SAUMIL MERCHANT

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Pathophysiology of Meniere's syndrome: are symptoms caused by endolymphatic hydrops?
    Saumil N Merchant
    Otopathology Laboratory, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114 3096, USA
    Otol Neurotol 26:74-81. 2005
  2. pmc Conductive hearing loss caused by third-window lesions of the inner ear
    Saumil N Merchant
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Division of Health Sciences and Technology, Harvard University Massachusetts Institute of Technology, Cambridge, Massachusetts 02114, USA
    Otol Neurotol 29:282-9. 2008
  3. pmc Sudden deafness: is it viral?
    Saumil N Merchant
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    ORL J Otorhinolaryngol Relat Spec 70:52-60; discussion 60-2. 2008
  4. ncbi request reprint Pathology and pathophysiology of idiopathic sudden sensorineural hearing loss
    Saumil N Merchant
    Otopathology Laboratory, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
    Otol Neurotol 26:151-60. 2005
  5. pmc Polyester wax: a new embedding medium for the histopathologic study of human temporal bones
    Saumil N Merchant
    Otopathology Laboratory and the Department of Otolaryngology, MA Eye and Ear Infirmary, and the Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Laryngoscope 116:245-9. 2006
  6. pmc Motion of the tympanic membrane after cartilage tympanoplasty determined by stroboscopic holography
    Antti A Aarnisalo
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA, USA
    Hear Res 263:78-84. 2010
  7. pmc Middle ear mechanics of cartilage tympanoplasty evaluated by laser holography and vibrometry
    Antti A Aarnisalo
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA
    Otol Neurotol 30:1209-14. 2009
  8. ncbi request reprint Middle-ear mechanics of Type III tympanoplasty (stapes columella): I. Experimental studies
    Ritvik P Mehta
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Otol Neurotol 24:176-85. 2003
  9. pmc Investigation of the mechanics of Type III stapes columella tympanoplasty using laser-Doppler vibrometry
    Wade Chien
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Otol Neurotol 28:782-7. 2007
  10. pmc Clinical investigation and mechanism of air-bone gaps in large vestibular aqueduct syndrome
    Saumil N Merchant
    Massachusetts Eye and Ear Infirmary, Department of Otolaryngology, 243 Charles St, Boston, MA 02114, USA
    Ann Otol Rhinol Laryngol 116:532-41. 2007

Research Grants

  1. Middle-ear Mechanics in Normal and Pathological Ears
    Saumil N Merchant; Fiscal Year: 2010
  2. Otopathology by Light Microscopy and Molecular Techniques
    SAUMIL MERCHANT; Fiscal Year: 2007
  3. Middle-ear Mechanics in Normal and Pathological Ears
    SAUMIL MERCHANT; Fiscal Year: 2007
  4. Middle-ear Mechanics in Normal and Pathological Ears
    SAUMIL MERCHANT; Fiscal Year: 2005
  5. DEVELOPMENT OF A MIDDLE EAR BALLOON IMPLANT
    SAUMIL MERCHANT; Fiscal Year: 2003
  6. Middle-ear Mechanics in Normal and Pathological Ears
    SAUMIL MERCHANT; Fiscal Year: 2009

Collaborators

Detail Information

Publications60

  1. ncbi request reprint Pathophysiology of Meniere's syndrome: are symptoms caused by endolymphatic hydrops?
    Saumil N Merchant
    Otopathology Laboratory, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114 3096, USA
    Otol Neurotol 26:74-81. 2005
    ..However, this hypothesis of hydrops as being the final common pathway has not been proven conclusively...
  2. pmc Conductive hearing loss caused by third-window lesions of the inner ear
    Saumil N Merchant
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Division of Health Sciences and Technology, Harvard University Massachusetts Institute of Technology, Cambridge, Massachusetts 02114, USA
    Otol Neurotol 29:282-9. 2008
    ..Recent investigations have suggested that many of these cases are due to disorders of the inner ear, resulting in pathologic third windows...
  3. pmc Sudden deafness: is it viral?
