Gregory M Miller

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint The dopamine transporter: relevance to attention deficit hyperactivity disorder (ADHD)
    Bertha K Madras
    Department of Psychiatry, New England Regional Primate Research Center, Harvard Medical School, 1 Pine Hill Drive, Southborough, MA 01772 9102, USA
    Behav Brain Res 130:57-63. 2002
  2. pmc The emerging role of trace amine-associated receptor 1 in the functional regulation of monoamine transporters and dopaminergic activity
    Gregory M Miller
    The New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA
    J Neurochem 116:164-76. 2011
  3. pmc Functional characterization of the human TPH2 5' regulatory region: untranslated region and polymorphisms modulate gene expression in vitro
    Guo Lin Chen
    New England Primate Research Center, Division of Neurochemistry, Harvard Medical School, One Pine Hill Drive, Southborough, MA, 01772 9102, USA
    Hum Genet 122:645-57. 2008
  4. pmc Cloning, expression, and functional analysis of rhesus monkey trace amine-associated receptor 6: evidence for lack of monoaminergic association
    Zhihua Xie
    Division of Neurochemistry, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA
    J Neurosci Res 86:3435-46. 2008
  5. ncbi request reprint Rhesus monkey trace amine-associated receptor 1 signaling: enhancement by monoamine transporters and attenuation by the D2 autoreceptor in vitro
    Zhihua Xie
    Division of Neurochemistry, New England Primate Research Center, Harvard Medical School, One Pine Hill Dr, Southborough, MA 01772, USA
    J Pharmacol Exp Ther 321:116-27. 2007
  6. pmc Normal thermoregulatory responses to 3-iodothyronamine, trace amines and amphetamine-like psychostimulants in trace amine associated receptor 1 knockout mice
    Helen N Panas
    Division of Neuroscience, Harvard Medical School NEPRC, Southborough, MA, USA
    J Neurosci Res 88:1962-9. 2010
  7. pmc Trace amine associated receptor 1 signaling in activated lymphocytes
    Michael W Panas
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    J Neuroimmune Pharmacol 7:866-76. 2012
  8. ncbi request reprint Trace amine-associated receptor 1 is a modulator of the dopamine transporter
    Zhihua Xie
    Division of Neurochemistry, New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772, USA
    J Pharmacol Exp Ther 321:128-36. 2007
  9. ncbi request reprint Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro
    Bertha K Madras
    Department of Psychiatry, Harvard Medical School, New England Primate Research Center, 1 Pine Hill Dr, Southborough, MA 01772 9102, USA
    J Pharmacol Exp Ther 319:561-9. 2006
  10. ncbi request reprint Receptor regulation of gene expression of axon guidance molecules: implications for adaptation
    Amy K Jassen
    Department of Psychiatry, Harvard Medical School, Division of Neurochemistry, New England Regional Primate Research Center, 1 Pine Hill Drive, Southborough, MA 01772 9102, USA
    Mol Pharmacol 70:71-7. 2006

Collaborators

Detail Information

Publications43

  1. ncbi request reprint The dopamine transporter: relevance to attention deficit hyperactivity disorder (ADHD)
    Bertha K Madras
    Department of Psychiatry, New England Regional Primate Research Center, Harvard Medical School, 1 Pine Hill Drive, Southborough, MA 01772 9102, USA
    Behav Brain Res 130:57-63. 2002
    ..The feasibility of exploring these mechanisms in animal models or in human subjects is explored...
  2. pmc The emerging role of trace amine-associated receptor 1 in the functional regulation of monoamine transporters and dopaminergic activity
    Gregory M Miller
    The New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA
    J Neurochem 116:164-76. 2011
    ..This overview focuses on recent studies which reveal a role for TAAR1 in the functional regulation of monoamine transporters and the neuronal regulatory mechanisms that modulate dopaminergic activity...
