A M Mercurio

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint The major non-integrin laminin binding protein of macrophages is identical to carbohydrate binding protein 35 (Mac-2)
    H J Woo
    Laboratory of Cancer Biology, New England Deaconess Hospital, Boston, Massachusetts 02115
    J Biol Chem 265:7097-9. 1990
  2. ncbi request reprint The alpha 6 beta 4 integrin and epithelial cell migration
    A M Mercurio
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Cell Biol 13:541-5. 2001
  3. ncbi request reprint The Met receptor and alpha 6 beta 4 integrin can function independently to promote carcinoma invasion
    Jun Chung
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 279:32287-93. 2004
  4. ncbi request reprint Ras stimulation of E2F activity and a consequent E2F regulation of integrin alpha6beta4 promote the invasion of breast carcinoma cells
    Sang Oh Yoon
    Division of Cancer Biology and Angiogenesis, Department of Pathology Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 66:6288-95. 2006
  5. ncbi request reprint Intrinsic signaling functions of the beta4 integrin intracellular domain
    Keith D Merdek
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 282:30322-30. 2007
  6. pmc Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells
    Jun Chung
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Cell Biol 158:165-74. 2002
  7. ncbi request reprint Towards a mechanistic understanding of tumor invasion--lessons from the alpha6beta 4 integrin
    A M Mercurio
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Semin Cancer Biol 11:129-41. 2001
  8. ncbi request reprint The metastatic odyssey: the integrin connection
    A M Mercurio
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Surg Oncol Clin N Am 10:313-28, viii-ix. 2001
  9. ncbi request reprint Integrin laminin receptors and breast carcinoma progression
    A M Mercurio
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Mammary Gland Biol Neoplasia 6:299-309. 2001
  10. pmc Lessons from the alpha2 integrin knockout mouse
    Arthur M Mercurio
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Pathol 161:3-6. 2002

Collaborators

Detail Information

Publications55

  1. ncbi request reprint The major non-integrin laminin binding protein of macrophages is identical to carbohydrate binding protein 35 (Mac-2)
    H J Woo
    Laboratory of Cancer Biology, New England Deaconess Hospital, Boston, Massachusetts 02115
    J Biol Chem 265:7097-9. 1990
    ..This murine galactose-specific lectin is the macrophage antigen Mac-2. Thus, these data suggest that the non-integrin LBPs may contribute to laminin adhesion by a mechanism involving protein-carbohydrate interactions...
  2. ncbi request reprint The alpha 6 beta 4 integrin and epithelial cell migration
    A M Mercurio
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Cell Biol 13:541-5. 2001
    ....
  3. ncbi request reprint The Met receptor and alpha 6 beta 4 integrin can function independently to promote carcinoma invasion
    Jun Chung
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 279:32287-93. 2004
    ..These data argue that the invasive function of Met can be independent of alpha(6)beta(4) and that alpha(6)beta(4) has a generic influence on the invasion of carcinoma cells that is not specific to Met...
  4. ncbi request reprint Ras stimulation of E2F activity and a consequent E2F regulation of integrin alpha6beta4 promote the invasion of breast carcinoma cells
    Sang Oh Yoon
    Division of Cancer Biology and Angiogenesis, Department of Pathology Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 66:6288-95. 2006
    ..This mechanism links active H-Ras, transcriptionally active E2F, and the alpha6beta4 integrin in a common pathway that culminates in enhanced alpha6beta4-dependent invasion...
  5. ncbi request reprint Intrinsic signaling functions of the beta4 integrin intracellular domain
    Keith D Merdek
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 282:30322-30. 2007
    ..These data also question the putative role of the beta4 intracellular domain as an "adaptor" for growth factor receptor signaling...
  6. pmc Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells
    Jun Chung
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Cell Biol 158:165-74. 2002
    ..These findings reveal that integrin-mediated activation of PI-3K-Akt is amplified by integrin-stimulated VEGF expression and they provide a mechanism that substantiates the reported role of alpha 6 beta 4 in carcinoma progression...
