Jack Mendelson

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Temporal concordance of cocaine effects on mood states and neuroendocrine hormones
    Jack H Mendelson
    Alcohol and Drug Abuse Research Center, McLean Hospital, Belmont, MA 02478, USA
    Psychoneuroendocrinology 27:71-82. 2002
  2. pmc Effects of low- and high-nicotine cigarette smoking on mood states and the HPA axis in men
    Jack H Mendelson
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Neuropsychopharmacology 30:1751-63. 2005
  3. ncbi request reprint Effects of smoking successive low- and high-nicotine cigarettes on hypothalamic-pituitary-adrenal axis hormones and mood in men
    Jack H Mendelson
    Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Neuropsychopharmacology 33:749-60. 2008
  4. ncbi request reprint Effects of intravenous cocaine and cigarette smoking on luteinizing hormone, testosterone, and prolactin in men
    Jack H Mendelson
    Alcohol and Drug Abuse Research Center, Harvard Medical School McLean Hospital, Belmont, MA 02478, USA
    J Pharmacol Exp Ther 307:339-48. 2003
  5. ncbi request reprint Ovarian steroid hormone modulation of the acute effects of cocaine on luteinizing hormone and prolactin levels in ovariectomized rhesus monkeys
    Nancy K Mello
    Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, Belmont, Massachusetts 02478, USA
    J Pharmacol Exp Ther 308:156-67. 2004
  6. ncbi request reprint Effects of the CRF1 antagonist antalarmin on cocaine self-administration and discrimination in rhesus monkeys
    Nancy K Mello
    Alcohol and Drug Abuse Research Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478 USA
    Pharmacol Biochem Behav 85:744-51. 2006
  7. ncbi request reprint Sex and menstrual cycle effects on progressive ratio measures of cocaine self-administration in cynomolgus monkeys
    Nancy K Mello
    Alcohol and Drug Abuse Research Center, Harvard Medical School McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Neuropsychopharmacology 32:1956-66. 2007
  8. pmc Effects of nalbuphine on anterior pituitary and adrenal hormones and subjective responses in male cocaine abusers
    Nathalie V Goletiani
    Alcohol and Drug Abuse Research Center, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
    Pharmacol Biochem Behav 86:667-77. 2007
  9. ncbi request reprint Effects of estradiol on cocaine self-administration and cocaine discrimination by female rhesus monkeys
    Nancy K Mello
    Department of Psychiatry, Alcohol and Drug Abuse Research Center, Harvard Medical School McLean Hospital, Belmont, MA 02478, USA
    Neuropsychopharmacology 33:783-95. 2008
  10. pmc Effects of the mixed mu/kappa opioid nalbuphine on cocaine-induced changes in subjective and cardiovascular responses in men
    Nancy K Mello
    Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Neuropsychopharmacology 30:618-32. 2005

Research Grants

  1. BRAIN ALCOHOL MRS AND FAMILY HISTORY OF ALCOHOLISM
    Jack Mendelson; Fiscal Year: 1999
  2. Neurobiology of Nicotine: Hormones and Behavior
    NANCY MELLO; Fiscal Year: 2007
  3. BIOBEHAVIORAL STUDIES OF NARCOTICS ABUSE
    Jack Mendelson; Fiscal Year: 2007
  4. BRAIN ALCOHOL MRS AND FAMILY HISTORY OF ALCOHOLISM
    Jack Mendelson; Fiscal Year: 2001
  5. DRUG ABUSE RESEARCH TRAINING PROGRAM
    NANCY MELLO; Fiscal Year: 2007

