E Mick

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Heterogeneity of irritability in attention-deficit/hyperactivity disorder subjects with and without mood disorders
    Eric Mick
    Pediatric Psychopharmacology Research Department, Massachusetts General Hospital, Boston, Massachusetts 02115, USA
    Biol Psychiatry 58:576-82. 2005
  2. ncbi Family and genetic association studies of bipolar disorder in children
    Eric Mick
    Departments of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Child Adolesc Psychiatr Clin N Am 18:441-53, x. 2009
  3. ncbi Family-based association study of the BDNF, COMT and serotonin transporter genes and DSM-IV bipolar-I disorder in children
    Eric Mick
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    BMC Psychiatry 9:2. 2009
  4. ncbi Genome-wide association study of response to methylphenidate in 187 children with attention-deficit/hyperactivity disorder
    Eric Mick
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1412-8. 2008
  5. ncbi Genome-wide association study of blood pressure response to methylphenidate treatment of attention-deficit/hyperactivity disorder
    Eric Mick
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, United States
    Prog Neuropsychopharmacol Biol Psychiatry 35:466-72. 2011
  6. ncbi Sleep disturbances associated with attention deficit hyperactivity disorder: the impact of psychiatric comorbidity and pharmacotherapy
    E Mick
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, USA
    J Child Adolesc Psychopharmacol 10:223-31. 2000
  7. ncbi Family based association study of pediatric bipolar disorder and the dopamine transporter gene (SLC6A3)
    Eric Mick
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1182-5. 2008
  8. ncbi Impact of maternal depression on ratings of comorbid depression in adolescents with attention-deficit/hyperactivity disorder
    E Mick
    Department of Epidemiology, Harvard School of Public Health, Boston, USA
    J Am Acad Child Adolesc Psychiatry 39:314-9. 2000
  9. ncbi Age-dependent expression of attention-deficit/hyperactivity disorder symptoms
    Eric Mick
    Department of Psychiatry, Massachusetts General Hospital, Boston 02114, USA
    Psychiatr Clin North Am 27:215-24. 2004
  10. ncbi Impact of low birth weight on attention-deficit hyperactivity disorder
    Eric Mick
    Department of Psychiatry, Harvard Medical School and Pediatric Psycopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Dev Behav Pediatr 23:16-22. 2002

Research Grants

  1. Validating Pediatric Bipolar Disorder with Extant Data
    Eric Mick; Fiscal Year: 2007

Detail Information

Publications102 found, 100 shown here

  1. ncbi Heterogeneity of irritability in attention-deficit/hyperactivity disorder subjects with and without mood disorders
    Eric Mick
    Pediatric Psychopharmacology Research Department, Massachusetts General Hospital, Boston, Massachusetts 02115, USA
    Biol Psychiatry 58:576-82. 2005
    ..We hypothesized that irritability is a heterogeneous symptom distinguished by severity and that attending to this heterogeneity would impact the relationship between irritability and bipolar disorder...
  2. ncbi Family and genetic association studies of bipolar disorder in children
    Eric Mick
    Departments of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Child Adolesc Psychiatr Clin N Am 18:441-53, x. 2009
    ..An adequately powered sample will likely require collaborative ascertainment of cases and families from multiple sites using valid and accepted measures of pediatric BPD...
  3. ncbi Family-based association study of the BDNF, COMT and serotonin transporter genes and DSM-IV bipolar-I disorder in children
    Eric Mick
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    BMC Psychiatry 9:2. 2009
    ..In this report we test for association with genes coding brain-derived neurotrophic factor (BDNF), the serotonin transporter (SLC6A4), and catechol-O-methyltransferase (COMT)...
  4. ncbi Genome-wide association study of response to methylphenidate in 187 children with attention-deficit/hyperactivity disorder
    Eric Mick
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1412-8. 2008
    ..These results should be considered preliminary until replicated in larger adequately powered, controlled samples but do suggest that noradrenergic and possibly glutaminergic genes may be involved with response to methylphenidate...
  5. ncbi Genome-wide association study of blood pressure response to methylphenidate treatment of attention-deficit/hyperactivity disorder
    Eric Mick
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, United States
    Prog Neuropsychopharmacol Biol Psychiatry 35:466-72. 2011
    ..We conducted a genome-wide association study of blood pressure in an open-label study of the methylphenidate transdermal system (MTS) for the treatment of attention-deficit/hyperactivity disorder (ADHD)...
  6. ncbi Sleep disturbances associated with attention deficit hyperactivity disorder: the impact of psychiatric comorbidity and pharmacotherapy
    E Mick
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, USA
    J Child Adolesc Psychopharmacol 10:223-31. 2000
    ..To estimate the relative risk of sleep problems associated with attention deficit hyperactivity disorder (ADHD), its pharmacotherapy, and its comorbid psychopathology...
  7. ncbi Family based association study of pediatric bipolar disorder and the dopamine transporter gene (SLC6A3)
    Eric Mick
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1182-5. 2008
    ..These data provide suggestive evidence supporting a role for SLC6A3 in the etiology of pediatric bipolar disorder...
