Alan M Michelson

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi A new turn (or two) for twist
    A M Michelson
    Howard Hughes Medical Institute, Brigham and Women s Hospital, Boston, MA 02115, USA
    Science 272:1449-50. 1996
  2. ncbi Running interference for hedgehog signaling
    Alan M Michelson
    Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women s Hospital, 20 Shattuck Street, Boston, MA 02115, USA
    Sci STKE 2003:PE30. 2003
  3. ncbi Dual functions of the heartless fibroblast growth factor receptor in development of the Drosophila embryonic mesoderm
    A M Michelson
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Dev Genet 22:212-29. 1998
  4. ncbi Heartbroken is a specific downstream mediator of FGF receptor signalling in Drosophila
    A M Michelson
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02115, USA
    Development 125:4379-89. 1998
  5. pmc Deciphering genetic regulatory codes: a challenge for functional genomics
    Alan M Michelson
    Howard Hughes Medical Institute, Division of Genetics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 20 Shattuck Street, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:546-8. 2002
  6. ncbi heartless encodes a fibroblast growth factor receptor (DFR1/DFGF-R2) involved in the directional migration of early mesodermal cells in the Drosophila embryo
    S Gisselbrecht
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 10:3003-17. 1996
  7. pmc The MARVEL domain protein, Singles Bar, is required for progression past the pre-fusion complex stage of myoblast fusion
    Beatriz Estrada
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Dev Biol 307:328-39. 2007
  8. ncbi The transmembrane protein Perdido interacts with Grip and integrins to mediate myotube projection and attachment in the Drosophila embryo
    Beatriz Estrada
    Division of Genetics, Department of Medicine, Brigham, MA 02115, USA
    Development 134:4469-78. 2007
  9. pmc An integrated strategy for analyzing the unique developmental programs of different myoblast subtypes
    Beatriz Estrada
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    PLoS Genet 2:e16. 2006
  10. ncbi Ras pathway specificity is determined by the integration of multiple signal-activated and tissue-restricted transcription factors
    M S Halfon
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School and Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
    Cell 103:63-74. 2000

