Nancy K Mello

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Antagonism of the antinociceptive and discriminative stimulus effects of heroin and morphine by 3-methoxynaltrexone and naltrexone in rhesus monkeys
    Carrie A Bowen
    Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    J Pharmacol Exp Ther 302:264-73. 2002
  2. pmc Effects of the selective delta opioid agonist SNC80 on cocaine- and food-maintained responding in rhesus monkeys
    Gail Pereira Do Carmo
    Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Eur J Pharmacol 547:92-100. 2006
  3. ncbi request reprint Sex and menstrual cycle effects on progressive ratio measures of cocaine self-administration in cynomolgus monkeys
    Nancy K Mello
    Alcohol and Drug Abuse Research Center, Harvard Medical School McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Neuropsychopharmacology 32:1956-66. 2007
  4. ncbi request reprint Effects of d-amphetamine and buprenorphine combinations on speedball (cocaine+heroin) self-administration by rhesus monkeys
    Nancy K Mello
    Alcohol and Drug Abuse Research Center, Harvard Medical School McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Neuropsychopharmacology 32:1985-94. 2007
  5. pmc Effects of progesterone and testosterone on cocaine self-administration and cocaine discrimination by female rhesus monkeys
    Nancy K Mello
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Neuropsychopharmacology 36:2187-99. 2011
  6. pmc Discriminative and reinforcing stimulus effects of nicotine, cocaine, and cocaine + nicotine combinations in rhesus monkeys
    Nancy K Mello
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Exp Clin Psychopharmacol 19:203-14. 2011
  7. ncbi request reprint The effects of cocaine on gonadal steroid hormones and LH in male and female rhesus monkeys
    Nancy K Mello
    Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, Belmont, MA, USA
    Neuropsychopharmacology 29:2024-34. 2004
  8. ncbi request reprint Effects of the CRF1 antagonist antalarmin on cocaine self-administration and discrimination in rhesus monkeys
    Nancy K Mello
    Alcohol and Drug Abuse Research Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478 USA
    Pharmacol Biochem Behav 85:744-51. 2006
  9. ncbi request reprint Effects of estradiol on cocaine self-administration and cocaine discrimination by female rhesus monkeys
    Nancy K Mello
    Department of Psychiatry, Alcohol and Drug Abuse Research Center, Harvard Medical School McLean Hospital, Belmont, MA 02478, USA
    Neuropsychopharmacology 33:783-95. 2008
  10. pmc Effects of the mixed mu/kappa opioid nalbuphine on cocaine-induced changes in subjective and cardiovascular responses in men
    Nancy K Mello
    Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Neuropsychopharmacology 30:618-32. 2005

Research Grants

  1. BUPRENORPHINE: A BEHAVIORAL ANALYSIS
    NANCY MELLO; Fiscal Year: 2005
  2. Cocaine Abuse and the Role of Gonadal Steroid Hormones
    NANCY MELLO; Fiscal Year: 2005
  3. BIOBEHAVIORAL STUDIES OF SUBSTANCE ABUSE
    NANCY MELLO; Fiscal Year: 2007
  4. Sex/Gender and Nicotine Addiction: Hormones, Behavior and Neuroimaging
    PERRY FRANKLIN RENSHAW; Fiscal Year: 2010
  5. BUPRENORPHINE: A BEHAVIORAL ANALYSIS
    Nancy K Mello; Fiscal Year: 2010
  6. Sex/Gender Factors in Nicotine Addiction
    Nancy K Mello; Fiscal Year: 2010
  7. BUPRENORPHINE--A BEHAVIORAL ANALYSIS
    NANCY MELLO; Fiscal Year: 1993
  8. BUPRENORPHINE--A BEHAVIORAL ANALYSIS
    NANCY MELLO; Fiscal Year: 1992
  9. Preclinical Evaluation of Medications to Treat Polydrug Addiction
    Nancy K Mello; Fiscal Year: 2010

Detail Information

Publications51

  1. ncbi request reprint Antagonism of the antinociceptive and discriminative stimulus effects of heroin and morphine by 3-methoxynaltrexone and naltrexone in rhesus monkeys
    Carrie A Bowen
    Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    J Pharmacol Exp Ther 302:264-73. 2002
    ....