  8. ncbi Impact of maternal depression on ratings of comorbid depression in adolescents with attention-deficit/hyperactivity disorder
    E Mick
    Department of Epidemiology, Harvard School of Public Health, Boston, USA
    J Am Acad Child Adolesc Psychiatry 39:314-9. 2000
    ..To assess the degree to which indirect maternal reports of comorbid major depression (MD) in adolescents with and without attention-deficit/hyperactivity disorder (ADHD) were influenced by the mother's personal history of MD...
  9. ncbi Age-dependent expression of attention-deficit/hyperactivity disorder symptoms
    Eric Mick
    Department of Psychiatry, Massachusetts General Hospital, Boston 02114, USA
    Psychiatr Clin North Am 27:215-24. 2004
    ..or hyperactive/'impulsive) should be considered separately...
  10. ncbi Impact of low birth weight on attention-deficit hyperactivity disorder
    Eric Mick
    Department of Psychiatry, Harvard Medical School and Pediatric Psycopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Dev Behav Pediatr 23:16-22. 2002
    ..These results converge with prior studies documenting similar associations and indicate that LBW is an independent risk factor for ADHD. Children with LBW, however, make up a relatively small proportion of children with ADHD...
  11. ncbi Clinical correlates of ADHD in females: findings from a large group of girls ascertained from pediatric and psychiatric referral sources
    J Biederman
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    J Am Acad Child Adolesc Psychiatry 38:966-75. 1999
    ..The aim of this study was to examine clinical correlates of ADHD in females using comprehensive assessments in multiple domains of functioning...
  12. ncbi Family study of girls with attention deficit hyperactivity disorder
    S V Faraone
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston 02114, USA
    Am J Psychiatry 157:1077-83. 2000
    ..To help fill this gap in the literature, the authors assessed the familial transmission of ADHD in families ascertained through girls...
  13. ncbi Sexually dimorphic effects of four genes (COMT, SLC6A2, MAOA, SLC6A4) in genetic associations of ADHD: a preliminary study
    Joseph Biederman
    Pediatric Psychopharmacology Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1511-8. 2008
    ..Although our results are not fully validated yet, they should motivate further investigation of gender effects in ADHD genetic association studies...
  14. ncbi A controlled family study of children with DSM-IV bipolar-I disorder and psychiatric co-morbidity
    J Wozniak
    Clinical and Research Program in Pediatric Psychopharmacology and Adult ADHD at Massachusetts General Hospital, Boston, MA 02114, USA
    Psychol Med 40:1079-88. 2010
    ..To estimate the spectrum of familial risk for psychopathology in first-degree relatives of children with unabridged DSM-IV bipolar-I disorder (BP-I)...
  15. ncbi Further evidence of association between two NET single-nucleotide polymorphisms with ADHD
    J W Kim
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Mol Psychiatry 13:624-30. 2008
    ..This is the first time that identical alleles of NET from different studies were implicated, and thus our report provides further evidence that the NET gene is involved in the etiology of ADHD...
  16. ncbi Pharmacotherapy of attention-deficit/hyperactivity disorder reduces risk for substance use disorder
    J Biederman
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Pediatrics 104:e20. 1999
    ..To assess the risk for substance use disorders (SUD) associated with previous exposure to psychotropic medication in a longitudinal study of boys with attention-deficit/hyperactivity disorder (ADHD)...
  17. ncbi Impact of tic disorders on ADHD outcome across the life cycle: findings from a large group of adults with and without ADHD
    T J Spencer
    Pediatric Psychopharmacology Unit (WACC 725, Massachusetts General Hospital, 15 Parkman Street, Boston, MA 02114-3117, USA
    Am J Psychiatry 158:611-7. 2001
    ....
  18. ncbi Systematic chart review of the pharmacologic treatment of comorbid attention deficit hyperactivity disorder in youth with bipolar disorder
    J Biederman
    Pediatric Psychopharmacology Unit of the Child Psychiatry Service, Massachusetts General Hospital, Boston, USA
    J Child Adolesc Psychopharmacol 9:247-56. 1999
    ..Although TCAs can be helpful in the management of ADHD children with manic symptoms, these drugs should be used with caution since they can also have a destabilizing effect on manic symptoms...
  19. ncbi Social impairment in girls with ADHD: patterns, gender comparisons, and correlates
    R W Greene
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston 02114, USA
    J Am Acad Child Adolesc Psychiatry 40:704-10. 2001
    ....
  20. ncbi Genetic risk for conduct disorder symptom subtypes in an ADHD sample: specificity to aggressive symptoms
    Michael C Monuteaux
    Massachusetts General Hospital, Boston, MA 02114, USA
    J Am Acad Child Adolesc Psychiatry 48:757-64. 2009
    ..The aim of this study was to examine the role of the COMT and SLC6A4 genes in the risk for CD and its symptomatic subtypes in the context of ADHD...
  21. ncbi Absence of gender differences in pediatric bipolar disorder: findings from a large sample of referred youth
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology of the Child Psychiatry Service, Massachusetts General Hospital, Pediatric Psychopharmacology Unit WACC 725, 15 Parkman Street, Boston, MA 02114, USA
    J Affect Disord 83:207-14. 2004
    ..Because little is known about gender differences in pediatric bipolar disorder, we evaluated whether gender moderates the expression of pediatric bipolar disorder in a large clinical sample...
