Research Topics
| SAUMIL MERCHANTSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Polyester wax: a new embedding medium for the histopathologic study of human temporal bonesSaumil N Merchant
Otopathology Laboratory and the Department of Otolaryngology, MA Eye and Ear Infirmary, and the Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02114, USA
Laryngoscope 116:245-9. 2006..Embedding in paraffin allows immunostaining to be performed, but preservation of cellular detail within the membranous labyrinth is relatively poor...- Pathology and pathophysiology of idiopathic sudden sensorineural hearing lossSaumil N Merchant
Otopathology Laboratory, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
Otol Neurotol 26:151-60. 2005..The cause and pathogenesis of idiopathic sudden sensorineural hearing loss remain unknown. Proposed theories include vascular occlusion, membrane breaks, and viral cochleitis... - Pathophysiology of Meniere's syndrome: are symptoms caused by endolymphatic hydrops?Saumil N Merchant
Otopathology Laboratory, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114 3096, USA
Otol Neurotol 26:74-81. 2005..If the central hypothesis were true, every case of Meniere's syndrome should have hydrops and every case of hydrops should show the typical symptoms... - Conductive hearing loss caused by third-window lesions of the inner earSaumil N Merchant
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Division of Health Sciences and Technology, Harvard University Massachusetts Institute of Technology, Cambridge, Massachusetts 02114, USA
Otol Neurotol 29:282-9. 2008..Recent investigations have suggested that many of these cases are due to disorders of the inner ear, resulting in pathologic third windows... - Sudden deafness: is it viral?Saumil N Merchant
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
ORL J Otorhinolaryngol Relat Spec 70:52-60; discussion 60-2. 2008..Finally, we review our recently proposed theory that abnormal cellular stress responses within the cochlea may be responsible for ISSHL... - Motion of the tympanic membrane after cartilage tympanoplasty determined by stroboscopic holographyAntti A Aarnisalo
Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA, USA
Hear Res 263:78-84. 2010..These obvious local changes occur even though the cartilage had little effect on the sound-induced motion of the stapes... - Middle ear mechanics of cartilage tympanoplasty evaluated by laser holography and vibrometryAntti A Aarnisalo
Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA
Otol Neurotol 30:1209-14. 2009..To assess the effects of thickness and position of cartilage used to reconstruct the tympanic membrane (TM) using a novel technique, time-averaged laser holography... - Middle-ear mechanics of Type III tympanoplasty (stapes columella): I. Experimental studiesRitvik P Mehta
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
Otol Neurotol 24:176-85. 2003..Improved results were achieved by interposing a thin cartilage disc between the graft and stapes head to increase the effective vibrating area of the graft... - Investigation of the mechanics of Type III stapes columella tympanoplasty using laser-Doppler vibrometryWade Chien
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
Otol Neurotol 28:782-7. 2007.... - Measurements of human middle- and inner-ear mechanics with dehiscence of the superior semicircular canalWade Chien
Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, USA
Otol Neurotol 28:250-7. 2007.... - Experimental ossicular fixations and the middle ear's response to sound: evidence for a flexible ossicular chainHideko Heidi Nakajima
Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02115, USA
Hear Res 204:60-77. 2005.... - Clinical investigation and mechanism of air-bone gaps in large vestibular aqueduct syndromeSaumil N Merchant
Massachusetts Eye and Ear Infirmary, Department of Otolaryngology, 243 Charles St, Boston, MA 02114, USA
Ann Otol Rhinol Laryngol 116:532-41. 2007..The mechanism causing such a gap has not been well elucidated. We investigated middle ear sound transmission in patients with LVAS, and present a hypothesis to explain the air-bone gap... - A normative study of tympanic membrane motion in humans using a laser Doppler vibrometer (LDV)Kenneth R Whittemore
Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02114, USA
Hear Res 187:85-104. 2004..These results provide a baseline normal response for studies of TM velocity with conductive hearing losses of different etiologies... - Otopathology in Mohr-Tranebjaerg syndromeFayez Bahmad
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114 3096, USA
Laryngoscope 117:1202-8. 2007..MTS is caused by mutations in the DDP/TIMM8A gene, which encodes for a 97 amino acid polypeptide; this polypeptide is a translocase of the inner mitochondrial membrane... - Histopathology of nonsyndromic autosomal dominant midfrequency sensorineural hearing lossFayez Bahmad
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114 3096, USA
