Matthew B McQueen

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc A QTL genome scan of the metabolic syndrome and its component traits
    Matthew B McQueen
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    BMC Genet 4:S96. 2003
  2. pmc Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q
    Matthew B McQueen
    Harvard School of Public Health, Department of Epidemiology, Boston, MA 02115, USA
    Am J Hum Genet 77:582-95. 2005
  3. pmc Comparison of linkage and association strategies for quantitative traits using the COGA dataset
    Matthew B McQueen
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    BMC Genet 6:S96. 2005
  4. pmc Variance calculations for identity-by-descent estimation
    Matthew B McQueen
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Hum Genet 78:914-21. 2006
  5. pmc An omnibus test for family-based association studies with multiple SNPs and multiple phenotypes
    Jessica Lasky-Su
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
    Eur J Hum Genet 18:720-5. 2010
  6. pmc Genomic screening in family-based association testing
    Amy Murphy
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    BMC Genet 6:S115. 2005
  7. doi request reprint Linkage disequilibrium mapping of the chromosome 6q21-22.31 bipolar I disorder susceptibility locus
    Jinbo Fan
    Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Boston, Massachusetts, USA
    Am J Med Genet B Neuropsychiatr Genet 153:29-37. 2010
  8. pmc Genomewide weighted hypothesis testing in family-based association studies, with an application to a 100K scan
    Iuliana Ionita-Laza
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Hum Genet 81:607-14. 2007
  9. ncbi request reprint Genomic screening and replication using the same data set in family-based association testing
    Kristel Van Steen
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nat Genet 37:683-91. 2005
  10. ncbi request reprint A common genetic variant is associated with adult and childhood obesity
    Alan Herbert
    Department of Genetics and Genomics, Boston University Medical School, E613, 715 Albany Street, Boston, MA 02118, USA
    Science 312:279-83. 2006

