215, USA
JAMA 289:1405-13. 2003..Alcohol consumption has been associated with complex changes in cerebral vasculature and structure in older adults. How alcohol consumption affects the incidence of dementia is less clear...
Alcohol consumption and inflammatory markers in older adults: the Cardiovascular Health StudyKenneth J Mukamal
Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, RO 114, Boston, MA, USA
Atherosclerosis 173:79-87. 2004..We sought to determine the relation of alcohol intake and systemic inflammation in a population-based sample of older adults...
Educational attainment and myocardial infarct-related congestive heart failure (the Determinants of Myocardial Infarction Onset Study)Kenneth J Mukamal
Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, RO 114, Boston, MA 02215, USA
Am J Cardiol 93:1288-91. 2004..75; 95% confidence interval, 0.57 to 0.99; p for trend 0.02), with similar findings among men, women, whites, and blacks...
Air pollution: small particles, big problems?Murray A Mittleman
Beth Israel Medical Center, Boston, MA 02215, USA
Epidemiology 14:512-3. 2003
Alcohol consumption and carotid atherosclerosis in older adults: the Cardiovascular Health StudyKenneth J Mukamal
Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, 330 Brookline Ave, RO 114, Boston, Mass 02215, USA
Arterioscler Thromb Vasc Biol 23:2252-9. 2003..The association of alcohol use with atherosclerosis is inconsistent in previous studies...
Air pollution and hospital admissions for ischemic and hemorrhagic stroke among medicare beneficiariesGregory A Wellenius
Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Stroke 36:2549-53. 2005..The association between short-term elevations in ambient air particles and increased cardiovascular morbidity and mortality is well documented. Ambient particles may similarly increase the risk of stroke...
Alcohol consumption, atherosclerotic progression, and prognosis among patients with coronary artery bypass graftsKenneth J Mukamal
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Am Heart J 151:368-72. 2006..Although moderate drinking has been associated with lower mortality among patients after myocardial infarction, its relationship with prognosis and graft obstruction among patients with coronary artery bypass grafts is unknown...
Particulate air pollution and hospital admissions for congestive heart failure in seven United States citiesGregory A Wellenius
Cardiovascular Epidemiology Research Unit, Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Am J Cardiol 97:404-8. 2006....
Alcohol consumption and risk of coronary heart disease in older adults: the Cardiovascular Health StudyKenneth J Mukamal
Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
J Am Geriatr Soc 54:30-7. 2006..To evaluate several aspects of the relationship between alcohol use and coronary heart disease in older adults, including beverage type, mediating factors, and type of outcome...
Instrumental variables I: instrumental variables exploit natural variation in nonexperimental data to estimate causal relationshipsJeremy A Rassen
Brigham and Women s Hospital, Boston, MA 02120, USA
J Clin Epidemiol 62:1226-32. 2009..It gives examples of instruments used in clinical epidemiology and concludes with an outline on estimation of effects...
Binge drinking and mortality after acute myocardial infarctionKenneth J Mukamal
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Circulation 112:3839-45. 2005..Moderate drinkers have a lower risk of mortality after myocardial infarction (MI). Although binge drinking has been associated with a higher risk of MI in some studies, its relation to prognosis after MI is uncertain...
Tea consumption and mortality after acute myocardial infarctionKenneth J Mukamal
Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Circulation 105:2476-81. 2002..Some studies have suggested that tea consumption may be associated with lower mortality among individuals with cardiovascular disease, but the effects of tea consumption on mortality after acute myocardial infarction are unknown...
Alcohol consumption and subclinical findings on magnetic resonance imaging of the brain in older adults: the cardiovascular health studyK J Mukamal
Division of General Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Stroke 32:1939-46. 2001..The extent to which these competing associations influence overall brain function will require further study...
Coffee and acute ischemic stroke onset: the Stroke Onset StudyE Mostofsky
Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, 375 Longwood Avenue, Boston, MA 02215, USA
Neurology 75:1583-8. 2010..However, the risk of ischemic stroke associated with transient exposure to coffee remains unclear. We hypothesized that caffeine intake is associated with a transiently increased risk of ischemic stroke...
Association of ventricular arrhythmias detected by implantable cardioverter defibrillator and ambient air pollutants in the St Louis, Missouri metropolitan areaD Q Rich
Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
Occup Environ Med 63:591-6. 2006..This is consistent with previous results from Boston, although the pollutants responsible for the increased risk are different...
Long-term prognostic value of preoperative dipyridamole thallium imaging and clinical indexes in patients with diabetes mellitus undergoing peripheral vascular surgeryM C Cohen
Department of Medicine, Maine Medical Center, Portland, USA
Am J Cardiol 83:1038-42. 1999..Combined clinical and thallium variables may identify a population in whom intensive medical or surgical interventions may be warranted to reduce both perioperative and late cardiac events...
Triggering of sudden death from cardiac causes by vigorous exertionC M Albert
Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215 1204, USA
N Engl J Med 343:1355-61. 2000..However, the role of physical activity in precipitating or preventing sudden death has not been assessed prospectively in a large number of subjects...
Effect of diabetes mellitus and its treatment on ventricular arrhythmias complicating acute myocardial infarctionJ S Rana
Department of Medicine, Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Diabet Med 22:576-82. 2005..This suggests that differences in the mechanism of action of different sulphonylureas may result in clinically relevant differences in arrhythmic risk...
Exposure to maternal smoking and incident SLE in a prospective cohort studyJ F Simard
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Lupus 18:431-5. 2009..0, 95% CI: 0.8 to 1.3) in combined analyses. Early-life exposure to cigarette smoke due to mothers' or fathers' smoking was not associated with increased risk of adult-onset SLE in women...