    Saumil N Merchant
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    ORL J Otorhinolaryngol Relat Spec 70:52-60; discussion 60-2. 2008
    ..Finally, we review our recently proposed theory that abnormal cellular stress responses within the cochlea may be responsible for ISSHL...
  4. ncbi request reprint Pathology and pathophysiology of idiopathic sudden sensorineural hearing loss
    Saumil N Merchant
    Otopathology Laboratory, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
    Otol Neurotol 26:151-60. 2005
    ..The cause and pathogenesis of idiopathic sudden sensorineural hearing loss remain unknown. Proposed theories include vascular occlusion, membrane breaks, and viral cochleitis...
  5. pmc Polyester wax: a new embedding medium for the histopathologic study of human temporal bones
    Saumil N Merchant
    Otopathology Laboratory and the Department of Otolaryngology, MA Eye and Ear Infirmary, and the Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Laryngoscope 116:245-9. 2006
    ..Embedding in paraffin allows immunostaining to be performed, but preservation of cellular detail within the membranous labyrinth is relatively poor...
  6. pmc Motion of the tympanic membrane after cartilage tympanoplasty determined by stroboscopic holography
    Antti A Aarnisalo
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA, USA
    Hear Res 263:78-84. 2010
    ..These obvious local changes occur even though the cartilage had little effect on the sound-induced motion of the stapes...
  7. pmc Middle ear mechanics of cartilage tympanoplasty evaluated by laser holography and vibrometry
    Antti A Aarnisalo
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA
    Otol Neurotol 30:1209-14. 2009
    ..To assess the effects of thickness and position of cartilage used to reconstruct the tympanic membrane (TM) using a novel technique, time-averaged laser holography...
  8. ncbi request reprint Middle-ear mechanics of Type III tympanoplasty (stapes columella): I. Experimental studies
    Ritvik P Mehta
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Otol Neurotol 24:176-85. 2003
    ..To investigate the mechanics of Type III tympanoplasty by developing a cadaveric temporal bone model...
  9. pmc Investigation of the mechanics of Type III stapes columella tympanoplasty using laser-Doppler vibrometry
    Wade Chien
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Otol Neurotol 28:782-7. 2007
    ....
  10. pmc Clinical investigation and mechanism of air-bone gaps in large vestibular aqueduct syndrome
    Saumil N Merchant
    Massachusetts Eye and Ear Infirmary, Department of Otolaryngology, 243 Charles St, Boston, MA 02114, USA
    Ann Otol Rhinol Laryngol 116:532-41. 2007
    ..The mechanism causing such a gap has not been well elucidated. We investigated middle ear sound transmission in patients with LVAS, and present a hypothesis to explain the air-bone gap...
  11. ncbi request reprint Experimental ossicular fixations and the middle ear's response to sound: evidence for a flexible ossicular chain
    Hideko Heidi Nakajima
    Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02115, USA
    Hear Res 204:60-77. 2005
    ....
  12. pmc Measurements of human middle- and inner-ear mechanics with dehiscence of the superior semicircular canal
    Wade Chien
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, USA
    Otol Neurotol 28:250-7. 2007
    ....
  13. ncbi request reprint A normative study of tympanic membrane motion in humans using a laser Doppler vibrometer (LDV)
    Kenneth R Whittemore
    Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02114, USA
    Hear Res 187:85-104. 2004
    ..These results provide a baseline normal response for studies of TM velocity with conductive hearing losses of different etiologies...
  14. pmc Histopathology of nonsyndromic autosomal dominant midfrequency sensorineural hearing loss
    Fayez Bahmad
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114 3096, USA
    Otol Neurotol 29:601-6. 2008
    ..Autosomal dominant, nonsyndromic, midfrequency sensorineural hearing loss (SNHL) is a well-known clinical entity. There are no reported histopathologic studies of temporal bones from individuals with such a hearing loss...
  15. pmc Otopathology in Mohr-Tranebjaerg syndrome
    Fayez Bahmad
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114 3096, USA
    Laryngoscope 117:1202-8. 2007
    ..MTS is caused by mutations in the DDP/TIMM8A gene, which encodes for a 97 amino acid polypeptide; this polypeptide is a translocase of the inner mitochondrial membrane...