  3. pmc Functional characterization of the human TPH2 5' regulatory region: untranslated region and polymorphisms modulate gene expression in vitro
    Guo Lin Chen
    New England Primate Research Center, Division of Neurochemistry, Harvard Medical School, One Pine Hill Drive, Southborough, MA, 01772 9102, USA
    Hum Genet 122:645-57. 2008
    ..In conclusion, our present study demonstrates that both the 5'-UTR and common polymorphisms (especially the 90A/G) in the 5' regulatory region of human TPH2 have a significant impact on gene expression...
  4. pmc Cloning, expression, and functional analysis of rhesus monkey trace amine-associated receptor 6: evidence for lack of monoaminergic association
    Zhihua Xie
    Division of Neurochemistry, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA
    J Neurosci Res 86:3435-46. 2008
    ..Together, the data reveal that TAAR6 is unresponsive to brain monoamines and is not expressed in rhesus monkey brain monoaminergic nuclei, suggesting TAAR6 lacks direct association with brain monoaminergic neuronal function...
  5. ncbi request reprint Rhesus monkey trace amine-associated receptor 1 signaling: enhancement by monoamine transporters and attenuation by the D2 autoreceptor in vitro
    Zhihua Xie
    Division of Neurochemistry, New England Primate Research Center, Harvard Medical School, One Pine Hill Dr, Southborough, MA 01772, USA
    J Pharmacol Exp Ther 321:116-27. 2007
    ....
  6. pmc Normal thermoregulatory responses to 3-iodothyronamine, trace amines and amphetamine-like psychostimulants in trace amine associated receptor 1 knockout mice
    Helen N Panas
    Division of Neuroscience, Harvard Medical School NEPRC, Southborough, MA, USA
    J Neurosci Res 88:1962-9. 2010
    ..Accordingly, TAAR1-directed compounds will likely not affect thermoregulation nor are they likely to be cryogens...
  7. pmc Trace amine associated receptor 1 signaling in activated lymphocytes
    Michael W Panas
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    J Neuroimmune Pharmacol 7:866-76. 2012
    ..TAAR1 is emerging as a potential therapeutic target, with regard to its ability to modulate brain monoamines. The current data raises the possibility that TAAR1-targeted drugs may also alter immune function...
  8. ncbi request reprint Trace amine-associated receptor 1 is a modulator of the dopamine transporter
    Zhihua Xie
    Division of Neurochemistry, New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772, USA
    J Pharmacol Exp Ther 321:128-36. 2007
    ..Taken together, this study provides evidence that TAAR1 is involved in functional regulation of DAT and suggests that TAAR1 is a potentially important target for therapeutics for methamphetamine addiction...
  9. ncbi request reprint Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro
    Bertha K Madras
    Department of Psychiatry, Harvard Medical School, New England Primate Research Center, 1 Pine Hill Dr, Southborough, MA 01772 9102, USA
    J Pharmacol Exp Ther 319:561-9. 2006
    ..The present data provide compelling evidence that modafinil occupies the DAT and NET in living brain of rhesus monkeys and raise the possibility that modafinil affects wakefulness by interacting with catecholamine transporters in brain...
  10. ncbi request reprint Receptor regulation of gene expression of axon guidance molecules: implications for adaptation
    Amy K Jassen
    Department of Psychiatry, Harvard Medical School, Division of Neurochemistry, New England Regional Primate Research Center, 1 Pine Hill Drive, Southborough, MA 01772 9102, USA
    Mol Pharmacol 70:71-7. 2006
    ....
  11. pmc A receptor mechanism for methamphetamine action in dopamine transporter regulation in brain
    Zhihua Xie
    New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772, USA
    J Pharmacol Exp Ther 330:316-25. 2009
    ..These findings demonstrate a mediatory role of TAAR1 in methamphetamine action in DAT regulation and implicate this receptor as a potential target of therapeutics drugs for methamphetamine addiction...
  12. doi request reprint Modulation of monoamine transporters by common biogenic amines via trace amine-associated receptor 1 and monoamine autoreceptors in human embryonic kidney 293 cells and brain synaptosomes
    Zhihua Xie
    New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772, USA
    J Pharmacol Exp Ther 325:629-40. 2008
    ..These data provide the first evidence that common biogenic amines modulate monoamine transporter function via both TAAR1 and monoamine autoreceptors, which may balance monoaminergic activity...