  22. ncbi Is oppositional defiant disorder a meaningful diagnosis in adults? Results from a large sample of adults with ADHD
    Theresa Harpold
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Nerv Ment Dis 195:601-5. 2007
    ..A better understanding of the course, phenomenology, and clinical significance of ODD in adults is needed to better understand therapeutic approaches for this disorder...
  23. ncbi Parsing pediatric bipolar disorder from its associated comorbidity with the disruptive behavior disorders
    T J Spencer
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts 02114-3139, USA
    Biol Psychiatry 49:1062-70. 2001
    ..What was previously considered refractory ADHD, oppositionality, aggression, and conduct disorder may respond after mood stabilization. We review these issues in this article...
  24. ncbi A family study of psychiatric comorbidity in girls and boys with attention-deficit/hyperactivity disorder
    S V Faraone
    Pediatric Psychopharmacology Unit, Child Psychiatry Service, Massachusetts General Hospital, Boston, Massachusetts 02114-3139, USA
    Biol Psychiatry 50:586-92. 2001
    ..Although this is consistent with prior work suggesting more similarities than differences in the nature of psychiatric comorbidity in ADHD boys and girls, we cannot make strong conclusions, owing to the possibility of cohort effects...
  25. ncbi Age-dependent decline of symptoms of attention deficit hyperactivity disorder: impact of remission definition and symptom type
    J Biederman
    Pediatric Psychopharmacology Unit, Psychiatry Service, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 157:816-8. 2000
    ..Symptom decline in attention deficit hyperactivity disorder (ADHD) was examined with different definitions of remission...
  26. ncbi Parsing the familiality of oppositional defiant disorder from that of conduct disorder: a familial risk analysis
    Carter R Petty
    Massachusetts General Hospital, Boston, MA 02114, USA
    J Psychiatr Res 43:345-52. 2009
    ..Family risk analysis can provide an improved understanding of the association between attention-deficit/hyperactivity disorder (ADHD) and oppositional defiant disorder (ODD), attending to the comorbidity with conduct disorder (CD)...
  27. ncbi The influence of sex on the course and psychiatric correlates of ADHD from childhood to adolescence: a longitudinal study
    Michael C Monuteaux
    Clinical and Research Programs in Pediatric Psychiatry and Adult ADHD, Psychiatry Department, Massachusetts General Hospital, Boston, MA 02114, USA
    J Child Psychol Psychiatry 51:233-41. 2010
    ..The purpose of this study was to examine the effect of sex on the course and psychiatric correlates of ADHD from childhood into adolescence...
  28. ncbi The long-term longitudinal course of oppositional defiant disorder and conduct disorder in ADHD boys: findings from a controlled 10-year prospective longitudinal follow-up study
    J Biederman
    Clinical and Research Programs in Pediatric Psychopharmacology and Adult ADHD, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Psychol Med 38:1027-36. 2008
    ....
  29. ncbi Methodological complexities in the diagnosis of major depression in youth: an analysis of mother and youth self-reports
    E B Braaten
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston 02114, USA
    J Child Adolesc Psychopharmacol 11:395-407. 2001
    ..To this end we evaluated whether morbidity and functional correlates on the diagnosis of MDD in youth vary by informant source...
  30. ncbi Patterns of remission and symptom decline in conduct disorder: a four-year prospective study of an ADHD sample
    J Biederman
    Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, USA
    J Am Acad Child Adolesc Psychiatry 40:290-8. 2001
    ..To evaluate systematically the longitudinal course of conduct disorder (CD) in a sample of youths with attention-deficit hyperactivity disorder (ADHD) to determine the effects of a persistent course on outcome...
  31. ncbi Meta-analysis of the association between the 7-repeat allele of the dopamine D(4) receptor gene and attention deficit hyperactivity disorder
    S V Faraone
    Pediatric Psychopharmacology Unit, Child Psychiatric Services, Massachusetts General Hospital, Boston 02114, USA
    Am J Psychiatry 158:1052-7. 2001
    ..Although several studies have shown an association between ADHD and the 7-repeat allele of the dopamine D(4) receptor gene (DRD4), several studies have not. Thus, the status of the ADHD-DRD4 association is uncertain...
  32. ncbi The longitudinal course of comorbid oppositional defiant disorder in girls with attention-deficit/hyperactivity disorder: findings from a controlled 5-year prospective longitudinal follow-up study
    Joseph Biederman
    Pediatric Psychopharmacology Unit of the Psychiatry Department, Massachusetts General Hospital, Boston, MA 02114, USA
    J Dev Behav Pediatr 29:501-7. 2008
    ..However, most of the available information on the subject derives from predominantly male samples. This study evaluated the longitudinal course and impact of comorbid ODD in a large sample of girls with ADHD...
  33. ncbi Childhood antecedent disorders to bipolar disorder in adults: a controlled study
    Aude Henin
    Pediatric Psychopharmacology Unit and Bipolar Clinic and Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02138, United States
    J Affect Disord 99:51-7. 2007
    ..The aim of the study was to examine antecedent childhood psychiatric disorders in adult patients with bipolar disorder...