  2. pmc Effects of the selective delta opioid agonist SNC80 on cocaine- and food-maintained responding in rhesus monkeys
    Gail Pereira Do Carmo
    Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Eur J Pharmacol 547:92-100. 2006
    ..These findings indicate that SNC80 produced dose-dependent and non-selective reductions in cocaine self-administration. These results suggest that SNC80 is unlikely to be useful as a treatment for cocaine dependence...
  3. ncbi request reprint Sex and menstrual cycle effects on progressive ratio measures of cocaine self-administration in cynomolgus monkeys
    Nancy K Mello
    Alcohol and Drug Abuse Research Center, Harvard Medical School McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Neuropsychopharmacology 32:1956-66. 2007
    ....
  4. ncbi request reprint Effects of d-amphetamine and buprenorphine combinations on speedball (cocaine+heroin) self-administration by rhesus monkeys
    Nancy K Mello
    Alcohol and Drug Abuse Research Center, Harvard Medical School McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Neuropsychopharmacology 32:1985-94. 2007
    ..These findings are consistent with our previous reports and suggest that medication mixtures designed to target both the stimulant and the opioid component of the speedball may be an effective approach to polydrug abuse treatment...
  5. pmc Effects of progesterone and testosterone on cocaine self-administration and cocaine discrimination by female rhesus monkeys
    Nancy K Mello
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Neuropsychopharmacology 36:2187-99. 2011
    ....
  6. pmc Discriminative and reinforcing stimulus effects of nicotine, cocaine, and cocaine + nicotine combinations in rhesus monkeys
    Nancy K Mello
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Exp Clin Psychopharmacol 19:203-14. 2011
    ..Further studies of the behavioral effects of nicotine + cocaine combinations will contribute to our understanding the pharmacology of dual nicotine and cocaine dependence, and will be useful for evaluation of new treatment medications...
  7. ncbi request reprint The effects of cocaine on gonadal steroid hormones and LH in male and female rhesus monkeys
    Nancy K Mello
    Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, Belmont, MA, USA
    Neuropsychopharmacology 29:2024-34. 2004
    ..These rapid hormonal changes may contribute to cocaine's abuse-related effects, as well as to disruptions of the menstrual cycle during chronic cocaine administration...
  8. ncbi request reprint Effects of the CRF1 antagonist antalarmin on cocaine self-administration and discrimination in rhesus monkeys
    Nancy K Mello
    Alcohol and Drug Abuse Research Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478 USA
    Pharmacol Biochem Behav 85:744-51. 2006
    ..Antalarmin (10 mg/kg) produced sedation, suggesting that it was centrally active, however, it did not attenuate cocaine's abuse-related effects in rhesus monkeys...
  9. ncbi request reprint Effects of estradiol on cocaine self-administration and cocaine discrimination by female rhesus monkeys
    Nancy K Mello
    Department of Psychiatry, Alcohol and Drug Abuse Research Center, Harvard Medical School McLean Hospital, Belmont, MA 02478, USA
    Neuropsychopharmacology 33:783-95. 2008
    ..Taken together, these data suggest that over the dose range studied, estradiol administration does not consistently alter the abuse-related effects of cocaine in female rhesus monkeys...
  10. pmc Effects of the mixed mu/kappa opioid nalbuphine on cocaine-induced changes in subjective and cardiovascular responses in men
    Nancy K Mello
    Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Neuropsychopharmacology 30:618-32. 2005
    ..01-0.003). Thus, there were no additive interactions between nalbuphine and cocaine on cardiovascular, subjective, or drug level measures after acute administration...