Detail Information

Publications20

  1. pmc A QTL genome scan of the metabolic syndrome and its component traits
    Matthew B McQueen
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    BMC Genet 4:S96. 2003
    ..We used genotype and phenotype data from the Framingham Heart Study to perform a full-genome scan for quantitative trait loci underlying the metabolic syndrome...
  2. pmc Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q
    Matthew B McQueen
    Harvard School of Public Health, Department of Epidemiology, Boston, MA 02115, USA
    Am J Hum Genet 77:582-95. 2005
    ..Our results establish genomewide significant linkage to BP on chromosomes 6q and 8q, which provides solid information to guide future gene-finding efforts that rely on fine-mapping and association approaches...
  3. pmc Comparison of linkage and association strategies for quantitative traits using the COGA dataset
    Matthew B McQueen
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    BMC Genet 6:S96. 2005
    ..We compare the results from the PBAT analysis to that of quantitative linkage analysis on chromosome 4 using the Collaborative Study on the Genetics of Alcoholism data, as released through Genetic Analysis Workshop 14...
  4. pmc Variance calculations for identity-by-descent estimation
    Matthew B McQueen
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Hum Genet 78:914-21. 2006
    ..Mean IBD and its standard errors are valuable tools for the further assessment and evaluation of linkage-scan samples involving complex disease...
  5. pmc An omnibus test for family-based association studies with multiple SNPs and multiple phenotypes
    Jessica Lasky-Su
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
    Eur J Hum Genet 18:720-5. 2010
    ..This program is available in the PBAT analysis package...
  6. pmc Genomic screening in family-based association testing
    Amy Murphy
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    BMC Genet 6:S115. 2005
    ..004) and ttth1-ttth4 (p = 0.004) phenotype(s). We find that both univariate- and multivariate-based screening techniques are powerful tools for detecting an association...
  7. doi request reprint Linkage disequilibrium mapping of the chromosome 6q21-22.31 bipolar I disorder susceptibility locus
    Jinbo Fan
    Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Boston, Massachusetts, USA
    Am J Med Genet B Neuropsychiatr Genet 153:29-37. 2010
    ..Further studies in larger samples are warranted to clarify which, if any, genes in the 6q region confer risk for bipolar disorder...
  8. pmc Genomewide weighted hypothesis testing in family-based association studies, with an application to a 100K scan
    Iuliana Ionita-Laza
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Hum Genet 81:607-14. 2007
    ..The proposed method is of general applicability; it extends to any setting in which prior, independent ranking of hypotheses is available...
  9. ncbi request reprint Genomic screening and replication using the same data set in family-based association testing
    Kristel Van Steen
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nat Genet 37:683-91. 2005
    ..Our methods use the entire sample and do not require separate screening and validation samples to establish genome-wide significance, as population-based designs do...
  10. ncbi request reprint A common genetic variant is associated with adult and childhood obesity
    Alan Herbert
    Department of Genetics and Genomics, Boston University Medical School, E613, 715 Albany Street, Boston, MA 02118, USA
    Science 312:279-83. 2006
    ..The obesity-predisposing genotype is present in 10% of individuals. Our study suggests that common genetic polymorphisms are important determinants of obesity...
  11. ncbi request reprint Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database
    Lars Bertram
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease MIND, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Nat Genet 39:17-23. 2007
    ..67 for protective alleles). Our database provides a powerful tool for deciphering the genetics of Alzheimer disease, and it serves as a potential model for tracking the most viable gene candidates in other genetically complex diseases...
  12. ncbi request reprint The LDLR locus in Alzheimer's disease: a family-based study and meta-analysis of case-control data
    Lars Bertram
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Neurobiol Aging 28:18.e1-4. 2007
    ..Based on our data, it seems unlikely that these genetic variants in LDLR make a significant contribution to AD risk in the general population...
  13. pmc The association between blood pressure and incident Alzheimer disease: a systematic review and meta-analysis
    Melinda C Power
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02215, USA
    Epidemiology 22:646-59. 2011
    ..Many epidemiologic studies have considered the association between blood pressure (BP) and Alzheimer disease, yet the relationship remains poorly understood...
  14. ncbi request reprint The neuronal nicotinic receptor subunit genes (CHRNA6 and CHRNB3) are associated with subjective responses to tobacco
    Joanna S Zeiger
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309, USA
    Hum Mol Genet 17:724-34. 2008
    ..These results indicate that early subjective response to nicotine may be a valuable endophenotype for genetic studies aimed at uncovering genes contributing to nicotine use and addiction...
  15. pmc The CHRNA5/A3/B4 gene cluster variability as an important determinant of early alcohol and tobacco initiation in young adults
    Isabel R Schlaepfer
    Institute for Behavioral Genetics, Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA
    Biol Psychiatry 63:1039-46. 2008
    ..Significant results were then replicated in a separate adult population-representative sample...
  16. pmc Association of candidate genes with antisocial drug dependence in adolescents
    Robin P Corley
    Institute for Behavioral Genetics, University of Colorado, 447 UCB, Boulder, CO 80309, USA
    Drug Alcohol Depend 96:90-8. 2008
    ..The custom-designed SNP chip served as an effective and flexible platform for rapid interrogation of a large number of plausible candidate genes...
  17. doi request reprint Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database
    Nicole C Allen
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Nat Genet 40:827-34. 2008
    ..As such, it could serve as a model for field synopses of genetic associations in other common and genetically complex disorders...
  18. ncbi request reprint On the parsing of statistical information in family-based association testing
    Matthew B McQueen
    Nat Genet 39:281-2. 2007
  19. ncbi request reprint Exploring candidate gene associations with neuropsychological performance
    Matthew B McQueen
    Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, Colorado 80309 0447, USA
    Am J Med Genet B Neuropsychiatr Genet 144:987-91. 2007
    ....
  20. pmc Evaluation of the potential excess of statistically significant findings in published genetic association studies: application to Alzheimer's disease
    Fotini K Kavvoura
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Am J Epidemiol 168:855-65. 2008
    ..The excess was seen for all levels of statistical significance and also for studies with borderline P values (P = 0.05-0.10). The excess of significant findings may represent significance-chasing biases in a setting of massive testing...