Research Topics
Species | Nancy K MelloSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Antagonism of the antinociceptive and discriminative stimulus effects of heroin and morphine by 3-methoxynaltrexone and naltrexone in rhesus monkeysCarrie A Bowen
Alcohol and Drug Abuse Research Center, McLean Hospital-Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
J Pharmacol Exp Ther 302:264-73. 2002....
Effects of the selective delta opioid agonist SNC80 on cocaine- and food-maintained responding in rhesus monkeysGail Pereira Do Carmo
Alcohol and Drug Abuse Research Center, McLean Hospital - Harvard Medical School, Belmont, MA 02478, USA
Eur J Pharmacol 547:92-100. 2006..These findings indicate that SNC80 produced dose-dependent and non-selective reductions in cocaine self-administration. These results suggest that SNC80 is unlikely to be useful as a treatment for cocaine dependence...- The effects of cocaine on gonadal steroid hormones and LH in male and female rhesus monkeysNancy K Mello
Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, Belmont, MA, USA
Neuropsychopharmacology 29:2024-34. 2004..These rapid hormonal changes may contribute to cocaine's abuse-related effects, as well as to disruptions of the menstrual cycle during chronic cocaine administration... - Effects of estradiol on cocaine self-administration and cocaine discrimination by female rhesus monkeysNancy K Mello
Department of Psychiatry, Alcohol and Drug Abuse Research Center, Harvard Medical School McLean Hospital, Belmont, MA 02478, USA
Neuropsychopharmacology 33:783-95. 2008..Taken together, these data suggest that over the dose range studied, estradiol administration does not consistently alter the abuse-related effects of cocaine in female rhesus monkeys... - Sex and menstrual cycle effects on progressive ratio measures of cocaine self-administration in cynomolgus monkeysNancy K Mello
Alcohol and Drug Abuse Research Center, Harvard Medical School McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Neuropsychopharmacology 32:1956-66. 2007.... - Effects of the mixed mu/kappa opioid nalbuphine on cocaine-induced changes in subjective and cardiovascular responses in menNancy K Mello
Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
Neuropsychopharmacology 30:618-32. 2005..01-0.003). Thus, there were no additive interactions between nalbuphine and cocaine on cardiovascular, subjective, or drug level measures after acute administration... - Hormones, nicotine, and cocaine: clinical studiesNancy K Mello
McLean Hospital Harvard Medical School, Alcohol and Drug Abuse Research Center, 115 Mill Street, Belmont, MA 02478, USA
Horm Behav 58:57-71. 2010..Only DHEA increased consistently after successive cigarettes. The possible influence of neuroactive hormones on nicotine dependence and cocaine abuse and the implications for treatment of these addictive disorders are discussed... - Effects of d-amphetamine and buprenorphine combinations on speedball (cocaine+heroin) self-administration by rhesus monkeysNancy K Mello
Alcohol and Drug Abuse Research Center, Harvard Medical School McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Neuropsychopharmacology 32:1985-94. 2007..These findings are consistent with our previous reports and suggest that medication mixtures designed to target both the stimulant and the opioid component of the speedball may be an effective approach to polydrug abuse treatment... - Discriminative and reinforcing stimulus effects of nicotine, cocaine, and cocaine + nicotine combinations in rhesus monkeysNancy K Mello
Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Exp Clin Psychopharmacol 19:203-14. 2011..Further studies of the behavioral effects of nicotine + cocaine combinations will contribute to our understanding the pharmacology of dual nicotine and cocaine dependence, and will be useful for evaluation of new treatment medications... - Effects of the CRF1 antagonist antalarmin on cocaine self-administration and discrimination in rhesus monkeysNancy K Mello
Alcohol and Drug Abuse Research Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478 USA