  7. ncbi request reprint Towards a mechanistic understanding of tumor invasion--lessons from the alpha6beta 4 integrin
    A M Mercurio
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Semin Cancer Biol 11:129-41. 2001
    ..Such studies have revealed novel insights into the mechanism of carcinoma invasion that involve both the dynamics of cell migration and signaling pathways that regulate this migration...
  8. ncbi request reprint The metastatic odyssey: the integrin connection
    A M Mercurio
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Surg Oncol Clin N Am 10:313-28, viii-ix. 2001
    ..Numerous studies have implicated these integrins in cancer progression and have provided a rationale for studying the mechanistic basis of their contribution to aggressive disease...
  9. ncbi request reprint Integrin laminin receptors and breast carcinoma progression
    A M Mercurio
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Mammary Gland Biol Neoplasia 6:299-309. 2001
    ..Recent work by our group and others on mechanisms of breast carcinoma invasion and survival that are influenced by the alpha6 integrins are discussed...
  10. pmc Lessons from the alpha2 integrin knockout mouse
    Arthur M Mercurio
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Pathol 161:3-6. 2002
  11. pmc Intestinal restitution: progression of actin cytoskeleton rearrangements and integrin function in a model of epithelial wound healing
    M M Lotz
    Department of Medicine, Gastroenterology Division, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Am J Pathol 156:985-96. 2000
    ..The alpha6 integrins, particularly alpha6beta4, help contain retraction and both the alpha6 integrins and alpha3beta1 integrin contribute to lamellae formation...
  12. ncbi request reprint Vascular endothelial growth factor is an autocrine survival factor for neuropilin-expressing breast carcinoma cells
    R E Bachelder
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Cancer Res 61:5736-40. 2001
    ..The identification of this VEGF autocrine signaling pathway has important implications for tumor metastasis and therapeutic intervention...
  13. ncbi request reprint Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression
    Elizabeth A Lipscomb
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Cancer Metastasis Rev 24:413-23. 2005
    ....
  14. ncbi request reprint Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion
    L M Shaw
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Cell 91:949-60. 1997
    ..The small G protein Rac is required downstream of PI3K for invasion. These studies define a mechanism by which the alpha6beta4 integrin promotes carcinoma invasion and invoke a novel function for PI3K signaling...
  15. pmc Protein kinase C-dependent mobilization of the alpha6beta4 integrin from hemidesmosomes and its association with actin-rich cell protrusions drive the chemotactic migration of carcinoma cells
    I Rabinovitz
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Cell Biol 146:1147-60. 1999
    ....
  16. pmc Traction forces mediated by alpha6beta4 integrin: implications for basement membrane organization and tumor invasion
    I Rabinovitz
    Department of Pathology, Division of Cancer Biology and Angiogenesis, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Mol Biol Cell 12:4030-43. 2001
    ..Importantly, we demonstrate remodeling of a native BM by epithelial cells and the involvement of alpha6beta4 in this remodeling. Our findings have important implications for the mechanism of both BM organization and tumor invasion...
  17. ncbi request reprint Activation of the p21 pathway of growth arrest and apoptosis by the beta 4 integrin cytoplasmic domain
    A S Clarke
    Laboratory of Cancer Biology, Deaconess Hospital, Boston, Massachusetts, USA
    J Biol Chem 270:22673-6. 1995
    ..These data suggest that the beta 4 integrin cytoplasmic domain is linked to a signaling pathway involved in cell cycle regulation in the beta 4 transfected RKO cells...
  18. pmc p53 inhibits alpha 6 beta 4 integrin survival signaling by promoting the caspase 3-dependent cleavage of AKT/PKB
    R E Bachelder
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Cell Biol 147:1063-72. 1999
    ..These studies demonstrate that the p53 tumor suppressor can inhibit integrin-associated survival signaling pathways...
  19. ncbi request reprint Hypoxia-induced vascular endothelial growth factor transcription and protection from apoptosis are dependent on alpha6beta1 integrin in breast carcinoma cells
    Jun Chung
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Cancer Res 64:4711-6. 2004
    ....
  20. ncbi request reprint The epithelial-mesenchymal transition (EMT) and colorectal cancer progression
    Richard C Bates
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachussetts, USA
    Cancer Biol Ther 4:365-70. 2005
    ..Thus, the EMT appears to be an integral component of colorectal cancer progression and its analysis can yield novel targets for prognosis and therapy...