  16. pmc Superior semicircular canal dehiscence mimicking otosclerotic hearing loss
    Saumil N Merchant
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114 3096, USA
    Adv Otorhinolaryngol 65:137-45. 2007
    ....
  17. pmc Three-dimensional virtual model of the human temporal bone: a stand-alone, downloadable teaching tool
    Haobing Wang
    Eaton Peabody Laboratory of Auditory Physiology, Massachusetts Eye and Ear Infirmary, Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Otol Neurotol 27:452-7. 2006
    ..To develop a three-dimensional virtual model of a human temporal bone based on serial histologic sections...
  18. pmc Motion of the surface of the human tympanic membrane measured with stroboscopic holography
    Jeffrey Tao Cheng
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Hear Res 263:66-77. 2010
    ..The observations of the dynamics of TM surface motion from this study will help us better understand the sound-receiving function of the TM and how it couples sound to the ossicular chain and inner ear...
  19. pmc Determinants of hearing loss in perforations of the tympanic membrane
    Ritvik P Mehta
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Otol Neurotol 27:136-43. 2006
    ....
  20. pmc Anatomy of the round window and hook region of the cochlea with implications for cochlear implantation and other endocochlear surgical procedures
    Peter M M C Li
    Department of Otology and Laryngology, Harvard Medical School Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Otol Neurotol 28:641-8. 2007
    ..The goal of this study was to create a three-dimensional model of the anatomy of the hook region to identify the optimal site for cochleostomy in cochlear implant surgery...
  21. pmc Clinical utility of laser-Doppler vibrometer measurements in live normal and pathologic human ears
    John J Rosowski
    Eaton Peabody Lab, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Ear Hear 29:3-19. 2008
    ..LDV measurements can also help differentiate air-bone gaps produced by ossicular pathologies from those associated with pathologies of inner-ear sound conduction such as a superior semicircular canal dehiscence...
  22. pmc Effects of fixative and embedding medium on morphology and immunostaining of the cochlea
    Jennifer T O'Malley
    Massachusetts Eye and Ear Infirmary, Boston, Mass 02114, USA
    Audiol Neurootol 14:78-87. 2009
    ..These results suggest that celloidin may be the embedding medium of choice for both morphological and pathological studies, including immunostaining when morphology must be optimized...
  23. pmc Differential intracochlear sound pressure measurements in normal human temporal bones
    Hideko Heidi Nakajima
    Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02115, USA
    J Assoc Res Otolaryngol 10:23-36. 2009
    ..g., round window stimulation and bone conduction)--situations that cannot be completely quantified by measurements of stapes velocity or scala vestibuli pressure by themselves...
  24. pmc Wolfram syndrome: a clinicopathologic correlation
    Justin B Hilson
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Acta Neuropathol 118:415-28. 2009
    ..Our findings extend prior neuropathologic reports of Wolfram syndrome by providing contributions to our understanding of eye, inner ear and olivopontine pathology in this disease...
  25. pmc Evaluation of round window stimulation using the floating mass transducer by intracochlear sound pressure measurements in human temporal bones
    Hideko Heidi Nakajima
    Department of Otology and Laryngology, Harvard Medical School, Cambridge, Massachusetts, U S A
    Otol Neurotol 31:506-11. 2010
    ..Round window (RW) stimulation with a floating mass transducer (FMT) can be studied experimentally and optimized to enhance auditory transduction...
  26. pmc Performance considerations of prosthetic actuators for round-window stimulation
    Hideko Heidi Nakajima
    Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02115, USA
    Hear Res 263:114-9. 2010
    ..This information is essential for adapting existing prostheses and for designing new actuators specifically for RW stimulation...
  27. pmc Results after revision stapedectomy with malleus grip prosthesis
    Sarp Sarac
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Ann Otol Rhinol Laryngol 115:317-22. 2006
    ..Our results are similar to those published in the literature for malleus attachment stapedectomy and conventional revision incus stapedectomy...
