Research Topics
Genomes and Genes | Gregory M MillerSummaryAffiliation: Harvard University Country: USA Publications
| Collaborators
|
Detail Information
Publications
The dopamine transporter: relevance to attention deficit hyperactivity disorder (ADHD)Bertha K Madras
Department of Psychiatry, New England Regional Primate Research Center, Harvard Medical School, 1 Pine Hill Drive, Southborough, MA 01772 9102, USA
Behav Brain Res 130:57-63. 2002..The feasibility of exploring these mechanisms in animal models or in human subjects is explored...
Functional characterization of the human TPH2 5' regulatory region: untranslated region and polymorphisms modulate gene expression in vitroGuo Lin Chen
New England Primate Research Center, Division of Neurochemistry, Harvard Medical School, One Pine Hill Drive, Southborough, MA, 01772 9102, USA
Hum Genet 122:645-57. 2008..In conclusion, our present study demonstrates that both the 5'-UTR and common polymorphisms (especially the 90A/G) in the 5' regulatory region of human TPH2 have a significant impact on gene expression...- The emerging role of trace amine-associated receptor 1 in the functional regulation of monoamine transporters and dopaminergic activityGregory M Miller
The New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA
J Neurochem 116:164-76. 2011..This overview focuses on recent studies which reveal a role for TAAR1 in the functional regulation of monoamine transporters and the neuronal regulatory mechanisms that modulate dopaminergic activity... - Cloning, expression, and functional analysis of rhesus monkey trace amine-associated receptor 6: evidence for lack of monoaminergic associationZhihua Xie
Division of Neurochemistry, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA
J Neurosci Res 86:3435-46. 2008..Together, the data reveal that TAAR6 is unresponsive to brain monoamines and is not expressed in rhesus monkey brain monoaminergic nuclei, suggesting TAAR6 lacks direct association with brain monoaminergic neuronal function... - Rhesus monkey trace amine-associated receptor 1 signaling: enhancement by monoamine transporters and attenuation by the D2 autoreceptor in vitroZhihua Xie
Division of Neurochemistry, New England Primate Research Center, Harvard Medical School, One Pine Hill Dr, Southborough, MA 01772, USA
J Pharmacol Exp Ther 321:116-27. 2007.... - Normal thermoregulatory responses to 3-iodothyronamine, trace amines and amphetamine-like psychostimulants in trace amine associated receptor 1 knockout miceHelen N Panas
Division of Neuroscience, Harvard Medical School NEPRC, Southborough, MA, USA
J Neurosci Res 88:1962-9. 2010..Accordingly, TAAR1-directed compounds will likely not affect thermoregulation nor are they likely to be cryogens... - Trace amine-associated receptor 1 is a modulator of the dopamine transporterZhihua Xie
Division of Neurochemistry, New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772, USA
J Pharmacol Exp Ther 321:128-36. 2007..Taken together, this study provides evidence that TAAR1 is involved in functional regulation of DAT and suggests that TAAR1 is a potentially important target for therapeutics for methamphetamine addiction... - Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitroBertha K Madras
Department of Psychiatry, Harvard Medical School, New England Primate Research Center, 1 Pine Hill Dr, Southborough, MA 01772 9102, USA
J Pharmacol Exp Ther 319:561-9. 2006..The present data provide compelling evidence that modafinil occupies the DAT and NET in living brain of rhesus monkeys and raise the possibility that modafinil affects wakefulness by interacting with catecholamine transporters in brain... - Receptor regulation of gene expression of axon guidance molecules: implications for adaptationAmy K Jassen
Department of Psychiatry, Harvard Medical School, Division of Neurochemistry, New England Regional Primate Research Center, 1 Pine Hill Drive, Southborough, MA 01772-9102, USA
Mol Pharmacol 70:71-7. 2006.... 
