Arthur M Mercurio

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc p53 inhibits alpha 6 beta 4 integrin survival signaling by promoting the caspase 3-dependent cleavage of AKT/PKB
    R E Bachelder
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Cell Biol 147:1063-72. 1999
  2. pmc Protein kinase C-dependent mobilization of the alpha6beta4 integrin from hemidesmosomes and its association with actin-rich cell protrusions drive the chemotactic migration of carcinoma cells
    I Rabinovitz
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Cell Biol 146:1147-60. 1999
  3. ncbi request reprint Autocrine signaling in carcinoma: VEGF and the alpha6beta4 integrin
    Arthur M Mercurio
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Semin Cancer Biol 14:115-22. 2004
  4. ncbi request reprint Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression
    Elizabeth A Lipscomb
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Cancer Metastasis Rev 24:413-23. 2005
  5. ncbi request reprint The Met receptor and alpha 6 beta 4 integrin can function independently to promote carcinoma invasion
    Jun Chung
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 279:32287-93. 2004
  6. ncbi request reprint Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells
    Robin E Bachelder
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Cancer Res 63:5230-3. 2003
  7. ncbi request reprint Hypoxia stimulates carcinoma invasion by stabilizing microtubules and promoting the Rab11 trafficking of the alpha6beta4 integrin
    Sang Oh Yoon
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Res 65:2761-9. 2005
  8. pmc Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma
    Richard C Bates
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 115:339-47. 2005
  9. ncbi request reprint Altered localization of p120 catenin during epithelial to mesenchymal transition of colon carcinoma is prognostic for aggressive disease
    David I Bellovin
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 65:10938-45. 2005
  10. ncbi request reprint The epithelial-mesenchymal transition (EMT) and colorectal cancer progression
    Richard C Bates
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachussetts, USA
    Cancer Biol Ther 4:365-70. 2005