  28. ncbi request reprint Postauricular periosteal-pericranial flap for mastoid obliteration and canal wall down tympanomastoidectomy
    Mitchell J Ramsey
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Otol Neurotol 25:873-8. 2004
    ..To describe an effective technique for mastoid cavity obliteration in canal wall down tympanomastoidectomy for chronic otitis media and review its efficacy in producing a dry, low-maintenance, small mastoid cavity...
  29. ncbi request reprint Temporal bone histopathology in alport syndrome
    Saumil N Merchant
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA
    Laryngoscope 114:1609-18. 2004
    ..To determine the histopathologic abnormalities within the cochlea in Alport syndrome...
  30. ncbi request reprint Middle ear mechanics of Type III tympanoplasty (stapes columella): II. Clinical studies
    Saumil N Merchant
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
    Otol Neurotol 24:186-94. 2003
    ....
  31. ncbi request reprint Mechanisms of hearing loss resulting from middle-ear fluid
    Michael E Ravicz
    The Eaton Peabody Laboratory of Auditory Physiology, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
    Hear Res 195:103-30. 2004
    ..Small amounts of air in the middle ear are sufficient to facilitate umbo motion at low frequencies...
  32. ncbi request reprint Clinical, experimental, and theoretical investigations of the effect of superior semicircular canal dehiscence on hearing mechanisms
    John J Rosowski
    Eaton Peabody Laboratory, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Otol Neurotol 25:323-32. 2004
    ....
  33. ncbi request reprint Superior semicircular canal dehiscence presenting as conductive hearing loss without vertigo
    Anthony A Mikulec
    Department of Otology and Laryngology, Harvard Medical School, and the Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Otol Neurotol 25:121-9. 2004
    ..The objective of this study was to describe superior semicircular canal dehiscence (SSCD) presenting as otherwise unexplained conductive hearing loss without vestibular symptoms...
  34. ncbi request reprint Deoxyribonucleic acid contamination in archival human temporal bones: a potentially significant problem
    Michael J McKenna
    Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts, USA
    Otol Neurotol 23:789-92. 2002
    ..Contamination of archival human temporal bones with extraneous deoxyribonucleic acid may represent a potentially significant problem in the analysis of nucleic acids isolated from archival specimens...
  35. pmc Diagnostic utility of laser-Doppler vibrometry in conductive hearing loss with normal tympanic membrane
    John J Rosowski
    Department of Otology and Laryngology, Harvard Medical School, Boston, MA, USA
    Otol Neurotol 24:165-75. 2003
    ..More generally, we hypothesize that laser-Doppler vibrometry measurements of umbo velocity can give information about how differences in the impedance that the ossicles work against affect middle-ear function...
  36. pmc Techniques of celloidin removal from temporal bone sections
    Jennifer T O'Malley
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114, USA
    Ann Otol Rhinol Laryngol 118:435-41. 2009
    ..We sought to determine whether the technique of celloidin removal influences the results of immunostaining in celloidin-embedded cochleae...
  37. pmc The effect of methodological differences in the measurement of stapes motion in live and cadaver ears
    Wade Chien
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, and Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02114, USA
    Audiol Neurootol 11:183-97. 2006
    ..This demonstrates that the commonly used method of estimating stapes translational velocity by dividing the measured velocity by the cosine of the measurement angle is not valid above 2 kHz...
  38. ncbi request reprint Experimental and clinical studies of malleus fixation
    Hideko Heidi Nakajima
    Department of Otology and Laryngology, Harvard Medical School, and the Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA, USA
    Laryngoscope 115:147-54. 2005
    ....
  39. pmc Osteoprotegrin knockout mice demonstrate abnormal remodeling of the otic capsule and progressive hearing loss
    Andreas F Zehnder
    Department of Otology and Laryngology, Harvard Medical School, and the Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114 3096, USA
    Laryngoscope 116:201-6. 2006
    ..We also tested the hearing in OPG knockout mice to determine whether OPG and its influence on surrounding bone is important for auditory function...