Otol Neurotol 29:601-6. 2008..Autosomal dominant, nonsyndromic, midfrequency sensorineural hearing loss (SNHL) is a well-known clinical entity. There are no reported histopathologic studies of temporal bones from individuals with such a hearing loss... - Three-dimensional virtual model of the human temporal bone: a stand-alone, downloadable teaching toolHaobing Wang
Eaton Peabody Laboratory of Auditory Physiology, Massachusetts Eye and Ear Infirmary, Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02114, USA
Otol Neurotol 27:452-7. 2006..To develop a three-dimensional virtual model of a human temporal bone based on serial histologic sections... - Motion of the surface of the human tympanic membrane measured with stroboscopic holographyJeffrey Tao Cheng
Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
Hear Res 263:66-77. 2010..The observations of the dynamics of TM surface motion from this study will help us better understand the sound-receiving function of the TM and how it couples sound to the ossicular chain and inner ear... - Superior semicircular canal dehiscence mimicking otosclerotic hearing lossSaumil N Merchant
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114 3096, USA
Adv Otorhinolaryngol 65:137-45. 2007.... - Results after revision stapedectomy with malleus grip prosthesisSarp Sarac
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
Ann Otol Rhinol Laryngol 115:317-22. 2006..Our results are similar to those published in the literature for malleus attachment stapedectomy and conventional revision incus stapedectomy... - Evaluation of round window stimulation using the floating mass transducer by intracochlear sound pressure measurements in human temporal bonesHideko Heidi Nakajima
Department of Otology and Laryngology, Harvard Medical School, Cambridge, Massachusetts, U S A
Otol Neurotol 31:506-11. 2010..Round window (RW) stimulation with a floating mass transducer (FMT) can be studied experimentally and optimized to enhance auditory transduction... - Wolfram syndrome: a clinicopathologic correlationJustin B Hilson
Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Acta Neuropathol 118:415-28. 2009..Our findings extend prior neuropathologic reports of Wolfram syndrome by providing contributions to our understanding of eye, inner ear and olivopontine pathology in this disease... - Anatomy of the round window and hook region of the cochlea with implications for cochlear implantation and other endocochlear surgical proceduresPeter M M C Li
Department of Otology and Laryngology, Harvard Medical School Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
Otol Neurotol 28:641-8. 2007..The goal of this study was to create a three-dimensional model of the anatomy of the hook region to identify the optimal site for cochleostomy in cochlear implant surgery... - Clinical utility of laser-Doppler vibrometer measurements in live normal and pathologic human earsJohn J Rosowski
Eaton Peabody Lab, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
Ear Hear 29:3-19. 2008..LDV measurements can also help differentiate air-bone gaps produced by ossicular pathologies from those associated with pathologies of inner-ear sound conduction such as a superior semicircular canal dehiscence... - Differential intracochlear sound pressure measurements in normal human temporal bonesHideko Heidi Nakajima
Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02115, USA
J Assoc Res Otolaryngol 10:23-36. 2009..g., round window stimulation and bone conduction)--situations that cannot be completely quantified by measurements of stapes velocity or scala vestibuli pressure by themselves... - Effects of fixative and embedding medium on morphology and immunostaining of the cochleaJennifer T O'Malley
Massachusetts Eye and Ear Infirmary, Boston, Mass 02114, USA
Audiol Neurootol 14:78-87. 2009..These results suggest that celloidin may be the embedding medium of choice for both morphological and pathological studies, including immunostaining when morphology must be optimized... - Performance considerations of prosthetic actuators for round-window stimulationHideko Heidi Nakajima
Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02115, USA
Hear Res 263:114-9. 2010..This information is essential for adapting existing prostheses and for designing new actuators specifically for RW stimulation... - Temporal bone histopathology in alport syndromeSaumil N Merchant
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA
Laryngoscope 114:1609-18. 2004..To determine the histopathologic abnormalities within the cochlea in Alport syndrome... - Superior semicircular canal dehiscence presenting as conductive hearing loss without vertigoAnthony A Mikulec
Department of Otology and Laryngology, Harvard Medical School, and the Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
Otol Neurotol 25:121-9. 2004.... - Mechanisms of hearing loss resulting from middle-ear fluidMichael E Ravicz
The Eaton Peabody Laboratory of Auditory Physiology, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
Hear Res 195:103-30. 2004..Small amounts of air in the middle ear are sufficient to facilitate umbo motion at low frequencies... - Middle ear mechanics of Type III tympanoplasty (stapes columella): II. Clinical studiesSaumil N Merchant
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