  13. pmc The effect of rearing experience and TPH2 genotype on HPA axis function and aggression in rhesus monkeys: a retrospective analysis
    Guo Lin Chen
    Harvard Medical School, New England Primate Research Center, Southborough, MA 01772, USA
    Horm Behav 57:184-91. 2010
    ..Our findings strengthen the involvement of G x E interactions at the loci of serotonergic genes and the utility of the nonhuman primate to model G x E interactions in the development of human neuropsychiatric diseases...
  14. pmc Polymorphisms in the 3' UTR of the serotonin transporter are associated with cognitive flexibility in rhesus macaques
    Eric J Vallender
    Division of Neurochemistry, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA
    Am J Med Genet B Neuropsychiatr Genet 150:467-75. 2009
    ....
  15. doi request reprint Human expression variation in the mu-opioid receptor is paralleled in rhesus macaque
    Eric J Vallender
    Division of Neurochemistry, New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
    Behav Genet 38:390-5. 2008
    ..Together, the functional variations reported here have implications for future studies seeking to model the opioid system and its associated phenotypes in rhesus macaques...
  16. pmc Inhibition of the dopamine D1 receptor signaling by PSD-95
    Jingping Zhang
    Department of Psychiatry, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts 01772, USA
    J Biol Chem 282:15778-89. 2007
    ..These studies demonstrate a role for a glutamatergic scaffold in dopamine receptor signaling and trafficking and identify a new potential target for the modulation of abnormal dopaminergic function...
  17. pmc Tryptophan hydroxylase-2: an emerging therapeutic target for stress disorders
    Guo Lin Chen
    Harvard Medical School, New England Primate Research Center, Division of Neuroscience, One Pine Hill Drive, Southborough, MA 01772 9102, USA
    Biochem Pharmacol 85:1227-33. 2013
    ....
  18. pmc Advances in tryptophan hydroxylase-2 gene expression regulation: new insights into serotonin-stress interaction and clinical implications
    Guo Lin Chen
    Harvard Medical School, New England Primate Research Center, Division of Neuroscience, Southborough, MA 01772 9102, USA
    Am J Med Genet B Neuropsychiatr Genet 159:152-71. 2012
    ....
  19. pmc Functional evolution of the trace amine associated receptors in mammals and the loss of TAAR1 in dogs
    Eric J Vallender
    New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772, USA
    BMC Evol Biol 10:51. 2010
    ..Other trace amine associated receptors appear to relate to environmental perception and show a birth-and-death pattern in mammals similar to olfactory receptors...
  20. ncbi request reprint Ephrin/Eph receptor expression in brain of adult nonhuman primates: implications for neuroadaptation
    Danqing Xiao
    Department of Psychiatry, Harvard Medical School, Division of Neurochemistry, New England Primate Research Center, Southborough, MA 01772 9102, USA
    Brain Res 1067:67-77. 2006
    ..The association of axonal guidance molecules with drug-induced reorganization of adult primate brain circuitry warrants investigation...
  21. ncbi request reprint MDMA (Ecstasy) and human dopamine, norepinephrine, and serotonin transporters: implications for MDMA-induced neurotoxicity and treatment
    Christopher D Verrico
    Department of Psychiatry, Division of Neurochemistry, New England Primate Research Center, Harvard Medical School, 1 Pine Hill Drive, Southborough, MA 01772 9102, USA
    Psychopharmacology (Berl) 189:489-503. 2007
    ..In rats, MDMA-mediated effects are attributed, in part, to selective high-affinity transport of MDMA into 5-HT neurons by the 5-HT transporter (SERT), followed by extensive 5-HT release...
  22. ncbi request reprint Primate trace amine receptor 1 modulation by the dopamine transporter
    Gregory M Miller
    Division of Neurochemistry, New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
    J Pharmacol Exp Ther 313:983-94. 2005
    ....