  11. pmc Hormones, nicotine, and cocaine: clinical studies
    Nancy K Mello
    McLean Hospital Harvard Medical School, Alcohol and Drug Abuse Research Center, 115 Mill Street, Belmont, MA 02478, USA
    Horm Behav 58:57-71. 2010
    ..Only DHEA increased consistently after successive cigarettes. The possible influence of neuroactive hormones on nicotine dependence and cocaine abuse and the implications for treatment of these addictive disorders are discussed...
  12. pmc Effects of low- and high-nicotine cigarette smoking on mood states and the HPA axis in men
    Jack H Mendelson
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Neuropsychopharmacology 30:1751-63. 2005
    ..These data suggest that activation of the HPA axis may contribute to the abuse-related effects of cigarette smoking...
  13. pmc Opioid and cocaine combined effect on cocaine-induced changes in HPA and HPG axes hormones in men
    Nathalie V Goletiani
    Alcohol and Drug Abuse Research Center, Harvard Medical School and McLean Hospital, Belmont, MA 02478, USA
    Pharmacol Biochem Behav 91:526-36. 2009
    ..These data are consistent with our earlier report that nalbuphine modestly attenuated cocaine's positive subjective effects, and that the subjective and cardiovascular effects of cocaine+nalbuphine in combination were not additive...
  14. ncbi request reprint Effects of smoking successive low- and high-nicotine cigarettes on hypothalamic-pituitary-adrenal axis hormones and mood in men
    Jack H Mendelson
    Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Neuropsychopharmacology 33:749-60. 2008
    ..Tolerance to the subjective and cardiovascular effects of nicotine developed rapidly during repeated cigarette smoking, but nicotine-stimulated increases in HPA axis hormones did not change significantly...
  15. ncbi request reprint Ovarian steroid hormone modulation of the acute effects of cocaine on luteinizing hormone and prolactin levels in ovariectomized rhesus monkeys
    Nancy K Mello
    Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, Belmont, Massachusetts 02478, USA
    J Pharmacol Exp Ther 308:156-67. 2004
    ....
  16. ncbi request reprint Effects of intravenous cocaine and cigarette smoking on luteinizing hormone, testosterone, and prolactin in men
    Jack H Mendelson
    Alcohol and Drug Abuse Research Center, Harvard Medical School McLean Hospital, Belmont, MA 02478, USA
    J Pharmacol Exp Ther 307:339-48. 2003
    ..v. cocaine and high nicotine cigarette smoking illustrate the similarities between these drugs and suggest a possible contribution of LH to their abuse-related effects...
  17. pmc Effects of nalbuphine on anterior pituitary and adrenal hormones and subjective responses in male cocaine abusers
    Nathalie V Goletiani
    Alcohol and Drug Abuse Research Center, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
    Pharmacol Biochem Behav 86:667-77. 2007
    ..Taken together, these data suggest that nalbuphine had both mu- and kappa-like effects on PRL (PRL increase) but did not increase ACTH and cortisol...
  18. ncbi request reprint Kappa opioid antagonist effects of the novel kappa antagonist 5'-guanidinonaltrindole (GNTI) in an assay of schedule-controlled behavior in rhesus monkeys
    S Stevens Negus
    Alcohol and Drug Abuse Research Center, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 163:412-9. 2002
    ..Receptor-selective antagonists are useful experimental tools for evaluation of opioid receptor-mediated processes. 5'-Guanidinonaltrindole (GNTI) was recently developed as a novel kappa-selective antagonist...
  19. ncbi request reprint Effect of gonadectomy and gonadal hormone replacement on cocaine self-administration in female and male rats
    S Barak Caine
    McLean Hospital, Alcohol and Drug Abuse Research Center, Harvard Medical School, Belmont, MA 02478, USA
    Neuropsychopharmacology 29:929-42. 2004
    ..These findings suggest that the behavioral training history, the unit dose of cocaine, and the schedule of reinforcement are important variables in studies of sex and gonadal hormone effects on cocaine self-administration...