Modulation of monoamine transporters by common biogenic amines via trace amine-associated receptor 1 and monoamine autoreceptors in human embryonic kidney 293 cells and brain synaptosomesZhihua Xie
New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772, USA
J Pharmacol Exp Ther 325:629-40. 2008..These data provide the first evidence that common biogenic amines modulate monoamine transporter function via both TAAR1 and monoamine autoreceptors, which may balance monoaminergic activity...- A receptor mechanism for methamphetamine action in dopamine transporter regulation in brainZhihua Xie
New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772, USA
J Pharmacol Exp Ther 330:316-25. 2009..These findings demonstrate a mediatory role of TAAR1 in methamphetamine action in DAT regulation and implicate this receptor as a potential target of therapeutics drugs for methamphetamine addiction... - Human expression variation in the mu-opioid receptor is paralleled in rhesus macaqueEric J Vallender
Division of Neurochemistry, New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
Behav Genet 38:390-5. 2008..Together, the functional variations reported here have implications for future studies seeking to model the opioid system and its associated phenotypes in rhesus macaques... - The effect of rearing experience and TPH2 genotype on HPA axis function and aggression in rhesus monkeys: a retrospective analysisGuo Lin Chen
Harvard Medical School, New England Primate Research Center, Southborough, MA 01772, USA
Horm Behav 57:184-91. 2010..Our findings strengthen the involvement of G x E interactions at the loci of serotonergic genes and the utility of the nonhuman primate to model G x E interactions in the development of human neuropsychiatric diseases... - Polymorphisms in the 3' UTR of the serotonin transporter are associated with cognitive flexibility in rhesus macaquesEric J Vallender
Division of Neurochemistry, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA
Am J Med Genet B Neuropsychiatr Genet 150:467-75. 2009.... - Inhibition of the dopamine D1 receptor signaling by PSD-95Jingping Zhang
Department of Psychiatry, Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts 01772, USA
J Biol Chem 282:15778-89. 2007..These studies demonstrate a role for a glutamatergic scaffold in dopamine receptor signaling and trafficking and identify a new potential target for the modulation of abnormal dopaminergic function... - Advances in tryptophan hydroxylase-2 gene expression regulation: new insights into serotonin-stress interaction and clinical implicationsGuo Lin Chen
Harvard Medical School, New England Primate Research Center, Division of Neuroscience, Southborough, MA 01772 9102, USA
Am J Med Genet B Neuropsychiatr Genet 159:152-71. 2012.... - Ephrin/Eph receptor expression in brain of adult nonhuman primates: implications for neuroadaptationDanqing Xiao
Department of Psychiatry, Harvard Medical School, Division of Neurochemistry, New England Primate Research Center, Southborough, MA 01772-9102, USA
Brain Res 1067:67-77. 2006..The association of axonal guidance molecules with drug-induced reorganization of adult primate brain circuitry warrants investigation... - Functional evolution of the trace amine associated receptors in mammals and the loss of TAAR1 in dogsEric J Vallender
New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772, USA
BMC Evol Biol 10:51. 2010..Other trace amine associated receptors appear to relate to environmental perception and show a birth-and-death pattern in mammals similar to olfactory receptors... - Primate trace amine receptor 1 modulation by the dopamine transporterGregory M Miller
Division of Neurochemistry, New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
J Pharmacol Exp Ther 313:983-94. 2005.... - The dopamine transporter and attention-deficit/hyperactivity disorderBertha K Madras
Department of Psychiatry, Harvard Medical School, New England Primate Research Center, Southborough, MA 01772 9102, USA
Biol Psychiatry 57:1397-409. 2005..Thus, ADHD medications targeting DAT or NET might disperse dopamine widely and consign dopamine storage and release to regulation by noradrenergic, as well as dopaminergic neurons... - MDMA (Ecstasy) and human dopamine, norepinephrine, and serotonin transporters: implications for MDMA-induced neurotoxicity and treatmentChristopher D Verrico
Department of Psychiatry, Division of Neurochemistry, New England Primate Research Center, Harvard Medical School, 1 Pine Hill Drive, Southborough, MA 01772 9102, USA
Psychopharmacology (Berl) 189:489-503. 2007..In rats, MDMA-mediated effects are attributed, in part, to selective high-affinity transport of MDMA into 5-HT neurons by the 5-HT transporter (SERT), followed by extensive 5-HT release... - Augmentation of methamphetamine-induced behaviors in transgenic mice lacking the trace amine-associated receptor 1Cindy Achat-Mendes
Division of Neuroscience, New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, United States
Pharmacol Biochem Behav 101:201-7. 2012..Collectively, these findings provide support for a regulatory role of TAAR1 in methamphetamine signaling... - Growth-associated protein-43 and ephrin B3 induction in the brain of adult SIV-infected rhesus macaquesSusan V Westmoreland
Division of Comparative Pathology, New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
J Neurovirol 17:455-68. 2011.... - 5'-Untranslated region of the tryptophan hydroxylase-2 gene harbors an asymmetric bidirectional promoter but not internal ribosome entry site in vitroGuo Lin Chen
Harvard Medical School, New England Primate Research Center, Southborough, MA 01772 9102, USA
Gene 435:53-62. 2009..Our findings point to the potential involvement of antisense transcription and non-coding RNA in the regulation of TPH2 gene expression... - MDMA-induced impairment in primates: antagonism by a selective norepinephrine or serotonin, but not by a dopamine/norepinephrine transport inhibitorChristopher D Verrico
Department of Psychiatry, Harvard Medical School and Division of Neurochemistry, New England Primate Research Center, Southborough, MA 01772 9102, USA