  34. ncbi New insights into the comorbidity between ADHD and major depression in adolescent and young adult females
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Am Acad Child Adolesc Psychiatry 47:426-34. 2008
    ..The main aim of this study was to evaluate the association between attention-deficit/hyperactivity disorder (ADHD) and major depression (MD) in adolescent and young adult females...
  35. ncbi How cardinal are cardinal symptoms in pediatric bipolar disorder? An examination of clinical correlates
    Janet Wozniak
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
    Biol Psychiatry 58:583-8. 2005
    ..The main goal of this study was to test whether the hypothesized cardinal symptom of euphoria results in differences in clinical correlates in bipolar youth ascertained with no a priori assumptions about cardinal symptoms...
  36. ncbi Is cigarette smoking a gateway to alcohol and illicit drug use disorders? A study of youths with and without attention deficit hyperactivity disorder
    Joseph Biederman
    Department of Psychiatry, Harvard Medical School, USA
    Biol Psychiatry 59:258-64. 2006
    ....
  37. ncbi Effect of candidate gene polymorphisms on the course of attention deficit hyperactivity disorder
    Joseph Biederman
    Pediatric Psychopharmacology Department, Massachusetts General Hospital, Boston, MA, USA
    Psychiatry Res 170:199-203. 2009
    ..94) and 5HTTLPR long allele. Our findings suggest that the DRD4 7-repeat allele is associated with a more persistent course of ADHD...
  38. ncbi Absence of gender effects on attention deficit hyperactivity disorder: findings in nonreferred subjects
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Psychiatry 162:1083-9. 2005
    ..However, because referral bias can affect outcome, these findings require replication in nonreferred groups of ADHD subjects...
  39. ncbi Defining a developmental subtype of bipolar disorder in a sample of nonreferred adults by age at onset
    Eric Mick
    Pediatric Psychopharmacology Unit of the Child Psychiatry Service, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Child Adolesc Psychopharmacol 13:453-62. 2003
    ..This pattern of correlates is consistent with findings documented in children with pediatric bipolar disorder and supports the hypothesis that child-onset bipolar disorder may represent a developmental subtype of the disorder...
  40. ncbi Can a subtype of conduct disorder linked to bipolar disorder be identified? Integration of findings from the Massachusetts General Hospital Pediatric Psychopharmacology Research Program
    Joseph Biederman
    Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA
    Biol Psychiatry 53:952-60. 2003
    ..Our data suggest that when BPD and CD co-occur in children, both are correctly diagnosed. In these comorbid cases, CD symptoms should not be viewed as secondary to BPD, and manic symptoms should not be viewed as secondary to CD...
  41. ncbi Therapeutic dilemmas in the pharmacotherapy of bipolar depression in the young
    J Biederman
    Child Psychiatry Service, Massachusetts General Hospital, Boston, USA
    J Child Adolesc Psychopharmacol 10:185-92. 2000
    ..Because bipolar youth commonly come to clinical practice with depression, these results underscore the importance of assessing a lifetime history of bipolar disorder in making treatment decisions in depressed youth...
  42. ncbi Case-control genome-wide association study of attention-deficit/hyperactivity disorder
    Benjamin M Neale
    Center for Human Genetic Research, Massachusettes General Hospital, Boston, MA, USA
    J Am Acad Child Adolesc Psychiatry 49:906-20. 2010
    ..Thus additional genomewide association studies (GWAS) are needed...
  43. ncbi Attention-deficit/hyperactivity disorder: diagnosis, lifespan, comorbidities, and neurobiology
    Thomas J Spencer
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Ambul Pediatr 7:73-81. 2007
    ....
  44. ncbi A preliminary meta-analysis of the child behavior checklist in pediatric bipolar disorder
    Eric Mick
    Pediatric Psychopharmacology Unit, Child Psychiatry Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Biol Psychiatry 53:1021-7. 2003
    ..CONCLUSIONS: While there was a significant heterogeneity in estimates between studies, a consistent pattern of elevations in inattention/hyperactivity, depression/anxiety, and aggression was identified...
  45. ncbi Risperidone for the treatment of affective symptoms in children with disruptive behavior disorder: a post hoc analysis of data from a 6-week, multicenter, randomized, double-blind, parallel-arm study
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology, Department of Psychiatry, Massachusetts General Hospital, Boston, 02114, USA
    Clin Ther 28:794-800. 2006
    ..Preliminary data from open-label trials in children suggest that these agents might be effective in treating pediatric bipolar disorder, however...
  46. ncbi Can bipolar disorder-specific neuropsychological impairments in children be identified?
    Aude Henin
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Cambridge, MA 02138, USA
    J Consult Clin Psychol 75:210-20. 2007
    ..Thus, comorbidity with ADHD may account for many of the neuropsychological deficits observed in children with bipolar disorder...
  47. ncbi Is psychopharmacologic treatment associated with neuropsychological deficits in bipolar youth?
    Aude Henin
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, 185 Alewife Brook Pkwy, Suite 2000, Cambridge, MA 02138, USA
    J Clin Psychiatry 70:1178-85. 2009
    ..To evaluate the impact of psychopharmacologic treatments on neuropsychological functioning in bipolar youth...
