Research Topics
| S N MerchantSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Middle ear mechanics of Type III tympanoplasty (stapes columella): II. Clinical studiesSaumil N Merchant
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
Otol Neurotol 24:186-94. 2003....- Temporal bone histopathology in alport syndromeSaumil N Merchant
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA
Laryngoscope 114:1609-18. 2004..To determine the histopathologic abnormalities within the cochlea in Alport syndrome... - Acoustic responses of the human middle earS E Voss
Eaton Peabody Laboratory of Auditory Physiology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
Hear Res 150:43-69. 2000.... - Effect of freezing and thawing on stapes-cochlear input impedance in human temporal bonesM E Ravicz
Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
Hear Res 150:215-24. 2000..Investigations of middle-ear function for which Z(SC) is critical should use fresh temporal bones only or should allow for the possible reduction in /Z(SC)/ in thawed frozen bones... - Temporal bone histopathologic and genetic studies in Mohr-Tranebjaerg syndrome (DFN-1)S N Merchant
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
Otol Neurotol 22:506-11. 2001..Sequence analysis from temporal bone DNA showed the 15ldelT DDP gene mutation. CONCLUSION: Sensorineural hearing loss in Mohr-Tranebjaerg syndrome is the result of a postnatal, progressive, severe auditory neuropathy... - Histologic studies of the posterior stapediovestibular joint in otosclerosisS N Merchant
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston 02114-3096, USA
Otol Neurotol 22:305-10. 2001..01). The audiogram could not be used to reliably predict otosclerotic involvement of the posterior SVJ or the degree of footplate pathologic changes, such as ankylosis... - How do tympanic-membrane perforations affect human middle-ear sound transmission?S E Voss
Easton Peabody Laboratory of Auditory Physiology, Massachusetts Eye and Ear Infirmary, Boston 02144, USA
Acta Otolaryngol 121:169-73. 2001..A quantitative model predicts the influence of middle-ear air-space volume on loss; with larger volumes, loss is smaller... 
Testing a method for quantifying the output of implantable middle ear hearing devicesJ J Rosowski
The Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
Audiol Neurootol 12:265-76. 2007..The practice calls for measurements in cadaveric ears in order to account for the varied anatomy and function of different human middle ears...- Decreasing hair cell counts in aging humansS D Rauch
Department of Otology and Laryngology, Harvard Medical School at Massachusetts Eye and Ear Infirmary, Boston 02114, USA
Ann N Y Acad Sci 942:220-7. 2001..They also provide a basis for drawing correlations between vestibular function testing and vestibular otopathology... - Anatomy of the normal human cochlear aqueduct with functional implicationsQ Gopen
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston 02114, USA
Hear Res 107:9-22. 1997..In pathological ears, such as those with ossicular disruption or after a type IV tympanoplasty, a patent aqueduct might affect hearing for frequencies below 150 Hz... - Histopathology and molecular genetics of hearing loss in the humanJ B Nadol
Department of Otology and Laryngology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114 3096, USA
Int J Pediatr Otorhinolaryngol 61:1-15. 2001.... - Otopathology in a case of type I Waardenburg's syndromeS N Merchant
Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts, USA
Ann Otol Rhinol Laryngol 110:875-82. 2001.... - Isolated fracture of the manubrium of the malleusW Chien
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA
J Laryngol Otol 122:898-904. 2008..To describe a series of five patients with isolated fracture of the manubrium of the malleus... - Mutations in a novel cochlear gene cause DFNA9, a human nonsyndromic deafness with vestibular dysfunctionN G Robertson
Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Genet 20:299-303. 1998..These areas correspond to human inner ear structures which show histopathological findings of acidophilic ground substance in DFNA9 patients... - A gene for non-syndromic autosomal dominant progressive postlingual sensorineural hearing loss maps to chromosome 14q12-13E N Manolis
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA
Hum Mol Genet 5:1047-50. 1996..19, theta = 0). Haplotype analysis of recombination events defined a 9 cM disease interval, between D14S252 and D14S49... - Non-ossicular signal transmission in human middle ears: Experimental assessment of the "acoustic route" with perforated tympanic membranesSusan E Voss