  20. ncbi request reprint Effects of heroin and its metabolites on schedule-controlled responding and thermal nociception in rhesus monkeys: sensitivity to antagonism by quadazocine, naltrindole and beta-funaltrexamine
    S Stevens Negus
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, 115 Mill St, Belmont, MA 02178, USA
    Drug Alcohol Depend 70:17-27. 2003
    ..The in vivo apparent efficacy of heroin at mu receptors was similar to or only slightly greater than that of morphine...
  21. ncbi request reprint Effects of chronic d-amphetamine treatment on cocaine- and food-maintained responding under a second-order schedule in rhesus monkeys
    S Stevens Negus
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Drug Alcohol Depend 70:39-52. 2003
    ....
  22. ncbi request reprint Effects of chronic d-amphetamine treatment on cocaine- and food-maintained responding under a progressive-ratio schedule in rhesus monkeys
    S Stevens Negus
    Alcohol and Drug Abuse Research Center, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 167:324-32. 2003
    ..d-Amphetamine is a candidate agonist medication for the treatment of cocaine dependence, and evaluation of d-amphetamine effects on abuse-related effects of cocaine in preclinical assays is warranted...
  23. ncbi request reprint Effects of gonadal steroid hormone treatments on opioid antinociception in ovariectomized rhesus monkeys
    Stevens S Negus
    Alcohol and Drug Abuse Research Center, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 159:275-83. 2002
    ..Sex differences have also been observed in the antinociceptive effects of opioid agonists. These findings suggest that gonadal hormones may modulate opioid antinociception...
  24. ncbi request reprint Effects of mu-opioid agonists on cocaine- and food-maintained responding and cocaine discrimination in rhesus monkeys: role of mu-agonist efficacy
    S Stevens Negus
    Alcohol and Drug Abuse Research Center of McLean Hospital at Harvard Medical School, Belmont, Massachusetts 02178 9106, USA
    J Pharmacol Exp Ther 300:1111-21. 2002
    ..These results suggest that low-efficacy mu-agonists may decrease cocaine self-administration to a greater degree and with fewer undesirable effects than high-efficacy mu-agonists...
  25. pmc Effects of gender and menstrual cycle phase on food-maintained responding under a progressive-ratio schedule in cynomolgus monkeys
    Megan E Roth
    Alcohol and Drug Abuse Research Center, Department of Psychiatry, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Pharmacol Biochem Behav 82:735-43. 2005
    ..Although fluctuations in ovarian steroid hormones may influence food consumption under some conditions, consistent patterns of food-maintained responding were not detected during ovulatory menstrual cycles in cynomolgus monkeys...
  26. ncbi request reprint Sex differences in thermal nociception and prostaglandin-induced thermal hypersensitivity in rhesus monkeys
    S Stevens Negus
    Alcohol and Drug Abuse Research Center, Harvard Medical School McLean Hospital, Belmont, MA 02478, USA
    J Pain 5:92-103. 2004
    ..These results suggest that sex and gonadal hormone levels have only a minor influence on thermal nociception or thermal hypersensitivity in rhesus monkeys...
  27. doi request reprint Modification of cocaine self-administration by buspirone (buspar®): potential involvement of D3 and D4 dopamine receptors
    Jack Bergman
    Harvard Medical School McLean Hospital, Alcohol and Drug Abuse Research Center, Belmont, MA, USA
    Int J Neuropsychopharmacol 16:445-58. 2013
    ..v. cocaine in each subject. These results support the further evaluation of buspirone as a candidate medication for the management of cocaine addiction...