  21. ncbi request reprint Reciprocal regulation of RhoA and RhoC characterizes the EMT and identifies RhoC as a prognostic marker of colon carcinoma
    D I Bellovin
    Division of Cancer Biology and Angiogenesis, Department of Pathology Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Oncogene 25:6959-67. 2006
    ..These data provide one mechanism for how RhoC expression is regulated in colon carcinoma and substantiate its utility as a prognostic marker...
  22. ncbi request reprint Inside-out integrin signaling in macrophages. Analysis of the role of the alpha 6A beta 1 and alpha 6B beta 1 integrin variants in laminin adhesion by cDNA expression in an alpha 6 integrin-deficient macrophage cell line
    L M Shaw
    Program in Cell and Developmental Biology, Harvard Medical School, Boston, Massachusetts 02115
    J Biol Chem 268:11401-8. 1993
    ..The data presented also demonstrate clearly that the alpha 6A and alpha 6B cytoplasmic domains do not differ in their ability to be regulated by PMA...
  23. ncbi request reprint Protein kinase A regulates Rac and is required for the growth factor-stimulated migration of carcinoma cells
    A M Mercurio
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 276:47895-900. 2001
    ..A novel implication of these findings is that carcinoma cell migration is controlled by cAMP-dependent as well as cAMP inhibitory signaling mechanisms...
  24. ncbi request reprint PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B
    T T Tani
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 276:36535-42. 2001
    ..The binding site in alpha(6)B defines a new subclass of type I PDZ interaction site, characterized by a non-aliphatic residue at position 0...
  25. ncbi request reprint Altered localization of p120 catenin during epithelial to mesenchymal transition of colon carcinoma is prognostic for aggressive disease
    David I Bellovin
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 65:10938-45. 2005
    ..These data provide a compelling argument for the importance of both p120ctn and the EMT itself in the progression of colorectal carcinoma...
  26. ncbi request reprint Use of RNA interference to inhibit integrin (alpha6beta4)-mediated invasion and migration of breast carcinoma cells
    Elizabeth A Lipscomb
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Clin Exp Metastasis 20:569-76. 2003
    ..Furthermore, these data suggest that the utilization of siRNA oligonucleotides to reduce the expression of the alpha6beta4 integrin may be a useful approach to prevent carcinoma cell progression...
  27. ncbi request reprint Hypoxia stimulates carcinoma invasion by stabilizing microtubules and promoting the Rab11 trafficking of the alpha6beta4 integrin
    Sang Oh Yoon
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Res 65:2761-9. 2005
    ..This increase is dependent on Rab11 and stable microtubules. In summary, we identify vesicle trafficking as a novel target of hypoxic stimulation that is important for tumor invasion...
  28. ncbi request reprint The alpha6beta4 integrin maintains the survival of human breast carcinoma cells in vivo
    Elizabeth A Lipscomb
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Res 65:10970-6. 2005
    ..Taken together, these data implicate the alpha6beta4 integrin in tumor formation by regulating tumor cell survival in a VEGF-dependent manner...
  29. ncbi request reprint The cleavage of Akt/protein kinase B by death receptor signaling is an important event in detachment-induced apoptosis
    R E Bachelder
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 276:34702-7. 2001
    ..These studies suggest that members of the death receptor family promote the caspase-mediated cleavage of Akt/PKB and that this event contributes to anoikis...
  30. ncbi request reprint Invasive skin carcinoma--Ras and alpha6beta4 integrin lead the way
    Arthur M Mercurio
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Cancer Cell 3:201-2. 2003
    ....
  31. pmc Protein kinase C-alpha phosphorylation of specific serines in the connecting segment of the beta 4 integrin regulates the dynamics of type II hemidesmosomes
    Isaac Rabinovitz
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 24:4351-60. 2004
    ....
  32. pmc Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma
    Richard C Bates
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 115:339-47. 2005
    ..These findings define the alphavbeta6 integrin as an important risk factor for early-stage disease and a novel therapeutic candidate for colorectal cancer...