Collaborators

Detail Information

Publications37

  1. pmc p53 inhibits alpha 6 beta 4 integrin survival signaling by promoting the caspase 3-dependent cleavage of AKT/PKB
    R E Bachelder
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Cell Biol 147:1063-72. 1999
    ..These studies demonstrate that the p53 tumor suppressor can inhibit integrin-associated survival signaling pathways...
  2. pmc Protein kinase C-dependent mobilization of the alpha6beta4 integrin from hemidesmosomes and its association with actin-rich cell protrusions drive the chemotactic migration of carcinoma cells
    I Rabinovitz
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Cell Biol 146:1147-60. 1999
    ....
  3. ncbi request reprint Autocrine signaling in carcinoma: VEGF and the alpha6beta4 integrin
    Arthur M Mercurio
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Semin Cancer Biol 14:115-22. 2004
    ....
  4. ncbi request reprint Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression
    Elizabeth A Lipscomb
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Cancer Metastasis Rev 24:413-23. 2005
    ....
  5. ncbi request reprint The Met receptor and alpha 6 beta 4 integrin can function independently to promote carcinoma invasion
    Jun Chung
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 279:32287-93. 2004
    ..These data argue that the invasive function of Met can be independent of alpha(6)beta(4) and that alpha(6)beta(4) has a generic influence on the invasion of carcinoma cells that is not specific to Met...
  6. ncbi request reprint Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells
    Robin E Bachelder
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Cancer Res 63:5230-3. 2003
    ..Our findings lead to the surprising conclusion that opposing autocrine loops involving NP1 regulate the chemotaxis of breast carcinoma cells. Moreover, our data indicate a novel autocrine function for VEGF in chemotaxis...
  7. ncbi request reprint Hypoxia stimulates carcinoma invasion by stabilizing microtubules and promoting the Rab11 trafficking of the alpha6beta4 integrin
    Sang Oh Yoon
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Res 65:2761-9. 2005
    ..This increase is dependent on Rab11 and stable microtubules. In summary, we identify vesicle trafficking as a novel target of hypoxic stimulation that is important for tumor invasion...
  8. pmc Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma
    Richard C Bates
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 115:339-47. 2005
    ..These findings define the alphavbeta6 integrin as an important risk factor for early-stage disease and a novel therapeutic candidate for colorectal cancer...
  9. ncbi request reprint Altered localization of p120 catenin during epithelial to mesenchymal transition of colon carcinoma is prognostic for aggressive disease
    David I Bellovin
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 65:10938-45. 2005
    ..These data provide a compelling argument for the importance of both p120ctn and the EMT itself in the progression of colorectal carcinoma...
  10. ncbi request reprint The epithelial-mesenchymal transition (EMT) and colorectal cancer progression
    Richard C Bates
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachussetts, USA
    Cancer Biol Ther 4:365-70. 2005
    ..Thus, the EMT appears to be an integral component of colorectal cancer progression and its analysis can yield novel targets for prognosis and therapy...
  11. ncbi request reprint Ras stimulation of E2F activity and a consequent E2F regulation of integrin alpha6beta4 promote the invasion of breast carcinoma cells
    Sang Oh Yoon
    Division of Cancer Biology and Angiogenesis, Department of Pathology Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 66:6288-95. 2006
    ..This mechanism links active H-Ras, transcriptionally active E2F, and the alpha6beta4 integrin in a common pathway that culminates in enhanced alpha6beta4-dependent invasion...
  12. ncbi request reprint The epithelial-mesenchymal transition of colon carcinoma involves expression of IL-8 and CXCR-1-mediated chemotaxis
    Richard C Bates
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston MA 02215, USA
    Exp Cell Res 299:315-24. 2004
    ..These studies establish that the regulated expression of a specific chemokine and its receptor are linked to the EMT and they provide a biochemical framework for understanding the mechanisms by which the EMT promotes migration...
  13. ncbi request reprint Hypoxia-induced vascular endothelial growth factor transcription and protection from apoptosis are dependent on alpha6beta1 integrin in breast carcinoma cells
    Jun Chung
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Cancer Res 64:4711-6. 2004
    ....
  14. ncbi request reprint The alpha6beta4 integrin maintains the survival of human breast carcinoma cells in vivo
    Elizabeth A Lipscomb
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Res 65:10970-6. 2005
    ..Taken together, these data implicate the alpha6beta4 integrin in tumor formation by regulating tumor cell survival in a VEGF-dependent manner...
  15. pmc Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells
    Jun Chung
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Cell Biol 158:165-74. 2002
    ..These findings reveal that integrin-mediated activation of PI-3K-Akt is amplified by integrin-stimulated VEGF expression and they provide a mechanism that substantiates the reported role of alpha 6 beta 4 in carcinoma progression...
  16. pmc Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition
    Robin E Bachelder
    Department of Pathology, Division of Cancer Biology and Angiogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Cell Biol 168:29-33. 2005
    ..These findings indicate that epithelial cells must sustain activation of a specific kinase to impede a mesenchymal transition...
  17. ncbi request reprint Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4
    Robin E Bachelder
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Res 62:7203-6. 2002
    ..Our findings indicate that a VEGF autocrine pathway induces chemokine receptor expression in breast carcinoma cells, thus promoting their directed migration toward specific chemokines...
  18. ncbi request reprint Flt-1-dependent survival characterizes the epithelial-mesenchymal transition of colonic organoids
    Richard C Bates
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Curr Biol 13:1721-7. 2003
    ..A role for Flt-1 in cell survival is unprecedented and has significant implications for Flt-1 function in tumor progression, as well as in other biological processes, including angiogenesis and development...
  19. pmc Protein kinase C-alpha phosphorylation of specific serines in the connecting segment of the beta 4 integrin regulates the dynamics of type II hemidesmosomes
    Isaac Rabinovitz
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 24:4351-60. 2004
    ....
  20. ncbi request reprint Use of RNA interference to inhibit integrin (alpha6beta4)-mediated invasion and migration of breast carcinoma cells
    Elizabeth A Lipscomb