  28. pmc Effect of GABA agonists and GABA-A receptor modulators on cocaine- and food-maintained responding and cocaine discrimination in rats
    Andrew C Barrett
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    J Pharmacol Exp Ther 315:858-71. 2005
    ..Together with previous studies, these data suggest that among mechanistically diverse GABA agonists, high-efficacy GABA-A modulators may be the most effective for modifying the abuse-related effects of cocaine...
  29. ncbi request reprint Effects of mixed-action kappa/mu opioids on cocaine self-administration and cocaine discrimination by rhesus monkeys
    Carrie A Bowen
    Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Neuropsychopharmacology 28:1125-39. 2003
    ..Mixed kappa/mu agonists appear to offer some advantages over selective kappa agonists as potential treatments for cocaine abuse...
  30. ncbi request reprint Diminished interleukin-6 response to proinflammatory challenge in men and women after intravenous cocaine administration
    John H Halpern
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    J Clin Endocrinol Metab 88:1188-93. 2003
    ..Because cocaine stimulates the hypothalamic-pituitary-adrenal axis, IL-6 suppression may be a consequence of corticosteroid release. Cocaine-induced suppression of proinflammatory IL-6 may mediate impaired host defenses to infections...
  31. ncbi request reprint Effects of the mixed-action kappa/mu opioid agonist 8-carboxamidocyclazocine on cocaine- and food-maintained responding in rhesus monkeys
    Glenn W Stevenson
    Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Eur J Pharmacol 506:133-41. 2004
    ..However, non-selective effects of 8-CAC on food-maintained responding and tolerance to 8-CAC effects on cocaine self-administration may limit its potential for the treatment of cocaine dependence...
  32. ncbi request reprint Hyponatremia in marathon runners due to inappropriate arginine vasopressin secretion
    Arthur J Siegel
    Department of Medicine, McLean Hospital, Belmont, Mass, USA
    Am J Med 120:461.e11-7. 2007
    ..Understanding the pathogenetic role of antidiuresis may lead to improved strategies for prevention and treatment...
  33. ncbi request reprint Effects of chronic methadone treatment on cocaine- and food-maintained responding under second-order, progressive-ratio and concurrent-choice schedules in rhesus monkeys
    S Stevens Negus
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478 9106, USA
    Drug Alcohol Depend 74:297-309. 2004
    ..These results provide little evidence to suggest that chronic methadone altered the reinforcing effects of cocaine; rather methadone appeared to non-selectively decrease rates of operant responding...
  34. pmc Behavioral evaluation of modafinil and the abuse-related effects of cocaine in rhesus monkeys
    Jennifer L Newman
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Exp Clin Psychopharmacol 18:395-408. 2010
    ..These data support clinical findings and indicate that these preclinical models may be useful for predicting the effectiveness of agonist medications for drug abuse treatment...
  35. ncbi request reprint Role of dopamine D2-like receptors in cocaine self-administration: studies with D2 receptor mutant mice and novel D2 receptor antagonists
    S Barak Caine
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    J Neurosci 22:2977-88. 2002
    ..Our results also suggest that D3 and D4 receptors do not play major roles in the modulation of cocaine self-administration by D2-like drugs...
  36. ncbi request reprint Temporal concordance of cocaine effects on mood states and neuroendocrine hormones
    Jack H Mendelson
    Alcohol and Drug Abuse Research Center, McLean Hospital, Belmont, MA 02478, USA
    Psychoneuroendocrinology 27:71-82. 2002
    ..The similarities between these hormonal profiles, the subjective effects of cocaine and the effects of "stress" are discussed...
  37. pmc Effects of chronic buspirone treatment on cocaine self-administration
    Nancy K Mello
    Alcohol and Drug Abuse Research Center, Harvard Medical School McLean Hospital, Belmont, MA 02478, USA
    Neuropsychopharmacology 38:455-67. 2013
    ..These findings indicate that buspirone selectively attenuates the reinforcing effects of cocaine in a nonhuman primate model of cocaine self-administration, and has variable effects on cocaine discrimination...