  23. ncbi request reprint The dopamine transporter and attention-deficit/hyperactivity disorder
    Bertha K Madras
    Department of Psychiatry, Harvard Medical School, New England Primate Research Center, Southborough, MA 01772 9102, USA
    Biol Psychiatry 57:1397-409. 2005
    ..Thus, ADHD medications targeting DAT or NET might disperse dopamine widely and consign dopamine storage and release to regulation by noradrenergic, as well as dopaminergic neurons...
  24. pmc Augmentation of methamphetamine-induced behaviors in transgenic mice lacking the trace amine-associated receptor 1
    Cindy Achat-Mendes
    Division of Neuroscience, New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, United States
    Pharmacol Biochem Behav 101:201-7. 2012
    ..Collectively, these findings provide support for a regulatory role of TAAR1 in methamphetamine signaling...
  25. pmc Growth-associated protein-43 and ephrin B3 induction in the brain of adult SIV-infected rhesus macaques
    Susan V Westmoreland
    Division of Comparative Pathology, New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
    J Neurovirol 17:455-68. 2011
    ....
  26. pmc A pharmacogenetic model of naltrexone-induced attenuation of alcohol consumption in rhesus monkeys
    Eric J Vallender
    New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772, USA
    Drug Alcohol Depend 109:252-6. 2010
    ..Naltrexone, an antagonist at the receptor, has been used to treat alcoholism in humans and has been reported to show differences in effectiveness depending on genotype...
  27. pmc Trace amine-associated receptor 1 as a monoaminergic modulator in brain
    Zhihua Xie
    Division of Neuroscience, New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772, USA
    Biochem Pharmacol 78:1095-104. 2009
    ....
  28. pmc 5'-Untranslated region of the tryptophan hydroxylase-2 gene harbors an asymmetric bidirectional promoter but not internal ribosome entry site in vitro
    Guo Lin Chen
    Harvard Medical School, New England Primate Research Center, Southborough, MA 01772 9102, USA
    Gene 435:53-62. 2009
    ..Our findings point to the potential involvement of antisense transcription and non-coding RNA in the regulation of TPH2 gene expression...
  29. doi request reprint MDMA-induced impairment in primates: antagonism by a selective norepinephrine or serotonin, but not by a dopamine/norepinephrine transport inhibitor
    Christopher D Verrico
    Department of Psychiatry, Harvard Medical School and Division of Neurochemistry, New England Primate Research Center, Southborough, MA 01772 9102, USA
    J Psychopharmacol 22:187-202. 2008
    ..Reversal of impaired executive function by a NET inhibitor implicates the NET and norepinephrine in MDMA-induced cognitive impairment and may be relevant to therapeutic strategies...
  30. doi request reprint Beta-phenylethylamine alters monoamine transporter function via trace amine-associated receptor 1: implication for modulatory roles of trace amines in brain
    Zhihua Xie
    New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772, USA
    J Pharmacol Exp Ther 325:617-28. 2008
    ..The functional profile of beta-PEA may reveal a common mechanism by which trace amines exert modulatory effects on monoamine transporters in brain...
  31. ncbi request reprint Variants of the primate vesicular monoamine transporter-2
    Amy K Jassen
    Department of Psychiatry, Harvard Medical School, New England Primate Research Center, One Pine Hill Drive, Southborough, MA 01772 9102, USA
    Brain Res Mol Brain Res 139:251-7. 2005
    ..We investigated this apparent mismatch between observed molecular size and predicted size...
  32. ncbi request reprint Dopamine transporter-dependent induction of C-Fos in HEK cells
    Servet M Yatin
    Harvard Medical School, New England Regional Primate Research Center, Southborough, Massachusetts 01772 9102, USA
    Synapse 45:52-65. 2002
    ....
  33. ncbi request reprint Non-amine-based dopamine transporter (reuptake) inhibitors retain properties of amine-based progenitors
    Bertha K Madras
    Department of Psychiatry, Harvard Medical School, New England Primate Research Center, 1 Pine Hill Drive, Southborough, MA 01772 9102, USA
    Eur J Pharmacol 479:41-51. 2003
    ..These novel drugs compel a revision of current concepts of drug-monoamine transporter complex formation and open avenues for discovery of a new generation of therapeutic drugs...