  33. pmc Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition
    Robin E Bachelder
    Department of Pathology, Division of Cancer Biology and Angiogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Cell Biol 168:29-33. 2005
    ..These findings indicate that epithelial cells must sustain activation of a specific kinase to impede a mesenchymal transition...
  34. ncbi request reprint The epithelial-mesenchymal transition of colon carcinoma involves expression of IL-8 and CXCR-1-mediated chemotaxis
    Richard C Bates
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston MA 02215, USA
    Exp Cell Res 299:315-24. 2004
    ..These studies establish that the regulated expression of a specific chemokine and its receptor are linked to the EMT and they provide a biochemical framework for understanding the mechanisms by which the EMT promotes migration...
  35. ncbi request reprint Contributions of the alpha6 integrins to breast carcinoma survival and progression
    Jun Chung
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Cells 17:203-9. 2004
    ..VEGF produced by breast carcinoma cells in response to alpha6 integrin regulation can function in an autocrine manner to promote survival signaling...
  36. pmc Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids
    Richard C Bates
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Biol Cell 14:1790-800. 2003
    ..These results establish a novel role for the stroma in influencing EMT in colon carcinoma, and they identify a selective advantage to the stromal presence of infiltrating leukocytes in regulating malignant tumor progression...
  37. ncbi request reprint Flt-1-dependent survival characterizes the epithelial-mesenchymal transition of colonic organoids
    Richard C Bates
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Curr Biol 13:1721-7. 2003
    ..A role for Flt-1 in cell survival is unprecedented and has significant implications for Flt-1 function in tumor progression, as well as in other biological processes, including angiogenesis and development...
  38. ncbi request reprint Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4
    Robin E Bachelder
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Res 62:7203-6. 2002
    ..Our findings indicate that a VEGF autocrine pathway induces chemokine receptor expression in breast carcinoma cells, thus promoting their directed migration toward specific chemokines...
  39. ncbi request reprint Autocrine signaling in carcinoma: VEGF and the alpha6beta4 integrin
    Arthur M Mercurio
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Semin Cancer Biol 14:115-22. 2004
    ....
  40. ncbi request reprint Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells
    Robin E Bachelder
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Cancer Res 63:5230-3. 2003
    ..Our findings lead to the surprising conclusion that opposing autocrine loops involving NP1 regulate the chemotaxis of breast carcinoma cells. Moreover, our data indicate a novel autocrine function for VEGF in chemotaxis...
  41. ncbi request reprint Functional analysis of the contribution of RhoA and RhoC GTPases to invasive breast carcinoma
    Kaylene J Simpson
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston Massachusetts 02215, USA
    Cancer Res 64:8694-701. 2004
    ..Unexpectedly, this analysis also revealed a compensatory relationship between RhoA and RhoC at the level of both their expression and activation, and a reciprocal relationship between RhoA and Rac1 activation...
  42. ncbi request reprint A novel structural variant of the human beta 4 integrin cDNA
    A S Clarke
    Laboratory of Cancer Biology, Deaconess Hospital, Harvard Medical School, Boston, MA 02115
    Cell Adhes Commun 2:1-6. 1994
    ..PCR analysis revealed that the 7aa variant is also expressed in RNA obtained from normal colon and placenta...
  43. pmc Decreased expression of Mac-2 (carbohydrate binding protein 35) and loss of its nuclear localization are associated with the neoplastic progression of colon carcinoma
    M M Lotz
    Laboratory of Cancer Biology, Deaconess Hospital, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 90:3466-70. 1993
    ..These observations suggest that Mac-2 exclusion from the nucleus and its decreased expression may be related to the neoplastic progression of colon cancer...
  44. ncbi request reprint Carbohydrate-binding protein 35 (Mac-2), a laminin-binding lectin, forms functional dimers using cysteine 186
    H J Woo
    Laboratory of Cancer Biology, Deaconess Hospital, Boston, Massachusetts 02115
    J Biol Chem 266:18419-22. 1991
    ..These results raise the possibility that homo- and heterodimeric forms of CBP35 contribute to its postulated functions in cell-matrix interactions and growth regulation...