Picker Engineering Program, Smith College, 51 College Lane, Northampton, Massachusetts 01063, USA
J Acoust Soc Am 122:2135-53. 2007..Some features of the frequency dependence of H(P(CAV) ) and H(WPD) can be interpreted in terms of a structure-based lumped-element acoustic model of the perforation and middle-ear cavities... - Polyester wax: a new embedding medium for the histopathologic study of human temporal bonesSaumil N Merchant
Otopathology Laboratory and the Department of Otolaryngology, MA Eye and Ear Infirmary, and the Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02114, USA
Laryngoscope 116:245-9. 2006..Embedding in paraffin allows immunostaining to be performed, but preservation of cellular detail within the membranous labyrinth is relatively poor... - Osteoprotegrin knockout mice demonstrate abnormal remodeling of the otic capsule and progressive hearing lossAndreas F Zehnder
Department of Otology and Laryngology, Harvard Medical School, and the Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114 3096, USA
Laryngoscope 116:201-6. 2006..We also tested the hearing in OPG knockout mice to determine whether OPG and its influence on surrounding bone is important for auditory function... - Determinants of hearing loss in perforations of the tympanic membraneRitvik P Mehta
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
Otol Neurotol 27:136-43. 2006..Effects of location, if any, are small... - Distribution of type IV collagen in the cochlea in Alport syndromeAndreas F Zehnder
Ear, Nose, and Throat Department, University Hospital Basel, Basel, Switzerland
Arch Otolaryngol Head Neck Surg 131:1007-13. 2005..The results are also consistent with the hypothesis that the sensorineural hearing loss in Alport syndrome may be due to alterations in cochlear micromechanics and/or dysfunction of the spiral ligament... - The effect of methodological differences in the measurement of stapes motion in live and cadaver earsWade Chien
Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, and Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02114, USA
Audiol Neurootol 11:183-97. 2006..This demonstrates that the commonly used method of estimating stapes translational velocity by dividing the measured velocity by the cosine of the measurement angle is not valid above 2 kHz... - Results after revision stapedectomy with malleus grip prosthesisSarp Sarac
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
Ann Otol Rhinol Laryngol 115:317-22. 2006..Our results are similar to those published in the literature for malleus attachment stapedectomy and conventional revision incus stapedectomy... - Three-dimensional virtual model of the human temporal bone: a stand-alone, downloadable teaching toolHaobing Wang
Eaton Peabody Laboratory of Auditory Physiology, Massachusetts Eye and Ear Infirmary, Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02114, USA
Otol Neurotol 27:452-7. 2006..To develop a three-dimensional virtual model of a human temporal bone based on serial histologic sections... - Cochleosaccular dysplasia associated with a connexin 26 mutation in keratitis-ichthyosis-deafness syndromeAndrew J Griffith
Section on Gene Structure and Function, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA
Laryngoscope 116:1404-8. 2006..CONCLUSIONS: GJB2 mutations can cause deafness in KID syndrome, and possibly in other GJB2 mutant phenotypes, by disrupting cochlear differentiation... - Anatomy of the round window and hook region of the cochlea with implications for cochlear implantation and other endocochlear surgical proceduresPeter M M C Li
Department of Otology and Laryngology, Harvard Medical School Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
Otol Neurotol 28:641-8. 2007..The goal of this study was to create a three-dimensional model of the anatomy of the hook region to identify the optimal site for cochleostomy in cochlear implant surgery... - Clinical investigation and mechanism of air-bone gaps in large vestibular aqueduct syndromeSaumil N Merchant
Massachusetts Eye and Ear Infirmary, Department of Otolaryngology, 243 Charles St, Boston, MA 02114, USA
Ann Otol Rhinol Laryngol 116:532-41. 2007..The mechanism causing such a gap has not been well elucidated. We investigated middle ear sound transmission in patients with LVAS, and present a hypothesis to explain the air-bone gap... - Superior semicircular canal dehiscence mimicking otosclerotic hearing lossSaumil N Merchant
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114 3096, USA
Adv Otorhinolaryngol 65:137-45. 2007.... - Measurements of human middle- and inner-ear mechanics with dehiscence of the superior semicircular canalWade Chien
Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, USA