Pharmacol Biochem Behav 85:744-51. 2006..Antalarmin (10 mg/kg) produced sedation, suggesting that it was centrally active, however, it did not attenuate cocaine's abuse-related effects in rhesus monkeys... - Effects of progesterone and testosterone on cocaine self-administration and cocaine discrimination by female rhesus monkeysNancy K Mello
Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
Neuropsychopharmacology 36:2187-99. 2011.... - Effects of low- and high-nicotine cigarette smoking on mood states and the HPA axis in menJack H Mendelson
Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
Neuropsychopharmacology 30:1751-63. 2005..These data suggest that activation of the HPA axis may contribute to the abuse-related effects of cigarette smoking... - Effects of smoking successive low- and high-nicotine cigarettes on hypothalamic-pituitary-adrenal axis hormones and mood in menJack H Mendelson
Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
Neuropsychopharmacology 33:749-60. 2008..Tolerance to the subjective and cardiovascular effects of nicotine developed rapidly during repeated cigarette smoking, but nicotine-stimulated increases in HPA axis hormones did not change significantly... - Opioid and cocaine combined effect on cocaine-induced changes in HPA and HPG axes hormones in menNathalie V Goletiani
Alcohol and Drug Abuse Research Center, Harvard Medical School and McLean Hospital, Belmont, MA 02478, USA
Pharmacol Biochem Behav 91:526-36. 2009..These data are consistent with our earlier report that nalbuphine modestly attenuated cocaine's positive subjective effects, and that the subjective and cardiovascular effects of cocaine+nalbuphine in combination were not additive... - Effects of nalbuphine on anterior pituitary and adrenal hormones and subjective responses in male cocaine abusersNathalie V Goletiani
Alcohol and Drug Abuse Research Center, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
Pharmacol Biochem Behav 86:667-77. 2007..Taken together, these data suggest that nalbuphine had both mu- and kappa-like effects on PRL (PRL increase) but did not increase ACTH and cortisol... - Ovarian steroid hormone modulation of the acute effects of cocaine on luteinizing hormone and prolactin levels in ovariectomized rhesus monkeysNancy K Mello
Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, Belmont, Massachusetts 02478, USA
J Pharmacol Exp Ther 308:156-67. 2004.... - Effects of intravenous cocaine and cigarette smoking on luteinizing hormone, testosterone, and prolactin in menJack H Mendelson
Alcohol and Drug Abuse Research Center, Harvard Medical School McLean Hospital, Belmont, MA 02478, USA
J Pharmacol Exp Ther 307:339-48. 2003..v. cocaine and high nicotine cigarette smoking illustrate the similarities between these drugs and suggest a possible contribution of LH to their abuse-related effects... - Effect of gonadectomy and gonadal hormone replacement on cocaine self-administration in female and male ratsS Barak Caine
McLean Hospital, Alcohol and Drug Abuse Research Center, Harvard Medical School, Belmont, MA 02478, USA
Neuropsychopharmacology 29:929-42. 2004..These findings suggest that the behavioral training history, the unit dose of cocaine, and the schedule of reinforcement are important variables in studies of sex and gonadal hormone effects on cocaine self-administration... - Kappa opioid antagonist effects of the novel kappa antagonist 5'-guanidinonaltrindole (GNTI) in an assay of schedule-controlled behavior in rhesus monkeysS Stevens Negus
Alcohol and Drug Abuse Research Center, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Psychopharmacology (Berl) 163:412-9. 2002..Receptor-selective antagonists are useful experimental tools for evaluation of opioid receptor-mediated processes. 5'-Guanidinonaltrindole (GNTI) was recently developed as a novel kappa-selective antagonist... - Effects of heroin and its metabolites on schedule-controlled responding and thermal nociception in rhesus monkeys: sensitivity to antagonism by quadazocine, naltrindole and beta-funaltrexamineS Stevens Negus
Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, 115 Mill St, Belmont, MA 02178, USA
Drug Alcohol Depend 70:17-27. 2003..The in vivo apparent efficacy of heroin at mu receptors was similar to or only slightly greater than that of morphine... - Effects of mu-opioid agonists on cocaine- and food-maintained responding and cocaine discrimination in rhesus monkeys: role of mu-agonist efficacyS Stevens Negus
Alcohol and Drug Abuse Research Center of McLean Hospital at Harvard Medical School, Belmont, Massachusetts 02178 9106, USA
J Pharmacol Exp Ther 300:1111-21. 2002..These results suggest that low-efficacy mu-agonists may decrease cocaine self-administration to a greater degree and with fewer undesirable effects than high-efficacy mu-agonists... - Effects of gonadal steroid hormone treatments on opioid antinociception in ovariectomized rhesus monkeysStevens S Negus
Alcohol and Drug Abuse Research Center, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Psychopharmacology (Berl) 159:275-83. 2002..Sex differences have also been observed in the antinociceptive effects of opioid agonists. These findings suggest that gonadal hormones may modulate opioid antinociception... - Effects of chronic d-amphetamine treatment on cocaine- and food-maintained responding under a progressive-ratio schedule in rhesus monkeysS Stevens Negus
Alcohol and Drug Abuse Research Center, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Psychopharmacology (Berl) 167:324-32. 2003..d-Amphetamine is a candidate agonist medication for the treatment of cocaine dependence, and evaluation of d-amphetamine effects on abuse-related effects of cocaine in preclinical assays is warranted... - Effects of gender and menstrual cycle phase on food-maintained responding under a progressive-ratio schedule in cynomolgus monkeysMegan E Roth
Alcohol and Drug Abuse Research Center, Department of Psychiatry, McLean Hospital/Harvard Medical School, Belmont, MA 02478, USA
Pharmacol Biochem Behav 82:735-43. 2005..Although fluctuations in ovarian steroid hormones may influence food consumption under some conditions, consistent patterns of food-maintained responding were not detected during ovulatory menstrual cycles in cynomolgus monkeys... - Effects of chronic d-amphetamine treatment on cocaine- and food-maintained responding under a second-order schedule in rhesus monkeysS Stevens Negus
Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Drug Alcohol Depend 70:39-52. 2003.... - Sex differences in thermal nociception and prostaglandin-induced thermal hypersensitivity in rhesus monkeysS Stevens Negus
Alcohol and Drug Abuse Research Center, Harvard Medical School McLean Hospital, Belmont, MA 02478, USA
J Pain 5:92-103. 2004.... - Diminished interleukin-6 response to proinflammatory challenge in men and women after intravenous cocaine administrationJohn H Halpern
Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
J Clin Endocrinol Metab 88:1188-93. 2003..Because cocaine stimulates the hypothalamic-pituitary-adrenal axis, IL-6 suppression may be a consequence of corticosteroid release. Cocaine-induced suppression of proinflammatory IL-6 may mediate impaired host defenses to infections... - Effect of GABA agonists and GABA-A receptor modulators on cocaine- and food-maintained responding and cocaine discrimination in ratsAndrew C Barrett
Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
J Pharmacol Exp Ther 315:858-71. 2005..Together with previous studies, these data suggest that among mechanistically diverse GABA agonists, high-efficacy GABA-A modulators may be the most effective for modifying the abuse-related effects of cocaine... - Effects of mixed-action kappa/mu opioids on cocaine self-administration and cocaine discrimination by rhesus monkeysCarrie A Bowen
Alcohol and Drug Abuse Research Center, McLean Hospital-Harvard Medical School, Belmont, MA 02478, USA
Neuropsychopharmacology 28:1125-39. 2003..Mixed kappa/mu agonists appear to offer some advantages over selective kappa agonists as potential treatments for cocaine abuse... - Hyponatremia in marathon runners due to inappropriate arginine vasopressin secretionArthur J Siegel