Detail Information

Publications20

  1. ncbi request reprint Temporal concordance of cocaine effects on mood states and neuroendocrine hormones
    Jack H Mendelson
    Alcohol and Drug Abuse Research Center, McLean Hospital, Belmont, MA 02478, USA
    Psychoneuroendocrinology 27:71-82. 2002
    ..The similarities between these hormonal profiles, the subjective effects of cocaine and the effects of "stress" are discussed...
  2. pmc Effects of low- and high-nicotine cigarette smoking on mood states and the HPA axis in men
    Jack H Mendelson
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Neuropsychopharmacology 30:1751-63. 2005
    ..These data suggest that activation of the HPA axis may contribute to the abuse-related effects of cigarette smoking...
  3. ncbi request reprint Effects of smoking successive low- and high-nicotine cigarettes on hypothalamic-pituitary-adrenal axis hormones and mood in men
    Jack H Mendelson
    Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Neuropsychopharmacology 33:749-60. 2008
    ..Tolerance to the subjective and cardiovascular effects of nicotine developed rapidly during repeated cigarette smoking, but nicotine-stimulated increases in HPA axis hormones did not change significantly...
  4. ncbi request reprint Effects of intravenous cocaine and cigarette smoking on luteinizing hormone, testosterone, and prolactin in men
    Jack H Mendelson
    Alcohol and Drug Abuse Research Center, Harvard Medical School McLean Hospital, Belmont, MA 02478, USA
    J Pharmacol Exp Ther 307:339-48. 2003
    ..v. cocaine and high nicotine cigarette smoking illustrate the similarities between these drugs and suggest a possible contribution of LH to their abuse-related effects...
  5. ncbi request reprint Ovarian steroid hormone modulation of the acute effects of cocaine on luteinizing hormone and prolactin levels in ovariectomized rhesus monkeys
    Nancy K Mello
    Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, Belmont, Massachusetts 02478, USA
    J Pharmacol Exp Ther 308:156-67. 2004
    ....
  6. ncbi request reprint Effects of the CRF1 antagonist antalarmin on cocaine self-administration and discrimination in rhesus monkeys
    Nancy K Mello
    Alcohol and Drug Abuse Research Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478 USA
    Pharmacol Biochem Behav 85:744-51. 2006
    ..Antalarmin (10 mg/kg) produced sedation, suggesting that it was centrally active, however, it did not attenuate cocaine's abuse-related effects in rhesus monkeys...
  7. ncbi request reprint Sex and menstrual cycle effects on progressive ratio measures of cocaine self-administration in cynomolgus monkeys
    Nancy K Mello
    Alcohol and Drug Abuse Research Center, Harvard Medical School McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Neuropsychopharmacology 32:1956-66. 2007
    ....
  8. pmc Effects of nalbuphine on anterior pituitary and adrenal hormones and subjective responses in male cocaine abusers
    Nathalie V Goletiani
    Alcohol and Drug Abuse Research Center, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
    Pharmacol Biochem Behav 86:667-77. 2007
    ..Taken together, these data suggest that nalbuphine had both mu- and kappa-like effects on PRL (PRL increase) but did not increase ACTH and cortisol...
  9. ncbi request reprint Effects of estradiol on cocaine self-administration and cocaine discrimination by female rhesus monkeys
    Nancy K Mello
    Department of Psychiatry, Alcohol and Drug Abuse Research Center, Harvard Medical School McLean Hospital, Belmont, MA 02478, USA
    Neuropsychopharmacology 33:783-95. 2008
    ..Taken together, these data suggest that over the dose range studied, estradiol administration does not consistently alter the abuse-related effects of cocaine in female rhesus monkeys...
  10. pmc Effects of the mixed mu/kappa opioid nalbuphine on cocaine-induced changes in subjective and cardiovascular responses in men
    Nancy K Mello
    Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Neuropsychopharmacology 30:618-32. 2005
    ..01-0.003). Thus, there were no additive interactions between nalbuphine and cocaine on cardiovascular, subjective, or drug level measures after acute administration...
  11. pmc Opioid and cocaine combined effect on cocaine-induced changes in HPA and HPG axes hormones in men
    Nathalie V Goletiani
    Alcohol and Drug Abuse Research Center, Harvard Medical School and McLean Hospital, Belmont, MA 02478, USA
    Pharmacol Biochem Behav 91:526-36. 2009
    ..These data are consistent with our earlier report that nalbuphine modestly attenuated cocaine's positive subjective effects, and that the subjective and cardiovascular effects of cocaine+nalbuphine in combination were not additive...
  12. ncbi request reprint The effects of cocaine on gonadal steroid hormones and LH in male and female rhesus monkeys
    Nancy K Mello
    Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, Belmont, MA, USA
    Neuropsychopharmacology 29:2024-34. 2004
    ..These rapid hormonal changes may contribute to cocaine's abuse-related effects, as well as to disruptions of the menstrual cycle during chronic cocaine administration...
  13. ncbi request reprint Diminished interleukin-6 response to proinflammatory challenge in men and women after intravenous cocaine administration
    John H Halpern
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    J Clin Endocrinol Metab 88:1188-93. 2003
    ..Because cocaine stimulates the hypothalamic-pituitary-adrenal axis, IL-6 suppression may be a consequence of corticosteroid release. Cocaine-induced suppression of proinflammatory IL-6 may mediate impaired host defenses to infections...
  14. ncbi request reprint Effect of cocaine usage on C-reactive protein, von Willebrand factor, and fibrinogen
    Arthur J Siegel
    Department of Medicine, McLean Hospital, Belmont, Massachusetts, USA
    Am J Cardiol 89:1133-5. 2002
  15. ncbi request reprint Hyponatremia in marathon runners due to inappropriate arginine vasopressin secretion
    Arthur J Siegel
    Department of Medicine, McLean Hospital, Belmont, Mass, USA
    Am J Med 120:461.e11-7. 2007
    ..Understanding the pathogenetic role of antidiuresis may lead to improved strategies for prevention and treatment...
  16. ncbi request reprint Comparison of plasma cocaine levels during a "binge" pattern of cocaine administration in male and female rhesus monkeys
    Nancy K Mello
    McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 164:19-26. 2002
    ..Moreover, the extent to which gender may influence plasma cocaine levels during a cocaine binge has not been studied in rhesus monkeys...
  17. ncbi request reprint An inpatient study of the effects of buprenorphine on cigarette smoking in men concurrently dependent on cocaine and opioids
    Nicole H Mutschler
    Alcohol and Drug Abuse Research Center, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Nicotine Tob Res 4:223-8. 2002
    ..These findings are consistent with previous reports of opioid-cigarette interactions...
  18. ncbi request reprint Oral methylphenidate challenge selectively decreases putaminal T2 in healthy subjects
    Marisa M Silveri
    Brain Imaging Center, McLean Hospital and Department of Psychiatry, Harvard Medical School, Belmont, MA 02478, USA
    Drug Alcohol Depend 76:173-80. 2004
    ..These data suggest that T2 relaxometry can be used to study the time course of regional cerebral blood volume responses to MPH and perhaps to other stimulant drugs...
  19. ncbi request reprint Cerebral phosphorus metabolite and transverse relaxation time abnormalities in heroin-dependent subjects at onset of methadone maintenance treatment
    Marisa M Silveri
    Brain Imaging Center, McLean Hospital, Department of Psychiatry, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Psychiatry Res 131:217-26. 2004
    ..Taken together, these cross-sectional data suggest that the first month of MM treatment may be associated with altered cerebral bioenergetics and phospholipid metabolite levels...
  20. ncbi request reprint Subjective and hormonal effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans
    Debra S Harris
    Drug Dependence Research Center, Langley Porter Psychiatric Institute, University of California, San Francisco, 401 Parnassus Avenue, San Francisco, CA 94143 0984, USA
    Psychopharmacology (Berl) 162:396-405. 2002
    ..3,4-Methylenedioxymethamphetamine (MDMA) is a widely used phenethylamine. Reports have described the effects of MDMA in a controlled laboratory setting, but the full range of effects of MDMA in humans is still not completely characterized...

Research Grants10

  1. BRAIN ALCOHOL MRS AND FAMILY HISTORY OF ALCOHOLISM
    Jack Mendelson; Fiscal Year: 1999
    ..To the best of our knowledge there have been no previous investigations of the concordance of neurobiological, genetic and alcohol consumption variables which may influence occurrence of alcohol dependence in men and women. ..
  2. Neurobiology of Nicotine: Hormones and Behavior
    NANCY MELLO; Fiscal Year: 2007
    ..An increased understanding of nicotine's acute effects on anterior pituitary, gonadal and adrenal hormones may suggest new strategies for the development of antinicotine medications as it has for cocaine. ..
  3. BIOBEHAVIORAL STUDIES OF NARCOTICS ABUSE
    Jack Mendelson; Fiscal Year: 2007
    ....
  4. BRAIN ALCOHOL MRS AND FAMILY HISTORY OF ALCOHOLISM
    Jack Mendelson; Fiscal Year: 2001
    ..To the best of our knowledge there have been no previous investigations of the concordance of neurobiological, genetic and alcohol consumption variables which may influence occurrence of alcohol dependence in men and women. ..
  5. DRUG ABUSE RESEARCH TRAINING PROGRAM
    NANCY MELLO; Fiscal Year: 2007
    ....