  38. ncbi request reprint Design and synthesis of novel dimeric morphinan ligands for kappa and micro opioid receptors
    John L Neumeyer
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, Massachusetts 02478, USA
    J Med Chem 46:5162-70. 2003
    ....
  39. ncbi request reprint Comparison of plasma cocaine levels during a "binge" pattern of cocaine administration in male and female rhesus monkeys
    Nancy K Mello
    McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 164:19-26. 2002
    ..Moreover, the extent to which gender may influence plasma cocaine levels during a cocaine binge has not been studied in rhesus monkeys...
  40. ncbi request reprint The effects of heroin on prolactin levels in male rhesus monkeys: use of cumulative-dosing procedures
    Carrie A Bowen
    Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Psychoneuroendocrinology 27:319-36. 2002
    ..These data suggest that a cumulative-dosing procedure similar to that used in behavioral pharmacology may be useful to study the endocrine pharmacology of mu opioids in rhesus monkeys...
  41. pmc Nicotine related brain activity: the influence of smoking history and blood nicotine levels, an exploratory study
    RINAH T YAMAMOTO
    Brain Imaging Center, McLean Hospital, Harvard Medical School, 115 Mill St, Belmont, MA 02478, United States
    Drug Alcohol Depend 129:137-44. 2013
    ..In this study, we sought to explore brain activity in nicotine-dependent men in response to acute intravenous nicotine using pharmacological magnetic resonance imaging (phMRI)...
  42. ncbi request reprint An inpatient study of the effects of buprenorphine on cigarette smoking in men concurrently dependent on cocaine and opioids
    Nicole H Mutschler
    Alcohol and Drug Abuse Research Center, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Nicotine Tob Res 4:223-8. 2002
    ..These findings are consistent with previous reports of opioid-cigarette interactions...
  43. ncbi request reprint Brain alcohol detectability in human subjects with and without a paternal history of alcoholism
    Tak Ming Chiu
    Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, Massachusetts 02478, USA
    J Stud Alcohol 65:16-21. 2004
    ..This study examined the putative effects of a paternal history of alcoholism on the apparent detectability of brain alcohol in human subjects...
  44. doi request reprint Nicotine levels after IV nicotine and cigarette smoking in men
    Nancy K Mello
    Alcohol and Drug Abuse Research Center, Harvard Medical School, USA
    Exp Clin Psychopharmacol 21:188-95. 2013
    ..Plasma nicotine levels did not appear to determine the magnitude or time course of subjective effects under these conditions...
  45. pmc Differential effects of acute and chronic treatment with the α2-adrenergic agonist, lofexidine, on cocaine self-administration in rhesus monkeys
    Stephen J Kohut
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA Electronic address
    Drug Alcohol Depend 133:593-9. 2013
    ..However, relatively little is known about lofexidine interactions with cocaine. The present study investigated the effects of acute and chronic treatment with lofexidine in a pre-clinical model of cocaine self-administration...
  46. doi request reprint Effects of methcathinone and 3-Cl-methcathinone (PAL-434) in cocaine discrimination or self-administration in rhesus monkeys
    Stephen J Kohut
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, MA, USA
    Int J Neuropsychopharmacol 16:1985-98. 2013
    ..6-fold more potent at decreasing cocaine- over food-maintained responding. These data suggest that compounds with moderate selectivity for DA vs. 5-HT release (8–15-fold) may be effective for the treatment of cocaine dependence...
  47. pmc Effects of chronic buspirone treatment on nicotine and concurrent nicotine+cocaine self-administration
    Nancy K Mello
    Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Neuropsychopharmacology 38:1264-75. 2013
    ..We conclude that buspirone selectively attenuates the reinforcing effects of nicotine alone and nicotine+cocaine polydrug combinations in a nonhuman primate model of drug self-administration...
