Joan W Miller

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint The Harvard angiogenesis story
    Joan W Miller
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA, USA Electronic address
    Surv Ophthalmol 59:361-4. 2014
  2. doi request reprint Vascular endothelial growth factor a in intraocular vascular disease
    Joan W Miller
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Ophthalmology 120:106-14. 2013
  3. doi request reprint Age-related macular degeneration revisited--piecing the puzzle: the LXIX Edward Jackson memorial lecture
    Joan W Miller
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Ophthalmol 155:1-35.e13. 2013
  4. doi request reprint Photoreceptor protection after photodynamic therapy using dexamethasone in a rat model of choroidal neovascularization
    Haicheng She
    Department of Ophthalmology, Angiogenesis and Laser Laboratories, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston 02114, Massachusetts, USA
    Invest Ophthalmol Vis Sci 49:5008-14. 2008
  5. doi request reprint Role of alpha 4 integrin (CD49d) in the pathogenesis of diabetic retinopathy
    Eirini Iliaki
    Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 50:4898-904. 2009
  6. ncbi request reprint Reduced photoreceptor damage after photodynamic therapy through blockade of nitric oxide synthase in a model of choroidal neovascularization
    Haicheng She
    Angiogenesis and Laser Laboratories, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 48:2268-77. 2007
  7. ncbi request reprint Photodynamic therapy induces caspase-dependent apoptosis in rat CNV model
    Akihisa Matsubara
    Angiogenesis and Laser Laboratories, Retina Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 48:4741-7. 2007
  8. pmc The regulatory roles of apoptosis-inducing factor in the formation and regression processes of ocular neovascularization
    Toshio Hisatomi
    Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Am J Pathol 181:53-61. 2012
  9. pmc Disruption of the blood-aqueous barrier and lens abnormalities in mice lacking lysyl oxidase-like 1 (LOXL1)
    Janey L Wiggs
    Department of Ophthalmology, Harvard Medical School, Howe, Berman Gund and Angiogenesis Laboratories, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts
    Invest Ophthalmol Vis Sci 55:856-64. 2014
  10. pmc Vascular adhesion protein-1 blockade suppresses choroidal neovascularization
    Kousuke Noda
    Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    FASEB J 22:2928-35. 2008

Collaborators

Detail Information

Publications69

  1. ncbi request reprint The Harvard angiogenesis story
    Joan W Miller
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA, USA Electronic address
    Surv Ophthalmol 59:361-4. 2014
    ..Together and separately, they investigated models of ocular neovascularization, exploring tumor angiogenesis in eye development and disease. ..
  2. doi request reprint Vascular endothelial growth factor a in intraocular vascular disease
    Joan W Miller
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Ophthalmology 120:106-14. 2013
    ..These findings are changing clinical practice and are stimuli for further study of the basic mechanisms controlling intraocular angiogenesis...
  3. doi request reprint Age-related macular degeneration revisited--piecing the puzzle: the LXIX Edward Jackson memorial lecture
    Joan W Miller
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Ophthalmol 155:1-35.e13. 2013
    ....
  4. doi request reprint Photoreceptor protection after photodynamic therapy using dexamethasone in a rat model of choroidal neovascularization
    Haicheng She
    Department of Ophthalmology, Angiogenesis and Laser Laboratories, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston 02114, Massachusetts, USA
    Invest Ophthalmol Vis Sci 49:5008-14. 2008
    ..To study whether corticosteroids protect photoreceptors when combined with photodynamic therapy (PDT) in a laser-induced model of choroidal neovascularization (CNV)...
  5. doi request reprint Role of alpha 4 integrin (CD49d) in the pathogenesis of diabetic retinopathy
    Eirini Iliaki
    Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 50:4898-904. 2009
    ..The authors have now studied the role of integrin alpha 4/CD49d in the pathogenesis of diabetic retinopathy...