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Clin Exp Metastasis 20:569-76. 2003
    ..Furthermore, these data suggest that the utilization of siRNA oligonucleotides to reduce the expression of the alpha6beta4 integrin may be a useful approach to prevent carcinoma cell progression...
  21. ncbi request reprint Functional analysis of the contribution of RhoA and RhoC GTPases to invasive breast carcinoma
    Kaylene J Simpson
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston Massachusetts 02215, USA
    Cancer Res 64:8694-701. 2004
    ..Unexpectedly, this analysis also revealed a compensatory relationship between RhoA and RhoC at the level of both their expression and activation, and a reciprocal relationship between RhoA and Rac1 activation...
  22. ncbi request reprint Invasive skin carcinoma--Ras and alpha6beta4 integrin lead the way
    Arthur M Mercurio
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Cancer Cell 3:201-2. 2003
    ....
  23. ncbi request reprint Contributions of the alpha6 integrins to breast carcinoma survival and progression
    Jun Chung
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Cells 17:203-9. 2004
    ..VEGF produced by breast carcinoma cells in response to alpha6 integrin regulation can function in an autocrine manner to promote survival signaling...
  24. doi request reprint IMP3, a new biomarker to predict progression of cervical intraepithelial neoplasia into invasive cancer
    Di Lu
    Department of Pathology, Division of Preventive and Behavioral Medicine, University of Massachusetts Medical Center, Worcester, USA
    Am J Surg Pathol 35:1638-45. 2011
    ..IMP3 plays a critical role in the development of invasive SCC from cervical dysplasia. IMP3 can be used at the time of initial diagnosis of CIN to identify a group of patients with an increased chance of developing invasive cancer...
  25. pmc Lessons from the alpha2 integrin knockout mouse
    Arthur M Mercurio
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Pathol 161:3-6. 2002
  26. pmc Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids
    Richard C Bates
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Biol Cell 14:1790-800. 2003
    ..These results establish a novel role for the stroma in influencing EMT in colon carcinoma, and they identify a selective advantage to the stromal presence of infiltrating leukocytes in regulating malignant tumor progression...
  27. ncbi request reprint Epithelial-mesenchymal transition and colorectal cancer: gaining insights into tumor progression using LIM 1863 cells
    Richard C Bates
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Mass 01605 2324, USA
    Cells Tissues Organs 185:29-39. 2007
    ....
  28. ncbi request reprint The alpha6beta4 integrin can regulate ErbB-3 expression: implications for alpha6beta4 signaling and function
    Valentina Folgiero
    Molecular Oncogenesis Laboratory, Department of Experimental Oncology, Regina Elena Cancer Institute, Via della Messi d Oro 156, 00158 Rome, Italy
    Cancer Res 67:1645-52. 2007
    ..These findings provide one mechanism to account for the activation of PI3K by alpha(6)beta(4) and they also provide insight into the regulation of ErbB-3 in carcinoma cells...
  29. ncbi request reprint Intrinsic signaling functions of the beta4 integrin intracellular domain
    Keith D Merdek
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 282:30322-30. 2007
    ..These data also question the putative role of the beta4 intracellular domain as an "adaptor" for growth factor receptor signaling...
  30. doi request reprint Analysis of integrin beta4 expression in human breast cancer: association with basal-like tumors and prognostic significance
    Shaolei Lu
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Clin Cancer Res 14:1050-8. 2008
    ..Data on its expression and relevance to human carcinomas, however, are relatively scant. The aim of this study was to assess its expression and prognostic significance in human breast carcinomas...
  31. ncbi request reprint Non-angiogenic functions of VEGF in breast cancer
    Arthur M Mercurio
    Department of Cancer Biology and the Cancer Center, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Mammary Gland Biol Neoplasia 10:283-90. 2005
    ..These findings imply that VEGF and VEGF receptor-based therapeutics, in addition to targeting angiogenesis, may also target tumor cells directly...
  32. ncbi request reprint Expression of the beta 4 integrin subunit induces monocytic differentiation of 32D/v-Abl cells
    Annarita Morena
    Molecular Oncogenesis Laboratory, Regina Elena Cancer Institute, Via delle Messi d oro, Rome, Italy
    Blood 100:96-106. 2002
    ..Overall, the reported findings indicate that alpha 6 beta 4 integrin promotes growth arrest and differentiation by modulating Abl kinases and p73 protein pathway(s)...
  33. ncbi request reprint A role for ADAM12 in breast tumor progression and stromal cell apoptosis
    Marie Kveiborg
    Institute of Molecular Pathology, University of Copenhagen, Denmark
    Cancer Res 65:4754-61. 2005
    ..Together, these results show that the ability of ADAM12 to influence apoptosis may contribute to tumor progression...
  34. ncbi request reprint ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA
    Charles Kumar Thodeti
    Institute of Molecular Pathology, University of Copenhagen, Frederik V s vej 11, DK 2100, Copenhagen, Denmark
    J Biol Chem 278:9576-84. 2003
    ..In summary, these data provide novel insights into syndecan-4 signaling. Syndecan-4 can promote cell spreading in a beta(1) integrin-dependent fashion through PKCalpha and RhoA, and PKCalpha and RhoA likely function in separate pathways...
  35. ncbi request reprint Malignant transformation of human cells by constitutive expression of platelet-derived growth factor-BB
    Baskaran Govindarajan
    Department of Dermatology, Emory University School of Medicine and Veterans Affairs Hospital, Atlanta, Georgia 30322, USA
    J Biol Chem 280:13936-43. 2005
    ..Our model allows the assessment of epigenetic changes that occur during human carcinogenesis. In addition, these studies provide insight into the clinical failure of tyrosine kinase inhibitors as monotherapy for advanced malignancy...
  36. ncbi request reprint ADAM12 induces actin cytoskeleton and extracellular matrix reorganization during early adipocyte differentiation by regulating beta1 integrin function
    Nobuko Kawaguchi
    Institute of Molecular Pathology, University of Copenhagen, Frederik V s vej 11, 2100 Copenhagen, Denmark
    J Cell Sci 116:3893-904. 2003
    ..These events may be necessary for early adipocyte differentiation...
  37. pmc Proteases, extracellular matrix, and cancer: a workshop of the path B study section
    Yves A DeClerck
    Department of Pediatrics and Biochemistry, University of Southern California Keck School of Medicine and The Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, California 90027, USA
    Am J Pathol 164:1131-9. 2004
    ..This review article summarizes some of the most relevant findings made over the recent years that were discussed at a workshop organized by the Path B Study Section of the National Institutes of Health in October 2002...