  48. pmc Effects of kappa opioid agonists alone and in combination with cocaine on heart rate and blood pressure in conscious squirrel monkeys
    Charles W Schindler
    Preclinical Pharmacology Section, Behavioral Neuroscience Branch, DHHS NIH NIDA Intramural Research Program, Baltimore MD CWS, ZG, JPG, SRG, United States
    Eur J Pharmacol 576:107-13. 2007
    ..When given in combination with cocaine, EKC produced effects that were sub-additive, suggesting that the kappa agonists may be used safely as cocaine abuse treatments...
  49. ncbi request reprint Development of a rationally designed, low abuse potential, biogenic amine releaser that suppresses cocaine self-administration
    Richard B Rothman
    Clinical Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 313:1361-9. 2005
    ..0 mg/kg/h. Collectively, the findings reported here demonstrate that nonamphetamine monoamine releasing agents such as PAL-287 might be promising candidate medications for the treatment of stimulant dependence...
  50. ncbi request reprint Kappa-opioid receptors are differentially labeled by arylacetamides and benzomorphans
    Daniela E Rusovici
    Department of Pharmacology and Physiology, School of Medicine and Dentistry, University of Rochester, P O Box 711, 601 Elmwood Avenue, Rochester, NY 14642 8711, USA
    Eur J Pharmacol 485:119-25. 2004
    ..These results suggest that pharmacologically defined 1 kappa-opioid receptor subtypes may be different affinity states of the same receptor...
  51. pmc Relationship between rate of drug uptake in brain and behavioral pharmacology of monoamine transporter inhibitors in rhesus monkeys
    Heather L Kimmel
    Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA
    Pharmacol Biochem Behav 90:453-62. 2008
    ..Collectively, these results indicate that the rate of drug entry in brain can play an important role in the behavioral pharmacology of psychomotor stimulants...

Research Grants38

  1. BUPRENORPHINE: A BEHAVIORAL ANALYSIS
    NANCY MELLO; Fiscal Year: 2005
    ..This comprehensive evaluation of the effects of novel mu, kappa and delta selective opioids on cocaine's abuse-related effects should suggest new approaches to cocaine abuse treatment. ..
  2. Cocaine Abuse and the Role of Gonadal Steroid Hormones
    NANCY MELLO; Fiscal Year: 2005
    ..Data obtained will help to clarify the neurobiologic substrates of cocaine abuse and may have heuristic implications for the development of new strategies for treatment. ..
  3. BIOBEHAVIORAL STUDIES OF SUBSTANCE ABUSE
    NANCY MELLO; Fiscal Year: 2007
    ..abstract_text> ..
  4. Sex/Gender and Nicotine Addiction: Hormones, Behavior and Neuroimaging
    PERRY FRANKLIN RENSHAW; Fiscal Year: 2010
    ..We propose to study how sex and phase of the menstrual cycle may influence the hormonal, neuroimaging and abuse-related effects of nicotine (the main addictive component of tobacco) in nicotine- dependent men and women. ..
  5. BUPRENORPHINE: A BEHAVIORAL ANALYSIS
    Nancy K Mello; Fiscal Year: 2010
    ....
  6. Sex/Gender Factors in Nicotine Addiction
    Nancy K Mello; Fiscal Year: 2010
    ....
  7. BUPRENORPHINE--A BEHAVIORAL ANALYSIS
    NANCY MELLO; Fiscal Year: 1993
    ..These studies should contribute to the understanding of the biological and behavioral bases of buprenorphine-cocaine interactions and suggest new directions for development of improved pharmacotherapies...
  8. BUPRENORPHINE--A BEHAVIORAL ANALYSIS
    NANCY MELLO; Fiscal Year: 1992
    ....
  9. Preclinical Evaluation of Medications to Treat Polydrug Addiction
    Nancy K Mello; Fiscal Year: 2010
    ..This strategy will facilitate translation of the most effective treatment medications into clinical trials. ..