  6. ncbi request reprint Reduced photoreceptor damage after photodynamic therapy through blockade of nitric oxide synthase in a model of choroidal neovascularization
    Haicheng She
    Angiogenesis and Laser Laboratories, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 48:2268-77. 2007
    ..To investigate the role of nitric oxide synthase (NOS) in photoreceptor degeneration associated with photodynamic therapy (PDT) in a laser-induced model of choroidal neovascularization (CNV)...
  7. ncbi request reprint Photodynamic therapy induces caspase-dependent apoptosis in rat CNV model
    Akihisa Matsubara
    Angiogenesis and Laser Laboratories, Retina Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 48:4741-7. 2007
    ..To investigate the mechanism of cell death in laser-induced choroidal neovascularization (CNV) after photodynamic therapy (PDT)...
  8. pmc The regulatory roles of apoptosis-inducing factor in the formation and regression processes of ocular neovascularization
    Toshio Hisatomi
    Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Am J Pathol 181:53-61. 2012
    ..Our data suggest that AIF-related apoptosis plays an important role in neovascularization and that mitochondria-regulated apoptosis could offer a new target for the treatment of pathological angiogenesis...
  9. pmc Disruption of the blood-aqueous barrier and lens abnormalities in mice lacking lysyl oxidase-like 1 (LOXL1)
    Janey L Wiggs
    Department of Ophthalmology, Harvard Medical School, Howe, Berman Gund and Angiogenesis Laboratories, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts
    Invest Ophthalmol Vis Sci 55:856-64. 2014
    ..LOXL1 gene variants are significantly associated with ES; however, the role of the protein in ES development remains unclear. The purpose of this study was to characterize the ocular phenotype in Loxl1(-/-) (null) mice...
  10. pmc Vascular adhesion protein-1 blockade suppresses choroidal neovascularization
    Kousuke Noda
    Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    FASEB J 22:2928-35. 2008
    ..Inhibition of VAP-1 may become a new therapeutic strategy in the treatment of AMD...
  11. doi request reprint Molecular sequelae of histone deacetylase inhibition in human retinoblastoma cell lines: clinical implications
    Vassiliki Poulaki
    Department of Ophthalmology, Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 50:4072-9. 2009
    ..Vorinostat has demonstrated significant anticancer activity against hematologic and solid tumors at doses well tolerated by patients and has been approved for the treatment of patients with cutaneous T-cell lymphoma...
  12. pmc Comprehensive analysis of CRP, CFH Y402H and environmental risk factors on risk of neovascular age-related macular degeneration
    Ivana K Kim
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Mol Vis 14:1487-95. 2008
    ..Additionally we examined the degree to which CRP common variation was in linkage disequilibrium (LD) within our cohort...
  13. ncbi request reprint Investigating the effect of ciliary body photodynamic therapy in a glaucoma mouse model
    Akihisa Matsubara
    Angiogenesis and Laser Laboratories, Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 47:2498-507. 2006
    ..To investigate the morphologic and functional effects of verteporfin ciliary body photodynamic therapy (PDT) in a murine glaucoma model and normal mouse eyes...
  14. pmc Increased choroidal neovascularization following laser induction in mice lacking lysyl oxidase-like 1
    Hyeong Gon Yu
    Angiogenesis Laboratory and Laser Laboratory, Retina Research Institute, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 49:2599-605. 2008
    ..This study investigated the influence of defective elastic fiber maintenance in the development of laser-induced CNV...
  15. pmc Comprehensive analysis of complement factor H and LOC387715/ARMS2/HTRA1 variants with respect to phenotype in advanced age-related macular degeneration
    Michael T Andreoli
    Ocular Molecular Genetics Institute, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Am J Ophthalmol 148:869-74. 2009
    ..To examine the interaction of genotypic variation of 16 single-nucleotide polymorphisms (SNP) in the complement factor H (CFH) and LOC387715/ARMS2/HTRA1 loci with clinical characteristics of age-related macular degeneration (AMD)...