Otol Neurotol 28:250-7. 2007.... - Otopathology in Mohr-Tranebjaerg syndromeFayez Bahmad
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114 3096, USA
Laryngoscope 117:1202-8. 2007..MTS is caused by mutations in the DDP/TIMM8A gene, which encodes for a 97 amino acid polypeptide; this polypeptide is a translocase of the inner mitochondrial membrane... - Experimental ossicular fixations and the middle ear's response to sound: evidence for a flexible ossicular chainHideko Heidi Nakajima
Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02115, USA
Hear Res 204:60-77. 2005.... - Pathology and pathophysiology of idiopathic sudden sensorineural hearing lossSaumil N Merchant
Otopathology Laboratory, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
Otol Neurotol 26:151-60. 2005..The cause and pathogenesis of idiopathic sudden sensorineural hearing loss remain unknown. Proposed theories include vascular occlusion, membrane breaks, and viral cochleitis... - Investigation of the mechanics of Type III stapes columella tympanoplasty using laser-Doppler vibrometryWade Chien
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
Otol Neurotol 28:782-7. 2007.... - Diagnostic utility of laser-Doppler vibrometry in conductive hearing loss with normal tympanic membraneJohn J Rosowski
Department of Otology and Laryngology, Harvard Medical School, Boston, MA, USA
Otol Neurotol 24:165-75. 2003..More generally, we hypothesize that laser-Doppler vibrometry measurements of umbo velocity can give information about how differences in the impedance that the ossicles work against affect middle-ear function... - Middle-ear mechanics of Type III tympanoplasty (stapes columella): I. Experimental studiesRitvik P Mehta
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
Otol Neurotol 24:176-85. 2003..Improved results were achieved by interposing a thin cartilage disc between the graft and stapes head to increase the effective vibrating area of the graft... - Temporal bone histopathological and quantitative analysis of mitochondrial DNA in MELASKatsumasa Takahashi
Department of Otolarynology, Gunma University, Maebashi, Japan
Laryngoscope 113:1362-8. 2003..CONCLUSION: Dysfunction of the stria vascularis and spiral ganglion cells causes sensorineural hearing loss in MELAS... - A normative study of tympanic membrane motion in humans using a laser Doppler vibrometer (LDV)Kenneth R Whittemore
Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02114, USA
Hear Res 187:85-104. 2004..These results provide a baseline normal response for studies of TM velocity with conductive hearing losses of different etiologies... - Sudden deafness: is it viral?Saumil N Merchant
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
ORL J Otorhinolaryngol Relat Spec 70:52-60; discussion 60-2. 2008..Finally, we review our recently proposed theory that abnormal cellular stress responses within the cochlea may be responsible for ISSHL... - Clinical, experimental, and theoretical investigations of the effect of superior semicircular canal dehiscence on hearing mechanismsJohn J Rosowski
Eaton Peabody Laboratory, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
Otol Neurotol 25:323-32. 2004.... - Deoxyribonucleic acid contamination in archival human temporal bones: a potentially significant problemMichael J McKenna
Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts, USA
Otol Neurotol 23:789-92. 2002..Contamination of archival human temporal bones with extraneous deoxyribonucleic acid may represent a potentially significant problem in the analysis of nucleic acids isolated from archival specimens... - Mechanisms of hearing loss resulting from middle-ear fluidMichael E Ravicz
The Eaton Peabody Laboratory of Auditory Physiology, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
Hear Res 195:103-30. 2004..Small amounts of air in the middle ear are sufficient to facilitate umbo motion at low frequencies... - Conductive hearing loss caused by third-window lesions of the inner earSaumil N Merchant
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Division of Health Sciences and Technology, Harvard University Massachusetts Institute of Technology, Cambridge, Massachusetts 02114, USA
Otol Neurotol 29:282-9. 2008..Recent investigations have suggested that many of these cases are due to disorders of the inner ear, resulting in pathologic third windows... - Clinical utility of laser-Doppler vibrometer measurements in live normal and pathologic human earsJohn J Rosowski
Eaton Peabody Lab, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