  48. ncbi A randomized, placebo-controlled trial of OROS methylphenidate in adults with attention-deficit/hyperactivity disorder
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology at the Massachusetts General Hospital, Boston, Massachusetts, USA
    Biol Psychiatry 59:829-35. 2006
    ..The objective of this study was to evaluate the safety and efficacy of once-daily OROS methylphenidate (MPH) in the treatment of adults with DSM-IV attention-deficit/hyperactivity disorder (ADHD)...
  49. ncbi Evidence for genetic association of RORB with bipolar disorder
    Casey L McGrath
    Department of Psychiatry, Laboratory of Neurophenomics, Indiana University School of Medicine, Indianapolis, IN, USA
    BMC Psychiatry 9:70. 2009
    ..Here we report association studies between bipolar disorder and single-nucleotide polymorphisms (SNPs) in RORA and RORB...
  50. ncbi A prospective open-label trial of extended-release carbamazepine monotherapy in children with bipolar disorder
    Gagan Joshi
    Pediatric Psychopharmacology Research Department, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Child Adolesc Psychopharmacol 20:7-14. 2010
    ..The aim of this study was to evaluate the safety and efficacy of extended release carbamazepine (CBZ-ER) monotherapy in the treatment of pediatric bipolar disorder (BD)...
  51. ncbi A large, double-blind, randomized clinical trial of methylphenidate in the treatment of adults with attention-deficit/hyperactivity disorder
    Thomas Spencer
    Pediatric Psychopharmacology Unit, Psychiatry Service Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Biol Psychiatry 57:456-63. 2005
    ..A previous, pilot study by our group suggested that these results were due to inadequate dosing...
  52. ncbi Effect of dopamine transporter gene (SLC6A3) variation on dorsal anterior cingulate function in attention-deficit/hyperactivity disorder
    Ariel B Brown
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Am J Med Genet B Neuropsychiatr Genet 153:365-75. 2010
    ..Alterations in activation of attention and EF networks found previously to be involved in ADHD are likely influenced by SLC6A3 genotype. This genotype may contribute to heterogeneity of brain alterations found within ADHD samples...
  53. ncbi Family-based genome-wide association scan of attention-deficit/hyperactivity disorder
    Eric Mick
    Massachusetts General Hospital, 55 Fruit Street Warren 705, Boston, MA 02114, USA
    J Am Acad Child Adolesc Psychiatry 49:898-905.e3. 2010
    ..We have conducted a third, independent, multisite GWAS of DSM-IV-TR ADHD...
  54. ncbi Impact of obsessive-compulsive disorder on the antimanic response to olanzapine therapy in youth with bipolar disorder
    Gagan Joshi
    Pediatric Psychopharmacology Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    Bipolar Disord 12:196-204. 2010
    ..To compare antimanic response to olanzapine therapy in youth with bipolar disorder (BPD) based on the status of comorbidity with obsessive-compulsive disorder (OCD)...
  55. ncbi A systematic chart review of the nature of psychiatric adverse events in children and adolescents treated with selective serotonin reuptake inhibitors
    Timothy E Wilens
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Child Adolesc Psychopharmacol 13:143-52. 2003
    ..To this end we completed a retrospective analysis of medical charts to determine the incidence, nature, and clinical correlates of treatment emergent adverse effects in the behavioral, cognitive, and emotional domains...
  56. ncbi Familial risk analyses of attention deficit hyperactivity disorder and substance use disorders
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, 55 Fruit St, Warren 705, Boston, MA 02114, USA
    Am J Psychiatry 165:107-15. 2008
    ..A robust and bidirectional comorbidity between attention deficit hyperactivity disorder (ADHD) and psychoactive substance use disorder (alcohol or drug abuse or dependence) has been consistently reported in the extant literature...
  57. ncbi Functional magnetic resonance imaging of methylphenidate and placebo in attention-deficit/hyperactivity disorder during the multi-source interference task
    George Bush
    Departments of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    Arch Gen Psychiatry 65:102-14. 2008
    ..Stimulant medications are effective treatments for ADHD, but their neural effects have not been fully characterized...
  58. ncbi On genome-wide association studies for family-based designs: an integrative analysis approach combining ascertained family samples with unselected controls
    Jessica Lasky-Su
    Channing Laboratories, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Hum Genet 86:573-80. 2010
    ..We illustrate the approach by an application to a GWAS of attention deficit hyperactivity disorder parent-offspring trios and publicly available controls...
  59. ncbi Current concepts in the validity, diagnosis and treatment of paediatric bipolar disorder
    Joseph Biederman
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114 3139, USA
    Int J Neuropsychopharmacol 6:293-300. 2003
    ..The goal of this article is to review our work and the extant literature within this framework to describe the evidence supporting bipolar disorder in children as a valid clinical diagnosis...
  60. ncbi A preliminary study of dopamine D4 receptor genotype and structural brain alterations in adults with ADHD
    Michael C Monuteaux
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1436-41. 2008
    ..These result support the heterogeneity of ADHD and provides insights as to its underlying pathophysiology...