  16. pmc Attenuated glial reactions and photoreceptor degeneration after retinal detachment in mice deficient in glial fibrillary acidic protein and vimentin
    Toru Nakazawa
    Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 48:2760-8. 2007
    ....
  17. ncbi request reprint Effect of intravitreal injection of ranibizumab in combination with verteporfin PDT on normal primate retina and choroid
    Ivana K Kim
    Angiogenesis and Laser Laboratory, Retina Research Institute, Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 47:357-63. 2006
    ..San Francisco, CA) directed against vascular endothelial growth factor (VEGF) in combination with verteporfin photodynamic therapy (PDT) on normal primate retina and choroid...
  18. doi request reprint Characterization of azurocidin as a permeability factor in the retina: involvement in VEGF-induced and early diabetic blood-retinal barrier breakdown
    Dimitra Skondra
    Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 49:726-31. 2008
    ..Azurocidin, released by neutrophils during leukocyte-endothelial interaction, is a main cause of neutrophil-evoked vascular leakage. Its role in the retina, however, is unknown...
  19. ncbi request reprint Alleles in the HtrA serine peptidase 1 gene alter the risk of neovascular age-related macular degeneration
    Margaret M DeAngelis
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Ophthalmology 115:1209-1215.e7. 2008
    ....
  20. doi request reprint In vivo evaluation of laser-induced choroidal neovascularization using spectral-domain optical coherence tomography
    Andrea Giani
    Angiogenesis and Laser Laboratories, Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 52:3880-7. 2011
    ..To describe the in vivo evolution of laser-induced choroidal neovascularization (CNV) in mice using spectral domain optical coherence tomography (SD-OCT)...
  21. doi request reprint Anti-vascular endothelial growth factor monotherapy versus combination treatment with photodynamic therapy for subfoveal choroidal neovascularization secondary to causes other than age-related macular degeneration
    Ling Chen
    Retina Service, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
    Retina 31:2078-83. 2011
    ..To compare the visual outcomes and retreatment rates of monotherapy with intravitreal bevacizumab versus combination with photodynamic therapy for choroidal neovascularization secondary to causes other than age-related macular degeneration...
  22. ncbi request reprint Tumor necrosis factor-alpha mediates oligodendrocyte death and delayed retinal ganglion cell loss in a mouse model of glaucoma
    Toru Nakazawa
    Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Neurosci 26:12633-41. 2006
    ..Thus TNF-alpha provides an essential, although indirect, link between OH and RGC loss in vivo. Blocking TNF-alpha signaling or inflammation, therefore, may be helpful in treating glaucoma...
  23. ncbi request reprint Inhibition of vascular adhesion protein-1 suppresses endotoxin-induced uveitis
    Kousuke Noda
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary and Harvard Medical School, Boston, Massachusetts, USA
    FASEB J 22:1094-103. 2008
    ..VAP-1 inhibition may become a novel strategy in the treatment of ocular inflammatory diseases...
  24. pmc Aminoimidazole carboxamide ribonucleotide ameliorates experimental autoimmune uveitis
    Jun Suzuki
    Retina Service, Angiogenesis Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 53:4158-69. 2012
    ..To investigate the anti-inflammatory effect of an adenosine monophosphate (AMP) analog, aminoimidazole carboxamide ribonucleotide (AICAR), in experimental autoimmune uveoretinitis (EAU)...
  25. pmc Etanercept, a widely used inhibitor of tumor necrosis factor-α (TNF-α), prevents retinal ganglion cell loss in a rat model of glaucoma
    Miin Roh
    Angiogenesis Laboratory and Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e40065. 2012
    ..Here, using a rat model of glaucoma, we investigated the source of elevated TNF-α and examined whether Etanercept, a TNF-α blocker that is in common clinical use for other indications, is protective against RGC death...
  26. pmc Identifying subtypes of patients with neovascular age-related macular degeneration by genotypic and cardiovascular risk characteristics
    Michael Feehan
    Ocular Molecular Genetics Institute and the Retina Service, Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
    BMC Med Genet 12:83. 2011
    ..In the present study, we identify patient subtypes or clusters which could represent several different targets for treatment development, based on genetic pathways in AMD and cardiovascular pathology...