Department of Medicine, McLean Hospital, Belmont, Mass, USA
Am J Med 120:461.e11-7. 2007..Understanding the pathogenetic role of antidiuresis may lead to improved strategies for prevention and treatment... - Effects of the mixed-action kappa/mu opioid agonist 8-carboxamidocyclazocine on cocaine- and food-maintained responding in rhesus monkeysGlenn W Stevenson
Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Eur J Pharmacol 506:133-41. 2004..However, non-selective effects of 8-CAC on food-maintained responding and tolerance to 8-CAC effects on cocaine self-administration may limit its potential for the treatment of cocaine dependence... - Effects of chronic methadone treatment on cocaine- and food-maintained responding under second-order, progressive-ratio and concurrent-choice schedules in rhesus monkeysS Stevens Negus
Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478 9106, USA
Drug Alcohol Depend 74:297-309. 2004..These results provide little evidence to suggest that chronic methadone altered the reinforcing effects of cocaine; rather methadone appeared to non-selectively decrease rates of operant responding... - Behavioral evaluation of modafinil and the abuse-related effects of cocaine in rhesus monkeysJennifer L Newman
Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
Exp Clin Psychopharmacol 18:395-408. 2010..These data support clinical findings and indicate that these preclinical models may be useful for predicting the effectiveness of agonist medications for drug abuse treatment... - Temporal concordance of cocaine effects on mood states and neuroendocrine hormonesJack H Mendelson
Alcohol and Drug Abuse Research Center, McLean Hospital, Belmont, MA 02478, USA
Psychoneuroendocrinology 27:71-82. 2002..The similarities between these hormonal profiles, the subjective effects of cocaine and the effects of "stress" are discussed... - Role of dopamine D2-like receptors in cocaine self-administration: studies with D2 receptor mutant mice and novel D2 receptor antagonistsS Barak Caine
Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
J Neurosci 22:2977-88. 2002..Our results also suggest that D3 and D4 receptors do not play major roles in the modulation of cocaine self-administration by D2-like drugs... - Design and synthesis of novel dimeric morphinan ligands for kappa and micro opioid receptorsJohn L Neumeyer
Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, Massachusetts 02478, USA
J Med Chem 46:5162-70. 2003.... - Comparison of plasma cocaine levels during a "binge" pattern of cocaine administration in male and female rhesus monkeysNancy K Mello
McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Psychopharmacology (Berl) 164:19-26. 2002..Moreover, the extent to which gender may influence plasma cocaine levels during a cocaine binge has not been studied in rhesus monkeys... - The effects of heroin on prolactin levels in male rhesus monkeys: use of cumulative-dosing proceduresCarrie A Bowen
Alcohol and Drug Abuse Research Center, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Psychoneuroendocrinology 27:319-36. 2002..These data suggest that a cumulative-dosing procedure similar to that used in behavioral pharmacology may be useful to study the endocrine pharmacology of mu opioids in rhesus monkeys... - An inpatient study of the effects of buprenorphine on cigarette smoking in men concurrently dependent on cocaine and opioidsNicole H Mutschler
Alcohol and Drug Abuse Research Center, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Nicotine Tob Res 4:223-8. 2002..These findings are consistent with previous reports of opioid-cigarette interactions... - Brain alcohol detectability in human subjects with and without a paternal history of alcoholismTak-Ming Chiu
Alcohol and Drug Abuse Research Center, McLean Hospital/Harvard Medical School, 115 Mill Street, Belmont, Massachusetts 02478, USA
J Stud Alcohol 65:16-21. 2004..Differences in the Subjective High Assessment Scale ratings between the two groups, however, indicate the importance of a genetic influence on the subjective response to alcohol... 