Otol Neurotol 24:186-94. 2003.... - Diagnostic utility of laser-Doppler vibrometry in conductive hearing loss with normal tympanic membraneJohn J Rosowski
Department of Otology and Laryngology, Harvard Medical School, Boston, MA, USA
Otol Neurotol 24:165-75. 2003..More generally, we hypothesize that laser-Doppler vibrometry measurements of umbo velocity can give information about how differences in the impedance that the ossicles work against affect middle-ear function... - Deoxyribonucleic acid contamination in archival human temporal bones: a potentially significant problemMichael J McKenna
Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts, USA
Otol Neurotol 23:789-92. 2002..Contamination of archival human temporal bones with extraneous deoxyribonucleic acid may represent a potentially significant problem in the analysis of nucleic acids isolated from archival specimens... - Determinants of hearing loss in perforations of the tympanic membraneRitvik P Mehta
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
Otol Neurotol 27:136-43. 2006..Effects of location, if any, are small... - Postauricular periosteal-pericranial flap for mastoid obliteration and canal wall down tympanomastoidectomyMitchell J Ramsey
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
Otol Neurotol 25:873-8. 2004.... - Clinical, experimental, and theoretical investigations of the effect of superior semicircular canal dehiscence on hearing mechanismsJohn J Rosowski
Eaton Peabody Laboratory, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
Otol Neurotol 25:323-32. 2004.... - Experimental and clinical studies of malleus fixationHideko Heidi Nakajima
Department of Otology and Laryngology, Harvard Medical School, and the Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA, USA
Laryngoscope 115:147-54. 2005..CONCLUSION: The study showed that measurements of umbo velocity and air-bone gap can enable one to diagnose malleus fixation and specifies how to differentiate malleus from stapes fixation... - Techniques of celloidin removal from temporal bone sectionsJennifer T O'Malley
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114, USA
Ann Otol Rhinol Laryngol 118:435-41. 2009..We sought to determine whether the technique of celloidin removal influences the results of immunostaining in celloidin-embedded cochleae... - Osteoprotegrin knockout mice demonstrate abnormal remodeling of the otic capsule and progressive hearing lossAndreas F Zehnder
Department of Otology and Laryngology, Harvard Medical School, and the Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114 3096, USA
Laryngoscope 116:201-6. 2006..We also tested the hearing in OPG knockout mice to determine whether OPG and its influence on surrounding bone is important for auditory function... - The effect of methodological differences in the measurement of stapes motion in live and cadaver earsWade Chien
Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, and Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02114, USA
Audiol Neurootol 11:183-97. 2006..This demonstrates that the commonly used method of estimating stapes translational velocity by dividing the measured velocity by the cosine of the measurement angle is not valid above 2 kHz... - Cochlin immunostaining of inner ear pathologic deposits and proteomic analysis in DFNA9 deafness and vestibular dysfunctionNahid G Robertson
Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Hum Mol Genet 15:1071-85. 2006.... - Measurements of stapes velocity in live human earsWade Chien
Department of Otolaryngology, Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
Hear Res 249:54-61. 2009..The primary interspecies differences were in the magnitude of the Vs as well as in the frequency of transitions in the magnitudes' frequency dependence from rising to flat or falling... - Efficient method for the proteomic analysis of fixed and embedded tissuesDarryl Erik Palmer-Toy
Harvard Partners Center for Genetics and Genomics, Cambridge, Massachusetts, USA
J Proteome Res 4:2404-11. 2005..Moreover, we demonstrate that a high level of sequence coverage can be observed for proteins of interest... - Anatomy of the distal incus in humansWade Chien
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA, 02114, USA
J Assoc Res Otolaryngol 10:485-96. 2009.... - Osteoprotegerin in the inner ear may inhibit bone remodeling in the otic capsuleAndreas F Zehnder
Department of Otolaryngology, MA Eye and Ear Infirmary, and Harvard Medical School, Boston, MA, USA
Laryngoscope 115:172-7. 2005..By this means, the cochlear soft tissue may control the nature of the surrounding petrous bone... - Transverse fracture of the temporal boneAndreas Zehnder
Otopathology Laboratory, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
Otol Neurotol 25:852-3. 2004 - Histopathology of ossicular grafts and implants in chronic otitis mediaFayez Bahmad
Otopathology Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, 02114, USA
Ann Otol Rhinol Laryngol 116:181-91. 2007..We describe the histopathology of ossicular grafts and implants so as to provide insight into factors that may influence functional results after surgery for chronic otitis media... - Erythromycin ototoxicityLee J McGhan