  27. ncbi request reprint Safety and efficacy of intravitreal injection of ranibizumab in combination with verteporfin PDT on experimental choroidal neovascularization in the monkey
    Deeba Husain
    Angiogenesis and Laser Laboratory, Retina Service, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Arch Ophthalmol 123:509-16. 2005
    ....
  28. ncbi request reprint Heat treatment of retinal pigment epithelium induces production of elastic lamina components and antiangiogenic activity
    Eiichi Sekiyama
    Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    FASEB J 26:567-75. 2012
    ..Heat treatment blocked the development of experimental CNV in vivo. These findings suggest that heat treatment may restore BrM integrity and barrier function against new vessel growth...
  29. ncbi request reprint Displayed reflectivity of choroidal neovascular membranes by optical coherence tomography correlates with presence of leakage by fluorescein angiography
    Andrea Giani
    Retina Service, Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA
    Retina 31:942-8. 2011
    ..To evaluate and correlate the displayed optical reflectivity of choroidal neovascularization (CNV) subretinal material on spectral-domain optical coherence tomography with the presence of dye leakage on fluorescein angiography (FA)...
  30. ncbi request reprint Dose-dependent effect of pitavastatin on VEGF and angiogenesis in a mouse model of choroidal neovascularization
    Hadi J Zambarakji
    Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston 02114, USA
    Invest Ophthalmol Vis Sci 47:2623-31. 2006
    ..To evaluate the relation between statin therapy, vascular endothelial growth factor (VEGF) expression, vascular leakage, and CNV size in experimentally induced choroidal neovascularization (CNV)...
  31. pmc AMP-dependent kinase inhibits oxidative stress-induced caveolin-1 phosphorylation and endocytosis by suppressing the dissociation between c-Abl and Prdx1 proteins in endothelial cells
    Kimio Takeuchi
    Retina Service, Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 288:20581-91. 2013
    ..Overall, our results suggest that activation of AMPK inhibits oxidative stress-induced caveolin-1 phosphorylation and endocytosis, and this effect is mediated in part by stabilizing the interaction between c-Abl and Prdx-1. ..
  32. pmc Aminoimidazole carboxamide ribonucleotide (AICAR) inhibits the growth of retinoblastoma in vivo by decreasing angiogenesis and inducing apoptosis
    Sofia Theodoropoulou
    Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Retina Service, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e52852. 2013
    ..AICAR is a promising novel non-chemotherapeutic drug that may be effective as an adjuvant in treating Retinoblastoma...
  33. pmc Receptor interacting protein kinase mediates necrotic cone but not rod cell death in a mouse model of inherited degeneration
    Yusuke Murakami
    Retina Service, Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 109:14598-603. 2012
    ....
  34. ncbi request reprint Endogenous endostatin inhibits choroidal neovascularization
    Alexander G Marneros
    Department of Developmental Biology, Harvard School of Dental Medicine, 188 Longwood Ave, Boston, MA 02115, USA
    FASEB J 21:3809-18. 2007
    ..Endostatin may have a regulatory role in the pathogenesis of CNV and could be used therapeutically to inhibit growth and leakage of CNV lesions...
  35. pmc Evidence for baseline retinal pigment epithelium pathology in the Trp1-Cre mouse
    Aristomenis Thanos
    Retina Service, Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Pathol 180:1917-27. 2012
    ....
  36. doi request reprint Inhibitory effect of aminoimidazole carboxamide ribonucleotide (AICAR) on endotoxin-induced uveitis in rats
    Jun Suzuki
    Retina Service, Angiogenesis Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, USA
    Invest Ophthalmol Vis Sci 52:6565-71. 2011
    ..CONCLUSIONS. AICAR reduces systemic LPS susceptibility and attenuates intraocular inflammation in a rat EIU model by limiting infiltration of leukocytes, suppressing inflammatory mediators, and inhibiting the NF-κB pathway...