Collaborators

Detail Information

Publications23

  1. ncbi A new turn (or two) for twist
    A M Michelson
    Howard Hughes Medical Institute, Brigham and Women s Hospital, Boston, MA 02115, USA
    Science 272:1449-50. 1996
  2. ncbi Running interference for hedgehog signaling
    Alan M Michelson
    Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women s Hospital, 20 Shattuck Street, Boston, MA 02115, USA
    Sci STKE 2003:PE30. 2003
    ..The results not only suggest unexpected overlap in the Hh and Wingless (Wg) pathways, but also provide proof of principle for the development of high-throughput assays using RNAi techniques...
  3. ncbi Dual functions of the heartless fibroblast growth factor receptor in development of the Drosophila embryonic mesoderm
    A M Michelson
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Dev Genet 22:212-29. 1998
    ..Finally, parallels between requirements for FGFR signaling in Drosophila and vertebrate mesoderm development are considered...
  4. ncbi Heartbroken is a specific downstream mediator of FGF receptor signalling in Drosophila
    A M Michelson
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02115, USA
    Development 125:4379-89. 1998
    ..A strong heartbroken allele also suppresses the effects of hyperactivated FGF but not EGF receptors. Thus, heartbroken may contribute to the specificity of developmental responses elicited by FGF receptor signalling...
  5. pmc Deciphering genetic regulatory codes: a challenge for functional genomics
    Alan M Michelson
    Howard Hughes Medical Institute, Division of Genetics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 20 Shattuck Street, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:546-8. 2002
  6. ncbi heartless encodes a fibroblast growth factor receptor (DFR1/DFGF-R2) involved in the directional migration of early mesodermal cells in the Drosophila embryo
    S Gisselbrecht
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 10:3003-17. 1996
    ..These studies establish that Htl signaling provides a vital connection between initial formation of the embryonic mesoderm in Drosophila and subsequent cell-fate specification within this germ layer...
  7. pmc The MARVEL domain protein, Singles Bar, is required for progression past the pre-fusion complex stage of myoblast fusion
    Beatriz Estrada
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Dev Biol 307:328-39. 2007
    ....
  8. ncbi The transmembrane protein Perdido interacts with Grip and integrins to mediate myotube projection and attachment in the Drosophila embryo
    Beatriz Estrada
    Division of Genetics, Department of Medicine, Brigham, MA 02115, USA
    Development 134:4469-78. 2007
    ....
  9. pmc An integrated strategy for analyzing the unique developmental programs of different myoblast subtypes
    Beatriz Estrada
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    PLoS Genet 2:e16. 2006
    ..This integrated strategy for examining embryonic gene expression and function provides a substantially expanded framework for further studies of this model developmental system...
  10. ncbi Ras pathway specificity is determined by the integration of multiple signal-activated and tissue-restricted transcription factors
    M S Halfon
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School and Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
    Cell 103:63-74. 2000
    ..The integration of Pointed with the combinatorial effects of dTCF, Mad, Twist, and Tinman determines inductive Ras signaling specificity in muscle and heart development...
  11. ncbi Heparan sulfate proteoglycans are essential for FGF receptor signaling during Drosophila embryonic development
    X Lin
    Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Development 126:3715-23. 1999
    ....
  12. pmc A genomic approach to myoblast fusion in Drosophila
    Beatriz Estrada
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Methods Mol Biol 475:299-314. 2008
    ..This experimental strategy led to the identification of several previously uncharacterized genes required for myoblast fusion in Drosophila...
  13. pmc Expression-guided in silico evaluation of candidate cis regulatory codes for Drosophila muscle founder cells
    Anthony A Philippakis
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    PLoS Comput Biol 2:e53. 2006
    ..We have confirmed this hypothesis by experimentally discovering six (out of 12 tested) new CRMs driving expression in the embryonic mesoderm, four of which drive expression in founder cells...
  14. ncbi Signalling by the Drosophila epidermal growth factor receptor is required for the specification and diversification of embryonic muscle progenitors
    E Buff
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02115, USA
    Development 125:2075-86. 1998
    ..Thus, the epidermal growth factor receptor contributes both to muscle progenitor specification and to the diversification of muscle identities...
  15. ncbi New fluorescent protein reporters for use with the Drosophila Gal4 expression system and for vital detection of balancer chromosomes
    Marc S Halfon
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital and Howard Hughes Medical Institute, Boston, Massachusetts, USA
    Genesis 34:135-8. 2002
  16. ncbi Muscle pattern diversification in Drosophila is determined by the autonomous function of homeotic genes in the embryonic mesoderm
    A M Michelson
    Department of Medicine, Brigham and Women s Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA
    Development 120:755-68. 1994
    ..Finally, these experiments reveal that homeotic cues specific to both the mesoderm and the ectoderm cooperate to specify the pattern of muscle attachment sites...
  17. pmc Preferred analysis methods for Affymetrix GeneChips revealed by a wholly defined control dataset
    Sung E Choe
    Department of Genetics, Harvard Medical School, New Research Building, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Genome Biol 6:R16. 2005
    ..As more methods are developed to analyze RNA-profiling data, assessing their performance using control datasets becomes increasingly important...
  18. pmc Computation-based discovery of related transcriptional regulatory modules and motifs using an experimentally validated combinatorial model
    Marc S Halfon
    Howard Hughes Medical Institute and Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Genome Res 12:1019-28. 2002
    ....
  19. ncbi Exploring genetic regulatory networks in metazoan development: methods and models
    Marc S Halfon
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital and Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
    Physiol Genomics 10:131-43. 2002
    ....
  20. ncbi Regulation of Pax6 expression is conserved between mice and flies
    P X Xu
    Division of Genetics, Department of Medicine and Howard Hughes Medical Institute, Brigham and Women s Hospital and Harvard Medical School, Boston MA 02115, USA
    Development 126:383-95. 1999
    ..These results suggest that in addition to conservation of Pax6 function, the upstream regulation of Pax6 has also been conserved during evolution...
  21. pmc Highly parallel assays of tissue-specific enhancers in whole Drosophila embryos
    Stephen S Gisselbrecht
    Department of Medicine, Division of Genetics, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Methods 10:774-80. 2013
    ..Application of eFS to other cell types and organisms should accelerate the cataloging of enhancers and understanding how transcriptional regulation is encoded in them. ..
  22. ncbi Reciprocal regulatory interactions between the Notch and Ras signaling pathways in the Drosophila embryonic mesoderm
    Ana Carmena
    Program in Molecular Biology, Memorial Sloan Kettering Cancer Institute, New York, New York 10021, USA
    Dev Biol 244:226-42. 2002
    ..These reciprocal interactions combine to generate the signal thresholds that are essential for proper specification of progenitors and nonprogenitors from groups of initially equivalent cells...
  23. pmc Biological code breaking in the 21st century
    Alan M Michelson
    Mol Syst Biol 2:2006.0018. 2006