  40. pmc Otopathology in Osteogenesis Imperfecta
    Felipe Santos
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
    Otol Neurotol 33:1562-6. 2012
    ..OI is caused by mutations that affect type I collagen. The hearing loss in OI is characterized by onset in early adulthood and can be conductive, sensorineural, or mixed...
  41. ncbi request reprint Cochlin immunostaining of inner ear pathologic deposits and proteomic analysis in DFNA9 deafness and vestibular dysfunction
    Nahid G Robertson
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Hum Mol Genet 15:1071-85. 2006
    ....
  42. ncbi request reprint Efficient method for the proteomic analysis of fixed and embedded tissues
    Darryl Erik Palmer-Toy
    Harvard Partners Center for Genetics and Genomics, Cambridge, Massachusetts, USA
    J Proteome Res 4:2404-11. 2005
    ..Moreover, we demonstrate that a high level of sequence coverage can be observed for proteins of interest...
  43. pmc Measurements of stapes velocity in live human ears
    Wade Chien
    Department of Otolaryngology, Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
    Hear Res 249:54-61. 2009
    ..The primary interspecies differences were in the magnitude of the Vs as well as in the frequency of transitions in the magnitudes' frequency dependence from rising to flat or falling...
  44. ncbi request reprint Osteoprotegerin in the inner ear may inhibit bone remodeling in the otic capsule
    Andreas F Zehnder
    Department of Otolaryngology, MA Eye and Ear Infirmary, and Harvard Medical School, Boston, MA, USA
    Laryngoscope 115:172-7. 2005
    ..To elucidate factors that may be responsible for the inhibition of remodeling of bone within the otic capsule...
  45. pmc Anatomy of the distal incus in humans
    Wade Chien
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA, 02114, USA
    J Assoc Res Otolaryngol 10:485-96. 2009
    ....
  46. ncbi request reprint Erythromycin ototoxicity
    Lee J McGhan
    Department of Otolaryngology, Massachussets Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Otol Neurotol 24:701-2. 2003
  47. ncbi request reprint Transverse fracture of the temporal bone
    Andreas Zehnder
    Otopathology Laboratory, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Otol Neurotol 25:852-3. 2004
  48. pmc Paget disease of the temporal bone
    Fayez Bahmad
    Otopathology Laboratory, Massachusetts Eye and Ear Infirmary, and Harvard Medical School, Boston, Massachusetts 02114, USA
    Otol Neurotol 28:1157-8. 2007
  49. pmc Histopathology of ossicular grafts and implants in chronic otitis media
    Fayez Bahmad
    Otopathology Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, 02114, USA
    Ann Otol Rhinol Laryngol 116:181-91. 2007
    ..We describe the histopathology of ossicular grafts and implants so as to provide insight into factors that may influence functional results after surgery for chronic otitis media...
  50. pmc A downloadable three-dimensional virtual model of the visible ear
    Haobing Wang
    Eaton Peabody Laboratory of Auditory Physiology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA
    ORL J Otorhinolaryngol Relat Spec 69:63-7. 2007
    ..To develop a three-dimensional (3-D) virtual model of a human temporal bone and surrounding structures...
  51. ncbi request reprint Axial mesodermal dysplasia sequence: autopsy findings
    Saumil N Merchant
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, USA
    Clin Dysmorphol 13:21-4. 2004
    ..Postmortem studies identified anomalies of the middle ear ossicles, and muscles, in association with microtia and atresia of the external auditory canals, but no cerebral abnormalities...
  52. pmc Locus for familial migrainous vertigo disease maps to chromosome 5q35
    Fayez Bahmad
    Department of Genetics, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Ann Otol Rhinol Laryngol 118:670-6. 2009
    ..However, neither disease genes nor loci that might be responsible have been reported. We sought to map the genetic locus for familial migrainous vertigo in a 4-generation family and to define the progression of disease in this family...