  37. pmc Higher irradiance and photodynamic therapy for age-related macular degeneration (an AOS thesis)
    Joan W Miller
    Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA
    Trans Am Ophthalmol Soc 106:357-82. 2008
    ..We set out to test the feasibility of irradiances up to 1800 mW/cm(2)...
  38. pmc Heat shock protein 70 (HSP70) is critical for the photoreceptor stress response after retinal detachment via modulating anti-apoptotic Akt kinase
    Maki Kayama
    Retina Service, Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, and the Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Pathol 178:1080-91. 2011
    ..Thus, HSP70 may be a favorable potential target to increase photoreceptor cell survival after RD...
  39. pmc Receptor interacting protein kinases mediate retinal detachment-induced photoreceptor necrosis and compensate for inhibition of apoptosis
    George Trichonas
    Retina Service, Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 107:21695-700. 2010
    ....
  40. pmc HIV protease inhibitors provide neuroprotection through inhibition of mitochondrial apoptosis in mice
    Toshio Hisatomi
    Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Invest 118:2025-38. 2008
    ....
  41. pmc Photoreceptor cell death and rescue in retinal detachment and degenerations
    Yusuke Murakami
    Retina Service, Angiogenesis Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Prog Retin Eye Res 37:114-40. 2013
    ....
  42. pmc Utilizing targeted gene therapy with nanoparticles binding alpha v beta 3 for imaging and treating choroidal neovascularization
    Hani Salehi-Had
    Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e18864. 2011
    ..We investigated whether a novel intravenously injectable αvβ3 integrin-ligand coupled nanoparticle (NP) can target choroidal neovascular membranes (CNV) for imaging and targeted gene therapy...
  43. ncbi request reprint Photodynamic therapy and combination treatments
    Sophia Pachydaki
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
    Int Ophthalmol Clin 47:95-115. 2007
  44. pmc Systems biology-based analysis implicates a novel role for vitamin D metabolism in the pathogenesis of age-related macular degeneration
    Margaux A Morrison
    Ocular Molecular Genetics Institute, Harvard Medical School, Massachusetts Eye and Ear, Boston, MA, USA
    Hum Genomics 5:538-68. 2011
    ..These data not only extend previous biological studies in the AMD field, but further emphasise common antecedents between several disorders with an inflammatory/immunogenic component such as cardiovascular disease, cancer and AMD...
  45. ncbi request reprint Proton beam irradiation for neovascular age-related macular degeneration
    Hadi J Zambarakji
    Retina Service, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Ophthalmology 113:2012-9. 2006
    ..To evaluate safety and visual outcomes after proton therapy for subfoveal neovascular age-related macular degeneration (AMD)...
  46. doi request reprint A novel nonradioactive method to evaluate vascular barrier breakdown and leakage
    George Trichonas
    Retina Service, Angiogenesis Laboratory Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 51:1677-82. 2010
    ..To identify a novel, sensitive, nonradioactive leakage assay that can be used in the assessment of retinal vascular permeability in rats and mice...
  47. doi request reprint In vivo imaging of endothelial injury in choriocapillaris during endotoxin-induced uveitis
    Shinsuke Miyahara
    Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114 USA
    FASEB J 22:1973-80. 2008
    ..This technique may help to diagnose subclinical signs of ocular inflammatory diseases...
  48. pmc The NEI/NCBI dbGAP database: genotypes and haplotypes that may specifically predispose to risk of neovascular age-related macular degeneration
    Hong Zhang
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA, USA
    BMC Med Genet 9:51. 2008
    ..Conditional logistic regression was used to determine significant gene-gene interactions. LRT was used to determine the best fit for each genotypic model tested (additive, dominant or recessive)...