  61. ncbi Association between attention-deficit/hyperactivity disorder and sleep impairment in adulthood: evidence from a large controlled study
    Craig B H Surman
    Clinical and Research Program in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Cambridge, MA 02138, USA
    J Clin Psychiatry 70:1523-9. 2009
    ..To examine whether sleep impairment is associated with attention-deficit/hyperactivity disorder (ADHD) in adults...
  62. ncbi Mania, glutamate/glutamine and risperidone in pediatric bipolar disorder: a proton magnetic resonance spectroscopy study of the anterior cingulate cortex
    Constance M Moore
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    J Affect Disord 99:19-25. 2007
    ..In this study, we hypothesized that the children with BPD in need of treatment would have lower Glx/Cr compared with the children with BPD being stably treated with risperidone...
  63. ncbi Influence of gender on attention deficit hyperactivity disorder in children referred to a psychiatric clinic
    Joseph Biederman
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 159:36-42. 2002
    ..In this study the authors systematically examined the impact of gender on the clinical features of ADHD in a group of children referred to a clinic...
  64. ncbi An open-label trial of OROS methylphenidate in adults with late-onset ADHD
    Joseph Biederman
    Joint Program, Pediatric Psychopharmacology Research Office, Massachusetts General Hospital, Boston, MA 02114, USA
    CNS Spectr 11:390-6. 2006
    ..We hypothesized that treatment with oral release osmotic system (OROS) methylphenidate (MPH) will be safe and efficacious for the treatment of adults with late-onset ADHD...
  65. ncbi A simulated workplace experience for nonmedicated adults with and without ADHD
    Joseph Biederman
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, ACC 7, Boston, Massachusetts 02114, USA
    Psychiatr Serv 56:1617-20. 2005
    ..The results of this study suggest that ADHD among adults is associated with significant deficits in performance of workplace tasks, internal experiences, and external observations of core symptoms of ADHD...
  66. ncbi Open-label, 8-week trial of olanzapine and risperidone for the treatment of bipolar disorder in preschool-age children
    Joseph Biederman
    Pediatric Psychopharmacology Research Department, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Biol Psychiatry 58:589-94. 2005
    ..To evaluate short-term safety and efficacy of atypical antipsychotics in a single-site, prospective, open-label, 8-week study of risperidone and olanzapine monotherapy in preschoolers with bipolar disorder (BPD)...
  67. ncbi Further evidence of unique developmental phenotypic correlates of pediatric bipolar disorder: findings from a large sample of clinically referred preadolescent children assessed over the last 7 years
    Joseph Biederman
    Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    J Affect Disord 82:S45-58. 2004
    ..A comparison of the prevalence, clinical correlates, and patterns of comorbidity among children with bipolar disorder (BPD) assessed in the early 1990s (1st cohort) with those evaluated over the last 7 years (2nd cohort)...
  68. ncbi Differences in brain chemistry in children and adolescents with attention deficit hyperactivity disorder with and without comorbid bipolar disorder: a proton magnetic resonance spectroscopy study
    Constance M Moore
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    Am J Psychiatry 163:316-8. 2006
    ....
  69. ncbi Assessing cannabis use in adolescents and young adults: what do urine screen and parental report tell you?
    Martin Gignac
    Pediatric Psychopharmacology Unit of the Psychiatry Department, Massachusetts General Hospital, Boston, MA, USA
    J Child Adolesc Psychopharmacol 15:742-50. 2005
    ..Our analysis compares three approaches to detect the most common drug abused in early adulthood, cannabis: (1) report on direct structured interview; (2) indirect parental report; and (3) urine toxicology screen...
  70. ncbi Comparison of open-label, 8-week trials of olanzapine monotherapy and topiramate augmentation of olanzapine for the treatment of pediatric bipolar disorder
    Janet Wozniak
    Pediatric Psychopharmacology Research Department, Massachusetts General Hospital, Department of Psychiatry at Harvard Medical School, Boston, Massachusetts, USA
    J Child Adolesc Psychopharmacol 19:539-45. 2009
    ..The aim of this study was to test the efficacy and safety of olanzapine + topiramate versus olanzapine monotherapy in the treatment of bipolar disorder (BPD) and treatment-attendant weight gain in children and adolescents...
  71. ncbi Psychopathology in the offspring of parents with bipolar disorder: a controlled study
    Aude Henin
    Pediatric Psychopharmacology Unit and Harvard Bipolar Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02138, USA
    Biol Psychiatry 58:554-61. 2005
    ..To examine the risk for psychopathology in offspring at risk for bipolar disorder and the course of psychiatric disorders in these youth...
  72. ncbi Clinical correlates of bipolar disorder in a large, referred sample of children and adolescents
    Joseph Biederman
    Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA
    J Psychiatr Res 39:611-22. 2005
    ..To compare the prevalence, clinical correlates, and comorbidity among children and adolescents with bipolar disorder (BPD) assessed in the early 1990s (first cohort) with those evaluated over the last 7 years (second cohort)...
  73. ncbi Functional impairments in adults with self-reports of diagnosed ADHD: A controlled study of 1001 adults in the community
    Joseph Biederman
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Yawkey Center for Outpatient Care, Boston, MA 02114, USA
    J Clin Psychiatry 67:524-40. 2006
    ..The objective of this study was to evaluate functional impairments in a nonreferred sample of adults identifying themselves as having been diagnosed with attention-deficit/hyperactivity disorder (ADHD) by a clinician in their community...