  53. ncbi request reprint Temporal bone histopathological and quantitative analysis of mitochondrial DNA in MELAS
    Katsumasa Takahashi
    Department of Otolarynology, Gunma University, Maebashi, Japan
    Laryngoscope 113:1362-8. 2003
    ..The purpose of the study was to report the otopathological findings from two patients with MELAS and quantitative mtDNA analysis in the inner ear of one of these patients...
  54. pmc Non-ossicular signal transmission in human middle ears: Experimental assessment of the "acoustic route" with perforated tympanic membranes
    Susan E Voss
    Picker Engineering Program, Smith College, 51 College Lane, Northampton, Massachusetts 01063, USA
    J Acoust Soc Am 122:2135-53. 2007
    ..Some features of the frequency dependence of H(P(CAV) ) and H(WPD) can be interpreted in terms of a structure-based lumped-element acoustic model of the perforation and middle-ear cavities...
  55. ncbi request reprint Distribution of type IV collagen in the cochlea in Alport syndrome
    Andreas F Zehnder
    Ear, Nose, and Throat Department, University Hospital Basel, Basel, Switzerland
    Arch Otolaryngol Head Neck Surg 131:1007-13. 2005
    ..To determine the distribution of alpha1, alpha3, and alpha5 chains of type IV collagen in the cochlea in Alport syndrome...
  56. pmc Cochleosaccular dysplasia associated with a connexin 26 mutation in keratitis-ichthyosis-deafness syndrome
    Andrew J Griffith
    Section on Gene Structure and Function, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA
    Laryngoscope 116:1404-8. 2006
    ..The objective of this study was to characterize the temporal bone phenotype associated with a mutation of GJB2 (encoding connexin 26)...
  57. ncbi request reprint Association between osteoporosis and otosclerosis in women
    Amy E Clayton
    University of Wales College of Medicine, Cardiff, UK
    J Laryngol Otol 118:617-21. 2004
    ..007) between otosclerosis and osteoporosis. This study suggests an association between otosclerosis and osteoporosis, providing impetus and justification for future prospective clinical studies and related research...
  58. ncbi request reprint Recent advances in otitis media. 3. Animal models; anatomy and pathology; pathogenesis; cell biology and genetics
    David J Lim
    Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, California, USA
    Ann Otol Rhinol Laryngol Suppl 194:31-41. 2005
  59. pmc Vestibular evoked myogenic potentials (VEMP) can detect asymptomatic saccular hydrops
    Ming Yee Lin
    Kaohsiung Veterans General Hospital, Haohsiung, Taiwan
    Laryngoscope 116:987-92. 2006
    ..The objective of this study was to explore the useful of vestibular evoked myogenic potential (VEMP) testing for detecting endolymphatic hydrops, especially in the second ear of patients with unilateral Ménière disease (MD)...
  60. pmc Human temporal bone consortium for research resource enhancement
    Saumil N Merchant
    Otol Neurotol 29:271-4. 2008

Research Grants15

  1. Middle-ear Mechanics in Normal and Pathological Ears
    Saumil N Merchant; Fiscal Year: 2010
    ..abstract_text> ..
  2. Otopathology by Light Microscopy and Molecular Techniques
    SAUMIL MERCHANT; Fiscal Year: 2007
    ..6. To cooperate with the Temporal Bone Research Consortium. This research will provide new knowledge about the causes of disorders of hearing and balance, which should lead to better methods of diagnosis and therapy. ..
  3. Middle-ear Mechanics in Normal and Pathological Ears
    SAUMIL MERCHANT; Fiscal Year: 2007
    ....
  4. Middle-ear Mechanics in Normal and Pathological Ears
    SAUMIL MERCHANT; Fiscal Year: 2005
    ..abstract_text> ..
  5. DEVELOPMENT OF A MIDDLE EAR BALLOON IMPLANT
    SAUMIL MERCHANT; Fiscal Year: 2003
    ..There is a large market potential for this implant, estimated at over 65,000 devices annually in the U.S. alone. ..
  6. Middle-ear Mechanics in Normal and Pathological Ears
    SAUMIL MERCHANT; Fiscal Year: 2009
    ..abstract_text> ..