  49. pmc Uveal Melanoma Cell Growth Is Inhibited by Aminoimidazole Carboxamide Ribonucleotide (AICAR) Partially Through Activation of AMP-Dependent Kinase
    Ahmad Al-Moujahed
    Retina Service, Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States
    Invest Ophthalmol Vis Sci 55:4175-85. 2014
    ..To evaluate the effects and mechanism of aminoimidazole carboxamide ribonucleotide (AICAR), an AMP-dependent kinase (AMPK) activator, on the growth of uveal melanoma cell lines...
  50. pmc Monocyte chemoattractant protein 1 mediates retinal detachment-induced photoreceptor apoptosis
    Toru Nakazawa
    Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, and Children s Hospital, Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 104:2425-30. 2007
    ..This pathway may be an important therapeutic target for preventing photoreceptor apoptosis in RD and other CNS diseases that share a common etiology...
  51. ncbi request reprint Maximum tolerated dose of a humanized anti-vascular endothelial growth factor antibody fragment for treating neovascular age-related macular degeneration
    Philip J Rosenfeld
    Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miami, Florida 33136, USA
    Ophthalmology 112:1048-53. 2005
    ..To investigate the maximum tolerated dose of ranibizumab administered as a single intravitreal injection...
  52. ncbi request reprint Predictors of visual outcome and choroidal neovascular membrane formation after traumatic choroidal rupture
    Christine Shortsleeve Ament
    Retina Service and Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    Arch Ophthalmol 124:957-66. 2006
    ..To determine predictors of choroidal neovascularization (CNV) and visual outcome after traumatic choroidal rupture...
  53. doi request reprint Spectral-domain optical coherence tomography as an indicator of fluorescein angiography leakage from choroidal neovascularization
    Andrea Giani
    Retina Service, Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 52:5579-86. 2011
    ..To evaluate spectral-domain optical coherence tomography (SD-OCT) findings that predict angiographic leakage in choroidal neovascularization (CNV)...
  54. pmc Convergence of linkage, gene expression and association data demonstrates the influence of the RAR-related orphan receptor alpha (RORA) gene on neovascular AMD: a systems biology based approach
    Alexandra C Silveira
    Ocular Molecular Genetics Institute and Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA, USA
    Vision Res 50:698-715. 2010
    ..Moreover, we found a significant interaction between RORA and the ARMS2/HTRA1 locus suggesting a novel pathway underlying AMD pathophysiology...
  55. pmc Edaravone, an ROS scavenger, ameliorates photoreceptor cell death after experimental retinal detachment
    Mi In Roh
    Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 52:3825-31. 2011
    ..To investigate whether edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a free radical scavenger, would be neuroprotective against photoreceptor cell death in a rat model of retinal detachment (RD)...
  56. doi request reprint Conversion to aflibercept for chronic refractory or recurrent neovascular age-related macular degeneration
    Yoshihiro Yonekawa
    Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Am J Ophthalmol 156:29-35.e2. 2013
    ..To explore the visual and anatomic outcomes of patients with refractory or recurrent neovascular age-related macular degeneration (AMD) who were converted from bevacizumab and/or ranibizumab to aflibercept...
  57. pmc Retinoblastoma cells are inhibited by aminoimidazole carboxamide ribonucleotide (AICAR) partially through activation of AMP-dependent kinase
    Sofia Theodoropoulou
    Retina Service, Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    FASEB J 24:2620-30. 2010
    ..Our results indicate that AICAR-induced activation of AMPK inhibits retinoblastoma cell growth. This is one of the first descriptions of a nonchemotherapeutic drug with low toxicity that may be effective in treating Rb patients...
  58. ncbi request reprint An antisense oligodeoxynucleotide against vascular endothelial growth factor in a nonhuman primate model of iris neovascularization
    Robert B Bhisitkul
    Department of Ophthalmology, Beckman Vision Center, University of California San Francisco, 94143, USA
    Arch Ophthalmol 123:214-9. 2005
    ..To evaluate an antisense oligodeoxynucleotide (AS-ODN) targeted against vascular endothelial growth factor for its effects on ocular angiogenesis and its intraocular localization in a nonhuman primate model of iris neovascularization...