  74. ncbi Examination of concordance between maternal and youth reports in the diagnosis of pediatric bipolar disorder
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, 55 Fruit Street, Warren 705, Boston, MA 02114, USA
    Bipolar Disord 11:298-306. 2009
    ..To this end we compared discordant (mother positive and youth negative) and concordant (mother and youth positive) cases...
  75. ncbi The influence of gender in the familial association between ADHD and major depression
    Eric Mick
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    J Nerv Ment Dis 191:699-705. 2003
    ....
  76. ncbi Absence of association with DAT1 polymorphism and response to methylphenidate in a sample of adults with ADHD
    Eric Mick
    Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Am J Med Genet B Neuropsychiatr Genet 141:890-4. 2006
    ..We failed to identify an association with DAT1 and the response or tolerability of methylphenidate in adults with ADHD...
  77. ncbi Convergence between the Achenbach youth self-report and structured diagnostic interview diagnoses in ADHD and non-ADHD youth
    Robert Doyle
    Department of Psychiatry, Harvard Medical School, Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Nerv Ment Dis 195:350-2. 2007
    ..These findings indicate that the YSR could serve as a rapid and cost-effective diagnostic tool to identify major psychopathology in high-risk adolescents...
  78. ncbi Informativeness of maternal reports on the diagnosis of ADHD: an analysis of mother and youth reports
    Joseph Biederman
    Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    J Atten Disord 10:410-7. 2007
    ..We evaluated correlates of the diagnosis of ADHD in youth by informant source...
  79. ncbi Familial risk analysis of the association between attention-deficit/hyperactivity disorder and psychoactive substance use disorder in female adolescents: a controlled study
    Joseph Biederman
    Clinical and Research Programs in Pediatric Psychopharmacology and Adult ADHD, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    J Child Psychol Psychiatry 50:352-8. 2009
    ..However, this literature has been based almost exclusively on male only samples and, therefore, the findings may not generalize to females...
  80. ncbi Olanzapine augmentation of fluoxetine for refractory generalized anxiety disorder: a placebo controlled study
    Mark H Pollack
    Center for Anxiety and Traumatic Stress Related Disorders, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Biol Psychiatry 59:211-5. 2006
    ..We present one of the first randomized controlled trials for refractory GAD, comprising double blind augmentation with olanzapine or placebo for patients remaining symptomatic on fluoxetine...
  81. ncbi A prospective open-label treatment trial of ziprasidone monotherapy in children and adolescents with bipolar disorder
    Joseph Biederman
    Massachusetts General Hospital, Pediatric Psychopharmacology Research Department, 32 Fruit Street, Yawkey Center for Outpatient Care Yaw 6A, Boston, MA 02114, USA
    Bipolar Disord 9:888-94. 2007
    ..To assess the effectiveness and tolerability of ziprasidone for treating pediatric mania...
  82. ncbi Utility of an abbreviated questionnaire to identify individuals with ADHD at risk for functional impairments
    Joseph Biederman
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Psychiatr Res 42:304-10. 2008
    ....
  83. ncbi An open-label trial of risperidone in children and adolescents with bipolar disorder
    Joseph Biederman
    Pediatric Psychopharmacology Research Department, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Child Adolesc Psychopharmacol 15:311-7. 2005
    ..The aim of this study was to evaluate the potential of risperidone as a treatment of pediatric bipolar disorder...
  84. ncbi Comparing ADHD in velocardiofacial syndrome to idiopathic ADHD: a preliminary study
    Kevin M Antshel
    SUNY Upstate Medical University, NY, USA
    J Atten Disord 11:64-73. 2007
    ..Children with velocardiofacial syndrome (VCFS), a contiguous deletion syndrome, have an increased prevalence of attention deficit/hyperactivity disorder (ADHD)...
  85. ncbi Case-control study of attention-deficit hyperactivity disorder and maternal smoking, alcohol use, and drug use during pregnancy
    Eric Mick
    Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, USA
    J Am Acad Child Adolesc Psychiatry 41:378-85. 2002
    ....
  86. ncbi Young adult outcome of attention deficit hyperactivity disorder: a controlled 10-year follow-up study
    Joseph Biederman
    Pediatric Psychopharmacology Unit of the Psychiatry Department, Massachusetts General Hospital, Boston, MA 02114, USA
    Psychol Med 36:167-79. 2006
    ..Our objective was to estimate the lifetime prevalence of psychopathology in a sample of youth with and without attention deficit hyperactivity disorder (ADHD) through young adulthood using contemporaneous diagnostic and analytic techniques...
  87. ncbi Correlates of ADHD among children in pediatric and psychiatric clinics
    Betsy Busch
    Department of Pediatrics, Tufts University School of Medicine in Boston, USA
    Psychiatr Serv 53:1103-11. 2002
    ..These findings suggest that children cared for in pediatric practice have similar levels of comorbidity and dysfunction as psychiatrically referred youth...
  88. ncbi Attention-deficit/hyperactivity disorder: diagnosis, lifespan, comorbidities, and neurobiology
    Thomas J Spencer
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
    J Pediatr Psychol 32:631-42. 2007
    ....
