DANIEL MERFELD

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Humans use internal models to estimate gravity and linear acceleration
    D M Merfeld
    Neurological Sciences Institute, Oregon Health Sciences University, Portland 97209, USA
    Nature 398:615-8. 1999
  2. pmc Potential solutions to several vestibular challenges facing clinicians
    Daniel M Merfeld
    Jenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    J Vestib Res 20:71-7. 2010
  3. doi request reprint Replacing semicircular canal function with a vestibular implant
    Daniel M Merfeld
    Jenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
    Curr Opin Otolaryngol Head Neck Surg 20:386-92. 2012
  4. pmc Alignment of angular velocity sensors for a vestibular prosthesis
    Jack DiGiovanna
    Neuroprosthetics Control Group Automatic Control Lab, ETH Zurich, Physikstrasse 3, ETL k24, 8092 Zurich, Switzerland
    J Neuroeng Rehabil 9:14. 2012
  5. pmc Frequency dependence of vestibuloocular reflex thresholds
    Csilla Haburcakova
    Jenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear Infirmary, and Otology and Laryngology, Harvard Medical School, Boston, Massachusetts, USA
    J Neurophysiol 107:973-83. 2012
  6. pmc Signal detection theory and vestibular thresholds: I. Basic theory and practical considerations
    Daniel M Merfeld
    Jenks Vestibular Research Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA, USA
    Exp Brain Res 210:389-405. 2011
  7. ncbi request reprint Chronic vestibulo-ocular reflexes evoked by a vestibular prosthesis
    Daniel M Merfeld
    Jenks Vestibular Physiology Lab, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    IEEE Trans Biomed Eng 54:1005-15. 2007
  8. ncbi request reprint Acclimation to chronic constant-rate peripheral stimulation provided by a vestibular prosthesis
    Daniel M Merfeld
    Jenks Vestibular Physiology Lab, Massachusetts Eye and Ear Infirmary, Room 421, 243 Charles Street, Boston, MA 02114, USA
    IEEE Trans Biomed Eng 53:2362-72. 2006
  9. ncbi request reprint Vestibular perception and action employ qualitatively different mechanisms. II. VOR and perceptual responses during combined Tilt&Translation
    Daniel M Merfeld
    Jenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear Infirmary, Room 421, MEEI, 243 Charles St, Boston, Massachusetts 02114, USA
    J Neurophysiol 94:199-205. 2005
  10. ncbi request reprint Neural processing of gravito-inertial cues in humans. II. Influence of the semicircular canals during eccentric rotation
    D M Merfeld
    Jenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurophysiol 85:1648-60. 2001