Dietary glycemic index, dietary glycemic load and mortality among men with established cardiovascular diseaseE B Levitan
Cardiovascular Epidemiology Research Unit, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Eur J Clin Nutr 63:552-7. 2009..We tested the hypothesis that diets with higher GI and GL are associated with increased mortality in men with established cardiovascular disease...
Clinical trials of sildenafil citrate (Viagra) demonstrate no increase in risk of myocardial infarction and cardiovascular death compared with placeboM A Mittleman
Institute for Prevention of Cardiovascular Disease, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Int J Clin Pract 57:597-600. 2003..The use of sildenafil was not associated with an increase in the risk of MI or cardiovascular death...
Ambulatory electrocardiogram-based tracking of T wave alternans in postmyocardial infarction patients to assess risk of cardiac arrest or arrhythmic deathRichard L Verrier
Beth Israel Deaconess Medical Center and Harvard Medical School, One Autumn Street, W KN 521, Boston, MA 02215, USA
J Cardiovasc Electrophysiol 14:705-11. 2003..This is the first study to assess T wave alternans (TWA) analyzed from routine ambulatory electrocardiograms (AECGs) to identify postmyocardial infarction (post-MI) patients at increased risk for arrhythmic events...
Comparison of courses of patients with acute myocardial infarction with chest pain appearing during exertion versus those with chest pain not occurring during exertionKenneth J Mukamal
Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, Masschusetts 021215, USA
Am J Cardiol 90:642-5. 2002
Comparing mortality of elderly patients on hemodialysis versus peritoneal dialysis: a propensity score approachWolfgang C Winkelmayer
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Am Soc Nephrol 13:2353-62. 2002....
Effects of sulfonylurea hypoglycemic agents and adenosine triphosphate dependent potassium channel antagonists on ventricular arrhythmias in patients with decompensated heart failureDoron Aronson
Division of Cardiology, Rambam Medical Center, Haifa, Israel
Pacing Clin Electrophysiol 26:1254-61. 2003..These results suggest that cardiac K(ATP) channel activation may be involved in the genesis of ventricular arrhythmias in CHF...
Late nephrologist referral and access to renal transplantationWolfgang C Winkelmayer
Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Transplantation 73:1918-23. 2002..Our aim was to explore a possible association between late nephrologist referral before onset of renal replacement therapy (RRT) and the likelihood of receiving a renal transplant...
Measures of heart period variability as predictors of mortality in hospitalized patients with decompensated congestive heart failureDoron Aronson
Division of Cardiology, Rambam Medical Center, Haifa, Israel
Am J Cardiol 93:59-63. 2004..Together with previous studies, our findings suggest that indexes of overall HRV provide useful prognostic information in the full spectrum of CHF severity...
Alcohol consumption in older adults and Medicare costsKenneth J Mukamal
Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Health Care Financ Rev 27:49-61. 2006..The lower costs associated with moderate drinking were most apparent among participants with cardiovascular disease (CVD) and for hospitalization costs for CVD among healthy participants. Former drinkers had the highest costs...
Depressive symptoms, social isolation, and progression of coronary artery atherosclerosis: the Stockholm Female Coronary Angiography StudyHui-Xin Wang
Division of Preventive Medicine, Department of Public Health Sciences, Karolinska Institute, Stockholm, Sweden
Psychother Psychosom 75:96-102. 2006..These findings provide an additional opportunity for therapeutic and preventive efforts against progression of coronary disease in women...
Effects of ambient air pollution on functional status in patients with chronic congestive heart failure: a repeated-measures studyGregory A Wellenius
Cardiovascular Epidemiology Research Unit, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
Environ Health 6:26. 2007..We tested the hypothesis that BNP levels would be positively associated with short-term changes in ambient pollution levels among 28 patients with chronic stable HF and impaired systolic function...
Systematic review of the effects of ginseng on cardiovascular risk factorsCatherine Buettner
Division for Research and Education in Complementary and Integrative Medical Therapies, Harvard Medical School, Boston, MA 02215 3325, USA
Ann Pharmacother 40:83-95. 2006..To examine the evidence for the efficacy of ginseng (Panax spp.) on cardiovascular risk factors, including blood pressure, lipid profiles, and blood glucose, and to summarize reported cardiovascular adverse events...
Alcohol consumption and platelet activation and aggregation among women and men: the Framingham Offspring StudyKenneth J Mukamal
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Alcohol Clin Exp Res 29:1906-12. 2005..Alcohol intake has been associated with lower platelet activity; however, few large-scale studies have included women, and to our knowledge, the relationship of alcohol intake with measures of platelet activation has not been studied...
An exploratory prospective study of marijuana use and mortality following acute myocardial infarctionKenneth J Mukamal
Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA 02446, USA
Am Heart J 155:465-70. 2008..The relationship of marijuana use with coronary heart disease, including prognosis among patients with coronary heart disease, is uncertain...
Association of air pollution with increased incidence of ventricular tachyarrhythmias recorded by implanted cardioverter defibrillatorsDouglas W Dockery
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
Environ Health Perspect 113:670-4. 2005..The associations with sulfate suggest a link with stationary fossil fuel combustion sources...
Obesity and undiagnosed diabetes in the U.SChristina C Wee
Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Diabetes Care 31:1813-5. 2008..To study whether obese individuals, who are at higher risk for diabetes and disparities in care than nonobese individuals, are more likely to have undiagnosed diabetes...