  89. ncbi A prospective follow-up study of pediatric bipolar disorder in boys with attention-deficit/hyperactivity disorder
    Joseph Biederman
    WACC 725, Massachusetts General Hospital, Pediatric Psychopharmacology Unit, MGH, 55 Fruit Street, Boston, MA 02114, USA
    J Affect Disord 82:S17-23. 2004
    ....
  90. ncbi Diagnosing adult attention deficit hyperactivity disorder: are late onset and subthreshold diagnoses valid?
    Stephen V Faraone
    Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, 750 East Adams St, Syracuse, NY 13210, USA
    Am J Psychiatry 163:1720-9; quiz 1859. 2006
    ....
  91. ncbi Drug-induced disinhibition in psychiatrically hospitalized children
    Gabrielle A Carlson
    State University of New York at Stony Brook, Stony Brook, New York 11794-8790, USA
    J Child Adolesc Psychopharmacol 13:153-63. 2003
    ..CONCLUSIONS: DIBD is a complex phenomenon that does not lend itself to simple conclusions and requires further study...
  92. ncbi A double-blind comparison of galantamine hydrogen bromide and placebo in adults with attention-deficit/hyperactivity disorder: a pilot study
    Joseph Biederman
    Clinical and Research Program, Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychopharmacol 26:163-6. 2006
    ..Because of its cholinergic nicotinic mechanism of action, galantamine HBr was hypothesized to have therapeutic activity in the treatment of attention-deficit/hyperactivity disorder (ADHD)...
  93. ncbi Does parental ADHD bias maternal reports of ADHD symptoms in children?
    Stephen V Faraone
    Department of Psychiatry, Harvard Medical School at Massachusetts General Hospital, Boston 02114, USA
    J Consult Clin Psychol 71:168-75. 2003
    ..Results were similar across child gender or referral status. These results do not support the notion that parental ADHD affects maternal reports of offspring ADHD...
  94. ncbi Attention-deficit/hyperactivity disorder and sleep
    Eric Mick
    Pediatrics 110:850-2; author reply 850-2. 2002
  95. ncbi An open-label trial of aripiprazole monotherapy in children and adolescents with bipolar disorder
    Joseph Biederman
    Joint Program in Pediatric Psychopharmacology Research Office, Massachusetts General Hospital, Boston, MA 02114, USA
    CNS Spectr 12:683-9. 2007
    ..Aripiprazole is a novel second-generation antipsychotic approved for the treatment of bipolar disorder in adults but there is no systematic data available in pediatric bipolar disorder...
  96. ncbi Revisiting the association between attention-deficit/hyperactivity disorder and anxiety disorders: a familial risk analysis
    Ellen B Braaten
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114-3139, USA
    Biol Psychiatry 53:93-9. 2003
    ..CONCLUSIONS: These findings are most consistent with the hypothesis that ADHD and anxiety disorders segregate independently in families...
  97. ncbi Assessing the validity of the Quality of Life Enjoyment and Satisfaction Questionnaire Short Form in adults with ADHD
    Eric Mick
    Massachusetts General Hospital, Pediatric Psychopharmacology Research Unit, Boston MA 02114, USA
    J Atten Disord 11:504-9. 2008
    ..The authors assessed the psychometric properties of the Quality of Life Enjoyment and Satisfaction Questionnaire-Short Form (Q-LES-QSF) in adults with ADHD...
  98. ncbi Omega-3 fatty acid monotherapy for pediatric bipolar disorder: a prospective open-label trial
    Janet Wozniak
    Pediatric Psychopharmacology Research Unit, Massachusetts General Hospital, Boston, MA 02138, USA
    Eur Neuropsychopharmacol 17:440-7. 2007
    ..To test the effectiveness and safety of omega-3 fatty acids (Omegabrite(R) brand) in the treatment of pediatric bipolar disorder (BPD)...
  99. ncbi Genetics of attention deficit hyperactivity disorder
    Eric Mick
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Warren 705, 55 Fruit Street, Boston, MA 02114 2622, USA
    Child Adolesc Psychiatr Clin N Am 17:261-84, vii-viii. 2008
    ..These small effects emphasize the need for future candidate gene studies to implement strategies that will provide enough statistical power to detect such small effects...
  100. ncbi The age-dependent decline of attention deficit hyperactivity disorder: a meta-analysis of follow-up studies
    Stephen V Faraone
    Medical Genetics Research Program and Department of Psychiatry, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Psychol Med 36:159-65. 2006
    ..This study examined the persistence of attention deficit hyperactivity disorder (ADHD) into adulthood...
  101. ncbi Aripiprazole in the treatment of pediatric bipolar disorder: a systematic chart review
    Joseph Biederman
    Pediatric Psychopharmacology Research Office, Massachusetts General Hospital, Boston, MA 02114, USA
    CNS Spectr 10:141-8. 2005
    ..Pediatric bipolar disorder is a serious neuropsychiatric disorder associated with high levels of morbidity and disability...

Research Grants1

  1. Validating Pediatric Bipolar Disorder with Extant Data
    Eric Mick; Fiscal Year: 2007
    ..This systematic approach of research and training may lead to advances in early intervention and prevention of pediatric bipolar disorder. ..