Detail Information

Publications26

  1. ncbi request reprint Humans use internal models to estimate gravity and linear acceleration
    D M Merfeld
    Neurological Sciences Institute, Oregon Health Sciences University, Portland 97209, USA
    Nature 398:615-8. 1999
    ..These measured responses are consistent with our internal model predictions that the nervous system can develop a non-zero estimate of linear acceleration even when no true linear acceleration is present...
  2. pmc Potential solutions to several vestibular challenges facing clinicians
    Daniel M Merfeld
    Jenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    J Vestib Res 20:71-7. 2010
    ..While electrical stimulation is a standard means of stimulation, optical stimulation is also being investigated as a way to improve prosthetic stimulation specificity...
  3. doi request reprint Replacing semicircular canal function with a vestibular implant
    Daniel M Merfeld
    Jenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
    Curr Opin Otolaryngol Head Neck Surg 20:386-92. 2012
    ..The review is timely because of the recent advances in the field and because MED-EL has recently announced that they are developing a vestibular implant for clinical applications...
  4. pmc Alignment of angular velocity sensors for a vestibular prosthesis
    Jack DiGiovanna
    Neuroprosthetics Control Group Automatic Control Lab, ETH Zurich, Physikstrasse 3, ETL k24, 8092 Zurich, Switzerland
    J Neuroeng Rehabil 9:14. 2012
    ..We benchmarked the method with simulated movements and obtain proof-of-concept with one healthy subject. The method was robust to misalignment, required little data, and minimal processing...
  5. pmc Frequency dependence of vestibuloocular reflex thresholds
    Csilla Haburcakova
    Jenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear Infirmary, and Otology and Laryngology, Harvard Medical School, Boston, Massachusetts, USA
    J Neurophysiol 107:973-83. 2012
    ....
  6. pmc Signal detection theory and vestibular thresholds: I. Basic theory and practical considerations
    Daniel M Merfeld
    Jenks Vestibular Research Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA, USA
    Exp Brain Res 210:389-405. 2011
    ..One-interval recognition is generally favored over two-interval recognition because it assesses vestibular bias and can require substantially less time than two-interval tasks...
  7. ncbi request reprint Chronic vestibulo-ocular reflexes evoked by a vestibular prosthesis
    Daniel M Merfeld
    Jenks Vestibular Physiology Lab, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    IEEE Trans Biomed Eng 54:1005-15. 2007
    ..This suggests that long-term functional replacement of absent vestibular function is feasible...
  8. ncbi request reprint Acclimation to chronic constant-rate peripheral stimulation provided by a vestibular prosthesis
    Daniel M Merfeld
    Jenks Vestibular Physiology Lab, Massachusetts Eye and Ear Infirmary, Room 421, 243 Charles Street, Boston, MA 02114, USA
    IEEE Trans Biomed Eng 53:2362-72. 2006
    ..In fact, after many such off-to-on or on-to-off transitions, little nystagmus was evoked by turning the stimulation on or off. These findings show that the brain acclimates to constant-rate stimulation...
  9. ncbi request reprint Vestibular perception and action employ qualitatively different mechanisms. II. VOR and perceptual responses during combined Tilt&Translation
    Daniel M Merfeld
    Jenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear Infirmary, Room 421, MEEI, 243 Charles St, Boston, Massachusetts 02114, USA
    J Neurophysiol 94:199-205. 2005
    ..We conclude that internal models govern human perception of tilt and translation at 0.8 Hz and that high-pass filtering governs the human translational VOR at this same frequency...
  10. ncbi request reprint Neural processing of gravito-inertial cues in humans. II. Influence of the semicircular canals during eccentric rotation
    D M Merfeld
    Jenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurophysiol 85:1648-60. 2001
    ..More generally, these findings are consistent with the hypothesis that the nervous system uses internal models to process and interpret sensory motor cues...
  11. ncbi request reprint Neural processing of gravitoinertial cues in humans. III. Modeling tilt and translation responses
    D M Merfeld
    Department of Otology and Laryngology, Jenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    J Neurophysiol 87:819-33. 2002
    ..Therefore these modeled response characteristics are consistent with available data and with the hypothesis that the nervous system uses internal models to estimate tilt and translation in the presence of ambiguous sensory cues...
  12. ncbi request reprint Vestibular perception and action employ qualitatively different mechanisms. I. Frequency response of VOR and perceptual responses during Translation and Tilt
    Daniel M Merfeld
    Jenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear Infirmary, Room 421, MEEI, 243 Charles St, Boston, Massachusetts 02114, USA
    J Neurophysiol 94:186-98. 2005
    ..2 hz...
  13. ncbi request reprint Rotation otolith tilt-translation reinterpretation (ROTTR) hypothesis: a new hypothesis to explain neurovestibular spaceflight adaptation
    Daniel M Merfeld
    Jenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear Infirmary, USA
    J Vestib Res 13:309-20. 2003
    ....
  14. pmc Electrical stimulation of semicircular canal afferents affects the perception of head orientation
    Richard F Lewis
    Jenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Neurosci 33:9530-5. 2013
    ....
  15. ncbi request reprint System design and performance of a unilateral horizontal semicircular canal prosthesis
    Wangsong Gong
    Department of Otology and Laryngology, Harvard Medical School and the Jenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear Infirmary, Boston 02114, USA
    IEEE Trans Biomed Eng 49:175-81. 2002
    ..The experiments also show that the nervous system adapts to the artificial rotational cue provided via electrical stimulation...
  16. pmc Interaural self-motion linear velocity thresholds are shifted by roll vection
    Lionel H Zupan
    Department of Otology and Laryngology, Harvard Medical School, Boston, MA, USA
    Exp Brain Res 191:505-11. 2008
    ..005) and is consistent with the prediction that illusory tilt should be accompanied by a non-zero neural estimate of linear velocity that, if large enough (supra-threshold), contributes to translation perception...
  17. ncbi request reprint Origin of orientation-dependent asymmetries in vestibulo-ocular reflexes evoked by caloric stimulation
    Robert J Peterka
    Neurological Sciences Institute, OHSU West Campus, Building 1, 505 NW 185th Ave, Beaverton, OR 97006, USA
    J Neurophysiol 92:2333-45. 2004
    ..These components evoke a horizontal angular VOR and linear VOR, which combine additively in the supine orientation, but subtract in the prone orientation, thus accounting for the majority of the observed prone/supine asymmetry...
  18. pmc Roll tilt psychophysics in rhesus monkeys during vestibular and visual stimulation
    Richard F Lewis
    Department of Otolaryngology, Harvard Medical School, Boston, Massachusetts, USA
    J Neurophysiol 100:140-53. 2008
    ....
  19. pmc Human ocular torsion and perceived roll responses to linear acceleration
    Lionel H Zupan
    Jenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    J Vestib Res 15:173-83. 2005
    ..In conclusion, OT and PR appear governed by qualitatively different neural mechanisms. OT appears mostly influenced by central low-pass filtering of interaural graviceptor cues, while PR appears mostly influenced by roll tilt of the GIF...
  20. pmc Roll rotation cues influence roll tilt perception assayed using a somatosensory technique
    Sukyung Park
    Jenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear Infirmary, Havard Medical School, Boston, MA 02114, USA
    J Neurophysiol 96:486-91. 2006
    ..Specifically, rotational cues provided by the semicircular canals help the CNS resolve ambiguous otolith cues during head tilt, yielding more accurate tilt perception...
  21. ncbi request reprint Vestibular adaptation studied with a prosthetic semicircular canal
    Richard F Lewis
    Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02114, USA
    J Vestib Res 12:87-94. 2002
    ..The results provided by this pilot study suggest that it may be feasible to study central adaptation by chronically modifying the afferent vestibular cue with a prosthetic semicircular canal...
  22. pmc Vestibuloocular reflex adaptation investigated with chronic motion-modulated electrical stimulation of semicircular canal afferents
    Richard F Lewis
    Department of Otolaryngology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston MA 02114, USA
    J Neurophysiol 103:1066-79. 2010
    ..These results demonstrate that the brain can adaptively modify the gain, axis, and symmetry of the VOR when provided with chronic motion-modulated electrical stimulation by a canal prosthesis...
  23. pmc Vestibulo-ocular responses evoked via bilateral electrical stimulation of the lateral semicircular canals
    Wangsong Gong
    Jenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    IEEE Trans Biomed Eng 55:2608-19. 2008
    ..However, at least for short-term stimulation such as that studied herein, no inherent advantage in terms of the response time constant ("velocity storage") was found...
  24. ncbi request reprint Tilt psychophysics measured in nonhuman primates
    Richard F Lewis
    Department of Otology and Laryngology, Harvard Medical School, Jenks Vestibular Physiology Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston MA 02114, USA
    Ann N Y Acad Sci 1039:294-305. 2005
    ..This new methodology sets the stage for innovative experimental approaches that will help to elucidate the neural mechanisms underlying the perception of spatial orientation...
  25. pmc Visual mental imagery during caloric vestibular stimulation
    Fred W Mast
    Harvard University, Department of Psychology, Cambridge, MA, USA
    Neuropsychologia 44:101-9. 2006
    ..In contrast, such stimulation did not affect performance of a low-imagery control task. These data document previously unsuspected interactions between the vestibular system and the high-level visual system...
  26. doi request reprint Vestibular thresholds for yaw rotation about an earth-vertical axis as a function of frequency
    Luzia Grabherr
    Department of Psychology, University of Lausanne, B√Ętiment Anthropole, 1015 Lausanne, Switzerland
    Exp Brain Res 186:677-81. 2008
    ..71 deg s(-1) and a cut-off frequency of 0.23 Hz, which corresponds to a time constant of approximately 0.70 s. These findings provide no evidence for an influence of velocity storage on perceptual yaw rotation thresholds...