Ear Hear 29:3-19. 2008..LDV measurements can also help differentiate air-bone gaps produced by ossicular pathologies from those associated with pathologies of inner-ear sound conduction such as a superior semicircular canal dehiscence... - Superior semicircular canal dehiscence presenting as conductive hearing loss without vertigoAnthony A Mikulec
Department of Otology and Laryngology, Harvard Medical School, and the Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
Otol Neurotol 25:121-9. 2004.... - Postauricular periosteal-pericranial flap for mastoid obliteration and canal wall down tympanomastoidectomyMitchell J Ramsey
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
Otol Neurotol 25:873-8. 2004.... - Experimental and clinical studies of malleus fixationHideko Heidi Nakajima
Department of Otology and Laryngology, Harvard Medical School, and the Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA, USA
Laryngoscope 115:147-54. 2005..CONCLUSION: The study showed that measurements of umbo velocity and air-bone gap can enable one to diagnose malleus fixation and specifies how to differentiate malleus from stapes fixation... - Pathophysiology of Meniere's syndrome: are symptoms caused by endolymphatic hydrops?Saumil N Merchant
Otopathology Laboratory, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114 3096, USA
Otol Neurotol 26:74-81. 2005..If the central hypothesis were true, every case of Meniere's syndrome should have hydrops and every case of hydrops should show the typical symptoms... - Human temporal bone consortium for research resource enhancementSaumil N Merchant
Otol Neurotol 29:271-4. 2008 - Paget disease of the temporal boneFayez Bahmad
Otopathology Laboratory, Massachusetts Eye and Ear Infirmary, and Harvard Medical School, Boston, Massachusetts 02114, USA
Otol Neurotol 28:1157-8. 2007 - Histopathology of ossicular grafts and implants in chronic otitis mediaFayez Bahmad
Otopathology Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, 02114, USA
Ann Otol Rhinol Laryngol 116:181-91. 2007..We describe the histopathology of ossicular grafts and implants so as to provide insight into factors that may influence functional results after surgery for chronic otitis media... - Axial mesodermal dysplasia sequence: autopsy findingsSaumil N Merchant
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, USA
Clin Dysmorphol 13:21-4. 2004..Postmortem studies identified anomalies of the middle ear ossicles, and muscles, in association with microtia and atresia of the external auditory canals, but no cerebral abnormalities... - Transverse fracture of the temporal boneAndreas Zehnder
Otopathology Laboratory, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
Otol Neurotol 25:852-3. 2004 - Association between osteoporosis and otosclerosis in womenAmy E Clayton
University of Wales College of Medicine, Cardiff, UK
J Laryngol Otol 118:617-21. 2004..007) between otosclerosis and osteoporosis. This study suggests an association between otosclerosis and osteoporosis, providing impetus and justification for future prospective clinical studies and related research... - Osteoprotegerin in the inner ear may inhibit bone remodeling in the otic capsuleAndreas F Zehnder
Department of Otolaryngology, MA Eye and Ear Infirmary, and Harvard Medical School, Boston, MA, USA
Laryngoscope 115:172-7. 2005..By this means, the cochlear soft tissue may control the nature of the surrounding petrous bone... - Recent advances in otitis media. 3. Animal models; anatomy and pathology; pathogenesis; cell biology and geneticsDavid J Lim
Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, California, USA
Ann Otol Rhinol Laryngol Suppl 194:31-41. 2005 - Cochlin immunostaining of inner ear pathologic deposits and proteomic analysis in DFNA9 deafness and vestibular dysfunctionNahid G Robertson
Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Hum Mol Genet 15:1071-85. 2006.... - Vestibular evoked myogenic potentials (VEMP) can detect asymptomatic saccular hydropsMing-Yee Lin
Kaohsiung Veterans General Hospital, Haohsiung, Taiwan
Laryngoscope 116:987-92. 2006..Changes in VEMP threshold and tuning appear to be sensitive to these structural changes in the saccule. If so, then VEMP may be useful as a detector of asymptomatic saccular hydrops and as a predictor of evolving bilateral MD... - A downloadable three-dimensional virtual model of the visible earHaobing Wang
Eaton Peabody Laboratory of Auditory Physiology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA
ORL J Otorhinolaryngol Relat Spec 69:63-7. 2007..To develop a three-dimensional (3-D) virtual model of a human temporal bone and surrounding structures... - Erythromycin ototoxicityLee J McGhan
Department of Otolaryngology, Massachussets Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
Otol Neurotol 24:701-2. 2003