Modification of cocaine self-administration by buspirone (buspar®): potential involvement of D3 and D4 dopamine receptorsJack Bergman
Harvard Medical School McLean Hospital, Alcohol and Drug Abuse Research Center, Belmont, MA, USA
Int J Neuropsychopharmacol 16:445-58. 2013..v. cocaine in each subject. These results support the further evaluation of buspirone as a candidate medication for the management of cocaine addiction...- Effects of chronic buspirone treatment on cocaine self-administrationNancy K Mello
Alcohol and Drug Abuse Research Center, Harvard Medical School McLean Hospital, Belmont, MA 02478, USA
Neuropsychopharmacology 38:455-67. 2013..These findings indicate that buspirone selectively attenuates the reinforcing effects of cocaine in a nonhuman primate model of cocaine self-administration, and has variable effects on cocaine discrimination... - Relationship between rate of drug uptake in brain and behavioral pharmacology of monoamine transporter inhibitors in rhesus monkeysHeather L Kimmel
Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA
Pharmacol Biochem Behav 90:453-62. 2008..Collectively, these results indicate that the rate of drug entry in brain can play an important role in the behavioral pharmacology of psychomotor stimulants... - Effects of kappa opioid agonists alone and in combination with cocaine on heart rate and blood pressure in conscious squirrel monkeysCharles W Schindler
Preclinical Pharmacology Section, Behavioral Neuroscience Branch, DHHS NIH NIDA Intramural Research Program, Baltimore MD CWS, ZG, JPG, SRG, United States
Eur J Pharmacol 576:107-13. 2007..When given in combination with cocaine, EKC produced effects that were sub-additive, suggesting that the kappa agonists may be used safely as cocaine abuse treatments... - Development of a rationally designed, low abuse potential, biogenic amine releaser that suppresses cocaine self-administrationRichard B Rothman
Clinical Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
J Pharmacol Exp Ther 313:1361-9. 2005..0 mg/kg/h. Collectively, the findings reported here demonstrate that nonamphetamine monoamine releasing agents such as PAL-287 might be promising candidate medications for the treatment of stimulant dependence... - Kappa-opioid receptors are differentially labeled by arylacetamides and benzomorphansDaniela E Rusovici
Department of Pharmacology and Physiology, School of Medicine and Dentistry, University of Rochester, P.O. Box 711, 601 Elmwood Avenue, Rochester, NY 14642-8711, USA
Eur J Pharmacol 485:119-25. 2004..These results suggest that pharmacologically defined 1 kappa-opioid receptor subtypes may be different affinity states of the same receptor...
Research Grants
- BUPRENORPHINE: A BEHAVIORAL ANALYSISNANCY MELLO; Fiscal Year: 2005..This comprehensive evaluation of the effects of novel mu, kappa and delta selective opioids on cocaine's abuse-related effects should suggest new approaches to cocaine abuse treatment. ..
- Cocaine Abuse and the Role of Gonadal Steroid HormonesNANCY MELLO; Fiscal Year: 2005..Data obtained will help to clarify the neurobiologic substrates of cocaine abuse and may have heuristic implications for the development of new strategies for treatment. ..
- BIOBEHAVIORAL STUDIES OF SUBSTANCE ABUSENANCY MELLO; Fiscal Year: 2007..abstract_text> ..
- Sex/Gender and Nicotine Addiction: Hormones, Behavior and NeuroimagingPERRY FRANKLIN RENSHAW; Fiscal Year: 2010..We propose to study how sex and phase of the menstrual cycle may influence the hormonal, neuroimaging and abuse-related effects of nicotine (the main addictive component of tobacco) in nicotine- dependent men and women. ..
- BUPRENORPHINE: A BEHAVIORAL ANALYSISNancy K Mello; Fiscal Year: 2010....
- Sex/Gender Factors in Nicotine AddictionNancy K Mello; Fiscal Year: 2010....
- BUPRENORPHINE--A BEHAVIORAL ANALYSISNANCY MELLO; Fiscal Year: 1993..These studies should contribute to the understanding of the biological and behavioral bases of buprenorphine-cocaine interactions and suggest new directions for development of improved pharmacotherapies...
- BUPRENORPHINE--A BEHAVIORAL ANALYSISNANCY MELLO; Fiscal Year: 1992....
- Preclinical Evaluation of Medications to Treat Polydrug AddictionNancy K Mello; Fiscal Year: 2010..This strategy will facilitate translation of the most effective treatment medications into clinical trials. ..