Research Grants18

  1. Vestibular thresholds, including psychophysical response dynamics
    DANIEL MERFELD; Fiscal Year: 2009
    ..Therefore, the clinical goal for the research proposed herein is to establish precise efficient methods to quantify motion perception in general and, more specifically, to assay perceptual thresholds. ..
  2. Development of semicircular canal prostheses for studies of vestibular plasticity
    DANIEL MERFELD; Fiscal Year: 2009
    ..abstract_text> ..
  3. Development of semicircular canal prostheses for studies of vestibular plasticity
    DANIEL MERFELD; Fiscal Year: 2007
    ....
  4. Decoding graviceptors, sensory and non-sensory influence
    DANIEL MERFELD; Fiscal Year: 2007
    ..3) Investigate the influence of efferent copy and neck receptor cues on the neural processes by which ambiguous otolith cues yield tilt and/or translation responses. ..
  5. Adaptation to controlled vestibular stimulation
    DANIEL MERFELD; Fiscal Year: 2005
    ..All of these proposed specific aims will be investigated by measuring changes in the vestibulo-ocular responses induced by changes in chronic, patterned, electrical stimulation of the peripheral vestibular system. ..
  6. DECODING OF GRAVICEPTOR CUES, INCLUDING ADAPTIVE CHANGES
    DANIEL MERFELD; Fiscal Year: 2003
    ..The experimental specific aims will be addressed by measuring eye movements and perceptual responses. The modeling specific aim will be addressed using numerical computer simulations. ..
  7. Vestibular thresholds, including psychophysical response dynamics
    Daniel M Merfeld; Fiscal Year: 2010
    ..Therefore, the clinical goal for the research proposed herein is to establish precise efficient methods to quantify motion perception in general and, more specifically, to assay perceptual thresholds. ..