  34. pmc Large-scale polymorphism discovery in macaque G-protein coupled receptors
    Dharmendra B Goswami
    New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772, USA
    BMC Genomics 14:703. 2013
    ..Initial efforts include resequencing 44 Indian-origin rhesus macaques (Macaca mulatta), 20 Chinese-origin rhesus macaques, and 32 cynomolgus macaques (M. fascicularis)...
  35. pmc Behavioral effects of clozapine: involvement of trace amine pathways in C. elegans and M. musculus
    Rakesh Karmacharya
    Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA
    Brain Res 1393:91-9. 2011
    ..In summary, we report a heretofore-unknown role for trace amine systems in clozapine-mediated effects across two species: C. elegans and mice...
  36. pmc Extensive alternative splicing of the repressor element silencing transcription factor linked to cancer
    Guo Lin Chen
    Division of Neuroscience, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, United States of America
    PLoS ONE 8:e62217. 2013
    ..These findings advance our understanding of the complex, context-dependent regulation of REST gene expression and function, and provide potential biomarkers and therapeutic targets for cancer...
  37. ncbi request reprint Dopamine and norepinephrine transporter-dependent c-Fos production in vitro: relevance to neuroadaptation
    Servet M Yatin
    Harvard Medical School, New England Primate Research Center, Division of Neurochemistry, One Pine Hill Drive, Southborough, MA 01772 9102, USA
    J Neurosci Methods 143:69-78. 2005
    ..These findings present a cell system and methodology for investigating the potential contribution of monoamine transporters to pre-synaptic neuroadaptation...
  38. pmc Balancing selection and the evolution of functional polymorphism in Old World monkey TRIM5alpha
    Ruchi M Newman
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Southborough, MA 01772, USA
    Proc Natl Acad Sci U S A 103:19134-9. 2006
    ....
  39. ncbi request reprint Chronic morphine exposure causes pronounced virus replication in cerebral compartment and accelerated onset of AIDS in SIV/SHIV-infected Indian rhesus macaques
    Rakesh Kumar
    Laboratory of Viral Immunology, AIDS Research Program and Department of Microbiology, Ponce School of Medicine, Ponce, PR 00732, Puerto Rico
    Virology 354:192-206. 2006
    ..Three morphine-exposed macaques (euthanized at weeks 18, 19 and 20) did not develop cellular or humoral immune responses, whereas the other 3 morphine-exposed and 3 control macaques developed both cellular and humoral immune responses...
  40. ncbi request reprint Epidermal growth factor receptor-induced circadian-time-dependent gene regulation in suprachiasmatic nucleus
    Rajanikanth Vadigepalli
    Department of Pathology, Anatomy and Cell Biology, Daniel Baugh Institute for Functional Genomics and Computational Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Neuroreport 17:1437-41. 2006
    ..Together, these results indicate that epidermal growth factor receptor has a circadian-time-dependent neuromodulatory function in the suprachiasmatic nucleus...
  41. doi request reprint Analysis of copy number variation in the rhesus macaque genome identifies candidate loci for evolutionary and human disease studies
    Arthur S Lee
    Department of Pathology, Brigham and Women s Hospital, 221 Longwood Ave, Boston, MA 02115, USA
    Hum Mol Genet 17:1127-36. 2008
    ..Therefore, the rhesus macaque offers an intriguing, non-human primate outbred model organism with which hypotheses concerning the specific functions of phenotypically relevant human CNVs can be tested...
  42. pmc Systems analysis of circadian time-dependent neuronal epidermal growth factor receptor signaling
    Daniel E Zak
    Daniel Baugh Institute for Functional Genomics and Computational Biology, Department of Pathology, Thomas Jefferson University, Locust St, Philadelphia, PA 19107, USA
    Genome Biol 7:R48. 2006
    ..The transcription networks downstream of EGFR in the SCN are unknown but, by analogy to other SCN inputs, we expect the response to EGFR activation to depend on circadian timing...