Department of Otolaryngology, Massachussets Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
Otol Neurotol 24:701-2. 2003 - Paget disease of the temporal boneFayez Bahmad
Otopathology Laboratory, Massachusetts Eye and Ear Infirmary, and Harvard Medical School, Boston, Massachusetts 02114, USA
Otol Neurotol 28:1157-8. 2007 - Locus for familial migrainous vertigo disease maps to chromosome 5q35Fayez Bahmad
Department of Genetics, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
Ann Otol Rhinol Laryngol 118:670-6. 2009..However, neither disease genes nor loci that might be responsible have been reported. We sought to map the genetic locus for familial migrainous vertigo in a 4-generation family and to define the progression of disease in this family... - Axial mesodermal dysplasia sequence: autopsy findingsSaumil N Merchant
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, USA
Clin Dysmorphol 13:21-4. 2004..Postmortem studies identified anomalies of the middle ear ossicles, and muscles, in association with microtia and atresia of the external auditory canals, but no cerebral abnormalities... - A downloadable three-dimensional virtual model of the visible earHaobing Wang
Eaton Peabody Laboratory of Auditory Physiology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA
ORL J Otorhinolaryngol Relat Spec 69:63-7. 2007..To develop a three-dimensional (3-D) virtual model of a human temporal bone and surrounding structures... - Cochleosaccular dysplasia associated with a connexin 26 mutation in keratitis-ichthyosis-deafness syndromeAndrew J Griffith
Section on Gene Structure and Function, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA
Laryngoscope 116:1404-8. 2006..CONCLUSIONS: GJB2 mutations can cause deafness in KID syndrome, and possibly in other GJB2 mutant phenotypes, by disrupting cochlear differentiation... - Non-ossicular signal transmission in human middle ears: Experimental assessment of the "acoustic route" with perforated tympanic membranesSusan E Voss
Picker Engineering Program, Smith College, 51 College Lane, Northampton, Massachusetts 01063, USA
J Acoust Soc Am 122:2135-53. 2007..Some features of the frequency dependence of H(P(CAV) ) and H(WPD) can be interpreted in terms of a structure-based lumped-element acoustic model of the perforation and middle-ear cavities... - Temporal bone histopathological and quantitative analysis of mitochondrial DNA in MELASKatsumasa Takahashi
Department of Otolarynology, Gunma University, Maebashi, Japan
Laryngoscope 113:1362-8. 2003..CONCLUSION: Dysfunction of the stria vascularis and spiral ganglion cells causes sensorineural hearing loss in MELAS... - Distribution of type IV collagen in the cochlea in Alport syndromeAndreas F Zehnder
Ear, Nose, and Throat Department, University Hospital Basel, Basel, Switzerland
Arch Otolaryngol Head Neck Surg 131:1007-13. 2005..The results are also consistent with the hypothesis that the sensorineural hearing loss in Alport syndrome may be due to alterations in cochlear micromechanics and/or dysfunction of the spiral ligament... - Recent advances in otitis media. 3. Animal models; anatomy and pathology; pathogenesis; cell biology and geneticsDavid J Lim
Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, California, USA
Ann Otol Rhinol Laryngol Suppl 194:31-41. 2005 - Human temporal bone consortium for research resource enhancementSaumil N Merchant
Otol Neurotol 29:271-4. 2008 - Vestibular evoked myogenic potentials (VEMP) can detect asymptomatic saccular hydropsMing-Yee Lin
Kaohsiung Veterans General Hospital, Haohsiung, Taiwan
Laryngoscope 116:987-92. 2006..Changes in VEMP threshold and tuning appear to be sensitive to these structural changes in the saccule. If so, then VEMP may be useful as a detector of asymptomatic saccular hydrops and as a predictor of evolving bilateral MD... - Association between osteoporosis and otosclerosis in womenAmy E Clayton
University of Wales College of Medicine, Cardiff, UK
J Laryngol Otol 118:617-21. 2004..007) between otosclerosis and osteoporosis. This study suggests an association between otosclerosis and osteoporosis, providing impetus and justification for future prospective clinical studies and related research...
Research Grants
- Middle-ear Mechanics in Normal and Pathological EarsSaumil N Merchant; Fiscal Year: 2010..abstract_text> ..
- Otopathology by Light Microscopy and Molecular TechniquesSAUMIL MERCHANT; Fiscal Year: 2007..6. To cooperate with the Temporal Bone Research Consortium. This research will provide new knowledge about the causes of disorders of hearing and balance, which should lead to better methods of diagnosis and therapy. ..
- Middle-ear Mechanics in Normal and Pathological EarsSAUMIL MERCHANT; Fiscal Year: 2007....
- Middle-ear Mechanics in Normal and Pathological EarsSAUMIL MERCHANT; Fiscal Year: 2005..abstract_text> ..
- DEVELOPMENT OF A MIDDLE EAR BALLOON IMPLANTSAUMIL MERCHANT; Fiscal Year: 2003..There is a large market potential for this implant, estimated at over 65,000 devices annually in the U.S. alone. ..
- Middle-ear Mechanics in Normal and Pathological EarsSAUMIL MERCHANT; Fiscal Year: 2009..abstract_text> ..