  45. ncbi request reprint Non-angiogenic functions of VEGF in breast cancer
    Arthur M Mercurio
    Department of Cancer Biology and the Cancer Center, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Mammary Gland Biol Neoplasia 10:283-90. 2005
    ..These findings imply that VEGF and VEGF receptor-based therapeutics, in addition to targeting angiogenesis, may also target tumor cells directly...
  46. ncbi request reprint The alpha6beta4 integrin can regulate ErbB-3 expression: implications for alpha6beta4 signaling and function
    Valentina Folgiero
    Molecular Oncogenesis Laboratory, Department of Experimental Oncology, Regina Elena Cancer Institute, Via della Messi d Oro 156, 00158 Rome, Italy
    Cancer Res 67:1645-52. 2007
    ..These findings provide one mechanism to account for the activation of PI3K by alpha(6)beta(4) and they also provide insight into the regulation of ErbB-3 in carcinoma cells...
  47. ncbi request reprint Epithelial-mesenchymal transition and colorectal cancer: gaining insights into tumor progression using LIM 1863 cells
    Richard C Bates
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Mass 01605 2324, USA
    Cells Tissues Organs 185:29-39. 2007
    ....
  48. ncbi request reprint Expression of the beta 4 integrin subunit induces monocytic differentiation of 32D/v-Abl cells
    Annarita Morena
    Molecular Oncogenesis Laboratory, Regina Elena Cancer Institute, Via delle Messi d oro, Rome, Italy
    Blood 100:96-106. 2002
    ..Overall, the reported findings indicate that alpha 6 beta 4 integrin promotes growth arrest and differentiation by modulating Abl kinases and p73 protein pathway(s)...
  49. ncbi request reprint ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA
    Charles Kumar Thodeti
    Institute of Molecular Pathology, University of Copenhagen, Frederik V s vej 11, DK 2100, Copenhagen, Denmark
    J Biol Chem 278:9576-84. 2003
    ..In summary, these data provide novel insights into syndecan-4 signaling. Syndecan-4 can promote cell spreading in a beta(1) integrin-dependent fashion through PKCalpha and RhoA, and PKCalpha and RhoA likely function in separate pathways...
  50. ncbi request reprint A role for ADAM12 in breast tumor progression and stromal cell apoptosis
    Marie Kveiborg
    Institute of Molecular Pathology, University of Copenhagen, Denmark
    Cancer Res 65:4754-61. 2005
    ..Together, these results show that the ability of ADAM12 to influence apoptosis may contribute to tumor progression...
  51. ncbi request reprint Malignant transformation of human cells by constitutive expression of platelet-derived growth factor-BB
    Baskaran Govindarajan
    Department of Dermatology, Emory University School of Medicine and Veterans Affairs Hospital, Atlanta, Georgia 30322, USA
    J Biol Chem 280:13936-43. 2005
    ..Our model allows the assessment of epigenetic changes that occur during human carcinogenesis. In addition, these studies provide insight into the clinical failure of tyrosine kinase inhibitors as monotherapy for advanced malignancy...
  52. doi request reprint Analysis of integrin beta4 expression in human breast cancer: association with basal-like tumors and prognostic significance
    Shaolei Lu
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Clin Cancer Res 14:1050-8. 2008
    ..Data on its expression and relevance to human carcinomas, however, are relatively scant. The aim of this study was to assess its expression and prognostic significance in human breast carcinomas...
  53. pmc Proteases, extracellular matrix, and cancer: a workshop of the path B study section
    Yves A DeClerck
    Department of Pediatrics and Biochemistry, University of Southern California Keck School of Medicine and The Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, California 90027, USA
    Am J Pathol 164:1131-9. 2004
    ..This review article summarizes some of the most relevant findings made over the recent years that were discussed at a workshop organized by the Path B Study Section of the National Institutes of Health in October 2002...
  54. ncbi request reprint ADAM12 induces actin cytoskeleton and extracellular matrix reorganization during early adipocyte differentiation by regulating beta1 integrin function
    Nobuko Kawaguchi
    Institute of Molecular Pathology, University of Copenhagen, Frederik V s vej 11, 2100 Copenhagen, Denmark
    J Cell Sci 116:3893-904. 2003
    ..These events may be necessary for early adipocyte differentiation...