J Psychopharmacol 22:187-202. 2008..Reversal of impaired executive function by a NET inhibitor implicates the NET and norepinephrine in MDMA-induced cognitive impairment and may be relevant to therapeutic strategies... - Trace amine-associated receptor 1 as a monoaminergic modulator in brainZhihua Xie
Division of Neuroscience, New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772, USA
Biochem Pharmacol 78:1095-104. 2009.... - A pharmacogenetic model of naltrexone-induced attenuation of alcohol consumption in rhesus monkeysEric J Vallender
New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772, USA
Drug Alcohol Depend 109:252-6. 2010..Naltrexone, an antagonist at the receptor, has been used to treat alcoholism in humans and has been reported to show differences in effectiveness depending on genotype... - Variants of the primate vesicular monoamine transporter-2Amy K Jassen
Department of Psychiatry, Harvard Medical School, New England Primate Research Center, One Pine Hill Drive, Southborough, MA 01772-9102, USA
Brain Res Mol Brain Res 139:251-7. 2005..We investigated this apparent mismatch between observed molecular size and predicted size... - Beta-phenylethylamine alters monoamine transporter function via trace amine-associated receptor 1: implication for modulatory roles of trace amines in brainZhihua Xie
New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772, USA
J Pharmacol Exp Ther 325:617-28. 2008..The functional profile of beta-PEA may reveal a common mechanism by which trace amines exert modulatory effects on monoamine transporters in brain... - Dopamine transporter-dependent induction of C-Fos in HEK cellsServet M Yatin
Harvard Medical School, New England Regional Primate Research Center, Southborough, Massachusetts 01772-9102, USA
Synapse 45:52-65. 2002.... - Non-amine-based dopamine transporter (reuptake) inhibitors retain properties of amine-based progenitorsBertha K Madras
Department of Psychiatry, Harvard Medical School, New England Primate Research Center, 1 Pine Hill Drive, Southborough, MA 01772 9102, USA
Eur J Pharmacol 479:41-51. 2003..These novel drugs compel a revision of current concepts of drug-monoamine transporter complex formation and open avenues for discovery of a new generation of therapeutic drugs... - Trace amine associated receptor 1 signaling in activated lymphocytesMichael W Panas
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
J Neuroimmune Pharmacol 7:866-76. 2012..TAAR1 is emerging as a potential therapeutic target, with regard to its ability to modulate brain monoamines. The current data raises the possibility that TAAR1-targeted drugs may also alter immune function... - Behavioral effects of clozapine: involvement of trace amine pathways in C. elegans and M. musculusRakesh Karmacharya
Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA
Brain Res 1393:91-9. 2011..In summary, we report a heretofore-unknown role for trace amine systems in clozapine-mediated effects across two species: C. elegans and mice... - Tryptophan hydroxylase-2: An emerging therapeutic target for stress disordersGuo Lin Chen
Harvard Medical School, New England Primate Research Center, Division of Neuroscience, One Pine Hill Drive, Southborough, MA 01772 9102, USA Electronic address
Biochem Pharmacol 85:1227-33. 2013.... - Dopamine and norepinephrine transporter-dependent c-Fos production in vitro: relevance to neuroadaptationServet M Yatin
Harvard Medical School, New England Primate Research Center, Division of Neurochemistry, One Pine Hill Drive, Southborough, MA 01772 9102, USA
J Neurosci Methods 143:69-78. 2005..These findings present a cell system and methodology for investigating the potential contribution of monoamine transporters to pre-synaptic neuroadaptation... - Balancing selection and the evolution of functional polymorphism in Old World monkey TRIM5alphaRuchi M Newman
Department of Microbiology and Molecular Genetics, Harvard Medical School, Southborough, MA 01772, USA
Proc Natl Acad Sci U S A 103:19134-9. 2006.... - Systems analysis of circadian time-dependent neuronal epidermal growth factor receptor signalingDaniel E Zak
Daniel Baugh Institute for Functional Genomics and Computational Biology, Department of Pathology, Thomas Jefferson University, Locust St, Philadelphia, PA 19107, USA
Genome Biol 7:R48. 2006..Our study suggests an important role for EGFR signaling in SCN function and provides an example for gaining physiological insights through systems-level analysis... - Chronic morphine exposure causes pronounced virus replication in cerebral compartment and accelerated onset of AIDS in SIV/SHIV-infected Indian rhesus macaquesRakesh Kumar
Laboratory of Viral Immunology, AIDS Research Program and Department of Microbiology, Ponce School of Medicine, Ponce, PR 00732, Puerto Rico
Virology 354:192-206. 2006..Three morphine-exposed macaques (euthanized at weeks 18, 19 and 20) did not develop cellular or humoral immune responses, whereas the other 3 morphine-exposed and 3 control macaques developed both cellular and humoral immune responses... - Epidermal growth factor receptor-induced circadian-time-dependent gene regulation in suprachiasmatic nucleusRajanikanth Vadigepalli
Department of Pathology, Anatomy and Cell Biology, Daniel Baugh Institute for Functional Genomics and Computational Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Neuroreport 17:1437-41. 2006..Together, these results indicate that epidermal growth factor receptor has a circadian-time-dependent neuromodulatory function in the suprachiasmatic nucleus... - Analysis of copy number variation in the rhesus macaque genome identifies candidate loci for evolutionary and human disease studiesArthur S Lee
Department of Pathology, Brigham and Women s Hospital, 221 Longwood Ave, Boston, MA 02115, USA
Hum Mol Genet 17:1127-36. 2008..Therefore, the rhesus macaque offers an intriguing, non-human primate outbred model organism with which hypotheses concerning the specific functions of phenotypically relevant human CNVs can be tested...