  59. pmc DNA sequence variants in the LOXL1 gene are associated with pseudoexfoliation glaucoma in a U.S. clinic-based population with broad ethnic diversity
    Bao Jian Fan
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA
    BMC Med Genet 9:5. 2008
    ....
  60. ncbi request reprint Characterization of cytokine responses to retinal detachment in rats
    Toru Nakazawa
    Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Mol Vis 12:867-78. 2006
    ..The aim of this study is to characterize the molecular and cellular responses that occur after RD. The expression of cytokines, chemokines, and growth factors were examined in a rat model of RD...
  61. doi request reprint Intravitreal injections at the Massachusetts Eye and Ear Infirmary: analysis of treatment indications and postinjection endophthalmitis rates
    Miriam Englander
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Br J Ophthalmol 97:460-5. 2013
    ..To report the incidence rate of acute postoperative endophthalmitis secondary to therapeutic intravitreal injections...
  62. doi request reprint Review of anti-VEGF therapy in proliferative diabetic retinopathy
    Maria Stephanie R Jardeleza
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA Stephanie
    Semin Ophthalmol 24:87-92. 2009
    ..This review summarizes results from published studies using intravitreal anti-VEGF agents singly and in combination with standard therapeutic regimens in the treatment of proliferative diabetic retinopathy...
  63. ncbi request reprint Inhibition of Hsp90 attenuates inflammation in endotoxin-induced uveitis
    Vassiliki Poulaki
    Angiogenesis Laser Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles St, Boston, MA 02114, USA
    FASEB J 21:2113-23. 2007
    ..17-AAG has demonstrated a favorable safety profile in clinical trials in cancer patients and represents a promising therapeutic agent for the treatment of inflammatory eye diseases...
  64. ncbi request reprint Anti-vascular endothelial growth factor therapy for ocular neovascular disease
    Christopher M Andreoli
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary and Harvard Medical School, Boston, Massachusetts 02114, USA
    Curr Opin Ophthalmol 18:502-8. 2007
    ..These agents have revolutionized the care of neovascular age related macular degeneration and have great potential for other blinding conditions such as diabetic retinopathy, retinopathy of prematurity, and neovascular glaucoma...
  65. pmc Tauroursodeoxycholic acid (TUDCA) protects photoreceptors from cell death after experimental retinal detachment
    Dimosthenis Mantopoulos
    Retina Service, Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e24245. 2011
    ..This study tests whether systemic administration of tauroursodeoxycholic acid (TUDCA) can protect photoreceptors from cell death after experimental retinal detachment in rodents...
  66. doi request reprint Review of the ocular angiogenesis animal models
    Sandra R Montezuma
    Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA sandra
    Semin Ophthalmol 24:52-61. 2009
    ..In addition, knockout or knock-in transgenic mice provide powerful tools in studying the role of specific proteins in angiogenesis...
  67. ncbi request reprint Expression of leukocyte adhesion molecules in human subfoveal choroidal neovascular membranes treated with and without photodynamic therapy
    Deborah C Yeh
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Invest Ophthalmol Vis Sci 45:2368-73. 2004
    ....
  68. ncbi request reprint The proteasome inhibitor bortezomib induces apoptosis in human retinoblastoma cell lines in vitro
    Vassiliki Poulaki
    Angiogenesis Laser Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 48:4706-19. 2007
    ..NF-kappaB, which is constitutively active in human retinoblastoma cells and promotes their survival, represents a therapeutic target for patients with this malignancy...
  69. ncbi request reprint Identification of Chlamydia pneumoniae within human choroidal neovascular membranes secondary to age-related macular degeneration
    Murat V Kalayoglu
    Angiogenesis Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Graefes Arch Clin Exp Ophthalmol 243:1080-90. 2005
    ..pneumoniae. These data indicate that a pathogen capable of inducing chronic inflammation and pro-angiogenic cytokines can be detected in some AMD CNV, and suggest that infection may contribute to the pathogenesis of AMD...